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BPIFA1 - BPI fold containing family A member 1 Gene

Also Known as LUNX; NASG; PLUNC; SPURT; SPLUNC1; bA49G10.5

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 51297

About BPIFA1

Cytogenetic location: 20q11.21 Genomic coordinates (GRCh38): 20:33,235,996-33,243,306 (from NCBI)

This gene has 4 transcripts (splice variants), 113 orthologues and 12 paralogues. Biased expression in lung (RPKM 1.2), urinary bladder (RPKM 0.9) and 2 other tissues.

Summary

This gene is the human homolog of murine plunc, and like the mouse gene, is specifically expressed in the upper airways and nasopharyngeal regions. The encoded antimicrobial protein displays Antibacterial activity against Gram-negative bacteria. It is thought to be involved in inflammatory responses to irritants in the upper airways and may also serve as a potential molecular marker for detection of micrometastasis in non-small-cell lung Cancer. Multiple transcript variants resulting from alternative splicing in the 3' UTR have been detected, but the full-length nature of only three are known. [provided by RefSeq, Aug 2014]

BPIFA1 Products (3)

mRNA	Protein	Name
NM_001243193.2	NP_001230122.1	BPI fold-containing family A member 1 precursor
NM_016583.4	NP_057667.1	BPI fold-containing family A member 1 precursor
NM_130852.3	NP_570913.1	BPI fold-containing family A member 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in antibacterial humoral response	IDA IDA: Inferred from direct assay	23499554	GOA
involved in antimicrobial humoral immune response mediated by antimicrobial peptide	IEP IEP: Inferred from expression pattern	21805676	GOA
involved in defense response to virus	IEP IEP: Inferred from expression pattern	21805676	GOA
involved in immune response in nasopharyngeal-associated lymphoid tissue	IEP IEP: Inferred from expression pattern	21805676	GOA
involved in innate immune response	IDA IDA: Inferred from direct assay	23499554	GOA
involved in multicellular organismal-level water homeostasis	IDA IDA: Inferred from direct assay	24124190	GOA
involved in negative regulation of single-species biofilm formation in or on host organism	IMP IMP: Inferred from mutant phenotype	23499554	GOA
involved in regulation of sodium ion transmembrane transport	IDA IDA: Inferred from direct assay	24124190	GOA
involved in surfactant homeostasis	IDA IDA: Inferred from direct assay	23499554	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in extracellular region	IDA IDA: Inferred from direct assay	11425234	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	21805676	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BPIFA1 Protein Structure

LBP_BPI_CETP

0
100
200
256 a.a.

Protein Preferred Names	Protein Names
BPI fold-containing family A member 1	ligand-binding protein RYA3

BPIFA1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	BPIFA1	Q9NP55	UBQLN1	Homo sapiens	Q9UMX0-2	Y2H Array	25416956
Intra	BPIFA1	Q9NP55	TCF7L2	Homo sapiens	Q9NQB0-10	Validated Y2H	32296183
Intra	BPIFA1	Q9NP55	INIP	Homo sapiens	Q9NRY2	Validated Y2H	32296183
Intra	BPIFA1	Q9NP55	MTIF3	Homo sapiens	Q9H2K0	Y2H Array	32296183
Intra	BPIFA1	Q9NP55	MTIF3	Homo sapiens	Q9H2K0	Y2H Prey Pooling	32296183
Intra	BPIFA1	Q9NP55	PEF1	Homo sapiens	Q9UBV8	Validated Y2H	32296183
Intra	BPIFA1	Q9NP55	UBQLN1	Homo sapiens	Q9UMX0	Y2H Array	32296183
Intra	BPIFA1	Q9NP55	UBQLN1	Homo sapiens	Q9UMX0	Y2H Prey Pooling	32296183
Intra	BPIFA1	Q9NP55	UBQLN1	Homo sapiens	Q9UMX0	Validated Y2H	32296183
Intra	BPIFA1	Q9NP55	RSPH14	Homo sapiens	Q9UHP6	Validated Y2H	32296183
Intra	BPIFA1	Q9NP55	ALKBH4	Homo sapiens	Q9NXW9	Validated Y2H	32296183
Intra	BPIFA1	Q9NP55	UBQLN2	Homo sapiens	Q9UHD9	Y2H Prey Pooling	32296183
Intra	BPIFA1	Q9NP55	UBQLN2	Homo sapiens	Q9UHD9	Validated Y2H	32296183
Intra	BPIFA1	Q9NP55	UBQLN2	Homo sapiens	Q9UHD9	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant BPIFA1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P700957	BPIFA1 Protein, Human	Q9NP55-1 (Q20-V256)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Nasopharyngeal Carcinoma	Malignant Neoplasm Of Nasopharynx Npc Nasopharyngeal Cancer Nasopharyngeal Carcinoma 1 Nasopharynx Carcinoma Nasopharyngeal Neoplasms Npca Carcinoma Of Nasopharynx Malignant Nasopharyngeal Tumor Nasopharynx Cancer Squamous Cell Carcinoma Of The Nasopharynx Nasopharyngeal Neoplasm Cancer Of Nasopharynx
Adenoiditis	Chronic Adenoiditis
Eye Disease	Eye Diseases Abnormality Of The Eye Toxoplasma Oculopathy
Chronic Purulent Otitis Media	Chronic Suppurative Otitis Media Csom - [Chronic Suppurative Otitis Media]
Suppurative Otitis Media	Otitis Media With Effusion - Purulent Purulent Otitis Media Otitis Media, Suppurative
Hepatoid Adenocarcinoma
Papillary Cystadenocarcinoma	Cystadenocarcinoma, Papillary
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Lung Disease	Lung Diseases Disorder Of Lung Abnormality Of The Lung
Cystic Fibrosis	Mucoviscidosis CF Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis Cystic Fibrosis Lung Disease, Modifier Of Cystic Fibrosis Of Pancreas Fibrocystic Disease Of Pancreas Cf - [Cystic Fibrosis] Cystic Fibrosis Nos Fibrocystic Disease Fibrocystic Disease Of The Pancreas Mucoviscidosis Of Pancreas Nonproliferative Fibrocystic Disease Pancreatic Cystic Fibrosis
Primary Ciliary Dyskinesia	Immotile Cilia Syndrome Kartagener Syndrome Dextrocardia Bronchiectasis And Sinusitis Pcd Ciliary Motility Disorders Ciliary Motility Disorder Immotile Ciliary Syndrome Ciliary Dyskinesia Primary Ics Polynesian Bronchiectasis Dextrocardia-Bronchiectasis-Sinusitis Syndrome Immotile Cilia Syndrome, Kartagener Type Primary Ciliary Dyskinesia And Situs Inversus Primary Ciliary Dyskinesia, Kartagener Type Siewert Syndrome Dyskinesia, Ciliary, Primary

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01581	BPIFA1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	BPIFA1	VGNC	VGNC:70317
Canis familiaris	BPIFA1	VGNC	VGNC:38504
Felis catus	BPIFA1	VGNC	VGNC:60153
Rattus norvegicus	BPIFA1	RGD	RGD:619818
Mus musculus	BPIFA1	MGD	MGI:1338036
Bos taurus	BPIFA1	VGNC	VGNC:26543
Others	BPIFA1	NCBI