ALKBH4 - alkB homolog 4, lysine demethylase Gene

Also Known as ABH4

Species: Homo sapiens (human)

Gene Type: protein coding
Gene ID: 54784

Summary

Enables 2-oxoglutarate-dependent dioxygenase activity and actin binding activity. Involved in actomyosin structure organization; cleavage furrow ingression; and protein demethylation. Located in contractile ring and midbody. [provided by Alliance of Genome Resources, Apr 2022]

ALKBH4 Products (1)

mRNA Protein Name
NM_017621.4 NP_060091.1 alpha-ketoglutarate-dependent dioxygenase alkB homolog 4

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables 2-oxoglutarate-dependent dioxygenase activity IDA
IDA: Inferred from direct assay
21166655 GOA
enables actin binding IDA
IDA: Inferred from direct assay
23673617 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
21516116 GOA
Biological Process GO Annotation Evidence References Source
involved in actomyosin structure organization IMP
IMP: Inferred from mutant phenotype
23673617 GOA
involved in cleavage furrow ingression IMP
IMP: Inferred from mutant phenotype
23673617 GOA
Cellular Component GO Annotation Evidence References Source
located in contractile ring IDA
IDA: Inferred from direct assay
23673617 GOA
located in midbody IDA
IDA: Inferred from direct assay
23673617 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

alpha-ketoglutarate-dependent dioxygenase alkB homolog 4

  • DNA N6-methyl adenine demethylase ALKBH4

  • alkB homolog 4, lysine demthylase

  • alkB, alkylation repair homolog 4

  • alkylated DNA repair protein alkB homolog 4

  • lysine-specific demethylase ALKBH4

  • probable alpha-ketoglutarate-dependent dioxygenase ABH4

ALKBH4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ALKBH4 Q9NXW9 TXNL4B Homo sapiens Q9NX01
Y2H Array
32296183
Intra
ALKBH4 Q9NXW9 TXNL4B Homo sapiens Q9NX01
Y2H Prey Pooling
32296183
Intra
ALKBH4 Q9NXW9 LCN2 Homo sapiens P80188
Y2H Array
32296183
Intra
ALKBH4 Q9NXW9 LCN2 Homo sapiens P80188
Y2H Prey Pooling
32296183
Intra
ALKBH4 Q9NXW9 FAM168A Homo sapiens Q92567-2
Y2H Array
32296183
Intra
ALKBH4 Q9NXW9 FAM168A Homo sapiens Q92567-2
Y2H Prey Pooling
32296183
Intra
ALKBH4 Q9NXW9 TCF4 Homo sapiens P15884-3
Y2H Prey Pooling
32296183
Intra
ALKBH4 Q9NXW9 TCF4 Homo sapiens P15884-3
Y2H Array
32296183
Intra
ALKBH4 Q9NXW9 MLLT3 Homo sapiens P42568
Y2H Array
32296183
Intra
ALKBH4 Q9NXW9 MLLT3 Homo sapiens P42568
Y2H Prey Pooling
32296183
Intra
ALKBH4 Q9NXW9 MLLT3 Homo sapiens P42568
Confocal
23145062
Intra
ALKBH4 Q9NXW9 GORASP2 Homo sapiens Q9H8Y8
Y2H Prey Pooling
32296183
Intra
ALKBH4 Q9NXW9 GORASP2 Homo sapiens Q9H8Y8
Y2H Array
32296183
Intra
ALKBH4 Q9NXW9 DTX2 Homo sapiens Q86UW9
Y2H Array
25416956
Intra
ALKBH4 Q9NXW9 DTX2 Homo sapiens Q86UW9
Y2H Array
32296183
Intra
ALKBH4 Q9NXW9 DTX2 Homo sapiens Q86UW9
Y2H Prey Pooling
25416956
Intra
ALKBH4 Q9NXW9 DTX2 Homo sapiens Q86UW9
Validated Y2H
25416956
Intra
ALKBH4 Q9NXW9 DTX2 Homo sapiens Q86UW9
Y2H Prey Pooling
32296183
Intra
ALKBH4 Q9NXW9 NIF3L1 Homo sapiens Q9GZT8
Y2H Array
32296183
Intra
ALKBH4 Q9NXW9 NIF3L1 Homo sapiens Q9GZT8
Y2H Prey Pooling
32296183
Intra
ALKBH4 Q9NXW9 BPIFA1 Homo sapiens Q9NP55
Y2H Prey Pooling
32296183
Intra
ALKBH4 Q9NXW9 BPIFA1 Homo sapiens Q9NP55
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

ALKBH4 Antibodies

Cat. No. 상품명 신청 Reactivity
HY-P82305 ALKBH4 Antibody (YA2050) WB, IP Human
HY-P82305A ALKBH4 Antibody (YA2050)(PBS only) WB, IP Human