SMYD1 - SET and MYND domain containing 1 Gene

Also Known as BOP; KMT3D; ZMYND18; ZMYND22

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 150572

About SMYD1

Cytogenetic location: 2p11.2 Genomic coordinates (GRCh38): 2:88,067,825-88,113,384 (from NCBI)

This gene has 4 transcripts (splice variants), 287 orthologues and 5 paralogues. Restricted expression toward heart (RPKM 63.9).

Summary

Predicted to enable histone-lysine N-methyltransferase activity. Involved in positive regulation of myoblast differentiation and positive regulation of myotube differentiation. Predicted to be located in cytoplasm. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

SMYD1 Products (2)

mRNA Protein Name
NM_001330364.2 NP_001317293.1 histone-lysine N-methyltransferase SMYD1 isoform 2
NM_198274.4 NP_938015.1 histone-lysine N-methyltransferase SMYD1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
23455924 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of myoblast differentiation IDA
IDA: Inferred from direct assay
19783823 GOA
involved in positive regulation of myotube differentiation IDA
IDA: Inferred from direct assay
19783823 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SMYD1 Protein Structure

SET

SET: SET domain (18 - 252)

zf-MYND

zf-MYND: MYND finger (52 - 90)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 490 a.a.
Protein Preferred Names Protein Names

histone-lysine N-methyltransferase SMYD1

  • CD8 beta opposite

SMYD1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SMYD1 Q8NB12 HOMEZ Homo sapiens Q8IX15-3
Validated Y2H
25416956
Intra
SMYD1 Q8NB12 DVL1 Homo sapiens Q86TH3
Y2H Prey Pooling
32296183
Intra
SMYD1 Q8NB12 DVL1 Homo sapiens Q86TH3
Y2H Array
32296183
Intra
SMYD1 Q8NB12 SNX11 Homo sapiens Q9Y5W9
Y2H Prey Pooling
32296183
Intra
SMYD1 Q8NB12 SNX11 Homo sapiens Q9Y5W9
Validated Y2H
32296183
Intra
SMYD1 Q8NB12 SNX11 Homo sapiens Q9Y5W9
Y2H Array
32296183
Intra
SMYD1 Q8NB12 ADSS2 Homo sapiens P30520
TAP
24981860
Intra
SMYD1 Q8NB12 ADSS2 Homo sapiens P30520
Anti Tag CoIP
33961781
Intra
SMYD1 Q8NB12 ADSS2 Homo sapiens P30520
Anti Tag CoIP
28514442
Intra
SMYD1 Q8NB12 KRT35 Homo sapiens Q92764
Validated Y2H
32296183
Intra
SMYD1 Q8NB12 KRT35 Homo sapiens Q92764
Y2H Array
32296183
Intra
SMYD1 Q8NB12 KRT35 Homo sapiens Q92764
Y2H Prey Pooling
32296183
Intra
SMYD1 Q8NB12 KIF16B Homo sapiens Q96L93-6
Y2H Prey Pooling
32296183
Intra
SMYD1 Q8NB12 KIF16B Homo sapiens Q96L93-6
Y2H Array
32296183
Intra
SMYD1 Q8NB12 KIF16B Homo sapiens Q96L93-6
Validated Y2H
32296183
Intra
SMYD1 Q8NB12 PATZ1 Homo sapiens Q9HBE1-4
Y2H Prey Pooling
32296183
Intra
SMYD1 Q8NB12 PATZ1 Homo sapiens Q9HBE1-4
Validated Y2H
32296183
Intra
SMYD1 Q8NB12 PATZ1 Homo sapiens Q9HBE1-4
Y2H Array
32296183
Intra
SMYD1 Q8NB12 SPAG8 Homo sapiens Q99932-2
Validated Y2H
32296183
Intra
SMYD1 Q8NB12 SPAG8 Homo sapiens Q99932-2
Y2H Array
32296183
Intra
SMYD1 Q8NB12 SPAG8 Homo sapiens Q99932-2
Y2H Prey Pooling
32296183
Intra
SMYD1 Q8NB12 USP54 Homo sapiens Q70EL1-9
Y2H Array
32296183
Intra
SMYD1 Q8NB12 USP54 Homo sapiens Q70EL1-9
Y2H Prey Pooling
32296183
Intra
SMYD1 Q8NB12 DISC1 Homo sapiens Q9NRI5-2
Validated Y2H
32296183
Intra
SMYD1 Q8NB12 DISC1 Homo sapiens Q9NRI5-2
Y2H Array
32296183
Intra
SMYD1 Q8NB12 DISC1 Homo sapiens Q9NRI5-2
Y2H Prey Pooling
32296183
Intra
SMYD1 Q8NB12 POU6F2 Homo sapiens P78424
Y2H Array
32296183
Intra
SMYD1 Q8NB12 POU6F2 Homo sapiens P78424
Y2H Prey Pooling
32296183
Intra
SMYD1 Q8NB12 RSPH6A Homo sapiens Q9H0K4
Y2H Array
32296183
Intra
SMYD1 Q8NB12 RSPH6A Homo sapiens Q9H0K4
Y2H Prey Pooling
32296183
Intra
SMYD1 Q8NB12 RSPH6A Homo sapiens Q9H0K4
Validated Y2H
32296183
Intra
SMYD1 Q8NB12 CIMIP2A Homo sapiens Q6J272
Y2H Prey Pooling
32296183
Intra
SMYD1 Q8NB12 CIMIP2A Homo sapiens Q6J272
Y2H Array
32296183
Intra
SMYD1 Q8NB12 MYH7B Homo sapiens A7E2Y1-2
Y2H Array
32296183
Intra
SMYD1 Q8NB12 MYH7B Homo sapiens A7E2Y1-2
Y2H Prey Pooling
32296183
Intra
SMYD1 Q8NB12 FAM86C1P Homo sapiens Q9NVL1-2
Y2H Prey Pooling
32296183
Intra
SMYD1 Q8NB12 FAM86C1P Homo sapiens Q9NVL1-2
Validated Y2H
32296183
Intra
SMYD1 Q8NB12 FAM86C1P Homo sapiens Q9NVL1-2
Y2H Array
32296183
Intra
SMYD1 Q8NB12 FAM83A Homo sapiens Q86UY5
Y2H Prey Pooling
32296183
Intra
SMYD1 Q8NB12 FAM83A Homo sapiens Q86UY5
Y2H Array
32296183
Intra
SMYD1 Q8NB12 BACH2 Homo sapiens Q9BYV9
Y2H Prey Pooling
32296183
Intra
SMYD1 Q8NB12 BACH2 Homo sapiens Q9BYV9
Validated Y2H
32296183
Intra
SMYD1 Q8NB12 BACH2 Homo sapiens Q9BYV9
Y2H Array
32296183
Intra
SMYD1 Q8NB12 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra
SMYD1 Q8NB12 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra
SMYD1 Q8NB12 TBRG1 Homo sapiens Q3YBR2
Y2H Prey Pooling
32296183
Intra
SMYD1 Q8NB12 TBRG1 Homo sapiens Q3YBR2
Y2H Array
32296183
Intra
SMYD1 Q8NB12 MYH7B Homo sapiens A7E2Y1
Y2H
23455924
Intra
SMYD1 Q8NB12 UTP14A Homo sapiens Q9BVJ6
Validated Y2H
32296183
Intra
SMYD1 Q8NB12 UTP14A Homo sapiens Q9BVJ6
Y2H Array
32296183
Intra
SMYD1 Q8NB12 UTP14A Homo sapiens Q9BVJ6
Y2H Prey Pooling
32296183
Intra
SMYD1 Q8NB12 NEFL Homo sapiens P07196
Y2H Array
32296183
Intra
SMYD1 Q8NB12 NEFL Homo sapiens P07196
Y2H Prey Pooling
32296183
Intra
SMYD1 Q8NB12 ZBTB44 Homo sapiens Q8NCP5
Validated Y2H
25416956
Intra
SMYD1 Q8NB12 ZBTB44 Homo sapiens Q8NCP5
Y2H Prey Pooling
25416956
Intra
SMYD1 Q8NB12 RUSC1 Homo sapiens Q9BVN2
Y2H Prey Pooling
32296183
Intra
SMYD1 Q8NB12 RUSC1 Homo sapiens Q9BVN2
Validated Y2H
32296183
Intra
SMYD1 Q8NB12 RUSC1 Homo sapiens Q9BVN2
Y2H Array
32296183
Intra
SMYD1 Q8NB12 BHLHE40 Homo sapiens O14503
Y2H Prey Pooling
32296183
Intra
SMYD1 Q8NB12 BHLHE40 Homo sapiens O14503
Y2H Array
32296183
Intra
SMYD1 Q8NB12 CFAP68 Homo sapiens Q9H5F2
Validated Y2H
32296183
Intra
SMYD1 Q8NB12 CFAP68 Homo sapiens Q9H5F2
Y2H Array
32296183
Intra
SMYD1 Q8NB12 CFAP68 Homo sapiens Q9H5F2
Y2H Prey Pooling
32296183
Intra
SMYD1 Q8NB12 ZBTB3 Homo sapiens Q9H5J0
Validated Y2H
32296183
Intra
SMYD1 Q8NB12 ZBTB3 Homo sapiens Q9H5J0
Y2H Array
32296183
Intra
SMYD1 Q8NB12 ZBTB3 Homo sapiens Q9H5J0
Y2H Prey Pooling
32296183
Intra
SMYD1 Q8NB12 MDFI Homo sapiens Q99750
Validated Y2H
32296183
Intra
SMYD1 Q8NB12 MDFI Homo sapiens Q99750
Y2H Array
32296183
Intra
SMYD1 Q8NB12 MDFI Homo sapiens Q99750
Y2H Prey Pooling
32296183
Intra
SMYD1 Q8NB12 HMG20A Homo sapiens Q9NP66
Y2H Prey Pooling
32296183
Intra
SMYD1 Q8NB12 HMG20A Homo sapiens Q9NP66
Y2H Array
32296183
Intra
SMYD1 Q8NB12 HMG20A Homo sapiens Q9NP66
Validated Y2H
32296183
Intra
SMYD1 Q8NB12 HDHD3 Homo sapiens Q9BSH5
Y2H Prey Pooling
32296183
Intra
SMYD1 Q8NB12 HDHD3 Homo sapiens Q9BSH5
Validated Y2H
32296183
Intra
SMYD1 Q8NB12 HDHD3 Homo sapiens Q9BSH5
Y2H Array
32296183
Intra
SMYD1 Q8NB12 FAM204A Homo sapiens Q9H8W3
Validated Y2H
32296183
Intra
SMYD1 Q8NB12 FAM204A Homo sapiens Q9H8W3
Y2H Prey Pooling
32296183
Intra
SMYD1 Q8NB12 FAM204A Homo sapiens Q9H8W3
Y2H Array
32296183
Intra
SMYD1 Q8NB12 ARID5A Homo sapiens Q03989
Y2H Array
32296183
Intra
SMYD1 Q8NB12 ARID5A Homo sapiens Q03989
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

SMYD1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P80895 SMYD1 Antibody (YA672) WB Rat
HY-P80895A SMYD1 Antibody (YA672)(PBS only) WB Rat
HY-P85501 SMYD1 Antibody (YA5193) WB Rat

Related Diseases

Diseases Alias
Distal Muscular Dystrophy With Anterior Tibial Onset

  • Dmat
Epiphyseal Dysplasia, Multiple, 1

  • EDM1

  • Multiple Epiphyseal Dysplasia 1

  • Multiple Epiphyseal Dysplasia Type 1

  • Med1

  • Multiple Epiphyseal Dysplasia Comp-Related

  • Polyepiphyseal Dysplasia Type 1

  • Multiple Epiphyseal Dysplasia, Comp-Related

  • Epiphyseal Dysplasia Multiple 1

  • Epiphyseal Dysplasia, Multiple 1

  • Dysplasia, Epiphyseal, Multiple, Type 1
Tetralogy Of Fallot

  • TOF

  • Fallot Tetralogy

  • Ventricular Septal Defect With Pulmonary Stenosis Or Atresia, Dextraposition Of Aorta, And Hypertrophy Of Right Ventricle

  • Tetrad Of Fallot

  • Fallot Tetrad

  • Fallot Disease

  • Fallot Complex

  • Subpulmonic Stenosis, Ventricular Septal Defect, Overriding Aorta, And Right Ventricular Hypertrophy

  • Interventricular Septal Defect With Dextroposition Of Aorta, Pulmonary Stenosis And Hypertrophy Of Right Ventricle

  • Interventricular Septal Defect, In Tetralogy Of Fallot

  • Ventricular Septal Defect With Obstructed Right Ventricular Outflow

  • Tof - [Tetralogy Of Fallot]

  • Pulmonary Atresia With Ventricular Septal Defect [Fallot Type]

  • Pulmonary Atresia, Ventricular Septal Defect And Mapcas

  • Pulmonary Atresia With Ventricular Septal Defect And Systemic-To-Pulmonary Collateral Arteries [Fallot Type]
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13461 SMYD1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21759 Smyd1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28277 Smyd1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris SMYD1 VGNC VGNC:46581
Bos taurus SMYD1 VGNC VGNC:35042
Macaca mulatta SMYD1 VGNC VGNC:77751
Rattus norvegicus SMYD1 RGD RGD:1305105
Felis catus SMYD1 VGNC VGNC:81223
Mus musculus SMYD1 MGD MGI:104790
Others SMYD1 NCBI