ADSS2 - adenylosuccinate synthase 2 Gene

Also Known as ADEH; ADSS; ADSS 2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 159

About ADSS2

Cytogenetic location: 1q44 Genomic coordinates (GRCh38): 1:244,408,494-244,452,060 (from NCBI)

This gene has 3 transcripts (splice variants), 220 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 31.2), thyroid (RPKM 14.9) and 25 other tissues.

Summary

This gene encodes the enzyme adenylosuccinate synthetase which catalyzes the first committed step in the conversion of Inosine monophosphate to Adenosine monophosphate. A pseudogene of this gene is found on chromosome 17.[provided by RefSeq, Nov 2010]

ADSS2 Products (2)

mRNA Protein Name
NM_001126.5 NP_001117.2 adenylosuccinate synthetase isozyme 2 isoform 1
NM_001365073.2 NP_001352002.1 adenylosuccinate synthetase isozyme 2 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables adenylosuccinate synthase activity IDA
IDA: Inferred from direct assay
2004783 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
23455924 GOA
Biological Process GO Annotation Evidence References Source
involved in 'de novo' AMP biosynthetic process IDA
IDA: Inferred from direct assay
27590927 GOA
involved in AMP biosynthetic process IDA
IDA: Inferred from direct assay
2004783 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ADSS2 Protein Structure

Adenylsucc_synt

Adenylsucc_synt: Adenylosuccinate synthetase (30 - 453)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 456 a.a.
Protein Preferred Names Protein Names

adenylosuccinate synthetase isozyme 2

  • AMPSase 2

ADSS2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ADSS2 P30520 ADSS1 Homo sapiens Q8N142
Anti Tag CoIP
33961781
Intra
ADSS2 P30520 ADSS1 Homo sapiens Q8N142
Anti Tag CoIP
28514442
Intra
ADSS2 P30520 SMYD1 Homo sapiens Q8NB12
Anti Tag CoIP
23455924
Intra
ADSS2 P30520 SMYD1 Homo sapiens Q8NB12
Y2H
23455924
Cross: Cross-species interaction Intra: Intraspecies interaction

ADSS2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82266 AdSS 2 Antibody (YA2011) WB, ICC/IF Human, Mouse, Rat
HY-P82266A AdSS 2 Antibody (YA2011)(PBS only) WB, ICC/IF Human, Mouse, Rat

Related Diseases

Diseases Alias
Eczema Herpeticum

  • Herpes Simplex Dermatitis

  • Herpes Simplex Eyelid Dermatitis

  • Kaposi Varicelliform Eruption

  • Herpes Simplex Dermatitis Of Eyelid

  • Herpes Simplex Virus Dermatitis

  • Herpes Simplex Virus Eyelid Dermatitis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00420 ADSS2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W264185 ADSS2-IN-1 / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta ADSS2 VGNC VGNC:69733
Mus musculus ADSS2 MGD MGI:87948
Canis familiaris ADSS2 VGNC VGNC:37679
Bos taurus ADSS2 VGNC VGNC:25700
Felis catus ADSS2 VGNC VGNC:59661
Rattus norvegicus ADSS2 RGD RGD:1310508
Others ADSS2 NCBI