MYH7B - myosin heavy chain 7B Gene

Also Known as MHC14; MYH14

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 57644

About MYH7B

Cytogenetic location: 20q11.22 Genomic coordinates (GRCh38): 20:34,955,868-35,002,437 (from NCBI)

This gene has 10 transcripts (splice variants), 124 orthologues, 43 paralogues and is associated with 1 phenotype. Biased expression in heart (RPKM 13.9), testis (RPKM 3.7) and 2 other tissues.

Summary

The Myosin II molecule is a multi-subunit complex consisting of two heavy chains and four light chains. This gene encodes a heavy chain of Myosin II, which is a member of the motor-domain superfamily. The heavy chain includes a globular motor domain, which catalyzes ATP hydrolysis and interacts with actin, and a tail domain in which heptad repeat sequences promote dimerization by interacting to form a rod-like alpha-helical coiled coil. This heavy chain subunit is a slow-twitch Myosin. Alternatively spliced transcript variants have been found, but the full-length nature of these variants is not determined. [provided by RefSeq, Mar 2010]

MYH7B Products (1)

mRNA Protein Name
NM_020884.7 NP_065935.4 myosin-7B

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
23455924 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MYH7B Protein Structure

Myosin_N

Myosin_N: Myosin N-terminal SH3-like domain (74 - 115)

Myosin_head

Myosin_head: Myosin head (motor domain) (129 - 815)

Myosin_tail_1

Myosin_tail_1: Myosin tail (1119 - 1974)

  • 0
  • 400
  • 800
  • 1200
  • 1600
  • 1983 a.a.
Protein Preferred Names Protein Names

myosin-7B

  • U937-associated antigen

MYH7B Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MYH7B A7E2Y1 SMYD1 Homo sapiens Q8NB12
Anti Tag CoIP
23455924
Cross: Cross-species interaction Intra: Intraspecies interaction

MYH7B Antibodies

Cat. No. 상품명 신청 Reactivity
HY-P83112 MYH7B Antibody (YA2857) WB, IHC-P Human, Mouse, Rat

Related Diseases

Diseases Alias
Cardiomyopathy, Familial Hypertrophic, 1

  • Asymmetric Septal Hypertrophy

  • Familial Hypertrophic Cardiomyopathy

  • Hypertrophic Cardiomyopathy 1

  • CMH1

  • Hypertrophic Cardiomyopathy 19

  • CMH

  • Ventricular Hypertrophy, Hereditary

  • Ash

  • Hypertrophic Subaortic Stenosis, Idiopathic

  • Cardiomyopathy, Familial Hypertrophic

  • Cardiomyopathy, Hypertrophic, 1, Digenic

  • Cardiomyopathy, Familial Hypertrophic 1

  • Hcm

  • Hereditary Ventricular Hypertrophy

  • Idiopathic Hypertrophic Subaortic Stenosis

  • Hypertrophic Cardiomyopathy

  • Cardiomyopathy, Hypertrophic, Familial

  • Cardiomyopathy, Hypertrophic, 1

  • Familial Asymmetric Septal Hypertrophy

  • Heritable Hypertrophic Cardiomyopathy

  • Fhc

  • Cardiomyopathy, Hypertrophic, Familial, Type 1
Left Ventricular Noncompaction

  • Noncompaction Cardiomyopathy

  • Left Ventricular Hypertrabeculation

  • Lvnc

  • Spongy Myocardium

  • Isolated Noncompaction Of The Ventricular Myocardium

  • Left Ventricular Myocardial Noncompaction Cardiomyopathy

  • Fetal Myocardium

  • Honeycomb Myocardium

  • Hypertrabeculation Syndrome

  • Left Ventricular Non-Compaction

  • Lvht

  • Non-Compaction Of The Left Ventricular Myocardium

  • Ventricular Noncompaction, Left

  • Non-Compaction Cardiomyopathy
Monocytic Leukemia

  • Monocytic Leukaemia

  • Schilling'S Leukaemia

  • Schilling'S Leukemia

  • M5b Acute Differentiated Monocytic Leukemia
Deafness, Autosomal Dominant 17

  • DFNA17

  • Autosomal Dominant Nonsyndromic Deafness 17

  • Deafness, Autosomal Dominant Nonsyndromic Sensorineural 17

  • Autosomal Dominant Deafness 17

  • Late-Onset Progressive Hereditary Hearing Impairment Due To Cochleosaccular Degeneration

  • Nonsyndromic Hereditary Deafness Dfna17

  • Deafness, Autosomal Dominant, 17

  • Cochleosaccular Degeneration

  • Deafness, Autosomal Dominant, Type 17

  • Cochleosaccular Degeneration Of The Inner Ear And Progressive Cataracts
Myh-9 Related Disease

  • Myh9-Related Disease

  • Myh9-Rd

  • Myh9-Related Disorder

  • Myh9-Related Syndrome

  • Myh9-Related Syndromic Thrombocytopenia

  • Sebastian Syndrome
Distal Arthrogryposis

  • Arthrogryposis Multiplex Congenita

  • Arthrogryposis

  • Congenital Multiple Arthrogryposis

  • Congenital Arthromyodysplasia

  • Fibrous Ankylosis Of Multiple Joints

  • Guerin-Stern Syndrome

  • Guérin-Stern Syndrome

  • Myodystrophia Fetalis Deformans

  • Otto Syndrome

  • Rocher-Sheldon Syndrome

  • Rossi Syndrome

  • Amc

  • Multiple Congenital Arthrogryposis

  • Arthrogryposis Syndrome

  • Arthrogryposis, Distal

  • Distal Arthrogryposis Syndrome

  • Freeman-Sheldon Syndrome

  • Arthrogryposis, Distal, Type 2b

  • Congenital Multiplex Arthrogryposis

  • Amyoplasia Congenita

  • Congenital Amyoplasia

  • Amc - [Arthrogryposis Multiplex Congenita]
Autosomal Dominant Nonsyndromic Deafness

  • Autosomal Dominant Deafness
Hypertrophic Cardiomyopathy

  • Hypertrophic Obstructive Cardiomyopathy

  • Cardiomyopathy, Hypertrophic

  • Cardiomyopathy Hypertrophic Obstructive

  • Cardiomyopathy, Hypertrophic, Familial

  • Idiopathic Myocardial Hypertrophy

  • Idiopathic Hypertrophic Cardiomyopathy

  • Obstructive Idiopathic Hypertrophic Cardiomyopathy

  • Obstructive Cardiomyopathy

  • Idiopathic Hypertrophic Subaortic Stenosis

  • Muscular Subaortic Stenosis

  • Hypertrophic Obstructive Subaortic Stenosis
Dilated Cardiomyopathy

  • Familial Dilated Cardiomyopathy

  • Primary Dilated Cardiomyopathy

  • Idiopathic Dilated Cardiomyopathy

  • Congestive Cardiomyopathy

  • Idiopathic Dilation Cardiomyopathy

  • Primary Familial Dilated Cardiomyopathy

  • Cardiomyopathy, Dilated

  • DCM

  • Cardiomyopathy, Familial Dilated

  • Dilated Cardiomyopathy, Familial

  • Hypokinetic Dilated Cardiomyopathy, Familial

  • Familial Idiopathic Cardiomyopathy

  • Fdc

  • Cardiomyopathy, Familial Idiopathic

  • Idiopathic Cardiomegaly

  • Dilated Congestive Cardiomyopathy

  • Chronic Dilated Cardiomyopathy

  • Ccm - [Congestive Cardiomyopathy]

  • Cocm - [Congestive Cardiomyopathy]

  • Dcm - [Dilated Cardiomyopathy]

  • Dilated-Hypokinetic Cardiomyopathy

  • Congestive Idiopathic Cardiomyopathy

  • Primary Idiopathic Dilated Cardiomyopathy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. 상품명
효과
Purity
Rare Diseases
HY-RS08906 MYH7B Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus MYH7B MGD MGI:3710243
Bos taurus MYH7B VGNC VGNC:50024
Canis familiaris MYH7B VGNC VGNC:43539
Macaca mulatta MYH7B VGNC VGNC:74965
Rattus norvegicus MYH7B RGD RGD:1307994
Others MYH7B NCBI