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FAM83A - family with sequence similarity 83 member A Gene

Also Known as BJ-TSA-9

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 84985

About FAM83A

This gene has 9 transcripts (splice variants), 161 orthologues and 7 paralogues. Biased expression in esophagus (RPKM 21.0), skin (RPKM 1.8) and 1 other tissue.

Summary

Enables identical protein binding activity; phosphatidylinositol 3-kinase regulatory subunit binding activity; and protein kinase binding activity. Involved in cell population proliferation and epidermal growth factor receptor signaling pathway. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

FAM83A Products (5)

mRNA	Protein	Name
NM_001288587.3	NP_001275516.1	protein FAM83A isoform c
NM_001321630.2	NP_001308559.1	protein FAM83A isoform d
NM_001394396.1	NP_001381325.1	protein FAM83A isoform a
NM_032899.6	NP_116288.2	protein FAM83A isoform a
NM_207006.3	NP_996889.1	protein FAM83A isoform b

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables phosphatidylinositol 3-kinase regulatory subunit binding	IDA IDA: Inferred from direct assay	22886303	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables protein kinase binding	IDA IDA: Inferred from direct assay	22886303	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	22886303	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cell population proliferation	IMP IMP: Inferred from mutant phenotype	22886303	GOA
involved in epidermal growth factor receptor signaling pathway	IDA IDA: Inferred from direct assay	22886303	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FAM83A Protein Structure

DUF1669

0
100
200
300
400
434 a.a.

Protein Preferred Names	Protein Names
protein FAM83A	tumor antigen BJ-TSA-9

FAM83A Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	FAM83A	Q86UY5	GPSM1	Homo sapiens	Q86YR5-3	Y2H Array	32296183
Intra	FAM83A	Q86UY5	GPSM1	Homo sapiens	Q86YR5-3	Y2H Prey Pooling	32296183
Intra	FAM83A	Q86UY5	GPSM1	Homo sapiens	Q86YR5-3	Validated Y2H	32296183
Intra	FAM83A	Q86UY5	KRTAP8-1	Homo sapiens	Q8IUC2	Y2H Prey Pooling	32296183
Intra	FAM83A	Q86UY5	KRTAP8-1	Homo sapiens	Q8IUC2	Validated Y2H	32296183
Intra	FAM83A	Q86UY5	KRTAP8-1	Homo sapiens	Q8IUC2	Y2H Array	32296183
Intra	FAM83A	Q86UY5	PPP1R16B	Homo sapiens	Q96T49	Y2H Array	32296183
Intra	FAM83A	Q86UY5	PPP1R16B	Homo sapiens	Q96T49	Y2H Prey Pooling	32296183
Intra	FAM83A	Q86UY5	PPP1R16B	Homo sapiens	Q96T49	Validated Y2H	32296183
Intra	FAM83A	Q86UY5	KRT34	Homo sapiens	O76011	Y2H Prey Pooling	32296183
Intra	FAM83A	Q86UY5	KRT34	Homo sapiens	O76011	Y2H Array	32296183
Intra	FAM83A	Q86UY5	KRTAP6-2	Homo sapiens	Q3LI66	Y2H Array	32296183
Intra	FAM83A	Q86UY5	KRTAP6-2	Homo sapiens	Q3LI66	Y2H Prey Pooling	32296183
Intra	FAM83A	Q86UY5	FOXI1	Homo sapiens	Q12951-2	Y2H Array	32296183
Intra	FAM83A	Q86UY5	FOXI1	Homo sapiens	Q12951-2	Y2H Prey Pooling	32296183
Intra	FAM83A	Q86UY5	CSNK1E	Homo sapiens	P49674	Anti Tag CoIP	29789297
Intra	FAM83A	Q86UY5	ccsb orf id: 14249	Homo sapiens	EBI-22320186	Y2H Array	32296183
Intra	FAM83A	Q86UY5	CSNK1E	Homo sapiens	P49674	Anti Tag CoIP	33961781
Intra	FAM83A	Q86UY5	ccsb orf id: 14249	Homo sapiens	EBI-22320186	Y2H Prey Pooling	32296183
Intra	FAM83A	Q86UY5	CSNK1E	Homo sapiens	P49674	Pull Down	29789297
Intra	FAM83A	Q86UY5	146664	Homo sapiens	EBI-10182452	Validated Y2H	25416956
Intra	FAM83A	Q86UY5	146664	Homo sapiens	EBI-10182452	Y2H Prey Pooling	25416956
Intra	FAM83A	Q86UY5	KRTAP6-3	Homo sapiens	Q3LI67	Y2H Array	32296183
Intra	FAM83A	Q86UY5	KRTAP6-3	Homo sapiens	Q3LI67	Y2H Prey Pooling	32296183
Intra	FAM83A	Q86UY5	q9y649_human	Homo sapiens	Q9Y649	Validated Y2H	32814053
Intra	FAM83A	Q86UY5	q9y649_human	Homo sapiens	Q9Y649	Y2H Pooling	32814053
Intra	FAM83A	Q86UY5	q9y649_human	Homo sapiens	Q9Y649	Y2H Array	32814053
Intra	FAM83A	Q86UY5	PLAGL2	Homo sapiens	Q9UPG8	Y2H Prey Pooling	32296183
Intra	FAM83A	Q86UY5	PLAGL2	Homo sapiens	Q9UPG8	Validated Y2H	32296183
Intra	FAM83A	Q86UY5	PLAGL2	Homo sapiens	Q9UPG8	Y2H Array	32296183
Intra	FAM83A	Q86UY5	PSMA3	Homo sapiens	P25788	Y2H Array	32296183
Intra	FAM83A	Q86UY5	PSMA3	Homo sapiens	P25788	Y2H Prey Pooling	32296183
Intra	FAM83A	Q86UY5	FGFR3	Homo sapiens	P22607	Validated Y2H	32814053
Intra	FAM83A	Q86UY5	FGFR3	Homo sapiens	P22607	Y2H Pooling	32814053
Intra	FAM83A	Q86UY5	FGFR3	Homo sapiens	P22607	Y2H Array	32814053
Intra	FAM83A	Q86UY5	GSN	Homo sapiens	P06396	Validated Y2H	32814053
Intra	FAM83A	Q86UY5	GSN	Homo sapiens	P06396	Y2H Array	32814053
Intra	FAM83A	Q86UY5	GSN	Homo sapiens	P06396	Y2H Pooling	32814053
Intra	FAM83A	Q86UY5	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183
Intra	FAM83A	Q86UY5	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183
Intra	FAM83A	Q86UY5	PRDM14	Homo sapiens	Q9GZV8	Y2H Prey Pooling	32296183
Intra	FAM83A	Q86UY5	PRDM14	Homo sapiens	Q9GZV8	Validated Y2H	32296183
Intra	FAM83A	Q86UY5	PRDM14	Homo sapiens	Q9GZV8	Y2H Array	32296183
Intra	FAM83A	Q86UY5	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Pooling	32814053
Intra	FAM83A	Q86UY5	PMP22	Homo sapiens	A0A6Q8PF08	Validated Y2H	32814053
Intra	FAM83A	Q86UY5	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Array	32814053
Intra	FAM83A	Q86UY5	BHLHE40	Homo sapiens	O14503	Y2H Prey Pooling	32296183
Intra	FAM83A	Q86UY5	BHLHE40	Homo sapiens	O14503	Y2H Array	32296183
Intra	FAM83A	Q86UY5	MAGED1	Homo sapiens	Q9Y5V3	Validated Y2H	32296183
Intra	FAM83A	Q86UY5	MAGED1	Homo sapiens	Q9Y5V3	Y2H Prey Pooling	32296183
Intra	FAM83A	Q86UY5	MAGED1	Homo sapiens	Q9Y5V3	Y2H Array	32296183
Intra	FAM83A	Q86UY5	TRIM27	Homo sapiens	P14373	Validated Y2H	25416956
Intra	FAM83A	Q86UY5	TRIM27	Homo sapiens	P14373	Y2H Array	25416956
Intra	FAM83A	Q86UY5	DAZAP2	Homo sapiens	Q15038	Y2H Array	32296183
Intra	FAM83A	Q86UY5	DAZAP2	Homo sapiens	Q15038	Y2H Prey Pooling	32296183
Intra	FAM83A	Q86UY5	TRIM23	Homo sapiens	P36406	Y2H Prey Pooling	25416956
Intra	FAM83A	Q86UY5	TRIM23	Homo sapiens	P36406	Validated Y2H	25416956
Intra	FAM83A	Q86UY5	UBQLN1	Homo sapiens	Q9UMX0	Y2H Pooling	32814053
Intra	FAM83A	Q86UY5	UBQLN1	Homo sapiens	Q9UMX0	Validated Y2H	32814053
Intra	FAM83A	Q86UY5	UBQLN1	Homo sapiens	Q9UMX0	Y2H Array	32814053
Intra	FAM83A	Q86UY5	GCC1	Homo sapiens	Q96CN9	Validated Y2H	32296183
Intra	FAM83A	Q86UY5	SMYD1	Homo sapiens	Q8NB12	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Amelogenesis Imperfecta, Type Iiia	Ai3 Adhcai Amelogenesis Imperfecta Type 3 AI3A Amelogenesis Imperfecta, Type Iii Amelogenesis Imperfecta, Hypocalcification Type, Autosomal Dominant Amelogenesis Imperfecta Type 3a Amelogenesis Imperfecta Hypomineralization Type Amelogenesis Imperfecta Type Iii Hypocalcified Amelogenesis Imperfecta Amelogenesis Imperfecta, Type 3 Amelogenesis Imperfecta, Hypomineralization Type Autosomal Dominant Amelogenesis Imperfecta Hypocalcification Type Amelogenesis Imperfecta 3a Amelogenesis Imperfecta Hypocalcification Type Autosomal Dominant

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04721	FAM83A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	FAM83A	VGNC	VGNC:72384
Canis familiaris	FAM83A	VGNC	VGNC:40699
Bos taurus	FAM83A	VGNC	VGNC:28832
Rattus norvegicus	FAM83A	RGD	RGD:1565606
Mus musculus	FAM83A	MGD	MGI:2447773
Felis catus	FAM83A	VGNC	VGNC:81657
Others	FAM83A	NCBI