2. Gene
  3. PPP1R16B - protein phosphatase 1 regulatory subunit 16B Gene

PPP1R16B - protein phosphatase 1 regulatory subunit 16B Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as TIMAP; ANKRD4

Gene ID: 26051 | Gene type: protein coding

About PPP1R16B

Cytogenetic location: 20q11.23 Genomic coordinates (GRCh38): 20:38,805,697-38,923,024 (from NCBI)

This gene has 4 transcripts (splice variants), 204 orthologues and 1 paralogue. Broad expression in lymph node (RPKM 19.5), brain (RPKM 18.4) and 18 other tissues.

Summary

The protein encoded by this gene is membrane-associated and contains five ankyrin repeats, a protein phosphatase-1-interacting domain, and a carboxy-terminal CAAX box domain. Synthesis of the encoded protein is inhibited by transforming growth factor beta-1. The protein may bind to the membrane through its CAAX box domain and may act as a signaling molecule through interaction with protein phosphatase-1. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Sep 2015]

PPP1R16B Products(2)

mRNA Protein Name
NM_001172735.3 NP_001166206.1 protein phosphatase 1 regulatory inhibitor subunit 16B isoform 2
NM_015568.4 NP_056383.1 protein phosphatase 1 regulatory inhibitor subunit 16B isoform 1 precursor

PPP1R16B Protein Structure

Ank_2

Ank_2: Ankyrin repeats (3 copies) (73 - 162)

Ank_2

Ank_2: Ankyrin repeats (3 copies) (213 - 291)

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  • 567 a.a.
Protein Preferred Names Protein Names

protein phosphatase 1 regulatory inhibitor subunit 16B

CAAX box protein TIMAP

Related Diseases

Diseases Alias
Ciliary Dyskinesia, Primary, 19

Primary Ciliary Dyskinesia 19

CILD19

Primary Ciliary Dyskinesia 19 With Or Without Situs Inversus

Ciliary Dyskinesia, Primary, 19, With Or Without Situs Inversus

Ics19

Immotile Cilia Syndrome 19

Dyskinesia, Ciliary, Primary, 19
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS10989 PPP1R16B Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta PPP1R16B VGNC VGNC:97123
Mus musculus PPP1R16B MGD MGI:2151841
Canis familiaris PPP1R16B VGNC VGNC:44885
Bos taurus PPP1R16B VGNC VGNC:33231
Rattus norvegicus PPP1R16B RGD RGD:1589460
Felis catus PPP1R16B VGNC VGNC:64321