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PPP1R16B - protein phosphatase 1 regulatory subunit 16B Gene

Also Known as TIMAP; ANKRD4

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 26051

About PPP1R16B

Cytogenetic location: 20q11.23 Genomic coordinates (GRCh38): 20:38,805,697-38,923,024 (from NCBI)

This gene has 4 transcripts (splice variants), 204 orthologues and 1 paralogue. Broad expression in lymph node (RPKM 19.5), brain (RPKM 18.4) and 18 other tissues.

Summary

The protein encoded by this gene is membrane-associated and contains five ankyrin repeats, a protein phosphatase-1-interacting domain, and a carboxy-terminal CAAX box domain. Synthesis of the encoded protein is inhibited by transforming growth factor beta-1. The protein may bind to the membrane through its CAAX box domain and may act as a signaling molecule through interaction with protein phosphatase-1. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Sep 2015]

PPP1R16B Products (2)

mRNA	Protein	Name
NM_001172735.3	NP_001166206.1	protein phosphatase 1 regulatory inhibitor subunit 16B isoform 2
NM_015568.4	NP_056383.1	protein phosphatase 1 regulatory inhibitor subunit 16B isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16263087	GOA
enables protein phosphatase regulator activity	IDA IDA: Inferred from direct assay	16263087	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in establishment of endothelial barrier	IMP IMP: Inferred from mutant phenotype	18586956	GOA
involved in positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	IMP IMP: Inferred from mutant phenotype	25007873	GOA
involved in positive regulation of endothelial cell proliferation	IMP IMP: Inferred from mutant phenotype	25007873	GOA
involved in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	25007873	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cell projection	IDA IDA: Inferred from direct assay	25007873	GOA
located in nucleus	IDA IDA: Inferred from direct assay	12055102	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	12055102	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	12055102	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PPP1R16B Protein Structure

Ank_2

0
100
200
300
400
500
567 a.a.

Protein Preferred Names	Protein Names
protein phosphatase 1 regulatory inhibitor subunit 16B	CAAX box protein TIMAP

PPP1R16B Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PPP1R16B	Q96T49	TASOR2	Homo sapiens	Q5VWN6-2	Y2H Array	25416956
Intra	PPP1R16B	Q96T49	NEFL	Homo sapiens	I6L9F6	Y2H Prey Pooling	25416956
Intra	PPP1R16B	Q96T49	NEFL	Homo sapiens	I6L9F6	Validated Y2H	25416956
Intra	PPP1R16B	Q96T49	ZNF564	Homo sapiens	Q8TBZ8	Anti Tag CoIP	28514442
Intra	PPP1R16B	Q96T49	ZNF564	Homo sapiens	Q8TBZ8	Anti Tag CoIP	33961781
Intra	PPP1R16B	Q96T49	PATZ1	Homo sapiens	Q9HBE1-4	Validated Y2H	32296183
Intra	PPP1R16B	Q96T49	ZNF410	Homo sapiens	Q86VK4-3	Validated Y2H	27107012
Intra	PPP1R16B	Q96T49	ZNF410	Homo sapiens	Q86VK4-3	BFG-2H	27107012
Intra	PPP1R16B	Q96T49	HAPLN2	Homo sapiens	Q9GZV7	Validated Y2H	32296183
Intra	PPP1R16B	Q96T49	TXN2	Homo sapiens	Q99757	Validated Y2H	32296183
Intra	PPP1R16B	Q96T49	SF3B4	Homo sapiens	Q15427	Validated Y2H	25416956
Intra	PPP1R16B	Q96T49	SF3B4	Homo sapiens	Q15427	Y2H Prey Pooling	25416956
Intra	PPP1R16B	Q96T49	SF3B4	Homo sapiens	Q15427	Y2H Array	25416956
Intra	PPP1R16B	Q96T49	PPP1CB	Homo sapiens	P62140	Anti Tag CoIP	33961781
Intra	PPP1R16B	Q96T49	PPP1CB	Homo sapiens	P62140	Anti Tag CoIP	28514442
Intra	PPP1R16B	Q96T49	PPP1CB	Homo sapiens	P62140	BioID	28330616
Intra	PPP1R16B	Q96T49	PPP1CB	Homo sapiens	P62140	Pull Down	28330616
Intra	PPP1R16B	Q96T49	PPP1CB	Homo sapiens	P62140	Validated Y2H	27107012
Intra	PPP1R16B	Q96T49	PPP1CA	Homo sapiens	P62136	Anti Tag CoIP	33961781
Intra	PPP1R16B	Q96T49	PPP1CA	Homo sapiens	P62136	Anti Tag CoIP	28514442
Intra	PPP1R16B	Q96T49	KCTD9	Homo sapiens	Q7L273	Y2H Array	25416956
Intra	PPP1R16B	Q96T49	HTRA2	Homo sapiens	O43464	Validated Y2H	32814053
Intra	PPP1R16B	Q96T49	HTRA2	Homo sapiens	O43464	Y2H Array	32814053
Intra	PPP1R16B	Q96T49	HTRA2	Homo sapiens	O43464	Y2H Pooling	32814053
Intra	PPP1R16B	Q96T49	GOLGA2	Homo sapiens	Q08379	Y2H Array	25416956
Intra	PPP1R16B	Q96T49	GOLGA2	Homo sapiens	Q08379	Validated Y2H	27107012
Intra	PPP1R16B	Q96T49	GOLGA2	Homo sapiens	Q08379	BFG-2H	27107012
Intra	PPP1R16B	Q96T49	PHC2	Homo sapiens	Q8IXK0	Y2H Array	25416956
Intra	PPP1R16B	Q96T49	PHC2	Homo sapiens	Q8IXK0	Y2H Prey Pooling	25416956
Intra	PPP1R16B	Q96T49	CEP70	Homo sapiens	Q8NHQ1	Y2H Prey Pooling	25416956
Intra	PPP1R16B	Q96T49	CEP70	Homo sapiens	Q8NHQ1	Validated Y2H	25416956
Intra	PPP1R16B	Q96T49	IKZF3	Homo sapiens	Q9UKT9	Y2H Array	25416956
Intra	PPP1R16B	Q96T49	IKZF3	Homo sapiens	Q9UKT9	BFG-2H	27107012
Intra	PPP1R16B	Q96T49	IKZF3	Homo sapiens	Q9UKT9	Y2H Array	31515488
Intra	PPP1R16B	Q96T49	IKZF3	Homo sapiens	Q9UKT9	Y2H Prey Pooling	25416956
Intra	PPP1R16B	Q96T49	CEP55	Homo sapiens	Q53EZ4	Validated Y2H	27107012
Intra	PPP1R16B	Q96T49	CEP55	Homo sapiens	Q53EZ4	BFG-2H	27107012
Intra	PPP1R16B	Q96T49	CEP55	Homo sapiens	Q53EZ4	Y2H Array	25416956
Intra	PPP1R16B	Q96T49	TACO1	Homo sapiens	Q9BSH4	Validated Y2H	32296183
Intra	PPP1R16B	Q96T49	CRX	Homo sapiens	O43186	Y2H Prey Pooling	25416956
Intra	PPP1R16B	Q96T49	CRX	Homo sapiens	O43186	Validated Y2H	25416956
Intra	PPP1R16B	Q96T49	SCNM1	Homo sapiens	Q9BWG6	Validated Y2H	32296183
Intra	PPP1R16B	Q96T49	PRPH	Homo sapiens	P41219	Validated Y2H	32814053
Intra	PPP1R16B	Q96T49	PRPH	Homo sapiens	P41219	Y2H Pooling	32814053
Intra	PPP1R16B	Q96T49	PRPH	Homo sapiens	P41219	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Ciliary Dyskinesia, Primary, 19	Primary Ciliary Dyskinesia 19 CILD19 Primary Ciliary Dyskinesia 19 With Or Without Situs Inversus Ciliary Dyskinesia, Primary, 19, With Or Without Situs Inversus Ics19 Immotile Cilia Syndrome 19 Dyskinesia, Ciliary, Primary, 19

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10989	PPP1R16B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	PPP1R16B	VGNC	VGNC:97123
Mus musculus	PPP1R16B	MGD	MGI:2151841
Canis familiaris	PPP1R16B	VGNC	VGNC:44885
Bos taurus	PPP1R16B	VGNC	VGNC:33231
Rattus norvegicus	PPP1R16B	RGD	RGD:1589460
Felis catus	PPP1R16B	VGNC	VGNC:64321
Others	PPP1R16B	NCBI