TACO1 - translational activator of cytochrome c oxidase I Gene

Also Known as CCDC44; MC4DN8

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 51204

About TACO1

Cytogenetic location: 17q23.3 Genomic coordinates (GRCh38): 17:63,600,895-63,608,365 (from NCBI)

This gene has 4 transcripts (splice variants), 190 orthologues and is associated with 3 phenotypes. Ubiquitous expression in kidney (RPKM 17.5), liver (RPKM 13.0) and 25 other tissues.

Summary

This gene encodes a mitochondrial protein that function as a translational activator of mitochondrially-encoded cytochrome c oxidase 1. Mutations in this gene are associated with Leigh syndrome.[provided by RefSeq, Mar 2010]

TACO1 Products (1)

mRNA	Protein	Name
NM_016360.4	NP_057444.2	translational activator of cytochrome c oxidase 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TACO1 Protein Structure

Transcrip_reg

0
100
200
297 a.a.

Protein Preferred Names	Protein Names
translational activator of cytochrome c oxidase 1	clone HQ0477 PRO0477p

TACO1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TACO1	Q9BSH4	KRT40	Homo sapiens	Q6A162	Y2H Array	32296183
Intra	TACO1	Q9BSH4	KRT40	Homo sapiens	Q6A162	Y2H Prey Pooling	32296183
Intra	TACO1	Q9BSH4	PPP1R16B	Homo sapiens	Q96T49	Y2H Array	32296183
Intra	TACO1	Q9BSH4	PPP1R16B	Homo sapiens	Q96T49	Y2H Prey Pooling	32296183
Intra	TACO1	Q9BSH4	KRT34	Homo sapiens	O76011	Y2H Prey Pooling	32296183
Intra	TACO1	Q9BSH4	KRT34	Homo sapiens	O76011	Y2H Array	32296183
Intra	TACO1	Q9BSH4	GTF3C3	Homo sapiens	Q9Y5Q9	Validated Y2H	32814053
Intra	TACO1	Q9BSH4	GTF3C3	Homo sapiens	Q9Y5Q9	Y2H Pooling	32814053
Intra	TACO1	Q9BSH4	GTF3C3	Homo sapiens	Q9Y5Q9	Y2H Array	32814053
Intra	TACO1	Q9BSH4	MTUS2	Homo sapiens	Q5JR59-3	Y2H Array	32296183
Intra	TACO1	Q9BSH4	MTUS2	Homo sapiens	Q5JR59-3	Y2H Prey Pooling	32296183
Intra	TACO1	Q9BSH4	CIB4	Homo sapiens	A0PJX0	Y2H Array	32296183
Intra	TACO1	Q9BSH4	CIB4	Homo sapiens	A0PJX0	Y2H Prey Pooling	32296183
Intra	TACO1	Q9BSH4	GOLGA6L9	Homo sapiens	A6NEM1	Y2H Prey Pooling	32296183
Intra	TACO1	Q9BSH4	GOLGA6L9	Homo sapiens	A6NEM1	Y2H Array	32296183
Intra	TACO1	Q9BSH4	SAT1	Homo sapiens	P21673	Y2H Prey Pooling	32296183
Intra	TACO1	Q9BSH4	SAT1	Homo sapiens	P21673	Y2H Array	32296183
Intra	TACO1	Q9BSH4	TRIM27	Homo sapiens	P14373	Y2H Prey Pooling	32296183
Intra	TACO1	Q9BSH4	TRIM27	Homo sapiens	P14373	Y2H Array	32296183
Intra	TACO1	Q9BSH4	MDFI	Homo sapiens	Q99750	Y2H Prey Pooling	32296183
Intra	TACO1	Q9BSH4	MDFI	Homo sapiens	Q99750	Y2H Array	32296183
Intra	TACO1	Q9BSH4	RINT1	Homo sapiens	Q6NUQ1	Y2H Array	32296183
Intra	TACO1	Q9BSH4	RINT1	Homo sapiens	Q6NUQ1	Y2H Prey Pooling	32296183
Intra	TACO1	Q9BSH4	CALCOCO2	Homo sapiens	Q13137	Y2H Prey Pooling	32296183
Intra	TACO1	Q9BSH4	CALCOCO2	Homo sapiens	Q13137	Y2H Array	32296183
Intra	TACO1	Q9BSH4	LNX1	Homo sapiens	Q8TBB1	Y2H Prey Pooling	32296183
Intra	TACO1	Q9BSH4	LNX1	Homo sapiens	Q8TBB1	Y2H Array	32296183
Intra	TACO1	Q9BSH4	TRIM23	Homo sapiens	P36406	Y2H Array	32296183
Intra	TACO1	Q9BSH4	TRIM23	Homo sapiens	P36406	Y2H Prey Pooling	32296183
Intra	TACO1	Q9BSH4	KRT31	Homo sapiens	Q15323	Y2H Prey Pooling	32296183
Intra	TACO1	Q9BSH4	KRT31	Homo sapiens	Q15323	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Mitochondrial Complex Iv Deficiency, Nuclear Type 8	MC4DN8 Mitochondrial Complex 4 Deficiency, Nuclear Type 8
Mitochondrial Complex Iv Deficiency, Nuclear Type 1	Cytochrome C Oxidase Deficiency Mitochondrial Complex Iv Deficiency Cox Deficiency Cytochrome-C Oxidase Deficiency Disease MC1DN4 Cytochrome-C Oxidase Deficiency MC4DN1 Mitochondrial Complex I Deficiency, Nuclear Type 4 Complex 4 Mitochondrial Respiratory Chain Deficiency Complex Iv Deficiency Mitochondrial Complex 1 Deficiency, Nuclear Type 4 Nuclear Type Mitochondrial Complex I Deficiency 4 Deficiency Of Mitochondrial Respiratory Chain Complex4 MT-C4D Complex Iv Mitochondrial Respiratory Chain Deficiency Lethal Neonatal Cardiomyopathy Hypertrophic Due To Cytochrome C Oxidase Deficiency Mitochondrial Complex Iv Deficiency, Nuclear, Type 1
Leigh Syndrome With Leukodystrophy	Infantile Subacute Necrotizing Encephalopathy With Leukodystrophy Leigh Disease With Leukodystrophy
Charcot-Marie-Tooth Disease, Type 4k	Charcot-Marie-Tooth Disease Type 4k CMT4K Charcot-Marie-Tooth Disease, Demyelinating, Autosomal Recessive, Type 4k Charcot-Marie-Tooth Neuropathy, Demyelinating, Autosomal Recessive, Type 4k Surf1-Related Charcot-Marie-Tooth Disease Type 4 Surf1-Related Cmt4 Surf1-Related Severe Demyelinating Charcot-Marie-Tooth Disease Autosomal Recessive Demyelinating Charcot-Marie-Tooth Disease Type 4k Autosomal Recessive Demyelinating Charcot-Marie-Tooth Neuropathy Type 4k Charcot-Marie-Tooth Disease 4k Charcot-Marie-Tooth Disease, Demyelinating, Type 4k Charcot-Marie-Tooth Neuropathy, Type 4k
Leigh Syndrome	Leigh Disease Infantile Subacute Necrotizing Encephalopathy Leigh Syndrome Due To Mitochondrial Complex Iv Deficiency LS Sne Leigh'S Disease Leigh Syndrome Due To Mitochondrial Complex I Deficiency Necrotizing Encephalopathy, Infantile Subacute, Of Leigh Subacute Necrotizing Encephalomyelopathy Necrotizing Encephalopathy Infantile Subacute Of Leigh Leigh Syndrome Due To Mitochondrial Complex Iii Deficiency Infantile Necrotizing Encephalomyelopathy Juvenile Subacute Necrotizing Encephalomyelopathy Leigh'S Necrotizing Encephalopathy Subacute Necrotizing Encephalopathy Juvenile Subacute Necrotizing Encephalopathy Leigh Syndrome Due To Mitochondrial Complex Ii Deficiency Leigh Syndrome Due To Mitochondrial Complex V Deficiency Encephalopathy, Subacute Necrotizing, Infantile Encephalopathy, Subacute Necrotizing, Juvenile Maternally Inherited Leigh Syndrome Subacute Necrotising Encephalomyelopathy Subacute Necrotising Encephalopathy
Charcot-Marie-Tooth Disease, Axonal, Type 2ee	CMT2EE Charcot-Marie-Tooth Neuropathy, Type 2ee Charcot-Marie-Tooth Disease Type 2ee Charcot-Marie-Tooth Disease, Axonal, 2ee
Mitochondrial Complex Iv Deficiency, Nuclear Type 5	Leigh Syndrome, French Canadian Type Mitochondrial Complex V Deficiency Nuclear Type 4 Cytochrome C Oxidase Deficiency, French Canadian Type Lsfc Cox Deficiency, French Canadian Type MC5DN4 MC4DN5 Cox Deficiency, Saguenay-Lac-Saint-Jean Type Leigh Syndrome, Saguenay-Lac-Saint-Jean Type Mitochondrial Complex V Deficiency, Nuclear Type 4 French Canadian Leigh Disease Leigh Syndrome, French-Canadian Type Leigh Syndrome , French Canadian Type Mitochondrial Complex V Deficiency, Atp5a1 Type French Canadian Type Cox Deficiency French Canadian Type Cytochrome C Oxidase Deficiency French Canadian Type Leigh Syndrome Saguenay Lac Saint Jean Type Cox Deficiency Saguenay Lac Saint Jean Type Leigh Syndrome Cox Deficiency, Saguenay Lac Saint Jean Type Leigh Syndrome, Saguenay Lac Saint Jean Type Mitochondrial Complex V Deficiency, Nuclear Type 4 Mitochondrial Complex V Deficiency Atp5a1 Type Mitochondrial Complex V Deficiency Type 4 Mitochondrial Complex V Deficiency, Nuclear, Type 4
Mitochondrial Metabolism Disease	Abnormality Of Mitochondrial Metabolism Mitochondrial Diseases
Pyruvate Dehydrogenase E1-Alpha Deficiency	Pyruvate Dehydrogenase Deficiency Pyruvate Dehydrogenase Complex Deficiency Pyruvate Decarboxylase Deficiency Pdh Deficiency PDHAD Pyruvate Dehydrogenase Complex Deficiency Disease Ataxia With Lactic Acidosis I Ataxia With Lactic Acidosis 1 Pdh Pdhc Ataxia With Lactic Acidosis Ataxia, Intermittent, With Abnormal Pyruvate Metabolism Ataxia, Intermittent, With Pyruvate Dehydrogenase Deficiency Deficiency Of Pyruvic Dehydrogenase Ataxia, Intermittent, With Pyruvate Dehydrogenase, Or Decarboxylase, Deficiency Pdc Deficiency Intermittent Ataxia With Pyruvate Dehydrogenase Deficiency Pdhc Deficiency Pyruvate Dehydrogenase Complex E1 Component Subunit Alpha Deficiency Ataxia Intermittent With Abnormal Pyruvate Metabolism Ataxia Intermittent With Pyruvate Dehydrogenase Or Decarboxylase Deficiency Pyruvate Dehydrogenase E1 Alpha Deficiency Pdc - [Pyruvate Dehydrogenase Complex] Deficiency Ataxia With Lactic Acidosis 2
Fatal Infantile Cardioencephalomyopathy Due To Cytochrome C Oxidase Deficiency	Cardioencephalomyopathy, Fatal Infantile, Due To Cytochrome C Oxidase Deficiency Fatal Infantile Cox Deficiency Fatal Infantile Cytochrome C Oxidase Deficiency Fatal Infantile Encephalocardiomyopathy
Dystonia	Dystonic Disease Dystonic Disorder Dystonia Disorders Neuroleptic Dyskinesia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS29491	Taco1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS14142	TACO1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	TACO1	VGNC	VGNC:104661
Mus musculus	TACO1	MGD	MGI:1917457
Bos taurus	TACO1	VGNC	VGNC:35559
Canis familiaris	TACO1	VGNC	VGNC:47065
Rattus norvegicus	TACO1	RGD	RGD:1306784
Felis catus	TACO1	VGNC	VGNC:99554
Others	TACO1	NCBI