RINT1 - RAD50 interactor 1 Gene

Also Known as ILFS3; RINT-1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 60561

About RINT1

Cytogenetic location: 7q22.3 Genomic coordinates (GRCh38): 7:105,532,201-105,567,677 (from NCBI)

This gene has 8 transcripts (splice variants), 207 orthologues and is associated with 3 phenotypes. Ubiquitous expression in testis (RPKM 8.2), bone marrow (RPKM 7.8) and 25 other tissues.

Summary

This gene encodes a protein first identified for its ability to interact with the RAD50 double strand break repair protein, with the resulting interaction implicated in the regulation of cell cycle progression and telomere length. The encoded protein may also play a role in trafficking of cellular cargo from the endosome to the trans-Golgi network. Mutations in this gene may be associated with breast Cancer in human patients. [provided by RefSeq, Oct 2016]

RINT1 Products (5)

mRNA	Protein	Name
NM_001346599.2	NP_001333528.1	RAD50-interacting protein 1 isoform 2
NM_001346600.2	NP_001333529.1	RAD50-interacting protein 1 isoform 3
NM_001346601.2	NP_001333530.1	RAD50-interacting protein 1 isoform 4
NM_001346603.2	NP_001333532.1	RAD50-interacting protein 1 isoform 3
NM_021930.6	NP_068749.3	RAD50-interacting protein 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	11096100	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in mitotic G2 DNA damage checkpoint signaling	IMP IMP: Inferred from mutant phenotype	11096100	GOA
involved in regulation of ER to Golgi vesicle-mediated transport	IMP IMP: Inferred from mutant phenotype	16571679	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of Dsl1/NZR complex	IDA IDA: Inferred from direct assay	20462495	GOA
part of Dsl1/NZR complex	IPI IPI: Inferred from physical interaction	20462495	GOA
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	15029241	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RINT1 Protein Structure

RINT1_TIP1

0
200
400
600
792 a.a.

Protein Preferred Names	Protein Names
RAD50-interacting protein 1

RINT1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RINT1	Q6NUQ1	ZW10	Homo sapiens	O43264	Pull Down	24056303
Intra	RINT1	Q6NUQ1	ZW10	Homo sapiens	O43264	Anti Bait CoIP	24056303
Intra	RINT1	Q6NUQ1	ZW10	Homo sapiens	O43264	Anti Bait CoIP	20462495
Intra	RINT1	Q6NUQ1	ZW10	Homo sapiens	O43264	GMS	24056303
Intra	RINT1	Q6NUQ1	ZW10	Homo sapiens	O43264	Anti Tag CoIP	20462495
Intra	RINT1	Q6NUQ1	ZW10	Homo sapiens	O43264	Anti Tag CoIP	33961781
Intra	RINT1	Q6NUQ1	ZW10	Homo sapiens	O43264	Anti Tag CoIP	28514442
Intra	RINT1	Q6NUQ1	CCHCR1	Homo sapiens	Q8TD31-3	Validated Y2H	32296183
Intra	RINT1	Q6NUQ1	CEP57L1	Homo sapiens	Q8IYX8-2	Y2H Array	25416956
Intra	RINT1	Q6NUQ1	FAM107A	Homo sapiens	O95990-3	Y2H Prey Pooling	25416956
Intra	RINT1	Q6NUQ1	FAM107A	Homo sapiens	O95990-3	Validated Y2H	25416956
Intra	RINT1	Q6NUQ1	RTP5	Homo sapiens	Q14D33	Y2H Prey Pooling	25416956
Intra	RINT1	Q6NUQ1	RTP5	Homo sapiens	Q14D33	Validated Y2H	25416956
Intra	RINT1	Q6NUQ1	LOC729862	Homo sapiens	Q0VAF8	Validated Y2H	25416956
Intra	RINT1	Q6NUQ1	LOC729862	Homo sapiens	Q0VAF8	Y2H Array	25416956
Intra	RINT1	Q6NUQ1	LOC729862	Homo sapiens	Q0VAF9	Y2H Prey Pooling	25416956
Intra	RINT1	Q6NUQ1	LOC729862	Homo sapiens	Q0VAF9	Validated Y2H	25416956
Intra	RINT1	Q6NUQ1	CCDC146	Homo sapiens	Q8IYE0-2	Y2H Prey Pooling	25416956
Intra	RINT1	Q6NUQ1	RSRC2	Homo sapiens	Q7L4I2-2	Validated Y2H	25416956
Intra	RINT1	Q6NUQ1	RSRC2	Homo sapiens	Q7L4I2-2	Y2H Array	25416956
Intra	RINT1	Q6NUQ1	RSRC2	Homo sapiens	Q7L4I2-2	Y2H Prey Pooling	25416956
Intra	RINT1	Q6NUQ1	RIBC1	Homo sapiens	Q8N443	Y2H Prey Pooling	25416956
Intra	RINT1	Q6NUQ1	RIBC1	Homo sapiens	Q8N443	Validated Y2H	32296183
Intra	RINT1	Q6NUQ1	ZNF697	Homo sapiens	Q8N508	Y2H Prey Pooling	25416956
Intra	RINT1	Q6NUQ1	JMY	Homo sapiens	Q8N9B5-2	Validated Y2H	32296183
Intra	RINT1	Q6NUQ1	FAM81B	Homo sapiens	Q96LP2	Validated Y2H	25416956
Intra	RINT1	Q6NUQ1	LYSMD1	Homo sapiens	Q96S90	Validated Y2H	32296183
Intra	RINT1	Q6NUQ1	SH2D4A	Homo sapiens	Q9H788-2	Validated Y2H	25416956
Intra	RINT1	Q6NUQ1	STRN	Homo sapiens	O43815	Validated Y2H	25416956
Intra	RINT1	Q6NUQ1	TSHZ2	Homo sapiens	Q9NRE2	Validated Y2H	32296183
Intra	RINT1	Q6NUQ1	SFR1	Homo sapiens	Q86XK3	Y2H Prey Pooling	25416956
Intra	RINT1	Q6NUQ1	CDR2L	Homo sapiens	Q86X02	Validated Y2H	32296183
Intra	RINT1	Q6NUQ1	TRIM69	Homo sapiens	Q86WT6-2	Validated Y2H	32296183
Intra	RINT1	Q6NUQ1	C19orf44	Homo sapiens	Q9H6X5-2	Validated Y2H	32296183
Intra	RINT1	Q6NUQ1	RNF39	Homo sapiens	Q9H2S5	Validated Y2H	32296183
Intra	RINT1	Q6NUQ1	MGC50722	Homo sapiens	Q8IVT4	Validated Y2H	32296183
Intra	RINT1	Q6NUQ1	ANKRD11	Homo sapiens	X5D778	Validated Y2H	32296183
Intra	RINT1	Q6NUQ1	FAM110A	Homo sapiens	Q9BQ89	Validated Y2H	32296183
Intra	RINT1	Q6NUQ1	MISP	Homo sapiens	Q8IVT2	Validated Y2H	32296183
Intra	RINT1	Q6NUQ1	TSEN54	Homo sapiens	Q7Z6J9	Validated Y2H	32296183
Intra	RINT1	Q6NUQ1	PRPF18	Homo sapiens	Q99633	Validated Y2H	32296183
Intra	RINT1	Q6NUQ1	ARHGAP45	Homo sapiens	Q92619	Validated Y2H	32296183
Intra	RINT1	Q6NUQ1	CCDC121	Homo sapiens	Q6ZUS5	Validated Y2H	25416956
Intra	RINT1	Q6NUQ1	UVRAG	Homo sapiens	Q9P2Y5	Anti Bait CoIP	24056303
Intra	RINT1	Q6NUQ1	UVRAG	Homo sapiens	Q9P2Y5	GMS	24056303
Intra	RINT1	Q6NUQ1	UVRAG	Homo sapiens	Q9P2Y5	Anti Tag CoIP	24056303
Intra	RINT1	Q6NUQ1	UVRAG	Homo sapiens	Q9P2Y5	Pull Down	24056303
Intra	RINT1	Q6NUQ1	VAV3	Homo sapiens	Q9UKW4	Validated Y2H	32296183
Intra	RINT1	Q6NUQ1	HDAC4	Homo sapiens	P56524	Y2H Array	25416956
Intra	RINT1	Q6NUQ1	HDAC4	Homo sapiens	P56524	Y2H Prey Pooling	25416956
Intra	RINT1	Q6NUQ1	PIK3R2	Homo sapiens	O00459	Y2H Array	25416956
Intra	RINT1	Q6NUQ1	PIK3R2	Homo sapiens	O00459	Y2H Prey Pooling	25416956
Intra	RINT1	Q6NUQ1	TXLNA	Homo sapiens	P40222	Validated Y2H	25416956
Intra	RINT1	Q6NUQ1	DPF2	Homo sapiens	Q92785	Validated Y2H	32296183
Intra	RINT1	Q6NUQ1	SMARCE1	Homo sapiens	Q969G3	Y2H Prey Pooling	25416956
Intra	RINT1	Q6NUQ1	BLOC1S6	Homo sapiens	Q9UL45	Validated Y2H	32296183
Intra	RINT1	Q6NUQ1	CWF19L2	Homo sapiens	Q2TBE0	Y2H Prey Pooling	25416956
Intra	RINT1	Q6NUQ1	MYOZ3	Homo sapiens	Q8TDC0	Validated Y2H	32296183
Intra	RINT1	Q6NUQ1	ZNF835	Homo sapiens	Q9Y2P0	Validated Y2H	32296183
Intra	RINT1	Q6NUQ1	ZNF655	Homo sapiens	Q8N720	Validated Y2H	25416956
Intra	RINT1	Q6NUQ1	ZNF655	Homo sapiens	Q8N720	Y2H Array	31515488
Intra	RINT1	Q6NUQ1	ZNF655	Homo sapiens	Q8N720	Y2H Prey Pooling	25416956
Intra	RINT1	Q6NUQ1	SNW1	Homo sapiens	Q13573	Validated Y2H	25416956
Intra	RINT1	Q6NUQ1	SNW1	Homo sapiens	Q13573	Y2H Array	25416956
Intra	RINT1	Q6NUQ1	FAM90A1	Homo sapiens	Q86YD7	Y2H Array	25416956
Intra	RINT1	Q6NUQ1	FAM90A1	Homo sapiens	Q86YD7	Y2H Prey Pooling	25416956
Intra	RINT1	Q6NUQ1	FAM161A	Homo sapiens	Q3B820	Y2H Prey Pooling	25416956
Intra	RINT1	Q6NUQ1	FAM161A	Homo sapiens	Q3B820	Validated Y2H	25416956
Intra	RINT1	Q6NUQ1	FAM161A	Homo sapiens	Q3B820	Y2H Array	25416956
Intra	RINT1	Q6NUQ1	FAM161B	Homo sapiens	Q96MY7	Validated Y2H	32296183
Intra	RINT1	Q6NUQ1	LMO2	Homo sapiens	P25791	Validated Y2H	25416956
Intra	RINT1	Q6NUQ1	USHBP1	Homo sapiens	Q8N6Y0	Validated Y2H	32296183
Intra	RINT1	Q6NUQ1	RBM41	Homo sapiens	Q96IZ5	Validated Y2H	32296183
Intra	RINT1	Q6NUQ1	RBM41	Homo sapiens	Q96IZ5	Y2H Array	25416956
Intra	RINT1	Q6NUQ1	C19orf25	Homo sapiens	Q9UFG5	Anti Tag CoIP	28514442
Intra	RINT1	Q6NUQ1	C19orf25	Homo sapiens	Q9UFG5	Anti Tag CoIP	33961781
Intra	RINT1	Q6NUQ1	C19orf25	Homo sapiens	Q9UFG5	Validated Y2H	32296183
Intra	RINT1	Q6NUQ1	FAM124B	Homo sapiens	Q9H5Z6	Validated Y2H	25416956
Intra	RINT1	Q6NUQ1	FAM124B	Homo sapiens	Q9H5Z6	Y2H Prey Pooling	25416956
Intra	RINT1	Q6NUQ1	EXOC8	Homo sapiens	Q8IYI6	Validated Y2H	32296183
Intra	RINT1	Q6NUQ1	MMTAG2	Homo sapiens	Q9BU76	Validated Y2H	32296183
Intra	RINT1	Q6NUQ1	SGF29	Homo sapiens	Q96ES7	Validated Y2H	32296183
Intra	RINT1	Q6NUQ1	SGF29	Homo sapiens	Q96ES7	Y2H Prey Pooling	25416956
Intra	RINT1	Q6NUQ1	RAMAC	Homo sapiens	Q9BTL3	Validated Y2H	32296183
Intra	RINT1	Q6NUQ1	CCDC120	Homo sapiens	Q96HB5	Validated Y2H	32296183
Intra	RINT1	Q6NUQ1	SH2D4A	Homo sapiens	Q9H788	Y2H Prey Pooling	25416956
Intra	RINT1	Q6NUQ1	SH2D4A	Homo sapiens	Q9H788	Validated Y2H	32296183
Intra	RINT1	Q6NUQ1	SH2D4A	Homo sapiens	Q9H788	Y2H Array	25416956
Intra	RINT1	Q6NUQ1	TACO1	Homo sapiens	Q9BSH4	Validated Y2H	32296183
Intra	RINT1	Q6NUQ1	SCNM1	Homo sapiens	Q9BWG6	Validated Y2H	27107012
Intra	RINT1	Q6NUQ1	SCNM1	Homo sapiens	Q9BWG6	Y2H Prey Pooling	25416956
Intra	RINT1	Q6NUQ1	SCNM1	Homo sapiens	Q9BWG6	Validated Y2H	25416956
Intra	RINT1	Q6NUQ1	SCNM1	Homo sapiens	Q9BWG6	Y2H Array	25416956
Intra	RINT1	Q6NUQ1	EPC1	Homo sapiens	Q9H2F5	MAPPIT	25416956
Intra	RINT1	Q6NUQ1	EPC1	Homo sapiens	Q9H2F5	Validated Y2H	25416956
Intra	RINT1	Q6NUQ1	AIRIM	Homo sapiens	Q9NX04	Y2H Prey Pooling	25416956
Intra	RINT1	Q6NUQ1	AIRIM	Homo sapiens	Q9NX04	Validated Y2H	32296183
Intra	RINT1	Q6NUQ1	DCX	Homo sapiens	O43602	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Infantile Liver Failure Syndrome 3	ILFS3
Acute Liver Failure	Fulminant Hepatic Failure Acute Hepatic Failure Liver Failure Acute Hepatic Failure Fulminant Liver Failure, Acute
Fever-Associated Acute Infantile Liver Failure Syndrome
Infantile Liver Failure Syndrome	Infantile Liver Failure
Hereditary Breast Ovarian Cancer Syndrome	Hereditary Breast And Ovarian Cancer Syndrome Brca1- And Brca2-Associated Hereditary Breast And Ovarian Cancer Breast And/Or Ovarian Cancer Breast And Ovarian Cancer Syndrome Hboc Syndrome Hereditary Breast And Ovarian Cancer Brca1- Brca2-Associated Hboc
Pelger-Huet Anomaly	PHA Pelger-Huët Anomaly Ovoid Neutrophil Nuclei, Developmental Delay, Epilepsy And Skeletal Abnormalities Pelger Huet Anomaly Pelger-Huet Nuclear Anomaly
Munchausen By Proxy	Munchausen Syndrome By Proxy Munchausen By Proxy Syndrome Münchausen Syndrome By Proxy
Optic Nerve Hypoplasia, Bilateral	Optic Nerve Hypoplasia Bilateral Optic Nerve Hypoplasia Optic Nerve Hypoplasia, Familial Bilateral Familial Bilateral Optic Nerve Hypoplasia Isolated Optic Nerve Hypoplasia/Aplasia Optic Nerve Aplasia, Bilateral Onh BONH Bilateral Optic Nerve Aplasia Hypoplasia, Optic Nerve, Bilateral
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Lynch Syndrome	Hereditary Nonpolyposis Colon Cancer Hereditary Nonpolyposis Colorectal Cancer Hereditary Nonpolyposis Colorectal Carcinoma Hereditary Nonpolyposis Colorectal Neoplasms Familial Nonpolyposis Colon Cancer Hnpcc Coca 1 Hereditary Defective Mismatch Repair Syndrome Hereditary Non-Polyposis Colon Cancer Hereditary Non-Polyposis Colon Cancer Syndrome Hereditary Non-Polyposis Colorectal Cancer Hereditary Non-Polyposis Colorectal Cancer Syndrome Hereditary Nonpolyposis Colon Cancer Syndrome Hereditary Nonpolyposis Colorectal Cancer Syndrome Hereditary Nonpolyposis Colorectal Neoplasm Hnpcc - Hereditary Nonpolyposis Colon Cancer Cancer Family Syndrome Familial Nonpolyposis Colorectal Cancer Colon Cancer, Familial Nonpolyposis Colorectal Neoplasms, Hereditary Nonpolyposis Cancer, Colorectal, Nonpolyposis, Hereditary Colorectal Cancer, Hereditary Nonpolyposis, Type 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11987	RINT1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	RINT1	VGNC	VGNC:33979
Rattus norvegicus	RINT1	RGD	RGD:1560433
Mus musculus	RINT1	MGD	MGI:1916233
Macaca mulatta	RINT1	VGNC	VGNC:76802
Felis catus	RINT1	VGNC	VGNC:64637
Canis familiaris	RINT1	VGNC	VGNC:45591
Others	RINT1	NCBI