DCX - doublecortin Gene

Homo sapiens

Also known as DC; DBCN; LISX; SCLH; XLIS

Gene ID: 1641 | Gene type: protein coding

About DCX

Cytogenetic location: Xq23 Genomic coordinates (GRCh38): X:111,293,779-111,412,192 (from NCBI)

This gene has 12 transcripts (splice variants), 123 orthologues, 6 paralogues and is associated with 5 phenotypes. Biased expression in brain (RPKM 4.3) and endometrium (RPKM 1.0).

Summary

This gene encodes a member of the doublecortin family. The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene cause abnormal migration of neurons during development and disrupt the layering of the cortex, leading to epilepsy, cognitive disability, subcortical band heterotopia ("double cortex" syndrome) in females and lissencephaly ("smooth brain" syndrome) in males. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010]

DCX Products(11)

mRNA	Protein	Name
NM_000555.3	NP_000546.2	neuronal migration protein doublecortin isoform a
NM_001195553.2	NP_001182482.1	neuronal migration protein doublecortin isoform d
NM_001369370.1	NP_001356299.1	neuronal migration protein doublecortin isoform d
NM_001369371.1	NP_001356300.1	neuronal migration protein doublecortin isoform b
NM_001369372.1	NP_001356301.1	neuronal migration protein doublecortin isoform e
NM_001369373.1	NP_001356302.1	neuronal migration protein doublecortin isoform f
NM_001369374.1	NP_001356303.1	neuronal migration protein doublecortin isoform f
NM_001410715.1	NP_001397644.1	neuronal migration protein doublecortin isoform g
NM_178151.3	NP_835364.1	neuronal migration protein doublecortin isoform c
NM_178152.3	NP_835365.1	neuronal migration protein doublecortin isoform b
NM_178153.3	NP_835366.1	neuronal migration protein doublecortin isoform c

DCX Protein Structure

DCX

0
100
200
300
400
441 a.a.

Protein Preferred Names

Protein Names

neuronal migration protein doublecortin

doublecortex

Recombinant DCX Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75282	Doublecortin/DCX Protein, Human (His)	O43602-2 (A45-V150)	≥95%

Related Diseases

Diseases

Alias

Lissencephaly, X-Linked, 1

Lissencephaly Type 1 Due To Doublecortin Gene Mutation	Xlis
Lissencephaly, X-Linked	LISX1
Lissencephaly And Agenesis Of Corpus Callosum	Subcortical Laminal Heterotopia, X-Linked
X-Linked Lissencephaly 1	X-Linked Lissencephaly
Double Cortex	Xlis1
Lissencephaly X-Linked	Lisx
X-Linked Lissencephaly Type 1	Lissencephaly, X-Linked 1
Subcortical Band Heterotopia X-Linked	SBHX
Sclh	Subcortical Laminar Heterotopia
Lissencephaly, X-Linked, Type 1	Subcortical Band Heterotopia

Band Heterotopia

Subcortical Band Heterotopia	Double Cortex Syndrome
Subcortical Laminar Heterotopia	Double Cortex
Band Heterotopia Of Brain	BH
Heco	Heterotopic Cortex
Familial Band Heterotopia	Dc
Dc Syndrome	Heterotopia, Subcortical Band
Sbh	Sclh
Bhy

Lissencephaly 1

LIS1	Classic Lissencephaly
Ils	Subcortical Laminar Heterotopia
Lissencephaly Due To Lis1 Mutation	Lissencephaly Sequence, Isolated
Lissencephaly, Classic	Pafah1b1-Related Lissencephaly
Classical Lissencephaly	Lissencephaly Type 1
Lissencephaly-1	Subcortical Band Heterotopia
Double Cortex	Lissencephaly Classic
Lissencephaly Sequence Isolated	Isolated Lissencephaly Sequence
Type 1 Lissencephaly	Lissencephaly Syndrome Type 1
SBH	Sclh
Lissencephaly, Type 1	Type I Lissencephaly

Nervous System Disease

Abnormality Of The Nervous System	Nervous System Diseases
Nervous System Disorder

Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder

Lissencephaly

Pachygyria	Broad Gyri Of Cerebrum
Large Gyri Of Cerebrum	Macrogyria

Fucosidosis

Alpha-L-Fucosidase Deficiency	Fucosidase Deficiency Disease
A-Fucosidase Deficiency	Alpha Fucosidase Deficiency
Lysosomal Storage Disease Caused By Defective Alpha-L-Fucosidase With Accumulation Of Fucose In The Tissues	Alpha-Fucosidase Deficiency
Fucosidase Deficiency	FUCA1D

Cerebellar Hypoplasia

Epilepsy

Epilepsy Syndrome	Epileptic Syndrome
Epilepsies	Symptomatic Epilepsies
Post Traumatic Epilepsy	Traumatic Epilepsy
Traumatic Epileptic	Epilepsy Due To Hippocampal Sclerosis
Epilepsy With Ammon'S Horn Sclerosis	Epilepsy Due To Cortical Dysplasia
Epilepsy Due To Neuronal Migration Disorders

Retinitis Pigmentosa 1

RP1	Retinitis Pigmentosa-1
Retinitis Pigmentosa, Type 1

Periventricular Nodular Heterotopia

Periventricular Heterotopia	Pvnh
Familial Nodular Heterotopia	Heterotopia, Periventricular
Periventricular Heterotopia, X-Linked

Tuberous Sclerosis

Tuberous Sclerosis Syndrome	Bourneville'S Disease
Epiloia	Cerebral Sclerosis
Tuberose Sclerosis	Tuberous Sclerosis 1
Bourneville Disease	Bourneville Phakomatosis
Pringle'S Disease

Lissencephaly 10

LIS10

Zellweger Syndrome

Cerebrohepatorenal Syndrome	Zellweger Leukodystrophy
Zs	Congenital Iron Overload
Chr	Zws
Severe Pbd-Zsd	Severe Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder

Ganglioglioma

Childhood Ganglioglioma	Adult Ganglioglioma
Cns Ganglioglioma	Mixed Cell Tumors Containing Both Neural Ganglionic Cells And Neural Glial Cell Components

Brain Oligodendroglioma

Oligodendroglioma Of Brain

Miller-Dieker Lissencephaly Syndrome

Miller-Dieker Syndrome	Mds
MDLS	Miller Dieker Syndrome
Classical Lissencephaly Syndrome	Lissencephaly Due To 17p13.3 Deletion
Monosomy 17p13.3	Telomeric Deletion 17p
Classical Lissencephaly

Pilocytic Astrocytoma

Juvenile Pilocytic Astrocytoma	Grade I Astrocytic Tumor
Piloid Astrocytoma

Lissencephaly 7 With Cerebellar Hypoplasia

LIS7	Lissencephaly 7, With Cerebellar Hypoplasia
Lissencephaly, Type 7, With Cerebellar Hypoplasia

Polymicrogyria, Bilateral Perisylvian, X-Linked

Bilateral Perisylvian Polymicrogyria	Polymicrogyria, Bilateral Perisylvian
Pmgx	Perisylvian Syndrome, Congenital Bilateral
Cbps	Congenital Bilateral Perisylvian Syndrome
Perisylvian Syndrome	BPPX
Bpp

Chromosome 17p13.3, Centromeric, Duplication Syndrome

Chromosome 17p13.3 Duplication Syndrome	17p13.3 Duplication Syndrome
17p13.3 Microduplication Syndrome	Trisomy 17p13.3
Chromosome 17p13.3 Centromeric Duplication Syndrome	Dup(17)(P13.3)

Schizophrenia 12

Sczd12

Schizophrenia Susceptibility Locus, Chromosome 1p-Related

Reading Disorder

Specific Reading Disorder	Reading
Dyslexia	Developmental Reading Disorder

Stroke, Ischemic

Cerebral Infarction	Stroke
Ischemic Stroke	Cerebrovascular Accident
Cerebral Infarction, Susceptibility To	Stroke, Ischemic, Susceptibility To
Cerebral Infarct	Ischemic Stroke, Susceptibility To
Stroke, Susceptibility To	Cva - Cerebral Infarction
ISCHSTR	Ischemic Cerebrovascular Accident

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-117787	TUG-905	Agonist	/	Unkown
HY-RS03601	DCX Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	DCX	MGD	MGI:1277171
Rattus norvegicus	DCX	RGD	RGD:620670
Bos taurus	DCX	VGNC	VGNC:56525
Canis familiaris	DCX	VGNC	VGNC:54132
Others	DCX	NCBI

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