PIK3R2 - phosphoinositide-3-kinase regulatory subunit 2 Gene

Also Known as p85; MPPH; P85B; MPPH1; p85beta; p85-BETA

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5296

About PIK3R2

Cytogenetic location: 19p13.11 Genomic coordinates (GRCh38): 19:18,153,163-18,170,532 (from NCBI)

This gene has 11 transcripts (splice variants), 248 orthologues, 2 paralogues and is associated with 3 phenotypes. Ubiquitous expression in brain (RPKM 16.0), skin (RPKM 12.1) and 25 other tissues.

Summary

Phosphatidylinositol 3-kinase (PI3K) is a lipid kinase that phosphorylates phosphatidylinositol and similar compounds, creating second messengers important in growth signaling pathways. PI3K functions as a heterodimer of a regulatory and a catalytic subunit. The protein encoded by this gene is a regulatory component of PI3K. Three transcript variants, one protein coding and the Other two non-protein coding, have been found for this gene. [provided by RefSeq, Apr 2019]

PIK3R2 Products (1)

mRNA	Protein	Name
NM_005027.4	NP_005018.2	phosphatidylinositol 3-kinase regulatory subunit beta

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables phosphotyrosine residue binding	IPI IPI: Inferred from physical interaction	20624904	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	7537096	GOA
enables protein phosphatase binding	IPI IPI: Inferred from physical interaction	23604317	GOA
enables receptor tyrosine kinase binding	IPI IPI: Inferred from physical interaction	10627473	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of MAPK cascade	IMP IMP: Inferred from mutant phenotype	18694566	GOA
involved in phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA IDA: Inferred from direct assay	23604317	GOA
involved in regulation of autophagy	IMP IMP: Inferred from mutant phenotype	23604317	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of phosphatidylinositol 3-kinase complex, class IA	IPI IPI: Inferred from physical interaction	22402981	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PIK3R2 Protein Structure

RhoGAP

SH2

0
200
400
600
728 a.a.

Protein Preferred Names	Protein Names
phosphatidylinositol 3-kinase regulatory subunit beta	PI3-kinase subunit p85-beta

PIK3R2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PIK3R2	O00459	MET	Homo sapiens	P08581	FPS	24728074
Intra	PIK3R2	O00459	KRT38	Homo sapiens	O76015	Y2H Array	25416956
Intra	PIK3R2	O00459	KRT38	Homo sapiens	O76015	Y2H Array	29892012
Intra	PIK3R2	O00459	KIT	Homo sapiens	P10721	CoIP	7537096
Intra	PIK3R2	O00459	KIT	Homo sapiens	P10721	FPS	24728074
Intra	PIK3R2	O00459	PIK3CB	Homo sapiens	P42338	Anti Bait CoIP	22402981
Intra	PIK3R2	O00459	PIK3CB	Homo sapiens	P42338	Anti Tag CoIP	35271311
Intra	PIK3R2	O00459	PIK3CB	Homo sapiens	P42338	Anti Tag CoIP	33961781
Intra	PIK3R2	O00459	PIK3CB	Homo sapiens	P42338	Anti Tag CoIP	28514442
Intra	PIK3R2	O00459	PIK3CB	Homo sapiens	P42338	TAP	19380743
Intra	PIK3R2	O00459	EGFR	Homo sapiens	P00533	Protein Array	16273093
Intra	PIK3R2	O00459	EGFR	Homo sapiens	P00533	Ub Reconstruction	31980649
Intra	PIK3R2	O00459	GRB2	Homo sapiens	P62993	Y2H Pooling	20936779
Intra	PIK3R2	O00459	GRB2	Homo sapiens	P62993	TAP	19380743
Intra	PIK3R2	O00459	HTT	Homo sapiens	P42858	Y2H	17500595
Intra	PIK3R2	O00459	IGF1R	Homo sapiens	P08069	Y2H	7541045
Intra	PIK3R2	O00459	GAB1	Homo sapiens	Q13480	FPS	24728074
Intra	PIK3R2	O00459	CBL	Homo sapiens	P22681	Y2H Array	25814554
Intra	PIK3R2	O00459	CBL	Homo sapiens	P22681	TAP	19380743
Intra	PIK3R2	O00459	CBL	Homo sapiens	P22681	Validated Y2H	25814554
Intra	PIK3R2	O00459	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	PIK3R2	O00459	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	PIK3R2	O00459	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	PIK3R2	O00459	AR	Homo sapiens	P10275	FPS	24728074
Intra	PIK3R2	O00459	ERBB2	Homo sapiens	P04626	Protein Array	16273093
Intra	PIK3R2	O00459	ERBB3	Homo sapiens	P21860	Protein Array	16273093
Intra	PIK3R2	O00459	RINT1	Homo sapiens	Q6NUQ1	Validated Y2H	25416956
Intra	PIK3R2	O00459	KRT15	Homo sapiens	P19012	Validated Y2H	25416956
Intra	PIK3R2	O00459	TRIM23	Homo sapiens	P36406	Y2H Array	25416956
Intra	PIK3R2	O00459	TRIM23	Homo sapiens	P36406	Validated Y2H	25416956
Intra	PIK3R2	O00459	TRIM23	Homo sapiens	P36406	Y2H Prey Pooling	25416956
Intra	PIK3R2	O00459	DYDC1	Homo sapiens	Q8WWB3	Validated Y2H	25416956
Intra	PIK3R2	O00459	DYDC1	Homo sapiens	Q8WWB3	Y2H Array	25416956
Intra	PIK3R2	O00459	KRT20	Homo sapiens	P35900	Y2H Prey Pooling	25416956
Intra	PIK3R2	O00459	IKZF3	Homo sapiens	Q9UKT9	Y2H Array	31515488
Intra	PIK3R2	O00459	IKZF3	Homo sapiens	Q9UKT9	Y2H Prey Pooling	25416956
Intra	PIK3R2	O00459	PIK3R1	Homo sapiens	P27986	Anti Tag CoIP	33961781
Intra	PIK3R2	O00459	PIK3R1	Homo sapiens	P27986	Anti Tag CoIP	35271311
Cross	PIK3R2	O00459	NS	Influenza A virus	P03496	Anti Tag CoIP	16963558
Cross	PIK3R2	O00459	NS	Influenza A virus	Q82506	Anti Tag CoIP	16963558

Cross: Cross-species interaction Intra: Intraspecies interaction

PIK3R2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80868	PI3 Kinase p85 beta Antibody (YA688)	WB	Human, Mouse, Rat
HY-P85585	PI3 Kinase p85 beta Antibody (YA5277)	WB	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Megalencephaly-Polymicrogyria-Polydactyly-Hydrocephalus Syndrome 1	Megalencephaly-Polymicrogyria-Polydactyly-Hydrocephalus Syndrome Mpph Syndrome Mpph MPPH1 Meg-Pmg-Megacc Syndrome Megalencephaly-Polymicrogyria-Postaxial Polydactyly-Hydrocephalus Syndrome Megalencephaly, Polymicrogyria, Mega Corpus Callosum Syndrome Megalencephaly, Mega Corpus Callosum, And Complete Lack Of Motor Development Megalencephaly And Perisylvian Polymicrogyria With Postaxial Polydactyly And Hydrocephalus Megalencephaly, Polymicrogyria, And Hydrocephalus Syndrome Meg-Pmg-Poly-Hyd Megalencephaly-Postaxial Polydactyly-Polymicrogyria-Hydrocephalus Syndrome Megalencephaly Mega Corpus Callosum And Complete Lack Of Motor Development Megalencephaly-Polymicrogyria-Mega Corpus Callosum Syndrome Megalencephaly-Polymicrogyria-Polydactyly-Hydrocephalus Syndrome, Type 1 Megalanecephaly Polymicrogyria-Polydactyly Hydrocephalus Syndrome
Megalencephaly-Capillary Malformation-Polymicrogyria Syndrome	Megalencephaly-Capillary Malformation Syndrome MCAP Macrocephaly-Capillary Malformation Mcmtc Mcm Megalencephaly Cutis Marmorata Telangiectatica Congenita Macrocephaly-Cutis Marmorata Telangiectatica Congenita Megalencephaly-Cutis Marmorata Telangiectatica Congenita Megalencephaly-Capillary Malformation-Polymicrogyria Syndrome, Somatic M-Cm Macrocephaly Cutis Marmorata Telangiectatica Congenita Macrocephaly-Capillary Malformation Syndrome M-Cmtc Megalocephaly Cutis Marmorata Telangiectatica Congenita Macrocephaly-Cutis Marmorata Telangiectatica Congenita Syndrome Megalencephaly-Cutis Marmorata Telangiectatica Congenita Syndrome
Endometrial Adenocarcinoma	Endometrial Endometrioid Adenocarcinoma Endometrial Adenoacanthoma Endometrial Endometrioid Adenocarcinoma, Variant With Squamous Differentiation Adenocarcinoma Of Endometrium Adenocarcinoma Of The Endometrium Adenocarcinoma Of Uterus Endometrial Endometrioid Adenocarcinoma With Squamous Differentiation Endometrioid Adenoma Or Carcinoma Endometrioid Adenomas And Carcinomas Endometrioid Carcinoma Of Endometrium Endometrium Adenocarcinoma
Megalencephaly	Macroencephaly Macrencephaly
Polymicrogyria	Pmg
Myeloma, Multiple	Multiple Myeloma Plasma Cell Myeloma Kahler Disease Myelomatosis Medullary Plasmacytoma Multiple Myeloma, Resistance To Myeloma Plasma Cell Dyscrasia Kahler'S Disease Multiple Myeloma, Susceptibility To Myeloma - Multiple Kahler-Bozzolo Disease Plasma Cell Myelomas MM Plasma Cell Neoplasm Primary Systemic Amyloidosis Primary Amyloidosis Immunoglobulin Deposition Disease Plasmacytic Myeloma Multiple Myelomata Multiple Myeloma Nos Multiple Myeloma Without Mention Of Remission Monostotic Plasma Cell Myeloma Mm - [Multiple Myeloma]
Plasma Cell Neoplasm	Plasma Cell Dyscrasia Paraproteinemias Plasma Cell Tumour Plasmacytic Tumor Multiple Myeloma Plasmacytoma Plasma Cell Tumours Plasma Cells Dyscrasia
Congenital Lipomatous Overgrowth, Vascular Malformations, And Epidermal Nevi	Cloves Syndrome Clove Syndrome Congenital Lipomatous Overgrowth, Vascular Malformations, Epidermal Nevi, And Skeletal/Spinal Abnormalities Clove Syndrome, Somatic Nevus Congenital Lipomatous Overgrowth - Vascular Malformation - Epidermal Nevi Congenital Lipomatous Overgrowth-Vascular Malformation-Epidermal Nevi-Skeletal Anomaly Syndrome Congenital Lipomatous Overgrowth-Vascular Malformation-Epidermal Nevi-Spinal Anomaly Syndrome CLOVE Congenital Lipomatous Overgrowth Vascular Malformations Epidermal Nevi And Skeletal/Spinal Abnormalities Congenital Arteriovenous Malformation Arteriovenous Hemangioma Melanocytic Nevus Benign Melanocytic Nevus
Polymicrogyria, Bilateral Perisylvian, X-Linked	Bilateral Perisylvian Polymicrogyria Polymicrogyria, Bilateral Perisylvian Pmgx Perisylvian Syndrome, Congenital Bilateral Cbps Congenital Bilateral Perisylvian Syndrome Perisylvian Syndrome BPPX Bpp
Endometrial Cancer	Endometrial Carcinoma Endometrial Neoplasm Malignant Neoplasm Of Endometrium Endometrioid Carcinoma Endometrial Neoplasms Carcinoma, Endometrioid Endometrial Cancer, Familial Endometrial Carcinoma, Somatic Endometrial Cancer, Susceptibility To Endometrial Ca Malignant Endometrial Neoplasm Neoplasm Of Endometrium Primary Malignant Neoplasm Of Endometrium Tumor Of Endometrium Carcinoma Of The Endometrium Endometrioid Carcinoma Of Female Reproductive System ENDMC Carcinoma Endometrioid Endometrial Cancers Cancer, Endometrial Uterine Corpus Cancer
Proteus Syndrome	Proteus Syndrome, Somatic Partial Gigantism-Nevi-Hemihypertrophy-Macrocephaly Syndrome Gigantism, Partial, Of Hands And Feet, Nevi, Hemihypertrophy, And Macrocephaly Wiedemann'S Syndrome Hemihypertrophy And Macrocephaly Partial Gigantism Of Hands And Feet, Nevi, Hemihypertrophy, Macrocephaly Ps PROTEUSS Partial Gigantism Of Hands And Feet Nevi Hemihypertrophy And Macrocephaly
Cowden Syndrome 1	Bannayan-Riley-Ruvalcaba Syndrome Pten Hamartoma Tumor Syndrome Lhermitte-Duclos Disease Bannayan-Zonana Syndrome Phts Riley-Smith Syndrome Bzs Ruvalcaba-Myhre-Smith Syndrome Multiple Hamartoma Syndrome Rmss Brrs Dysplastic Gangliocytoma Of The Cerebellum CWS1 Cs Cd Mham Pten Hamartoma Tumor Syndrome With Granular Cell Tumor Macrocephaly Multiple Lipomas And Hemangiomata Bannayan-Ruvalcaba-Riley Syndrome Myhre-Riley-Smith Syndrome LDD Cerebelloparenchymal Disorder Vi Hamartoma Syndrome, Multiple Bbrs Macrocephaly, Pseudopapilledema, And Multiple Hemangiomata Macrocephaly, Multiple Lipomas, And Hemangiomata Macrocephaly Pseudopapilledema And Multiple Hemangiomas Ruvalcaba -Myhre-Smith Syndrome Ruvalcaba-Myhre Syndrome Cowden Disease Macrocephaly Pseudopapilledema And Multiple Hemangiomata Cerebellar Granule Cell Hypertrophy And Megalencephaly Cpd6 Pten Hamartoma Tumor Syndromes Cowden Syndrome, Type 1
Hydrocephalus	Hydrocephalus, Nonsyndromic, Autosomal Recessive Hydrocephalus, X-Linked Hydrocephalus Adverse Event Hydrocephaly Nos
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Polydactyly	Non-Syndromic Polydactyly Polydactyly, Postaxial Postaxial Polydactyly Supernumerary Digit Extra Digits Hyperdactyly Polydactylia Polydactylism Supernumerary Digits
Immunodeficiency 14	Activated Pi3k-Delta Syndrome Apds Pasli Disease Imd14 Senescent T-Cells-Lymphadenopathy-Immunodeficiency Syndrome Due To P110delta-Activating Mutation P110 Delta-Activating Mutation Causing Senescent T Cells, Lymphadenopathy, And Immunodeficiency
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Klippel-Feil Syndrome 4
Nevus, Epidermal	Epidermal Nevus Woolly Hair Nevus Epidermal Naevus Epidermal Nevus Syndrome Nevus, Keratinocytic, Nonepidermolytic Epidermal Nevus, Somatic Nevus, Epidermal, Somatic Nevus Sebaceous Or Woolly Hair Nevus, Somatic Nonepidermolytic Keratinocytic Nevus Epidermal Hamartoma Syndrome Wooly Hair Nevus Keratinocytic Non-Epidermolytic Nevus KNEN Pigmented Moles Organoid Nevus Phakomatosis Nevus Sebaceous Melanocytic Nevus Melanocytic Nevus Of Skin
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Klippel-Trenaunay-Weber Syndrome	Klippel-Trenaunay Syndrome KTS Ktw Syndrome Angioosteohypertrophy Syndrome Angio-Osteohypertrophy Syndrome Klippel Trenaunay Syndrome Klippel-Trénaunay-Weber Syndrome Haemangiectatic Hypertrophy Weber-Klippel-Trenaunay Congenital Dysplastic Angiopathy Klippel-Trenaunay Disease Weber Klippel Trenaunay
Cowden Syndrome	Cowden Disease Multiple Hamartoma Syndrome Cowden'S Disease Lhermitte-Duclos Disease Cd Cs Mham Dysplastic Gangliocytoma Of Cerebellum Cowden'S Syndrome Hamartoma Syndrome, Multiple

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-174976	FHND5032	Inhibitor	99.49%	Unkown
HY-RS10537	PIK3R2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21907	Pik3r2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28424	Pik3r2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	PIK3R2	VGNC	VGNC:80654
Bos taurus	PIK3R2	VGNC	VGNC:52862
Rattus norvegicus	PIK3R2	RGD	RGD:68341
Canis familiaris	PIK3R2	VGNC	VGNC:81919
Mus musculus	PIK3R2	MGD	MGI:1098772
Others	PIK3R2	NCBI