KRT20 - keratin 20 Gene
Also Known as K20; CD20; CK20; CK-20; KRT21
Species: Homo sapiens
About KRT20
This gene has 2 transcripts (splice variants), 1 gene allele, 103 orthologues and 68 paralogues. Biased expression in small intestine (RPKM 435.8), colon (RPKM 405.3) and 3 other tissues.
Summary
The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. This cytokeratin is a major cellular protein of mature enterocytes and goblet cells and is specifically expressed in the gastric and intestinal mucosa. The type I cytokeratin genes are clustered in a region of chromosome 17q12-q21. [provided by RefSeq, Jul 2008]
KRT20 Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_019010.3 | NP_061883.1 | keratin, type I cytoskeletal 20 |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
16189514 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in intermediate filament organization |
IMP
IMP: Inferred from mutant phenotype
|
12857878 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in cytoplasm |
IDA
IDA: Inferred from direct assay
|
10973561 | GOA |
KRT20 Protein Structure
Filament: Intermediate filament protein (69 - 379)
- 0
- 100
- 200
- 300
- 400
- 424 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
keratin, type I cytoskeletal 20 |
|
|
KRT20 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
KRT20 | P35900 | KRT13 | Homo sapiens | A1A4E9 | 25416956 | |
|
Intra
|
KRT20 | P35900 | KRT13 | Homo sapiens | A1A4E9 | 25416956 | |
|
Intra
|
KRT20 | P35900 | KRT40 | Homo sapiens | Q6A162 | 25416956 | |
|
Intra
|
KRT20 | P35900 | KRT40 | Homo sapiens | Q6A162 | 25416956 | |
|
Intra
|
KRT20 | P35900 | KRT40 | Homo sapiens | Q6A162 | 25416956 | |
|
Intra
|
KRT20 | P35900 | KRTAP10-8 | Homo sapiens | P60410 | 32296183 | |
|
Intra
|
KRT20 | P35900 | KRTAP10-8 | Homo sapiens | P60410 | 32296183 | |
|
Intra
|
KRT20 | P35900 | KRTAP10-8 | Homo sapiens | P60410 | 32296183 | |
|
Intra
|
KRT20 | P35900 | KRTAP10-9 | Homo sapiens | P60411 | 25416956 | |
|
Intra
|
KRT20 | P35900 | KRTAP10-9 | Homo sapiens | P60411 | 25416956 | |
|
Intra
|
KRT20 | P35900 | KRTAP10-7 | Homo sapiens | P60409 | 25416956 | |
|
Intra
|
KRT20 | P35900 | KRTAP10-7 | Homo sapiens | P60409 | 25416956 | |
|
Intra
|
KRT20 | P35900 | CCDC196 | Homo sapiens | A0A1B0GWI1 | 32296183 | |
|
Intra
|
KRT20 | P35900 | CCDC196 | Homo sapiens | A0A1B0GWI1 | 32296183 | |
|
Intra
|
KRT20 | P35900 | AMOTL2 | Homo sapiens | Q9Y2J4-4 | 25416956 | |
|
Intra
|
KRT20 | P35900 | KRT34 | Homo sapiens | O76011 | 32296183 | |
|
Intra
|
KRT20 | P35900 | KRT34 | Homo sapiens | O76011 | 32296183 | |
|
Intra
|
KRT20 | P35900 | BCAS2 | Homo sapiens | O75934 | 32296183 | |
|
Intra
|
KRT20 | P35900 | BCAS2 | Homo sapiens | O75934 | 32296183 | |
|
Intra
|
KRT20 | P35900 | DES | Homo sapiens | P17661 | 32296183 | |
|
Intra
|
KRT20 | P35900 | DES | Homo sapiens | P17661 | 32296183 | |
|
Intra
|
KRT20 | P35900 | PPP1R13B | Homo sapiens | Q96KQ4 | 32296183 | |
|
Intra
|
KRT20 | P35900 | PPP1R13B | Homo sapiens | Q96KQ4 | 32296183 | |
|
Intra
|
KRT20 | P35900 | PPP1R13B | Homo sapiens | Q96KQ4 | 32296183 | |
|
Intra
|
KRT20 | P35900 | TFIP11 | Homo sapiens | Q9UBB9 | 32296183 | |
|
Intra
|
KRT20 | P35900 | TFIP11 | Homo sapiens | Q9UBB9 | 21516116 | |
|
Intra
|
KRT20 | P35900 | TFIP11 | Homo sapiens | Q9UBB9 | 32296183 | |
|
Intra
|
KRT20 | P35900 | TFIP11 | Homo sapiens | Q9UBB9 | 32296183 | |
|
Intra
|
KRT20 | P35900 | TFIP11 | Homo sapiens | Q9UBB9 | 25416956 | |
|
Intra
|
KRT20 | P35900 | KRTAP12-3 | Homo sapiens | P60328 | 32296183 | |
|
Intra
|
KRT20 | P35900 | KRTAP12-3 | Homo sapiens | P60328 | 32296183 | |
|
Intra
|
KRT20 | P35900 | KRTAP12-3 | Homo sapiens | P60328 | 32296183 | |
|
Intra
|
KRT20 | P35900 | KRTAP1-1 | Homo sapiens | Q07627 | 32296183 | |
|
Intra
|
KRT20 | P35900 | KRTAP1-1 | Homo sapiens | Q07627 | 32296183 | |
|
Intra
|
KRT20 | P35900 | KRTAP1-1 | Homo sapiens | Q07627 | 32296183 | |
|
Intra
|
KRT20 | P35900 | KRT80 | Homo sapiens | Q6KB66-2 | 32296183 | |
|
Intra
|
KRT20 | P35900 | KRT72 | Homo sapiens | Q14CN4 | 32296183 | |
|
Intra
|
KRT20 | P35900 | KRT72 | Homo sapiens | Q14CN4 | 32296183 | |
|
Intra
|
KRT20 | P35900 | KRT72 | Homo sapiens | Q14CN4 | 32296183 | |
|
Intra
|
KRT20 | P35900 | KRTAP6-3 | Homo sapiens | Q3LI67 | 32296183 | |
|
Intra
|
KRT20 | P35900 | KRTAP6-3 | Homo sapiens | Q3LI67 | 32296183 | |
|
Intra
|
KRT20 | P35900 | KRT3 | Homo sapiens | P12035 | 32296183 | |
|
Intra
|
KRT20 | P35900 | KRT3 | Homo sapiens | P12035 | 32296183 | |
|
Intra
|
KRT20 | P35900 | KRT75 | Homo sapiens | O95678 | 32296183 | |
|
Intra
|
KRT20 | P35900 | KRT75 | Homo sapiens | O95678 | 32296183 | |
|
Intra
|
KRT20 | P35900 | KRT24 | Homo sapiens | Q2M2I5 | 32296183 | |
|
Intra
|
KRT20 | P35900 | KRT24 | Homo sapiens | Q2M2I5 | 32296183 | |
|
Intra
|
KRT20 | P35900 | KRT24 | Homo sapiens | Q2M2I5 | 32296183 | |
|
Intra
|
KRT20 | P35900 | KRT76 | Homo sapiens | Q01546 | 32296183 | |
|
Intra
|
KRT20 | P35900 | KRT76 | Homo sapiens | Q01546 | 32296183 | |
|
Intra
|
KRT20 | P35900 | KRT76 | Homo sapiens | Q01546 | 32296183 | |
|
Intra
|
KRT20 | P35900 | SNAPIN | Homo sapiens | O95295 | 32296183 | |
|
Intra
|
KRT20 | P35900 | SNAPIN | Homo sapiens | O95295 | 32296183 | |
|
Intra
|
KRT20 | P35900 | KRT27 | Homo sapiens | Q7Z3Y8 | 32296183 | |
|
Intra
|
KRT20 | P35900 | KRT27 | Homo sapiens | Q7Z3Y8 | 32296183 | |
|
Intra
|
KRT20 | P35900 | KRT27 | Homo sapiens | Q7Z3Y8 | 32296183 | |
|
Intra
|
KRT20 | P35900 | KRT80 | Homo sapiens | Q6KB66 | 25416956 | |
|
Intra
|
KRT20 | P35900 | PIK3R2 | Homo sapiens | O00459 | 25416956 | |
|
Intra
|
KRT20 | P35900 | PIK3R2 | Homo sapiens | O00459 | 25416956 | |
|
Intra
|
KRT20 | P35900 | NUP62 | Homo sapiens | P37198 | 32296183 | |
|
Intra
|
KRT20 | P35900 | NUP62 | Homo sapiens | P37198 | 32296183 | |
|
Intra
|
KRT20 | P35900 | NUP62 | Homo sapiens | P37198 | 25416956 | |
|
Intra
|
KRT20 | P35900 | NUP62 | Homo sapiens | P37198 | 32296183 | |
|
Intra
|
KRT20 | P35900 | NUP62 | Homo sapiens | P37198 | 32296183 | |
|
Intra
|
KRT20 | P35900 | VIM | Homo sapiens | P08670 | 32296183 | |
|
Intra
|
KRT20 | P35900 | VIM | Homo sapiens | P08670 | 25416956 | |
|
Intra
|
KRT20 | P35900 | VIM | Homo sapiens | P08670 | 32296183 | |
|
Intra
|
KRT20 | P35900 | TXLNA | Homo sapiens | P40222 | 32296183 | |
|
Intra
|
KRT20 | P35900 | TXLNA | Homo sapiens | P40222 | 25416956 | |
|
Intra
|
KRT20 | P35900 | TXLNA | Homo sapiens | P40222 | 32296183 | |
|
Intra
|
KRT20 | P35900 | TXLNA | Homo sapiens | P40222 | 32296183 | |
|
Intra
|
KRT20 | P35900 | TXLNA | Homo sapiens | P40222 | 25416956 | |
|
Intra
|
KRT20 | P35900 | CYSRT1 | Homo sapiens | A8MQ03 | 32296183 | |
|
Intra
|
KRT20 | P35900 | CYSRT1 | Homo sapiens | A8MQ03 | 32296183 | |
|
Intra
|
KRT20 | P35900 | HTT | Homo sapiens | P42858 | 32814053 | |
|
Intra
|
KRT20 | P35900 | HTT | Homo sapiens | P42858 | 32814053 | |
|
Intra
|
KRT20 | P35900 | HTT | Homo sapiens | P42858 | 32814053 | |
|
Intra
|
KRT20 | P35900 | KRT15 | Homo sapiens | P19012 | 25416956 | |
|
Intra
|
KRT20 | P35900 | KRT15 | Homo sapiens | P19012 | 25416956 | |
|
Intra
|
KRT20 | P35900 | USHBP1 | Homo sapiens | Q8N6Y0 | 25416956 | |
|
Intra
|
KRT20 | P35900 | USHBP1 | Homo sapiens | Q8N6Y0 | 25416956 | |
|
Intra
|
KRT20 | P35900 | ABI2 | Homo sapiens | Q9NYB9 | 29892012 | |
|
Intra
|
KRT20 | P35900 | PRPH | Homo sapiens | P41219 | 32296183 | |
|
Intra
|
KRT20 | P35900 | PRPH | Homo sapiens | P41219 | 32814053 | |
|
Intra
|
KRT20 | P35900 | PRPH | Homo sapiens | P41219 | 32296183 | |
|
Intra
|
KRT20 | P35900 | PRPH | Homo sapiens | P41219 | 32814053 | |
|
Intra
|
KRT20 | P35900 | PRPH | Homo sapiens | P41219 | 32814053 | |
|
Intra
|
KRT20 | P35900 | PRPH | Homo sapiens | P41219 | 32296183 | |
|
Intra
|
KRT20 | P35900 | BBLN | Homo sapiens | Q9BUW7 | 32296183 | |
|
Intra
|
KRT20 | P35900 | BBLN | Homo sapiens | Q9BUW7 | 32296183 | |
|
Intra
|
KRT20 | P35900 | BBLN | Homo sapiens | Q9BUW7 | 16189514 | |
|
Intra
|
KRT20 | P35900 | BBLN | Homo sapiens | Q9BUW7 | 25416956 | |
|
Intra
|
KRT20 | P35900 | BBLN | Homo sapiens | Q9BUW7 | 25416956 | |
|
Intra
|
KRT20 | P35900 | BBLN | Homo sapiens | Q9BUW7 | 32296183 | |
|
Intra
|
KRT20 | P35900 | NOTCH2NLA | Homo sapiens | Q7Z3S9 | 25416956 | |
|
Intra
|
KRT20 | P35900 | KRT31 | Homo sapiens | Q15323 | 32296183 | |
|
Intra
|
KRT20 | P35900 | KRT31 | Homo sapiens | Q15323 | 32296183 | |
|
Intra
|
KRT20 | P35900 | KRT31 | Homo sapiens | Q15323 | 32296183 |
KRT20 Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P80982 | Cytokeratin 20 Antibody (YA3506) | WB, IHC-P, ICC/IF, IP, FC | Human, Rat |
| HY-P85905 | Cytokeratin 20 Antibody (YA5597) | IHC-P, WB, ICC/IF, ELISA | Human, Mouse, Rat |
| HY-P86033 | Cytokeratin 20 Antibody (YA5725) | IHC-P, ELISA | Human, Mouse, Rat |
| HY-P86129 | Cytokeratin 20 Antibody (YA5821) | WB, IHC-P, ICC/IF, IP, ELISA | Human, Rat |
| HY-P86660 | Cytokeratin 20 Antibody (YA6352) | WB, IHC-P, IHC-F, ICC/IF, IF-Tissue, FC | Human, Rat |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Bladder Transitional Cell Papilloma |
|
|
| Colorectal Adenocarcinoma |
|
|
| Bladder Benign Neoplasm |
|
|
| Mucinous Bronchioloalveolar Adenocarcinoma |
|
|
| Sarcomatoid Basal Cell Carcinoma |
|
|
| Thyroid Gland Cancer |
|
|
| Urinary Bladder Villous Adenoma |
|
|
| Krukenberg Carcinoma |
|
|
| Bronchiolo-Alveolar Adenocarcinoma |
|
|
| Bladder Urothelial Carcinoma |
|
|
| Ureteral Benign Neoplasm |
|
|
| Neuroendocrine Carcinoma |
|
|
| Intratubular Embryonal Carcinoma |
|
|
| Adenosquamous Carcinoma |
|
|
| Cholangiocarcinoma |
|
|
| Mediastinum Sarcoma |
|
|
| Urinary System Disease |
|
|
| Nephrogenic Adenoma Of Urinary Bladder |
|
|
| Non-Invasive Bladder Papillary Urothelial Neoplasm |
|
|
| Squamous Papillomatosis |
|
|
| Lymphoepithelioma-Like Carcinoma |
|
|
| Fibroepithelial Basal Cell Carcinoma |
|
|
| Bile Duct Cystadenocarcinoma |
|
|
| Tubular Adenocarcinoma |
|
|
| Ovarian Cancer |
|
|
| Vaginal Tubulovillous Adenoma |
|
|
| Seminal Vesicle Adenocarcinoma |
|
|
| Rectum Adenocarcinoma |
|
|
| Bladder Clear Cell Adenocarcinoma |
|
|
| Lung Cancer Susceptibility 3 |
|
|
| Small Cell Carcinoma |
|
|
| Internal Hemorrhoid |
|
|
| Linitis Plastica |
|
|
| Ovarian Benign Neoplasm |
|
|
| Small Intestine Cancer |
|
|
| Gastric Adenocarcinoma |
|
|
| Cecum Carcinoma |
|
|
| Endometrial Transitional Cell Carcinoma |
|
|
| Central Epithelioid Sarcoma |
|
|
| Paraganglioma |
|
|
| Gastrointestinal Carcinoma |
|
|
| Sweat Gland Cancer |
|
|
| Fuchs' Endothelial Dystrophy |
|
|
| Nephrogenic Adenoma Of The Urethra |
|
|
| Papillary Transitional Carcinoma |
|
|
| Intestinal Obstruction |
|
|
| Bladder Papillary Transitional Cell Neoplasm |
|
|
| Vulvar Proximal-Type Epithelioid Sarcoma |
|
|
| Anal Canal Adenocarcinoma |
|
|
| Eccrine Papillary Adenoma |
|
|
| Transitional Cell Carcinoma |
|
|
| Adenoma |
|
|
| Nonmucinous Bronchioloalveolar Adenocarcinoma |
|
|
| Endometrial Cancer |
|
|
| Ethmoid Sinus Adenocarcinoma |
|
|
| Gastric Diffuse Adenocarcinoma |
|
|
| Papillary Carcinoma |
|
|
| Colorectal Cancer |
|
|
| Parotid Gland Adenoid Cystic Carcinoma |
|
|
| Rectosigmoid Junction Neoplasm |
|
|
| Basal Cell Carcinoma |
|
|
| Borst-Jadassohn Intraepidermal Carcinoma |
|
|
| Ovarian Mucinous Adenocarcinoma |
|
|
| Colonic Lymphangioma |
|
|
| Cystitis |
|
|
| Ampulla Of Vater Cancer |
|
|
| Clear Cell Basal Cell Carcinoma |
|
|
| Rectum Cancer |
|
|
| Polycystic Liver Disease 1 With Or Without Kidney Cysts |
|
|
| Male Urethral Cancer |
|
|
| Bile Duct Cancer |
|
|
| Female Urethral Cancer |
|
|
| Vaginal Benign Neoplasm |
|
|
| Atrophic Vulva |
|
|
| Ovarian Mucinous Neoplasm |
|
|
| Cystitis Cystica |
|
|
| Ovarian Large-Cell Neuroendocrine Carcinoma |
|
|
| Bladder Adenocarcinoma |
|
|
| Ischemic Fasciitis |
|
|
| Appendix Cancer |
|
|
| Urethral Benign Neoplasm |
|
|
| Rectal Benign Neoplasm |
|
|
| Gallbladder Signet Ring Cell Adenocarcinoma |
|
|
| Lung Cancer |
|
|
| Transverse Colon Cancer |
|
|
| Mucinous Ovarian Cystadenoma |
|
|
| Glandular Cystitis |
|
|
| Adenoid Cystic Carcinoma |
|
|
| Colonic Benign Neoplasm |
|
|
| Anal Fistula |
|
|
| Amelanotic Melanoma |
|
|
| Clear Cell Adenocarcinoma |
|
|
| Anal Canal Carcinoma |
|
|
| Lymphangioma |
|
|
| Chronic Cystitis |
|
|
| Large Cell Carcinoma |
|
|
| Bladder Cancer |
|
|
| Malignant Syringoma |
|
|
| Bile Duct Signet Ring Cell Carcinoma |
|
|
| Skin Benign Neoplasm |
|
|
| Appendix Disease |
|
|
| Sigmoid Neoplasm |
|
|
| Barrett Esophagus |
|
|
| Neuroendocrine Tumor |
|
|
| Orbit Rhabdomyosarcoma |
|
|
| Hemorrhoid |
|
|
| Colon Adenocarcinoma |
|
|
| Benign Teratoma |
|
|
| Adenocarcinoma |
|
|
| Ovarian Brenner Tumor |
|
|
| Signet Ring Cell Adenocarcinoma |
|
|
| Vulvar Apocrine Adenocarcinoma |
|
|
| Skin Carcinoma |
|
|
| Pancreatic Ductal Carcinoma |
|
|
| Cystic Basal Cell Carcinoma |
|
|
| Follicular Infundibulum Tumor |
|
|
| Papillary Cystadenocarcinoma |
|
|
| Paget Disease, Extramammary |
|
|
| Mesothelioma, Malignant |
|
|
| Inverted Papilloma |
|
|
| Aortic Malignant Tumor |
|
|
| Supine Hypotensive Syndrome |
|
|
| Cystic Teratoma |
|
|
| Bladder Lymphoma |
|
|
| Merkel Cell Carcinoma |
|
|
| Prostate Neuroendocrine Neoplasm |
|
|
| Pancreatic Serous Cystadenocarcinoma |
|
|
| Urinary Bladder Small Cell Neuroendocrine Carcinoma |
|
|
| Urethral Villous Adenoma |
|
|
| Urinary Tract Papillary Transitional Cell Benign Neoplasm |
|
|
| Vulva Adenocarcinoma |
|
|
| Urethral Diverticulum |
|
|
| Mucinous Adenocarcinoma |
|
|
| Lacrimal Gland Mucoepidermoid Carcinoma |
|
|
| Papilloma |
|
|
| Renal Cell Carcinoma, Nonpapillary |
|
|
| Ampulla Of Vater Adenocarcinoma |
|
|
| Cervical Adenocarcinoma |
|
|
| Dysgerminoma |
|
|
| Pancreatic Cancer |
|
|
| Cutaneous Ganglioneuroma |
|
|
| Nipples, Supernumerary |
|
|
| Teratoma |
|
|
| Lung Benign Neoplasm |
|
|
| Mammary Paget'S Disease |
|
|
| Anal Paget'S Disease |
|
|
| Benign Mesothelioma |
|
|
| Eyelid Benign Neoplasm |
|
|
| Appendix Adenocarcinoma |
|
|
| Vaginal Adenoma |
|
|
| Cystadenoma |
|
|
| Eyelid Carcinoma |
|
|
| Thymus Adenocarcinoma |
|
|
| Breast Cancer |
|
|
| Small Cell Cancer Of The Lung |
|
|
| Urethral Syndrome |
|
|
| Gastric Cancer |
|
|
| Pseudomyxoma Peritonei |
|
|
| Intrahepatic Bile Duct Adenoma |
|
|
| Oncocytoma |
|
|
| Mucinous Cystadenocarcinoma |
|
|
| Morpheaform Basal Cell Carcinoma |
|
|
| Pulmonary Artery Leiomyosarcoma |
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Rattus norvegicus | KRT20 | RGD | RGD:628646 |
| Mus musculus | KRT20 | MGD | MGI:1914059 |
| Felis catus | KRT20 | VGNC | VGNC:99096 |
| Macaca mulatta | KRT20 | VGNC | VGNC:74088 |
| Canis familiaris | KRT20 | VGNC | VGNC:42521 |
| Others | KRT20 | NCBI |