ZW10 - zw10 kinetochore protein Gene

Also Known as HZW10; KNTC1AP

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9183

About ZW10

Cytogenetic location: 11q23.2 Genomic coordinates (GRCh38): 11:113,733,187-113,773,692 (from NCBI)

This gene has 3 transcripts (splice variants) and 204 orthologues. Ubiquitous expression in testis (RPKM 9.8), skin (RPKM 6.7) and 25 other tissues.

Summary

This gene encodes a protein that is one of many involved in mechanisms to ensure proper chromosome segregation during cell division. This protein is an essential component of the mitotic checkpoint, which prevents cells from prematurely exiting Mitosis. [provided by RefSeq, Aug 2011]

ZW10 Products (1)

mRNA	Protein	Name
NM_004724.4	NP_004715.1	centromere/kinetochore protein zw10 homolog

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	11146660	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in Golgi organization	IGI IGI: Inferred from genetic interaction	20163571	GOA
involved in Golgi organization	IMP IMP: Inferred from mutant phenotype	20163571	GOA
involved in endoplasmic reticulum to Golgi vesicle-mediated transport	IMP IMP: Inferred from mutant phenotype	15029241	GOA
involved in establishment of mitotic spindle orientation	IMP IMP: Inferred from mutant phenotype	19468067	GOA
involved in mitotic metaphase chromosome alignment	IMP IMP: Inferred from mutant phenotype	19468067	GOA
involved in mitotic sister chromatid segregation	IDA IDA: Inferred from direct assay	11146660	GOA
involved in mitotic spindle assembly checkpoint signaling	IDA IDA: Inferred from direct assay	11146660	GOA
involved in mitotic spindle assembly checkpoint signaling	IMP IMP: Inferred from mutant phenotype	15824131	GOA
involved in protein localization to kinetochore	IMP IMP: Inferred from mutant phenotype	19468067	GOA
involved in protein-containing complex assembly	IDA IDA: Inferred from direct assay	11146660	GOA
involved in regulation of exit from mitosis	IDA IDA: Inferred from direct assay	11146660	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of Dsl1/NZR complex	IDA IDA: Inferred from direct assay	20462495	GOA
part of Dsl1/NZR complex	IPI IPI: Inferred from physical interaction	20462495	GOA
part of RZZ complex	IDA IDA: Inferred from direct assay	20462495	GOA
part of RZZ complex	IPI IPI: Inferred from physical interaction	25849506	GOA
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	15029241	GOA
located in kinetochore	IDA IDA: Inferred from direct assay	11682612	GOA
located in kinetochore microtubule	IDA IDA: Inferred from direct assay	11146660	GOA
located in lipid droplet	IDA IDA: Inferred from direct assay	30970241	GOA
located in nucleus	IDA IDA: Inferred from direct assay	15485811	GOA
located in spindle pole	IDA IDA: Inferred from direct assay	11146660	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZW10 Protein Structure

Zw10

0
200
400
600
779 a.a.

Protein Preferred Names	Protein Names
centromere/kinetochore protein zw10 homolog	ZW10 homolog, centromere/kinetochore protein

ZW10 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ZW10	O43264	ZWINT	Homo sapiens	O95229	IF	15824131
Intra	ZW10	O43264	ZWINT	Homo sapiens	O95229	IF	16732327
Intra	ZW10	O43264	ZWINT	Homo sapiens	O95229	Pull Down	16732327
Intra	ZW10	O43264	RINT1	Homo sapiens	Q6NUQ1	Anti Bait CoIP	20462495
Intra	ZW10	O43264	RINT1	Homo sapiens	Q6NUQ1	Anti Tag CoIP	20462495
Intra	ZW10	O43264	RINT1	Homo sapiens	Q6NUQ1	Anti Bait CoIP	24056303
Intra	ZW10	O43264	RINT1	Homo sapiens	Q6NUQ1	TAP	15824131

Cross: Cross-species interaction Intra: Intraspecies interaction

ZW10 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P810269	ZW10 Antibody (YA9613)	WB, IP, FC	human

Related Diseases

Diseases	Alias
Pelger-Huet Anomaly	PHA Pelger-Huët Anomaly Ovoid Neutrophil Nuclei, Developmental Delay, Epilepsy And Skeletal Abnormalities Pelger Huet Anomaly Pelger-Huet Nuclear Anomaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16208	ZW10 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21464	Zw10 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27982	Zw10 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	ZW10	VGNC	VGNC:48864
Rattus norvegicus	ZW10	RGD	RGD:1309197
Felis catus	ZW10	VGNC	VGNC:81067
Bos taurus	ZW10	VGNC	VGNC:37390
Macaca mulatta	ZW10	VGNC	VGNC:78915
Mus musculus	ZW10	MGD	MGI:1349478
Others	ZW10	NCBI