RNF39 - ring finger protein 39 Gene

Also Known as HZF; HZFW; LIRF; FAP216

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 80352

About RNF39

Cytogenetic location: 6p22.1 Genomic coordinates (GRCh38): 6:30,070,270-30,075,769 (from NCBI)

This gene has 2 transcripts (splice variants), 1 gene allele, 83 orthologues and 80 paralogues. Ubiquitous expression in small intestine (RPKM 5.5), duodenum (RPKM 5.3) and 25 other tissues.

Summary

This gene lies within the major histocompatibility complex class I region on chromosome 6. Studies of a similar rat protein suggest that this gene encodes a protein that plays a role in an early phase of synaptic plasticity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

RNF39 Products (2)

mRNA	Protein	Name
NM_025236.4	NP_079512.3	RING finger protein 39 isoform 1
NM_170769.3	NP_739575.3	RING finger protein 39 isoform 2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RNF39 Protein Structure

zf-C3HC4_4

PRY

SPRY

0
100
200
300
400
420 a.a.

Protein Preferred Names	Protein Names
RING finger protein 39	LTP (long-term potentiation) induced RING finger protein

RNF39 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RNF39	Q9H2S5	DNAAF6	Homo sapiens	Q9NQM4	Validated Y2H	32296183
Intra	RNF39	Q9H2S5	DNAAF6	Homo sapiens	Q9NQM4	Y2H Array	32296183
Intra	RNF39	Q9H2S5	DNAAF6	Homo sapiens	Q9NQM4	Y2H Prey Pooling	32296183
Intra	RNF39	Q9H2S5	AP1B1	Homo sapiens	Q10567-3	Y2H Prey Pooling	32296183
Intra	RNF39	Q9H2S5	AP1B1	Homo sapiens	Q10567-3	Y2H Array	32296183
Intra	RNF39	Q9H2S5	KRT27	Homo sapiens	Q7Z3Y8	Y2H Array	32296183
Intra	RNF39	Q9H2S5	KRT27	Homo sapiens	Q7Z3Y8	Y2H Prey Pooling	32296183
Intra	RNF39	Q9H2S5	RABEP1	Homo sapiens	Q15276	Y2H Prey Pooling	32296183
Intra	RNF39	Q9H2S5	RABEP1	Homo sapiens	Q15276	Y2H Array	32296183
Intra	RNF39	Q9H2S5	GOLGA6L9	Homo sapiens	A6NEM1	Y2H Prey Pooling	32296183
Intra	RNF39	Q9H2S5	GOLGA6L9	Homo sapiens	A6NEM1	Y2H Array	32296183
Intra	RNF39	Q9H2S5	RINT1	Homo sapiens	Q6NUQ1	Y2H Prey Pooling	32296183
Intra	RNF39	Q9H2S5	RINT1	Homo sapiens	Q6NUQ1	Y2H Array	32296183
Intra	RNF39	Q9H2S5	MORN3	Homo sapiens	Q6PF18	Y2H Prey Pooling	32296183
Intra	RNF39	Q9H2S5	MORN3	Homo sapiens	Q6PF18	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Psoriasis 10	PSORS10 Psoriasis Susceptibility 10 Psoriasis 10, Susceptibility To
Behcet Syndrome	Behcet Disease Behcet'S Syndrome Behcet'S Disease Behçet Disease Bd Adamantiades-Behcet Disease Triple Symptom Complex Behçet'S Disease Behet'S Syndrome Bd Syndrome Behçet Syndrome Behçet'S Syndrome Behcet Triple Symptom Complex Malignant Aphthosis Old Silk Route Disease Adamantiades-Behçet Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12089	RNF39 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	RNF39	VGNC	VGNC:106899
Macaca mulatta	RNF39	VGNC	VGNC:83458
Rattus norvegicus	RNF39	RGD	RGD:628854
Canis familiaris	RNF39	VGNC	VGNC:54988
Mus musculus	RNF39	MGD	MGI:2156378
Others	RNF39	NCBI