DNAAF6 - dynein axonemal assembly factor 6 Gene

Also Known as CILD36; PIH1D3; CXorf41; NYSAR97; TWISTER

Species: Homo sapiens (human)

Gene Type: protein coding
Gene ID: 139212

Summary

Enables dynein intermediate chain binding activity. Involved in flagellated sperm motility; inner dynein arm assembly; and outer dynein arm assembly. Located in trans-Golgi network. Implicated in primary ciliary dyskinesia 36. [provided by Alliance of Genome Resources, Apr 2022]

DNAAF6 Products (1)

mRNA Protein Name
NM_001169154.2 NP_001162625.1 dynein axonemal assembly factor 6

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables dynein intermediate chain binding IMP
IMP: Inferred from mutant phenotype
28176794 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence References Source
involved in axonemal dynein complex assembly IMP
IMP: Inferred from mutant phenotype
28041644 GOA
involved in cilium movement IMP
IMP: Inferred from mutant phenotype
28041644 GOA
involved in flagellated sperm motility IMP
IMP: Inferred from mutant phenotype
28041644 GOA
involved in inner dynein arm assembly IMP
IMP: Inferred from mutant phenotype
28176794 GOA
involved in outer dynein arm assembly IMP
IMP: Inferred from mutant phenotype
28176794 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
28176794 GOA
located in trans-Golgi network IDA
IDA: Inferred from direct assay
28176794 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

dynein axonemal assembly factor 6

  • PIH1 domain containing 3

  • PIH1 domain-containing protein 3

  • dynein assembly factor 6, axonemal

  • protein PIH1D3

  • sarcoma antigen NY-SAR-97

DNAAF6 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
DNAAF6 Q9NQM4 BTAF1 Homo sapiens Q2M1V9
Validated Y2H
25416956
Intra
DNAAF6 Q9NQM4 BTAF1 Homo sapiens Q2M1V9
Y2H Prey Pooling
25416956
Intra
DNAAF6 Q9NQM4 BTAF1 Homo sapiens Q2M1V9
Y2H Array
25416956
Intra
DNAAF6 Q9NQM4 KIF13A Homo sapiens Q9H1H9
Y2H Prey Pooling
25416956
Intra
DNAAF6 Q9NQM4 P2RX4 Homo sapiens Q99571
Y2H Prey Pooling
25416956
Intra
DNAAF6 Q9NQM4 P2RX4 Homo sapiens Q99571
Validated Y2H
25416956
Intra
DNAAF6 Q9NQM4 P2RX4 Homo sapiens Q99571
Y2H Array
25416956
Intra
DNAAF6 Q9NQM4 CCAR1 Homo sapiens Q8IX12
Validated Y2H
25416956
Intra
DNAAF6 Q9NQM4 CCAR1 Homo sapiens Q8IX12
Y2H Array
25416956
Intra
DNAAF6 Q9NQM4 CDKL3 Homo sapiens Q8IVW4
Validated Y2H
25416956
Intra
DNAAF6 Q9NQM4 POLDIP2 Homo sapiens Q9Y2S7
Validated Y2H
32296183
Intra
DNAAF6 Q9NQM4 GAS2L2 Homo sapiens Q8NHY3
MAPPIT
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03839 DNAAF1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03840 DNAAF3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03841 DNAAF5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown