KIF13A - kinesin family member 13A Gene

Also Known as RBKIN; bA500C11.2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 63971

About KIF13A

Cytogenetic location: 6p22.3 Genomic coordinates (GRCh38): 6:17,759,126-17,987,635 (from NCBI)

This gene has 13 transcripts (splice variants), 204 orthologues and 41 paralogues. Ubiquitous expression in heart (RPKM 12.6), thyroid (RPKM 10.1) and 25 other tissues.

Summary

This gene encodes a member of the Kinesin family of microtubule-based motor proteins that function in the positioning of endosomes. This family member can direct mannose-6-phosphate receptor-containing vesicles from the trans-Golgi network to the plasma membrane, and it is necessary for the steady-state distribution of late endosomes/lysosomes. It is also required for the translocation of FYVE-CENT and TTC19 from the centrosome to the midbody during cytokinesis, and it plays a role in melanosome maturation. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011]

KIF13A Products (5)

mRNA	Protein	Name
NM_001105566.3	NP_001099036.1	kinesin-like protein KIF13A isoform b
NM_001105567.3	NP_001099037.1	kinesin-like protein KIF13A isoform c
NM_001105568.4	NP_001099038.1	kinesin-like protein KIF13A isoform d
NM_001243423.2	NP_001230352.1	kinesin-like protein KIF13A isoform e
NM_022113.6	NP_071396.4	kinesin-like protein KIF13A isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19841138	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in endosome to lysosome transport	IMP IMP: Inferred from mutant phenotype	19841138	GOA
involved in intracellular protein transport	IMP IMP: Inferred from mutant phenotype	20208530	GOA
involved in melanosome organization	IMP IMP: Inferred from mutant phenotype	19841138	GOA
involved in regulation of cytokinesis	IMP IMP: Inferred from mutant phenotype	20208530	GOA
involved in vesicle cargo loading	IMP IMP: Inferred from mutant phenotype	19841138	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in centrosome	IDA IDA: Inferred from direct assay	20208530	GOA
located in endosome membrane	IDA IDA: Inferred from direct assay	19841138	GOA
located in midbody	IDA IDA: Inferred from direct assay	20208530	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KIF13A Protein Structure

Kinesin

FHA

KIF1B

DUF3694

0
300
600
900
1200
1500
1805 a.a.

Protein Preferred Names	Protein Names
kinesin-like protein KIF13A	homolog of mouse KIF13A mannose-6-phosphate receptor transporter

KIF13A Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	KIF13A	Q9H1H9	DNAAF6	Homo sapiens	Q9NQM4	Y2H Array	25416956
Intra	KIF13A	Q9H1H9	DNAAF6	Homo sapiens	Q9NQM4	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Hypomelanosis Of Ito	Incontinentia Pigmenti Achromians Nevus Of Ito Ipa Ito Hypomelanosis Ito Pigmentation Disorders HMI Incontinentia Pigmenti, Type I, Formerly Ip1, Formerly Bloch-Siemans Syndrome Incontinentia Pigmenti Achromians Syndrome Ito'S Nevus Incontinentia Pigmenti Type 1 Nevi Of Ito Nevus Fuscocaeruleus Acromiodeltoideus Bloch Sulzberger Syndrome Skin Pigmentation Disorder
Hermansky-Pudlak Syndrome	Hps Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Cells Hermanski-Pudlak Syndrome Hermansky Pudlak Syndrome Platelet Storage Pool Deficiency

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07259	KIF13A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	KIF13A	VGNC	VGNC:42381
Mus musculus	KIF13A	MGD	MGI:1098264
Bos taurus	KIF13A	VGNC	VGNC:54226
Felis catus	KIF13A	VGNC	VGNC:63102
Rattus norvegicus	KIF13A	RGD	RGD:1307825
Macaca mulatta	KIF13A	VGNC	VGNC:73830
Others	KIF13A	NCBI