2. Gene
  3. CDKL3 - cyclin dependent kinase like 3 Gene

CDKL3 - cyclin dependent kinase like 3 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as NKIAMRE

Gene ID: 51265 | Gene type: protein coding

About CDKL3

Cytogenetic location: 5q31.1 Genomic coordinates (GRCh38): 5:134,283,345-134,371,624 (from NCBI)

This gene has 10 transcripts (splice variants), 116 orthologues and 26 paralogues. Biased expression in testis (RPKM 4.9), brain (RPKM 1.0) and 12 other tissues.

Summary

The protein encoded by this gene is a member of cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This gene was identified as a gene absent in leukemic patients with chromosome 5q deletion. This loss may be an important determinant of dysmyelopoiesis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

CDKL3 Products(7)

mRNA Protein Name
NM_001113575.2 NP_001107047.1 cyclin-dependent kinase-like 3 isoform 1
NM_001300853.2 NP_001287782.1 cyclin-dependent kinase-like 3 isoform 3
NM_001349363.2 NP_001336292.1 cyclin-dependent kinase-like 3 isoform 4
NM_001349364.2 NP_001336293.1 cyclin-dependent kinase-like 3 isoform 5
NM_001349365.2 NP_001336294.1 cyclin-dependent kinase-like 3 isoform 5
NM_001349366.2 NP_001336295.1 cyclin-dependent kinase-like 3 isoform 5
NM_016508.4 NP_057592.2 cyclin-dependent kinase-like 3 isoform 2

CDKL3 Protein Structure

Pkinase

Pkinase: Protein kinase domain (4 - 286)

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  • 592 a.a.
Protein Preferred Names Protein Names

cyclin-dependent kinase-like 3

serine-threonine protein kinase NKIAMRE

Related Diseases

Diseases Alias
Meckel Syndrome, Type 4

Meckel Syndrome 4

MKS4

Meckel-Gruber Syndrome, Type 4

Meckel Syndrome Type 4
Orofaciodigital Syndrome Vi

OFD6

Varadi-Papp Syndrome

Varadi Syndrome

Joubert Syndrome With Orofaciodigital Defect

Orofaciodigital Syndrome Type 6

Orofaciodigital Syndrome 6

Oral-Facial-Digital Syndrome, Type Vi

Ofds Vi

Polydactyly, Cleft Lip/Palate Or Lingual Lump, And Psychomotor Retardation

Polydactyly Cleft Lip Palate Psychomotor Retardation

Oral-Facial-Digital Syndrome Type 6

Polydactyly-Cleft Lip/Palate-Psychomotor Retardation Syndrome

Polydactyly - Cleft Lip/Palate - Psychomotor Retardation

Váradi Syndrome

Váradi-Papp Syndrome

Joubert Syndrome With Oral-Facial-Digital Syndrome

Oral-Facial-Digital Syndrome 6

Joubert-Orofaciodigital Syndrome

Orofaciodigital Syndrome, Type Vi
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS02407 CDKL3 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus CDKL3 RGD RGD:619874
Macaca mulatta CDKL3 VGNC VGNC:70953
Bos taurus CDKL3 VGNC VGNC:27140
Felis catus CDKL3 VGNC VGNC:60710
Mus musculus CDKL3 MGD MGI:2388268