HZ1
Based on 1 Customer Validation
HZ1 is an orally active first-in-class cyclin-dependent kinase like 3 (CDKL3)-specific inhibitor. HZ1 shows a strong tumor-suppressing effect, and has the potential to overcome the resistance of CDK4/6 inhibitor.
For research use only. We do not sell to patients.
- Purity: 99.20%
- CAS No.: 3030492-40-8
- Formula: C20H22N6O
- Molecular Weight:362.43
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
HZ1 (2-10 h; 100 nM) markedly decreases the levels of pRb and CDK4 hence effectively triggering cell cycle arrest and tumor death[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:DLD-1 cells
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Concentration:100 nM
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Incubation Time:2 h, 4 h, 6 h, 8 h, 10 h
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Result:Reduced the levels of pRb and CDK4.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:6-week-old female athymic nude mice injected with DLD-1 cells[1]
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Dosage:1 mg/kg
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Administration:Oral gavage; daily for 12-14 days
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Result:Suppressed tumor volume in a mouse model of colon cancer.
Chemical Information
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CAS No. 3030492-40-8
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Appearance Solid
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Molecular Weight 362.43
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Formula C20H22N6O
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Color White to off-white
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SMILES
O=C(C)C(C=C1)=CC=C1NC2=NC(NC3=CC(C4CCCC4)=NN3)=CC=N2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 50 mg/mL (137.96 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (270 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.7592 mL | 13.7958 mL | 27.5915 mL | 68.9788 mL |
| 5 mM | 0.5518 mL | 2.7592 mL | 5.5183 mL | 13.7958 mL | |
| 10 mM | 0.2759 mL | 1.3796 mL | 2.7592 mL | 6.8979 mL | |
| 15 mM | 0.1839 mL | 0.9197 mL | 1.8394 mL | 4.5986 mL | |
| 20 mM | 0.1380 mL | 0.6898 mL | 1.3796 mL | 3.4489 mL | |
| 25 mM | 0.1104 mL | 0.5518 mL | 1.1037 mL | 2.7592 mL | |
| 30 mM | 0.0920 mL | 0.4599 mL | 0.9197 mL | 2.2993 mL | |
| 40 mM | 0.0690 mL | 0.3449 mL | 0.6898 mL | 1.7245 mL | |
| 50 mM | 0.0552 mL | 0.2759 mL | 0.5518 mL | 1.3796 mL | |
| 60 mM | 0.0460 mL | 0.2299 mL | 0.4599 mL | 1.1496 mL | |
| 80 mM | 0.0345 mL | 0.1724 mL | 0.3449 mL | 0.8622 mL | |
| 100 mM | 0.0276 mL | 0.1380 mL | 0.2759 mL | 0.6898 mL |
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