ZRANB1 - zinc finger RANBP2-type containing 1 Gene

Also Known as TRABID

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 54764

About ZRANB1

Cytogenetic location: 10q26.13 Genomic coordinates (GRCh38): 10:124,916,894-124,988,189 (from NCBI)

This gene has 2 transcripts (splice variants) and 259 orthologues. Ubiquitous expression in adrenal (RPKM 10.7), testis (RPKM 10.1) and 25 other tissues.

Summary

Enables K63-linked polyubiquitin modification-dependent protein binding activity and thiol-dependent Deubiquitinase. Involved in several processes, including positive regulation of Wnt signaling pathway; protein deubiquitination; and regulation of cell morphogenesis. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

ZRANB1 Products (1)

mRNA Protein Name
NM_017580.3 NP_060050.2 ubiquitin thioesterase ZRANB1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables K63-linked polyubiquitin modification-dependent protein binding IDA
IDA: Inferred from direct assay
18281465 GOA
enables cysteine-type deubiquitinase activity IDA
IDA: Inferred from direct assay
18281465 GOA
enables cysteine-type deubiquitinase activity IMP
IMP: Inferred from mutant phenotype
18281465 GOA
enables deubiquitinase activity IDA
IDA: Inferred from direct assay
33637724 GOA
enables polyubiquitin modification-dependent protein binding IDA
IDA: Inferred from direct assay
25752573 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
11463333 GOA
Biological Process GO Annotation Evidence References Source
involved in cell migration IMP
IMP: Inferred from mutant phenotype
21834987 GOA
involved in cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
21834987 GOA
involved in positive regulation of Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
18281465 GOA
involved in protein K29-linked deubiquitination IDA
IDA: Inferred from direct assay
23827681 GOA
involved in protein K33-linked deubiquitination IDA
IDA: Inferred from direct assay
23827681 GOA
involved in protein K63-linked deubiquitination IDA
IDA: Inferred from direct assay
23827681 GOA
involved in protein K63-linked deubiquitination IMP
IMP: Inferred from mutant phenotype
18281465 GOA
involved in protein deubiquitination IDA
IDA: Inferred from direct assay
33637724 GOA
involved in protein deubiquitination involved in ubiquitin-dependent protein catabolic process IMP
IMP: Inferred from mutant phenotype
18281465 GOA
involved in regulation of cell morphogenesis IMP
IMP: Inferred from mutant phenotype
21834987 GOA
Cellular Component GO Annotation Evidence References Source
is active in cytoplasm IDA
IDA: Inferred from direct assay
25752577 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
11463333 GOA
is active in nucleus IDA
IDA: Inferred from direct assay
25752577 GOA
located in nucleus IDA
IDA: Inferred from direct assay
11463333 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZRANB1 Protein Structure

zf-RanBP

zf-RanBP: Zn-finger in Ran binding protein and others (7 - 33)

zf-RanBP

zf-RanBP: Zn-finger in Ran binding protein and others (151 - 177)

OTU

OTU: OTU-like cysteine protease (439 - 586)

  • 0
  • 200
  • 400
  • 600
  • 708 a.a.
Protein Preferred Names Protein Names

ubiquitin thioesterase ZRANB1

  • TRAF-binding domain-containing protein

ZRANB1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ZRANB1 Q9UGI0 MID2 Homo sapiens Q9UJV3-2
Validated Y2H
32296183
Intra
ZRANB1 Q9UGI0 POLL Homo sapiens Q9UGP5-2
Validated Y2H
32296183
Intra
ZRANB1 Q9UGI0 METAP1 Homo sapiens P53582
MAPPIT
32296183
Intra
ZRANB1 Q9UGI0 ZNF490 Homo sapiens Q9ULM2
Validated Y2H
32296183
Intra
ZRANB1 Q9UGI0 PSPC1 Homo sapiens Q8WXF1-2
Y2H Array
32296183
Intra
ZRANB1 Q9UGI0 ANKRD11 Homo sapiens X5D778
Validated Y2H
32296183
Intra
ZRANB1 Q9UGI0 TBC1D30 Homo sapiens Q9Y2I9-2
Validated Y2H
32296183
Intra
ZRANB1 Q9UGI0 CCNL1 Homo sapiens Q9UK58
Validated Y2H
32296183
Intra
ZRANB1 Q9UGI0 VAV3 Homo sapiens Q9UKW4
Validated Y2H
32296183
Intra
ZRANB1 Q9UGI0 TSPYL4 Homo sapiens Q9UJ04
Validated Y2H
32296183
Intra
ZRANB1 Q9UGI0 UBC Homo sapiens P0CG48
Enzymatic Study
19373254
Intra
ZRANB1 Q9UGI0 UBC Homo sapiens P0CG48
Pull Down
19373254
Intra
ZRANB1 Q9UGI0 TRAF6 Homo sapiens Q9Y4K3
Validated Y2H
32296183
Intra
ZRANB1 Q9UGI0 ARHGEF5 Homo sapiens Q12774
Y2H Prey Pooling
32296183
Intra
ZRANB1 Q9UGI0 BAHD1 Homo sapiens Q8TBE0
Y2H Array
32296183
Intra
ZRANB1 Q9UGI0 FAM50B Homo sapiens Q9Y247
Validated Y2H
32296183
Intra
ZRANB1 Q9UGI0 DUSP13B Homo sapiens Q9UII6
Validated Y2H
32296183
Intra
ZRANB1 Q9UGI0 TRAF3IP3 Homo sapiens Q9Y228
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS16193 ZRANB1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta ZRANB1 VGNC VGNC:79119
Canis familiaris ZRANB1 VGNC VGNC:48847
Mus musculus ZRANB1 MGD MGI:106441
Rattus norvegicus ZRANB1 RGD RGD:2321751
Felis catus ZRANB1 VGNC VGNC:67379
Bos taurus ZRANB1 VGNC VGNC:37371
Others ZRANB1 NCBI