VAV3 - vav guanine nucleotide exchange factor 3 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10451

About VAV3

Cytogenetic location: 1p13.3 Genomic coordinates (GRCh38): 1:107,571,161-107,965,180 (from NCBI)

This gene has 15 transcripts (splice variants), 296 orthologues and 22 paralogues. Broad expression in kidney (RPKM 10.0), skin (RPKM 8.3) and 17 other tissues.

Summary

This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. This gene product acts as a GEF preferentially for RhoG, RhoA, and to a lesser extent, RAC1, and it associates maximally with the nucleotide-free states of these GTPases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

VAV3 Products (2)

mRNA Protein Name
NM_001079874.2 NP_001073343.1 guanine nucleotide exchange factor VAV3 isoform 2
NM_006113.5 NP_006104.4 guanine nucleotide exchange factor VAV3 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables guanyl-nucleotide exchange factor activity EXP
EXP: Inferred from Experiment
8990121 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
12577067 GOA
Biological Process GO Annotation Evidence References Source
involved in B cell receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
17875758 GOA
involved in DNA damage response IMP
IMP: Inferred from mutant phenotype
17875758 GOA
involved in positive regulation of B cell proliferation IMP
IMP: Inferred from mutant phenotype
17875758 GOA
involved in regulation of GTPase activity IGI
IGI: Inferred from genetic interaction
22467863 GOA
NOT involved in regulation of cell size IGI
IGI: Inferred from genetic interaction
22467863 GOA
involved in regulation of cell size IGI
IGI: Inferred from genetic interaction
22467863 GOA
involved in response to xenobiotic stimulus IMP
IMP: Inferred from mutant phenotype
17875758 GOA
Cellular Component GO Annotation Evidence References Source
located in immunological synapse IDA
IDA: Inferred from direct assay
15708849 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

VAV3 Protein Structure

CAMSAP_CH

CAMSAP_CH: CAMSAP CH domain (19 - 103)

RhoGEF

RhoGEF: RhoGEF domain (196 - 370)

PH

PH: PH domain (411 - 501)

C1_1

C1_1: Phorbol esters/diacylglycerol binding domain (C1 domain) (514 - 563)

SH3_2

SH3_2: Variant SH3 domain (597 - 658)

SH2

SH2: SH2 domain (672 - 746)

SH3_2

SH3_2: Variant SH3 domain (798 - 845)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 847 a.a.
Protein Preferred Names Protein Names

guanine nucleotide exchange factor VAV3

  • VAV-3

VAV3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
VAV3 Q9UKW4 MET Homo sapiens P08581
FPS
24728074
Intra
VAV3 Q9UKW4 GRB2 Homo sapiens P62993
Y2H
18654987
Intra
VAV3 Q9UKW4 GRB2 Homo sapiens P62993
Y2H Array
32296183
Intra
VAV3 Q9UKW4 GRB2 Homo sapiens P62993
Y2H Prey Pooling
32296183
Intra
VAV3 Q9UKW4 GRB2 Homo sapiens P62993
Y2H Pooling
20936779
Intra
VAV3 Q9UKW4 GAB1 Homo sapiens Q13480
FPS
24728074
Intra
VAV3 Q9UKW4 ZRANB1 Homo sapiens Q9UGI0
Y2H Prey Pooling
32296183
Intra
VAV3 Q9UKW4 ZRANB1 Homo sapiens Q9UGI0
Y2H Array
32296183
Intra
VAV3 Q9UKW4 RINT1 Homo sapiens Q6NUQ1
Y2H Prey Pooling
32296183
Intra
VAV3 Q9UKW4 RINT1 Homo sapiens Q6NUQ1
Y2H Array
32296183
Intra
VAV3 Q9UKW4 CBLB Homo sapiens Q13191
Y2H Prey Pooling
32296183
Intra
VAV3 Q9UKW4 CBLB Homo sapiens Q13191
Y2H Array
32296183
Intra
VAV3 Q9UKW4 PIK3R1 Homo sapiens P27986
Anti Bait CoIP
16982329
Cross: Cross-species interaction Intra: Intraspecies interaction

VAV3 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82770 VAV3 Antibody (YA2515) WB, ICC/IF, IP, FC Human, Mouse

Related Diseases

Diseases Alias
Anterior Foramen Magnum Meningioma

  • Meningioma Of The Anterior Foramen Magnum
Osteopetrosis

  • Marble Bone Disease

  • Albers-Schonberg Disease

  • Osteopetroses

  • Marble Bones

  • Osteopetrosis And Related Disorders

  • Congenital Osteopetrosis

  • Marble Bone

  • Albers-Schoenberg Disease

  • Albers-Schonberg Osteopetrosis

  • Osteosclerosis Fragilis

  • Ivory Bones
Ovarian Cancer

  • Ovarian Carcinoma

  • Ovarian Neoplasm

  • Malignant Tumour Of Ovary

  • Cancer Of The Ovary

  • Epithelial Ovarian Cancer

  • Neoplasm Of Ovary

  • Ovarian Neoplasms

  • Ovarian Cancers

  • Malignant Neoplasm Of Ovary

  • Primary Malignant Neoplasm Of Ovary

  • Ovarian Cancer, Somatic

  • Malignant Ovarian Tumor

  • Ovary Neoplasm

  • Primary Ovarian Cancer

  • Tumor Of The Ovary

  • Malignant Neoplasm Of The Ovary

  • Malignant Tumor Of The Ovary

  • Ovarian Malignant Tumor

  • OC

  • Ovarian Carcinomas

  • Cancer, Ovarian

  • Cancer Of Ovary

  • Ovary Cancer

  • Ca Ovary
Prostate Cancer

  • Prostate Carcinoma

  • Prostate Cancer, Familial

  • Prostate Neoplasm

  • Prostate Cancer, Somatic

  • Prostate Cancer, Susceptibility To

  • Prostatic Cancer

  • Prostatic Neoplasms

  • Hereditary Prostate Cancer

  • Prostatic Neoplasm

  • Cancer Of Prostate

  • Carcinoma Of Prostate

  • Familial Prostate Cancer

  • Familial Prostate Carcinoma

  • Malignant Tumor Of Prostate

  • Malignant Neoplasm Of Prostate

  • Prostate Cancer, Familial, Susceptibility To

  • Malignant Tumor Of The Prostate

  • Ngp - New Growth Of Prostate

  • Tumor Of The Prostate

  • Prostate Cancer, Hereditary

  • Cancer Of The Prostate

  • Malignant Neoplasm Of The Prostate

  • Prostatic Carcinoma

  • PC

  • Prca

  • Cancer, Prostate

  • Malignant Prostatic Tumour

  • Malignant Tumour Of Prostate

  • Primary Prostate Cancer

  • Primary Malignant Neoplasm Of Prostate

  • Prostate Gland Cancer
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15614 VAV3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20835 Vav3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27349 Vav3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus VAV3 MGD MGI:1888518
Bos taurus VAV3 VGNC VGNC:36774
Rattus norvegicus VAV3 RGD RGD:1565941
Canis familiaris VAV3 VGNC VGNC:48237
Macaca mulatta VAV3 VGNC VGNC:78759
Felis catus VAV3 VGNC VGNC:66927
Others VAV3 NCBI