TRAF6 - TNF receptor associated factor 6 Gene

Also Known as RNF85; MGC:3310

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7189

About TRAF6

Cytogenetic location: 11p12 Genomic coordinates (GRCh38): 11:36,483,769-36,510,272 (from NCBI)

This gene has 3 transcripts (splice variants), 210 orthologues, 5 paralogues and is associated with 1 phenotype. Ubiquitous expression in bone marrow (RPKM 5.9), thyroid (RPKM 3.6) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the TNF Receptor associated factor (TRAF) protein family. TRAF proteins are associated with, and mediate signal transduction from, members of the TNF Receptor Superfamily. This protein has an amino terminal RING domain which is followed by four zinc-finger motifs, a central coiled-coil region and a highly conserved carboxyl terminal domain, known as the TRAF-C domain and mediates signaling from members of the TNF Receptor Superfamily as well as the Toll/IL-1 family. Signals from receptors such as CD40, TNFSF11/RANCE and IL-1 have been shown to be mediated by this protein. This protein also interacts with various protein kinases including IRAK1/IRAK, Src and PKCzeta, which provides a link between distinct signaling pathways. This protein functions as a signal transducer in the NF-kappaB pathway that activates IkappaB kinase (IKK) in response to proinflammatory cytokines. The interaction of this protein with UBE2N/UBC13, and UBE2V1/UEV1A, which are ubiquitin conjugating Enzymes catalyzing the formation of polyubiquitin chains, has been found to be required for IKK activation by this protein. This protein also interacts with the transforming growth factor (TGF) beta receptor complex and is required for Smad-independent activation of the JNK and p38 kinases. The protein encoded by this gene is a key molecule in Antiviral innate and antigen-specific immune responses. [provided by RefSeq, Nov 2021]

TRAF6 Products (2)

mRNA	Protein	Name
NM_004620.4	NP_004611.1	TNF receptor-associated factor 6
NM_145803.3	NP_665802.1	TNF receptor-associated factor 6

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables histone deacetylase binding	IPI IPI: Inferred from physical interaction	18093978	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	19465916	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10094049	GOA
enables protein kinase B binding	IPI IPI: Inferred from physical interaction	19713527	GOA
enables protein-macromolecule adaptor activity	IDA IDA: Inferred from direct assay	18758450	GOA
enables ubiquitin conjugating enzyme binding	IDA IDA: Inferred from direct assay	23776175	GOA
enables ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	15125833	GOA
enables ubiquitin-protein transferase activity	EXP EXP: Inferred from Experiment	15361868	GOA
enables ubiquitin-ubiquitin ligase activity	IDA IDA: Inferred from direct assay	15465037	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in CD40 signaling pathway	IDA IDA: Inferred from direct assay	8910514	GOA
involved in T cell receptor signaling pathway	IDA IDA: Inferred from direct assay	23514740	GOA
involved in T cell receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	15125833	GOA
involved in activation of protein kinase activity	IDA IDA: Inferred from direct assay	17135271	GOA
involved in antiviral innate immune response	IDA IDA: Inferred from direct assay	18984593	GOA
involved in autophagosome assembly	IDA IDA: Inferred from direct assay	23524951	GOA
involved in canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	20038579	GOA
involved in canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	25515214	GOA
involved in cellular response to cytokine stimulus	IMP IMP: Inferred from mutant phenotype	25515214	GOA
acts upstream of or within cellular response to lipopolysaccharide	IDA IDA: Inferred from direct assay	23776175	GOA
involved in cytoplasmic pattern recognition receptor signaling pathway	IDA IDA: Inferred from direct assay	20501938	GOA
involved in interleukin-17A-mediated signaling pathway	IDA IDA: Inferred from direct assay	35183823	GOA
involved in interleukin-33-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	31435003	GOA
involved in negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	18093978	GOA
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	18093978	GOA
involved in non-canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	19675569	GOA
involved in positive regulation of DNA-binding transcription factor activity	IMP IMP: Inferred from mutant phenotype	12296995	GOA
involved in positive regulation of JUN kinase activity	IDA IDA: Inferred from direct assay	11751921	GOA
involved in positive regulation of NF-kappaB transcription factor activity	IDA IDA: Inferred from direct assay	11279055	GOA
involved in positive regulation of NF-kappaB transcription factor activity	IMP IMP: Inferred from mutant phenotype	12296995	GOA
involved in positive regulation of T cell cytokine production	IMP IMP: Inferred from mutant phenotype	15125833	GOA
involved in positive regulation of canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	17135271	GOA
involved in positive regulation of interleukin-2 production	IMP IMP: Inferred from mutant phenotype	15125833	GOA
involved in positive regulation of leukocyte adhesion to vascular endothelial cell	IMP IMP: Inferred from mutant phenotype	25515214	GOA
involved in positive regulation of osteoclast differentiation	IDA IDA: Inferred from direct assay	17135271	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	11751921	GOA
involved in positive regulation of transcription regulatory region DNA binding	IDA IDA: Inferred from direct assay	11751921	GOA
involved in protein K63-linked ubiquitination	IDA IDA: Inferred from direct assay	19713527	GOA
involved in protein K63-linked ubiquitination	IGI IGI: Inferred from genetic interaction	17135271	GOA
acts upstream of or within protein autoubiquitination	IDA IDA: Inferred from direct assay	23776175	GOA
involved in protein autoubiquitination	IDA IDA: Inferred from direct assay	17135271	GOA
involved in protein polyubiquitination	IDA IDA: Inferred from direct assay	15125833	GOA
involved in response to interleukin-1	IDA IDA: Inferred from direct assay	17135271	GOA
involved in toll-like receptor 4 signaling pathway	IDA IDA: Inferred from direct assay	25371197	GOA

Cellular Component GO Annotation	Evidence	References	Source
is active in cytoplasm	IDA IDA: Inferred from direct assay	22851693	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	16378096	GOA
is active in extrinsic component of cytoplasmic side of plasma membrane	IDA IDA: Inferred from direct assay	23514740	GOA
located in nucleus	IDA IDA: Inferred from direct assay	18093978	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	11751921	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	18093978	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	23776175	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRAF6 Protein Structure

zf-C3HC4_2

zf-TRAF

MATH

0
100
200
300
400
522 a.a.

Protein Preferred Names	Protein Names
TNF receptor-associated factor 6	E3 ubiquitin-protein ligase TRAF6

TRAF6 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TRAF6	Q9Y4K3	MALT1	Homo sapiens	Q9UDY8	Anti Bait CoIP	17948050
Intra	TRAF6	Q9Y4K3	UBE2N	Homo sapiens	P61088	X-Ray Diffraction	19465916
Intra	TRAF6	Q9Y4K3	UBE2N	Homo sapiens	P61088	GMS	19465916
Intra	TRAF6	Q9Y4K3	UBE2N	Homo sapiens	P61088	Y2H	19465916
Intra	TRAF6	Q9Y4K3	UBE2N	Homo sapiens	P61088	Enzymatic Study	19549727
Intra	TRAF6	Q9Y4K3	UBE2N	Homo sapiens	P61088	SPR	19465916
Intra	TRAF6	Q9Y4K3	AMBRA1	Homo sapiens	Q9C0C7-3	Anti Tag CoIP	23524951
Intra	TRAF6	Q9Y4K3	SYK	Homo sapiens	P43405-2	Y2H Array	32814053
Intra	TRAF6	Q9Y4K3	SYK	Homo sapiens	P43405-2	Y2H Pooling	32814053
Intra	TRAF6	Q9Y4K3	SYK	Homo sapiens	P43405-2	Validated Y2H	32814053
Intra	TRAF6	Q9Y4K3	VPS52	Homo sapiens	Q8N1B4	Y2H Prey Pooling	25416956
Intra	TRAF6	Q9Y4K3	VPS52	Homo sapiens	Q8N1B4	Y2H Prey Pooling	32296183
Intra	TRAF6	Q9Y4K3	VPS52	Homo sapiens	Q8N1B4	Y2H Array	25416956
Intra	TRAF6	Q9Y4K3	VPS52	Homo sapiens	Q8N1B4	Y2H Array	32296183
Intra	TRAF6	Q9Y4K3	EDARADD	Homo sapiens	Q8WWZ3	Y2H Prey Pooling	25416956
Intra	TRAF6	Q9Y4K3	EDARADD	Homo sapiens	Q8WWZ3	Validated Y2H	25416956
Intra	TRAF6	Q9Y4K3	SQSTM1	Homo sapiens	Q13501	Anti Tag CoIP	17389358
Intra	TRAF6	Q9Y4K3	SQSTM1	Homo sapiens	Q13501	Anti Tag CoIP	16874300
Intra	TRAF6	Q9Y4K3	SQSTM1	Homo sapiens	Q13501	Anti Bait CoIP	16874300
Intra	TRAF6	Q9Y4K3	UBC	Homo sapiens	P0CG48	Anti Tag CoIP	19820695
Intra	TRAF6	Q9Y4K3	UBC	Homo sapiens	P0CG48	Anti Tag CoIP	18239685
Intra	TRAF6	Q9Y4K3	UBE2D2	Homo sapiens	P62837	Enzymatic Study	19549727
Intra	TRAF6	Q9Y4K3	UBE2D3	Homo sapiens	P61077	Enzymatic Study	19549727
Intra	TRAF6	Q9Y4K3	UBE2D3	Homo sapiens	P61077	Anti Bait CoIP	17353931
Intra	TRAF6	Q9Y4K3	UBE2D3	Homo sapiens	P61077	Y2H Array	19549727
Intra	TRAF6	Q9Y4K3	TRAF2	Homo sapiens	Q12933	Y2H Array	25416956
Intra	TRAF6	Q9Y4K3	TRAF2	Homo sapiens	Q12933	Y2H	21516116
Intra	TRAF6	Q9Y4K3	IRAK1	Homo sapiens	P51617	Anti Tag CoIP	10383454
Intra	TRAF6	Q9Y4K3	IRAK1	Homo sapiens	P51617	Anti Bait CoIP	12242293
Intra	TRAF6	Q9Y4K3	MAP3K7	Homo sapiens	O43318	CoIP	10094049
Intra	TRAF6	Q9Y4K3	MAP3K7	Homo sapiens	O43318	Anti Tag CoIP	12496252
Intra	TRAF6	Q9Y4K3	TAB2	Homo sapiens	Q9NYJ8	Y2H	21988832
Intra	TRAF6	Q9Y4K3	TAB2	Homo sapiens	Q9NYJ8	CoIP	11518704
Intra	TRAF6	Q9Y4K3	TRAF1	Homo sapiens	Q13077	Y2H Prey Pooling	32296183
Intra	TRAF6	Q9Y4K3	TRAF1	Homo sapiens	Q13077	BFG-2H	27107012
Intra	TRAF6	Q9Y4K3	TRAF1	Homo sapiens	Q13077	Y2H Array	32296183
Intra	TRAF6	Q9Y4K3	TRAF6	Homo sapiens	Q9Y4K3	SAXS	19465916
Intra	TRAF6	Q9Y4K3	TRAF6	Homo sapiens	Q9Y4K3	GMS	19465916
Intra	TRAF6	Q9Y4K3	TRAF6	Homo sapiens	Q9Y4K3	Y2H	21988832
Intra	TRAF6	Q9Y4K3	TRAF6	Homo sapiens	Q9Y4K3	Y2H Array	22493164
Intra	TRAF6	Q9Y4K3	TRAF6	Homo sapiens	Q9Y4K3	X-Ray Diffraction	19465916
Cross	TRAF6	Q9Y4K3	a52_vaccw	vaccinia virus	Q01220	Anti Tag CoIP	15998638
Intra	TRAF6	Q9Y4K3	IRAK3	Homo sapiens	Q9Y616	Validated Y2H	32296183
Intra	TRAF6	Q9Y4K3	IRAK2	Homo sapiens	O43187	Anti Tag CoIP	10383454
Intra	TRAF6	Q9Y4K3	S100B	Homo sapiens	P04271	Validated Y2H	32814053
Intra	TRAF6	Q9Y4K3	S100B	Homo sapiens	P04271	Y2H Array	32814053
Intra	TRAF6	Q9Y4K3	S100B	Homo sapiens	P04271	Y2H Pooling	32814053
Intra	TRAF6	Q9Y4K3	YES1	Homo sapiens	P07947	Validated Y2H	25416956
Intra	TRAF6	Q9Y4K3	YES1	Homo sapiens	P07947	Y2H Array	25416956
Intra	TRAF6	Q9Y4K3	TRAF5	Homo sapiens	O00463	Y2H Prey Pooling	25416956
Intra	TRAF6	Q9Y4K3	TRAF5	Homo sapiens	O00463	Validated Y2H	25416956
Intra	TRAF6	Q9Y4K3	TRAF5	Homo sapiens	O00463	Y2H Array	22493164
Intra	TRAF6	Q9Y4K3	TRAF5	Homo sapiens	O00463	Y2H Array	25416956
Intra	TRAF6	Q9Y4K3	TRAF5	Homo sapiens	O00463	BFG-2H	27107012
Intra	TRAF6	Q9Y4K3	TRAF5	Homo sapiens	O00463	Y2H	21516116
Intra	TRAF6	Q9Y4K3	CD40	Homo sapiens	P25942	X-Ray Diffraction	12140561
Intra	TRAF6	Q9Y4K3	ZRANB1	Homo sapiens	Q9UGI0	Anti Tag CoIP	11463333
Intra	TRAF6	Q9Y4K3	ZRANB1	Homo sapiens	Q9UGI0	Y2H Array	32296183
Intra	TRAF6	Q9Y4K3	ZRANB1	Homo sapiens	Q9UGI0	Y2H Prey Pooling	32296183
Intra	TRAF6	Q9Y4K3	ZNF675	Homo sapiens	Q8TD23	Y2H	11751921
Intra	TRAF6	Q9Y4K3	ZNF675	Homo sapiens	Q8TD23	IF	11751921
Intra	TRAF6	Q9Y4K3	TAX1BP1	Homo sapiens	Q86VP1	Anti Tag CoIP	18239685
Intra	TRAF6	Q9Y4K3	TAX1BP1	Homo sapiens	Q86VP1	Anti Tag CoIP	17703191
Intra	TRAF6	Q9Y4K3	RUSC1	Homo sapiens	Q9BVN2-2	Anti Tag CoIP	19365808
Intra	TRAF6	Q9Y4K3	UCHL1	Homo sapiens	P09936	Anti Bait CoIP	17353931
Intra	TRAF6	Q9Y4K3	UCHL1	Homo sapiens	P09936	Validated Y2H	32814053
Intra	TRAF6	Q9Y4K3	UCHL1	Homo sapiens	P09936	Y2H Array	32814053
Intra	TRAF6	Q9Y4K3	UCHL1	Homo sapiens	P09936	Y2H Pooling	32814053
Intra	TRAF6	Q9Y4K3	TIFA	Homo sapiens	Q96CG3	Anti Bait CoIP	26068852
Intra	TRAF6	Q9Y4K3	TIFA	Homo sapiens	Q96CG3	Validated Y2H	27107012
Intra	TRAF6	Q9Y4K3	POLI	Homo sapiens	Q9UNA4	Validated Y2H	25416956
Intra	TRAF6	Q9Y4K3	PLEKHF2	Homo sapiens	Q9H8W4	Y2H Array	25416956
Intra	TRAF6	Q9Y4K3	USP2	Homo sapiens	O75604	Validated Y2H	25416956
Intra	TRAF6	Q9Y4K3	UBE2D1	Homo sapiens	P51668	Y2H Array	19549727
Intra	TRAF6	Q9Y4K3	TRAF3IP2	Homo sapiens	O43734	Y2H Prey Pooling	25416956
Intra	TRAF6	Q9Y4K3	TRAF3IP2	Homo sapiens	O43734	Y2H Array	25416956
Intra	TRAF6	Q9Y4K3	TRAF3IP2	Homo sapiens	O43734	Y2H	21516116
Intra	TRAF6	Q9Y4K3	MEOX2	Homo sapiens	P50222	Y2H Prey Pooling	25416956
Intra	TRAF6	Q9Y4K3	MEOX2	Homo sapiens	P50222	Y2H Array	25416956
Intra	TRAF6	Q9Y4K3	ULK1	Homo sapiens	O75385	Anti Tag CoIP	23524951
Intra	TRAF6	Q9Y4K3	SPHK1	Homo sapiens	Q9NYA1	Anti Bait CoIP	17124500
Cross	TRAF6	Q9Y4K3	UL37	Human herpesvirus 1	P10221	Anti Bait CoIP	18682563

Cross: Cross-species interaction Intra: Intraspecies interaction

TRAF6 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80919	TRAF6 Antibody (YA031)	WB	Human, Rat
HY-P80919A	TRAF6 Antibody (YA031)(PBS only)	WB	Human, Rat
HY-P86111	TRAF6 Antibody (YA5803)	WB, IHC-P, ICC/IF, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Ectodermal Dysplasia 10a, Hypohidrotic/Hair/Nail Type, Autosomal Dominant	ECTD10A Hed Ectodermal Dysplasia 10a Ectodermal Dysplasia Hypohidrotic Autosomal Dominant Autosomal Dominant Hypohidrotic Ectodermal Dysplasia Ectodermal Dysplasia, Hypohidrotic, Autosomal Dominant Hypohidrotic Ectodermal Dysplasia Autosomal Dominant Ad-Hed Autosomal Dominant Anhidrotic Ectodermal Dysplasia Ectodermal Dysplasia 3 Ed3 Eda3 Ectodermal Dysplasia, Anhidrotic, Autosomal Dominant Dysplasia, Ectodermal, Type 10a, Hypohidrotic/Hair/Nail, Autosomal Dominant Dysplasia, Ectodermal, Type 3
Osteopetrosis	Marble Bone Disease Albers-Schonberg Disease Osteopetroses Marble Bones Osteopetrosis And Related Disorders Congenital Osteopetrosis Marble Bone Albers-Schoenberg Disease Albers-Schonberg Osteopetrosis Osteosclerosis Fragilis Ivory Bones
Incontinentia Pigmenti	Bloch-Sulzberger Syndrome IP Incontinentia Pigmenti, Familial Male-Lethal Type Incontinentia Pigmenti Syndrome Bloch-Siemens Syndrome Ip2 Incontinentia Pigmenti, Type Ii, Formerly Ip2, Formerly Incontinentia Pigmenti Type 2 Bloch-Siemens-Sulzberger Syndrome Familial Incontinentia Pigmenti Male-Lethal Type Familial Incontinentia Pigmenti Type Ii Incontinentia Pigmenti, Type Ii Bloch Sulzberger Syndrome Incontinentia Pigmenti Achromians Incontinentia Pigmenti Of Bloch-Sulzberger Nevus Pigmentosus Systematicus
Ectodermal Dysplasia	Congenital Ectodermal Defect Congenital Ectodermal Dysplasia Ectodermal Dysplasia Syndrome Dysplasia, Ectodermal
B-Cell Lymphoma	Lymphoma, B-Cell B-Cell Lymphomas B-Cell Lymphocytic Neoplasm Lymphoma B-Cell B-Cell Lymphoma Nos
Folliculitis
Lymphoma	Lymphoid Cancer Lymphomas Lymphoid Cancers Lymphoid Neoplasm Lymphoma Nos Nhl - [Non-Hodgkin Lymphoma] Non-Hodgkin Lymphoma Non-Hodgkin Lymphoma, Nos Non-Hodgkin Malignant Lymphoma Nos
Brucellosis	Mediterranean Fever Malta Fever Undulant Fever Gibraltar Fever Bang'S Disease Maltese Fever Cyprus Fever Rock Fever Brucellosis Infection Brucella Infection
Immunodeficiency With Hyper-Igm, Type 3	HIGM3 Immunodeficiency With Hyper Igm Type 3 Hyper-Igm Syndrome Type 3 Hyper-Igm Syndrome 3 Hyper-Igm Syndrome Due To Cd40 Deficiency Cd40 Deficiency Type 3 Hyper-Igm Immunodeficiency Hyper Igm Syndrome 3 Immunodeficiency With Hyper-Igm 3 Hyper-Igm Immunodeficiency Type 3 Immunodeficiency, With Hyper Igm, Type 3 Hyper-Igm Immunodeficiency Syndrome, Type 3
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Osteoporosis	Postmenopausal Osteoporosis Osteoporosis, Postmenopausal Bone Mineral Density Quantitative Trait Locus Bmnd Osteoporosis, Involutional Osteoporosis, Susceptibility To Osteoporosis, Postmenopausal, Susceptibility Bone Mineral Density Variation Qtl, Osteoporosis OSTEOP Involutional Osteoporosis Senile Osteoporosis Osteoporosis Postmenopausal Bone Mineral Density, Quantitative Trait Locus Osteoporosis, Senile Idiopathic Osteoporosis Bone Rarefaction Nos Type 1 Osteoporosis
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Ectodermal Dysplasia 10b, Hypohidrotic/Hair/Tooth Type, Autosomal Recessive	Hypohidrotic Ectodermal Dysplasia Hed Anhidrotic Ectodermal Dysplasia Ectodermal Dysplasia, Hypohidrotic Eda Christ-Siemens-Touraine Syndrome ECTD10B Ectodermal Dysplasia Anhidrotic Ectodermal Dysplasia, Anhidrotic Cst Syndrome Ectodermal Dysplasia Hypohidrotic Autosomal Recessive Dysplasia, Ectodermal, Type 10b, Hypohidrotic/Hair/Tooth, Autosomal Recessive Dysplasia, Ectodermal, Hypohidrotic Ectodermal Dysplasia 11b, Hypohidrotic/Hair/Tooth Type, Autosomal Recessive Ectodermal Dysplasia 3, Anhidrotic Ectodermal Dysplasia, Hypohidrotic, Autosomal Recessive
Salivary Gland Adenoid Cystic Carcinoma	Cylindroma
Mammary Paget'S Disease	Paget'S Disease Mammary Paget Disease Paget'S Disease Of The Breast Paget Disease Of The Breast Paget'S Disease Of The Nipple Paget'S Disease, Mammary Paget Cell Neoplasm Paget Disease Of The Nipple Pagets Disease Mammary Osteitis Deformans
Ectodermal Dysplasia 1, Hypohidrotic, X-Linked	Christ-Siemens-Touraine Syndrome XHED Ectodermal Dysplasia 1 Xlhed Ed1 Cst Syndrome Ectodermal Dysplasia 1, Hypohidrotic/Hair/Tooth Type, X-Linked Ectd1 Ectodermal Dysplasia, Anhidrotic, X-Linked Eda Eda1 Hed1 Ectodermal Dysplasia 1, Anhidrotic X-Linked Anhidrotic Ectodermal Dysplasia X-Linked Hypohidrotic Ectodermal Dysplasia Hypohidrotic X-Linked Ectodermal Dysplasia Ectodermal Dysplasia, Hypohidrotic, 1 Hypohidrotic Ectodermal Dysplasia, X-Linked Anhidrotic Ectodermal Dysplasia X-Linked Hypohidrotic Ectodermal Dysplasia X-Linked Ectodermal Dysplasia 1 Hypohidrotic/Hair/Tooth Type X-Linked Ectodermal Dysplasia Anhidrotic
Rheumatoid Arthritis	RA Arthritis, Rheumatoid Rheumatoid Arthritis, Susceptibility To Arthritis Or Polyarthritis, Rheumatic Atrophic Arthritis Rheumatism Arthritis Rheumatoid Polyarthritis
Paget'S Disease Of Bone	Osteitis Deformans Paget Disease Of Bone Osseous Paget'S Disease Paget Disease Of Bone, Familial Bone Paget Disease Familial Paget'S Disease Of Bone Paget'S Bone Disease Familial Paget Disease Of Bone Paget Disease, Bone Pdb Pagets Bone Disease
Autoimmune Disease	Autoimmune Diseases Autoimmune Hypersensitivity Disease Hypersensitivity Reaction Type Ii Disease Type Ii Hypersensitivity Reaction Disease
Bone Disease	Bone Diseases Skeletal Disease Skeletal Disorder Disorder Of Skeletal System
Malaria	Malaria, Susceptibility To Malaria, Resistance To Malaria, Cerebral Cerebral Malaria Malaria, Severe, Susceptibility To Malaria, Severe, Resistance To Malaria, Cerebral, Susceptibility To Induced Malaria Malaria, Vivax, Protection Against Malaria, Severe Malaria, Cerebral, Reduced Risk Of Malaria, Protection Against Resistance To Malaria Due To G6pd Deficiency Malaria Due To G6pd Deficiency Malarial Encephalitis CM Malaria Cerebral Susceptibility To Malaria Acute Pernicious Fever Aestivo-Autumnal Fever Aestivo Autumnal Malaria Chagres Fever Continued Malaria Fever Estivo-Autumnal Fever Estivo-Autumnal Malaria Estivo-Autumnal Malarial Fever Falciparum Fever Malignant Tertian Fever Malignant Tertian Malaria Pernicious Intermittent Fever Pernicious Malaria Quotidian Malaria Subtertian Fever Subtertian Malaria Fever Subtertian Malignant Tertian Malaria Tropical Malaria Algid Malaria Bilious Haemoglobinuric Fever Black Water Fever Blackwater Fever Malarial Blackwater Fever Severe Malarial Falciparum West African Fever Malarial Haematinuria Haemoglobinuric Fever Haemoglobinuric Malaria Severe Plasmodium Falciparum Malaria Malarial Haemoglobinuria Malarial Haematuria Falciparum Malaria [Malignant Tertian] Malaria Tropica Malarial Shock Chagres Virus Disease Malignant Malaria Mtm - [Malignant Tertian Malaria] Tm -[Malignant Tertian Malaria] Panama Fever St - [Subtertian Malaria] Malarial Quotidian Benign Tertian Malaria Tertian Ague Vivax Fever Plasmodium Vivax Malaria Nos Btm - [Benign Tertian Malaria] Bt - [Benign Tertian Malaria] Vivax Malaria Benign Tertian Vivax Malaria Tertian Malaria Quartan Malaria Quartan Ague Quartan Fever Plasmodium Malariae Malaria Nos Quartan Malarial Malaria By Plasmodium Malariae Malariae Malaria Ovale Tertian Malaria Plasmodium Ovale Fever Malaria Fever By Plasmodium Ovale Ovale Malaria Malaria By Plasmodium Ovale Malarial Ovale Marsh Fever Remittent Congestive Fever Coastal Fever Remittent Gastric Fever Miasmatic Fever Congestive Remittent Fever Intermittent Fever Jungle Fever Paludism Cameroon Fever Ague Corsican Fever Intermittent Bilious Fever Disease Due To Plasmodiidae Malarial Fever Plasmodiosis Remittent Fever Roman Fever Malaria Fever Nos Malaria Nos Paludal Fever Clinically Diagnosed Malaria Clinically Diagnosed Malaria Without Parasitological Confirmation Congestive Fever Malarial Cachexia Marsh Cachexia Paludal Cachexia Recurrent Malaria Remittent Malaria
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]
Anaerobic Meningitis
Immunodeficiency 58	IMD58 Severe Combined Immunodeficiency Due To Carmil2 Deficiency Combined Immunodeficiency Due To Carmil2 Deficiency Combined Immunodeficiency Due To Rltpr Deficiency
Thrombocytopenia	Low Platelet Count Low Platelets Decreased Platelets Platelet Dysfunction Nos
Lymphoma, Mucosa-Associated Lymphoid Type	Malt Lymphoma Gastric Lymphoma, Primary Lymphoma, Malt, Somatic Mucosa-Associated Lymphoid Tissue Lymphoma Extranodal Marginal Zone B-Cell Lymphoma MALTOMA Marginal Zone B-Cell Lymphoma Mucosa-Associated Lymphatic Tissue Lymphoma Primary Gastric Lymphoma Gastric Lymphoma Familial Primary Gastric Lymphoma
Diabetes Mellitus	Diabetes
Breast Adenocarcinoma	Mammary Adenocarcinoma Adenocarcinoma Of Breast
Connective Tissue Disease	Connective Tissue Diseases Connective Tissue Disorder Abnormality Of Connective Tissue Disorder Of Connective Tissue Connective Tissue Disorders
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Pre-clinical Phase

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B1829A	Dexamethasone phosphate disodium		99.94%	Yes
HY-B1829AR	Dexamethasone phosphate disodium (Standard)		99.88%	Unkown

Pre-clinical Phase

Bioactive Molecules (26)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-120934	C25-140	Inhibitor	99.92%	Unkown
HY-110247	TRAF-STOP inhibitor 6877002	Inhibitor	99.67%	Unkown
HY-N0481	Roburic acid		99.93%	Unkown
HY-N1431	Tabersonine		98.13%	Unkown
HY-N0026	2'-Acetylacteoside	Inhibitor	99.73%	Unkown
HY-142026	Vitisin A		96%	Unkown
HY-N0320	Salvianolic acid D		95.15%	Unkown
HY-P3709A	TRAF6 peptide TFA	Inhibitor	98.20%	Unkown
HY-W013636C	2-Ketoglutaric acid potassium	Inhibitor	98.0%	Unkown
HY-125025	SMI 6860766	Inhibitor	/	Unkown
HY-164670	D228	Inhibitor	99.77%	Unkown
HY-NP134	Flagellin from S. typhimurium		95%	Unkown
HY-P3709	TRAF6 peptide	Inhibitor	/	Unkown
HY-B1829	Dexamethasone phosphate		98.89%	Yes
HY-RS23098	Traf6 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-155801	CRX 527		/	Unkown
HY-176220	GPX4-AUTAC		/	Unkown
HY-184160	Mcl1 Degrader-1		/	Unkown
HY-P11001	RANK-derived TRAF6 inhibitor	Inhibitor	/	Unkown
HY-P11002	PTD	Control	/	Unkown
HY-P3708	TRAF6 control peptide	Control	/	Unkown
HY-RS14975	TRAF6 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-174520	Human TLR8 mRNA		/	Unkown
HY-B1829R	Dexamethasone phosphate (Standard)		/	Unkown
HY-N1431A	Tabersonine hydrochloride		98.55%	Unkown
HY-RS16663	Traf6 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	TRAF6	VGNC	VGNC:81101
Bos taurus	TRAF6	VGNC	VGNC:36278
Canis familiaris	TRAF6	VGNC	VGNC:52058
Macaca mulatta	TRAF6	VGNC	VGNC:101417
Mus musculus	TRAF6	MGD	MGI:108072
Rattus norvegicus	TRAF6	RGD	RGD:1306853
Others	TRAF6	NCBI