SMI 6860766
SMI 6860766, a small molecule inhibitor of CD40-TRAF6 interaction, improves glucose tolerance, reduces immune cell accumulation in adipose tissue, and reduces AT inflammation.
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- CAS No.: 433234-16-3
- Formule: C15H11BrClNO
- Masse moléculaire:336.61
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Stockage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Description
In Vitro
SMI 6860766 (0-100 μM; 1 h) dose-dependently suppresses CD40-induced gene expression of IL-1β and IL-6 cytokines in BM-derived macrophages[1].
SMI 6860766 reduces the levels of CCL2 in CD40+/+, CD40-Twt and CD40-TRAF2/3/5−/− macrophages[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:BM-derived macrophages
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Concentration:0.001, 0.01, 0.1, 1, 10, 100 μM
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Incubation Time:1 h
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Result:Dose-dependently suppressed CD40-induced gene expression of IL-1β and IL-6 cytokines in BM-derived macrophages.
In Vivo
SMI 6860766 reduces the number of total leukocytes (CD45+ cells) in mouse EpAT by 68.5%[1].
SMI 6860766 does not induce differences in hepatosteatosis[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 433234-16-3
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Appearance Solid
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Masse moléculaire 336.61
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Formule C15H11BrClNO
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Color Light yellow to yellow
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SMILES
O=C(C1=CC=CC=C1)/C=C/NC2=CC=C(Br)C=C2Cl
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Pureté et documentation
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Fiche technique (270 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SMI 6860766 Related Classifications
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