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Cat. No.: HY-125025

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SMI 6860766

SMI 6860766, a small molecule inhibitor of CD40-TRAF6 interaction, improves glucose tolerance, reduces immune cell accumulation in adipose tissue, and reduces AT inflammation.

For research use only. We do not sell to patients.

CAS No.: 433234-16-3
Formula: C₁₅H₁₁BrClNO
Molecular Weight:336.61

Storage:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Data Sheet (270 KB)

SMI 6860766 Chemical Structure

CAS No.: 433234-16-3

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

SMI 6860766, a small molecule inhibitor of CD40-TRAF6 interaction, improves glucose tolerance, reduces immune cell accumulation in adipose tissue, and reduces AT inflammation^[1].

All TNF Receptor Isoforms :

In Vitro

SMI 6860766 (0-100 μM; 1 h) dose-dependently suppresses CD40-induced gene expression of IL-1β and IL-6 cytokines in BM-derived macrophages^[1].
SMI 6860766 reduces the levels of CCL2 in CD40+/+, CD40-Twt and CD40-TRAF2/3/5−/− macrophages^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Real Time qPCR^[1]

Cell Line:

BM-derived macrophages
Concentration:

0.001, 0.01, 0.1, 1, 10, 100 μM
Incubation Time:

1 h
Result:

Dose-dependently suppressed CD40-induced gene expression of IL-1β and IL-6 cytokines in BM-derived macrophages.

In Vivo

SMI 6860766 increases the number of adipocytes per field of view by 15.3% in mouse EpAT, indicating that SMI reduces adipocyte size, indicating reduces lipid storage and improves metabolic function^[1].
SMI 6860766 reduces the number of total leukocytes (CD45+ cells) in mouse EpAT by 68.5%^[1].
SMI 6860766 does not induce differences in hepatosteatosis^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 433234-16-3
Appearance Solid
Molecular Weight 336.61
Formula C₁₅H₁₁BrClNO
Color Light yellow to yellow
SMILES

O=C(C1=CC=CC=C1)/C=C/NC2=CC=C(Br)C=C2Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Van den Berg SM, et al. Blocking CD40-TRAF6 interactions by small-molecule inhibitor 6860766 ameliorates the complications of diet-induced obesity in mice. Int J Obes (Lond). 2015 May;39(5):782-90. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References

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SMI 6860766

High-Throughput Bioactive Compound Library

All TNF Receptor Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

SMI 6860766 Related Classifications

HY-125025 Related Classifications