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Dehydrocorydaline chloride

(Synonyms: 13-Methylpalmatine chloride)
45 Cited Publications
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Based on 45 publication(s) in Google Scholar

Dehydrocorydaline chloride (13-Methylpalmatine chloride) is an alkaloid that regulates protein expression of Bax, Bcl-2; activates caspase-7, caspase-8, and inactivates PARP. Dehydrocorydaline chloride elevates p38 MAPK activation. Anti-inflammatory and anti-cancer activities. Dehydrocorydaline chloride shows strong anti-malarial effects (IC50?=38 nM), and low cytotoxicity (cell viability?>?90%) using P. falciparum 3D7 strain.

For research use only. We do not sell to patients.

  • Purity: 99.75%
  • CAS No.: 10605-03-5
  • Formula: C22H24ClNO4
  • Molecular Weight:401.88
  • Storage:

    4°C, sealed storage, away from moisture

    * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

  • Dehydrocorydaline chloride Chemical Structure
    Dehydrocorydaline chloride Chemical Structure
  • Experimental Validation Results for Dehydrocorydaline chloride
  • Experimental Validation Results for Dehydrocorydaline chloride
  • Experimental Validation Results for Dehydrocorydaline chloride
  • Experimental Validation Results for Dehydrocorydaline chloride
  • Experimental Validation Results for Dehydrocorydaline chloride
  • Experimental Validation Results for Dehydrocorydaline chloride
  • Experimental Validation Results for Dehydrocorydaline chloride
CAS No.: 10605-03-5
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Histological Imaging/StainingRT-PCRIFCell Proliferation/Viability AssayWB
  • Histological Imaging/Staining
  • RT-PCR
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  • Cell Proliferation/Viability Assay
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  • Dehydrocorydaline chloride Chemical Structure
    Dehydrocorydaline chloride Chemical Structure
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    Dehydrocorydaline chloride purchased from MedChemExpress. Usage Cited in: Respir Res. 2025 Apr 12;26(1):136. [Abstract]

    Customer Validation
     Images of mice lung tissue slices stained with H&E, Masson, and Sirius Red treated with L-DHC (Dehydrocorydaline) 5 mg/kg, H-DHC: 10 mg/kg.

  • 1/16

    Dehydrocorydaline chloride purchased from MedChemExpress. Usage Cited in: Respir Res. 2025 Apr 12;26(1):136. [Abstract]

    Customer Validation
     RT-qPCR results for Col1a1 and Fn1 expression levels of mice lung tissue treated with L-DHC (Dehydrocorydaline) 5 mg/kg, H-DHC: 10 mg/kg.

  • 1/16

    Dehydrocorydaline chloride purchased from MedChemExpress. Usage Cited in: Respir Res. 2025 Apr 12;26(1):136. [Abstract]

    Customer Validation
     Collagen 1 and Fibronectin of mice lung tissues are analyzed using Western blot treated with L-DHC (Dehydrocorydaline) 5 mg/kg, H-DHC: 10 mg/kg.

  • 1/16

    Dehydrocorydaline chloride purchased from MedChemExpress. Usage Cited in: Respir Res. 2025 Apr 12;26(1):136. [Abstract]

    Customer Validation
     Immunofluorescence images of α-SMA, Collagen 1, and Fibronectin in mice lung tissue slices treated with L-DHC (Dehydrocorydaline) 5 mg/kg, H-DHC: 10 mg/kg.

  • 1/16

    Dehydrocorydaline chloride purchased from MedChemExpress. Usage Cited in: Respir Res. 2025 Apr 12;26(1):136. [Abstract]

    Customer Validation
     CCK8 assay to determine the impact of Dehydrocorydaline (DHC) (5, 10, 30, 50, 80, 100, 150 μM) on HPFs viability.

  • 1/16

    Dehydrocorydaline chloride purchased from MedChemExpress. Usage Cited in: Biochem Biophys Res Commun. 2018 May 23;499(4):743-750. [Abstract]

    Customer Validation
     Astrocytes are cultured with p38 and JNK activator of DHC and ANS, respectively, at the indicated concentrations for 24 h. Then, all cells are harvested for western blot analysis of p-p38 and p-JNK. Astrocytes are pretreated with DHC (500 nM) or ANS (10 mM) for 24 h, followed by Fru (5 mM) for an additional 24 h.

  • 1/16

    Dehydrocorydaline chloride purchased from MedChemExpress. Usage Cited in: Biochem Biophys Res Commun. 2018 Sep 5;503(2):467-473. [Abstract]

    Customer Validation
     The increase of Bcl-2 and decrease of Bax, cleaved Caspase-3 and PARP induced by Ulk1- inhibition in LPS-exposed AST are abrogated by the Dehydrocorydaline chloride (DHC) or Anisomycin (ANS) pre-treatment

  • Dehydrocorydaline chloride