Dehydrocorydaline chloride
Based on 47 publication(s) in Google Scholar
Dehydrocorydaline chloride (13-Methylpalmatine chloride) is an alkaloid that regulates protein expression of Bax, Bcl-2; activates caspase-7, caspase-8, and inactivates PARP. Dehydrocorydaline chloride elevates p38 MAPK activation. Anti-inflammatory and anti-cancer activities. Dehydrocorydaline chloride shows strong anti-malarial effects (IC50 =38 nM), and low cytotoxicity (cell viability > 90%) using P. falciparum 3D7 strain.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.75%
- No. CAS: 10605-03-5
- Fòrmula: C22H24ClNO4
- Peso molecular:401.88
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Almacenamiento:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Protocolo
- Pureza y Documentación
- Referencias
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Dehydrocorydaline chloride
More- J Nanobiotechnology. 2025 Jul 22;23(1):535. [Abstract]
- J Clin Invest. 2024 Jun 18;134(16):e178303. [Abstract]
- Phytomedicine. 2021 Nov:92:153740. [Abstract]
- Mater Today Bio. 2026 Mar 24:38:103059. [Abstract]
- New Phytol. 2024 Jul;243(1):381-397. [Abstract]
- Int J Biol Macromol. 2024 May;266(Pt 1):130939. [Abstract]
- Phytother Res. 2026 May;40(5):2473-2490. [Abstract]
- J Ethnopharmacol. 2025 Jan 30;337(Pt 1):118738. [Abstract]
- J Agric Food Chem. 2023 Oct 25;71(42):15538-15552. [Abstract]
- Ecotoxicol Environ Saf. 2025 Jul 15:300:118460. [Abstract]
- Biochem Pharmacol. 2025 May:235:116820. [Abstract]
- Biochem Pharmacol. 2024 Dec;230(Pt 1):116574. [Abstract]
- Mol Metab. 2026 Apr:106:102341. [Abstract]
- Eur J Pharmacol. 2026 Jan 20:1012:178500. [Abstract]
- Respir Res. 2025 Apr 12;26(1):136. [Abstract]
- Eur J Pharmacol. 2021 Jun 5:900:174069. [Abstract]
- Int Immunopharmacol. 2026 Jul 15:181:116715. [Abstract]
- Int Immunopharmacol. 2026 Jun 1:178:116594. [Abstract]
- Int Immunopharmacol. 2024 Sep 30:139:112720. [Abstract]
- Bone Joint Res. 2023 Nov 1;12(11):677-690. [Abstract]
- Arthritis Res Ther. 2025 May 31;27(1):118. [Abstract]
- Front Pharmacol. 2021 May 31:12:653272. [Abstract]
- J Inflamm Res. 2021 Sep 16;14:4669-4686. [Abstract]
- FASEB J. 2025 Aug 31;39(16):e70945. [Abstract]
- J Nutr. 2020 Jul 1;150(7):1731-1737. [Abstract]
- Front Biosci (Landmark Ed). 2025 Apr 25;30(4):25221. [Abstract]
- J Food Sci. 2025 Apr;90(4):e70217. [Abstract]
- J Cell Physiol. 2019 Dec;234(12):22463-22476. [Abstract]
- Genomics. 2025 Jul;117(4):111067. [Abstract]
- Mol Carcinog. 2024 Nov;63(11):2190-2204. [Abstract]
- Andrology. 2025 Jun 16. [Abstract]
- Tissue Cell. 2023 Dec:85:102218. [Abstract]
- Exp Eye Res. 2023 Feb:227:109365. [Abstract]
- BMC Musculoskelet Disord. 2022 May 30;23(1):514. [Abstract]
- Infect Genet Evol. 2022 Jan:97:105158. [Abstract]
- J Mol Histol. 2021 Jun;52(3):521-537. [Abstract]
- Biochem Biophys Res Commun. 2018 Sep 5;503(2):467-473. [Abstract]
- Biochem Biophys Res Commun. 2018 May 23;499(4):743-750. [Abstract]
- Eur J Histochem. 2025 Jan 21;69(1). [Abstract]
- J Clin Neurosci. 2020 Aug:78:365-370. [Abstract]
- J Cardiothorac Surg. 2024 Dec 20;19(1):665. [Abstract]
- bioRxiv. 2026 May 7.
- Bioengineered. 2022 May;13(5):12847-12862. [Abstract]
- Aging (Albany NY). 2021 Oct 7;13(19):23133-23148. [Abstract]
- Comput Math Methods Med. 2021 Aug 2:2021:3337514. [Abstract]
- Aging (Albany NY). 2021 May 11;13(9):12780-12799. [Abstract]
- Research Square Preprint. 2020 Dec.
Customer Validation & Images
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Histological Imaging/Staining
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RT-PCR
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WB
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IF
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Cell Proliferation/Viability Assay
Ver todos los productos específicos de isoformas Caspase
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Actividad biológica
Descripciòn
IC50 & Target
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Plasmodium |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
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| KB | ED50 |
4.76 μg/mL
Compound: 9
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Cytotoxicity against human KB cells
Cytotoxicity against human KB cells
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[PMID: 423218] |
In Vitro
Treatment of C2C12 myoblasts with 500 nM Dehydrocorydaline increases the expression levels of muscle-specific proteins, including MyoD, myogenin and myosin heavy chain. Treatment with Dehydrocorydaline elevates p38 MAPK activation and the interaction of MyoD with an E protein. Furthermore, defects in differentiation-induced p38 MAPK activation and myoblast differentiation induced by depletion of the promyogenic receptor protein Cdo in C2C12 myoblasts are restored by Dehydrocorydaline treatment[2]. Dehydrocorydaline significantly inhibits MCF-7 cell proliferation in a dose- dependent manner, which can be reversed by a caspase-8 inhibitor, Z-IETD-FMK. Dehydrocorydaline increases DNA fragments without affecting ΔΨm. Western blotting assay shows that dehydrocorydaline dose-dependently increases Bax protein expression and decreases Bcl-2 protein expression. Furthermore, dehydrocorydaline induces activation of caspase-7,-8 and the cleavage of PARP without affecting caspase-9. These results show that dehydrocorydaline inhibits MCF-7 cell proliferation by inducing apoptosis mediated by regulating Bax/Bcl-2, activating caspases as well as cleaving PARP[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 10605-03-5
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Appearance Solid
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Peso molecular 401.88
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Fòrmula C22H24ClNO4
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Color Light yellow to yellow
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SMILES
CC1=C(C=CC(OC)=C2OC)C2=C[N+]3=C1C4=CC(OC)=C(OC)C=C4CC3.[Cl-]
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Synonyms
13-Methylpalmatine chloride
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Structure Classification
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Initial Source
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (47)
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Journal Impact Factor
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Most Recent
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J Nanobiotechnology
A fibrin gel-loaded Gouqi-derived nanovesicle (GqDNV) repairs the heart after myocardial infarction by inhibiting p38 MAPK/NF-κB p65 pathway. [Abstract]2025 Jul 22;23(1):535. PMID: 40696398 -
J Clin Invest
Myostatin regulates energy homeostasis through autocrine- and paracrine-mediated microenvironment communications. [Abstract]2024 Jun 18;134(16):e178303. PMID: 38889010 -
Phytomedicine
The role of daurisoline treatment in hepatocellular carcinoma: Inhibiting vasculogenic mimicry formation and enhancing sensitivity to sorafenib. [Abstract]2021 Nov:92:153740. PMID: 34600176 -
Mater Today Bio
Dual targeted gene delivery strategy mediated by GalNAc-modified lipid nanoparticles enhances liver regeneration through specific knockdown of MKK4. [Abstract]2026 Mar 24:38:103059. PMID: 41970250 -
New Phytol
LbSakA-mediated phosphorylation of the scaffolding protein LbNoxR in the ectomycorrhizal basidiomycete Laccaria bicolor regulates NADPH oxidase activity, ROS accumulation and symbiosis development. [Abstract]2024 Jul;243(1):381-397. PMID: 38741469 -
Int J Biol Macromol
2024 May;266(Pt 1):130939. PMID: 38493816 -
Phytother Res
Dehydrocorydaline Promotes STAT3/Bcl-2 Axis-Mediated Macrophage Efferocytosis to Attenuate Apoptosis in Atherosclerotic Plaques. [Abstract]2026 May;40(5):2473-2490. PMID: 41699991 -
J Ethnopharmacol
Dehydrocorydaline attenuates myocardial ischemia-reperfusion injury via the FoXO signalling pathway: A multimodal study based on network pharmacology, molecular docking, and experimental study. [Abstract]2025 Jan 30;337(Pt 1):118738. PMID: 39222757 -
J Agric Food Chem
Sulforaphene Inhibits Periodontitis through Regulating Macrophage Polarization via Upregulating Dendritic Cell Immunoreceptor. [Abstract]2023 Oct 25;71(42):15538-15552. PMID: 37823224 -
Ecotoxicol Environ Saf
Dibutyl phthalate promotes central precocious puberty through primordial follicle activation by downregulating BMP15. [Abstract]2025 Jul 15:300:118460. PMID: 40472697 -
Biochem Pharmacol
STM2457 decreases m6A methylation to reduce cisplatin-induced ototoxicity via MAPK signaling. [Abstract]2025 May:235:116820. PMID: 39983847 -
Biochem Pharmacol
Ursodeoxycholic acid alleviates fat embolism syndrome-induced acute lung injury by inhibiting the p38 MAPK/NF-κB signalling pathway through FXR. [Abstract]2024 Dec;230(Pt 1):116574. PMID: 39396648 -
Mol Metab
2026 Apr:106:102341. PMID: 41747880 -
Eur J Pharmacol
Therapeutic potential of oral edaravone in diabetic endothelial dysfunction through NF-κB and p38 pathway inhibition. [Abstract]2026 Jan 20:1012:178500. PMID: 41421410 -
Respir Res
Dehydrocorydaline attenuates bleomycin-induced pulmonary fibrosis by inhibiting fibroblast activation. [Abstract]2025 Apr 12;26(1):136. PMID: 40221718
Dehydrocorydaline chloride purchased from MedChemExpress. Usage Cited in: Respir Res. 2025 Apr 12;26(1):136. [Abstract]
Images of mice lung tissue slices stained with H&E, Masson, and Sirius Red treated with L-DHC (Dehydrocorydaline) 5 mg/kg, H-DHC: 10 mg/kg.
Dehydrocorydaline chloride purchased from MedChemExpress. Usage Cited in: Respir Res. 2025 Apr 12;26(1):136. [Abstract]
RT-qPCR results for Col1a1 and Fn1 expression levels of mice lung tissue treated with L-DHC (Dehydrocorydaline) 5 mg/kg, H-DHC: 10 mg/kg.
Dehydrocorydaline chloride purchased from MedChemExpress. Usage Cited in: Respir Res. 2025 Apr 12;26(1):136. [Abstract]
Collagen 1 and Fibronectin of mice lung tissues are analyzed using Western blot treated with L-DHC (Dehydrocorydaline) 5 mg/kg, H-DHC: 10 mg/kg.
Dehydrocorydaline chloride purchased from MedChemExpress. Usage Cited in: Respir Res. 2025 Apr 12;26(1):136. [Abstract]
Immunofluorescence images of α-SMA, Collagen 1, and Fibronectin in mice lung tissue slices treated with L-DHC (Dehydrocorydaline) 5 mg/kg, H-DHC: 10 mg/kg.
Dehydrocorydaline chloride purchased from MedChemExpress. Usage Cited in: Respir Res. 2025 Apr 12;26(1):136. [Abstract]
CCK8 assay to determine the impact of Dehydrocorydaline (DHC) (5, 10, 30, 50, 80, 100, 150 μM) on HPFs viability.
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Eur J Pharmacol
Eriodictyol inhibits glioblastoma migration and invasion by reversing EMT via downregulation of the P38 MAPK/GSK-3β/ZEB1 pathway. [Abstract]2021 Jun 5:900:174069. PMID: 33811837 -
Int Immunopharmacol
MCPIP1 modulates host antifungal immunity and exacerbates lethal Candida albicans infection. [Abstract]2026 Jul 15:181:116715. PMID: 42066549 -
Int Immunopharmacol
Salvianolic acid a inhibits neuroinflammation and ameliorates Alzheimer's disease pathology via the p38 MAPK/NF-κB pathway based on network pharmacology and experimental validation. [Abstract]2026 Jun 1:178:116594. PMID: 41930874 -
Int Immunopharmacol
Eupatilin suppresses osteoclastogenesis and periodontal bone loss by inhibiting the MAPKs/Siglec-15 pathway. [Abstract]2024 Sep 30:139:112720. PMID: 39047450 -
Bone Joint Res
Melatonin induces RAW264.7 cell apoptosis via the BMAL1/ROS/MAPK-p38 pathway to improve postmenopausal osteoporosis. [Abstract]2023 Nov 1;12(11):677-690. PMID: 37907083 -
Arthritis Res Ther
Roles of VWA1 and Rac2 in compensatory and decompensatory responses via FGF9/FGFR3 and p38 MAPK signaling pathways in condylar chondrocytes under distinct mechanical stress. [Abstract]2025 May 31;27(1):118. PMID: 40450276 -
Front Pharmacol
Inhibition of ASIC1a-Mediated ERS Improves the Activation of HSCs and Copper Transport Under Copper Load. [Abstract]2021 May 31:12:653272. PMID: 34135753 -
J Inflamm Res
The Effects of Adoptively Transferred IL-23/IL-18-Polarized Neutrophils on Tumor and Collagen-Induced Arthritis in Mice. [Abstract]2021 Sep 16;14:4669-4686. PMID: 34557012 -
FASEB J
USP44 Regulates Chemoresistance Induced by ROS and the MAPK/NF-κB Pathway Through the Stabilization of ITGB4 in Gastric Cancer. [Abstract]2025 Aug 31;39(16):e70945. PMID: 40824171 -
J Nutr
A-Type Cinnamon Procyanidin Oligomers Protect Against 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Induced Neurotoxicity in Mice Through Inhibiting the P38 Mitogen-Activated Protein Kinase/P53/BCL-2 Associated X Protein Signaling Pathway. [Abstract]2020 Jul 1;150(7):1731-1737. PMID: 32386222 -
Front Biosci (Landmark Ed)
2025 Apr 25;30(4):25221. PMID: 40302325 -
J Food Sci
Curcumin Alleviates DON-Induced Intestinal Epithelial Barrier Disruption by Improving Ribotoxic Stress-Associated p38 Pathway-Mediated TJ Injury, Apoptosis, and Cell Cycle Arrest. [Abstract]2025 Apr;90(4):e70217. PMID: 40271829 -
J Cell Physiol
STRIP2 silencing inhibits vascular smooth muscle cell proliferation and migration via P38-AKT-MMP-2 signaling pathway. [Abstract]2019 Dec;234(12):22463-22476. PMID: 31093976 -
Genomics
MiR-100-5p as a biomarker in hand-arm vibration disease: Mediating pathogenesis through angiogenesis suppression. [Abstract]2025 Jul;117(4):111067. PMID: 40460899 -
Mol Carcinog
ITGB3-enriched extracellular vesicles mediate the formation of osteoclastic pre-metastatic niche to promote lung adenocarcinoma bone metastasis. [Abstract]2024 Nov;63(11):2190-2204. PMID: 39136603 -
Andrology
Expression of IL-33 in rodent testes and its role in Leydig cell steroidogenesis and aging. [Abstract]2025 Jun 16. PMID: 40521800 -
Tissue Cell
Placental mesenchymal stem cells-secreted proenkephalin suppresses the p38 MAPK signaling to block hyperproliferation of keloid fibroblasts. [Abstract]2023 Dec:85:102218. PMID: 37913601 -
Exp Eye Res
Embryonic stem cell extracellular vesicles reverse the senescence of retinal pigment epithelial cells by the p38MAPK pathway. [Abstract]2023 Feb:227:109365. PMID: 36577484 -
BMC Musculoskelet Disord
Knockdown of PAR2 alleviates cancer-induced bone pain by inhibiting the activation of astrocytes and the ERK pathway. [Abstract]2022 May 30;23(1):514. PMID: 35637468 -
Infect Genet Evol
Knockdown of GBP1 inhibits BCG-induced apoptosis in macrophage RAW 264.7 cells via p38/JNK pathway. [Abstract]2022 Jan:97:105158. PMID: 34826624 -
J Mol Histol
Nogo-A-Δ20/EphA4 interaction antagonizes apoptosis of neural stem cells by integrating p38 and JNK MAPK signaling. [Abstract]2021 Jun;52(3):521-537. PMID: 33555537 -
Biochem Biophys Res Commun
Deficiency of unc-51 like kinase 1 (Ulk1) protects against mice traumatic brain injury (TBI) by suppression of p38 and JNK pathway. [Abstract]2018 Sep 5;503(2):467-473. PMID: 29680658
Dehydrocorydaline chloride purchased from MedChemExpress. Usage Cited in: Biochem Biophys Res Commun. 2018 Sep 5;503(2):467-473. [Abstract]
The increase of Bcl-2 and decrease of Bax, cleaved Caspase-3 and PARP induced by Ulk1- inhibition in LPS-exposed AST are abrogated by the Dehydrocorydaline chloride (DHC) or Anisomycin (ANS) pre-treatment
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Biochem Biophys Res Commun
NFATc3 deficiency protects against high fat diet (HFD)-induced hypothalamus inflammation and apoptosis via p38 and JNK suppression. [Abstract]2018 May 23;499(4):743-750. PMID: 29596828
Dehydrocorydaline chloride purchased from MedChemExpress. Usage Cited in: Biochem Biophys Res Commun. 2018 May 23;499(4):743-750. [Abstract]
Astrocytes are cultured with p38 and JNK activator of DHC and ANS, respectively, at the indicated concentrations for 24 h. Then, all cells are harvested for western blot analysis of p-p38 and p-JNK. Astrocytes are pretreated with DHC (500 nM) or ANS (10 mM) for 24 h, followed by Fru (5 mM) for an additional 24 h.
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Eur J Histochem
Adipose-derived stem cells promote the recovery of intestinal barrier function by inhibiting the p38 MAPK signaling pathway. [Abstract]2025 Jan 21;69(1). PMID: 39836101 -
J Clin Neurosci
Effects of p38 MAPK signaling pathway on cognitive function and recovery of neuronal function after hypoxic-ischemic brain injury in newborn rats. [Abstract]2020 Aug:78:365-370. PMID: 32360159 -
J Cardiothorac Surg
Aconitine promotes ROS-activated P38/MAPK/Nrf2 pathway to inhibit autophagy and promote myocardial injury. [Abstract]2024 Dec 20;19(1):665. PMID: 39707526 -
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Bioengineered
Deleted in lymphocytic leukemia 2 induces retinoic acid receptor beta promoter methylation and mitogen activated kinase-like protein activation to enhance viability and mobility of colorectal cancer cells. [Abstract]2022 May;13(5):12847-12862. PMID: 35611845 -
Aging (Albany NY)
Short-term high-fat diet favors the appearances of apoptosis and gliosis by activation of ERK1/2/p38MAPK pathways in brain. [Abstract]2021 Oct 7;13(19):23133-23148. PMID: 34620734 -
Comput Math Methods Med
Efficacy of Low Molecular Heparin on Preeclampsia by Inhibiting Apoptosis of Trophoblasts via the p38MAPK Signaling Pathway. [Abstract]2021 Aug 2:2021:3337514. PMID: 34394705 -
Aging (Albany NY)
2021 May 11;13(9):12780-12799. PMID: 33973871 -
Solvente y solubilidad
In Vitro:
DMSO : 25 mg/mL (62.21 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (6.22 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (6.22 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Protocolo
Cell Assay[1]
Briefly, MCF-7 cells (1×104 cells/well) are seeded in 96-well plates and treated with different concentrations of dehydrocorydaline (0-200 μM) for 24 h. The cell viability is determined. To explore the role of caspase-8 in dehydrocorydaline induced cytotoxicity, a caspase-8 inhibitor Z-IETD-FMK (10 μM) is co-incubated with 200 μM dehydrocorydaline.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Administration[4]
Briefly, the mice are placed individually in glass beakers and are allowed to acclimate for 30 min before the test. The vehicle or Dehydrocorydaline (3.6, 6 or 10 mg/kg) are injected (10 ml/kg, i.p.) 15 min prior to the formalin injection. Morphine (10 mg/kg) or diclofenac sodium (20 mg/kg) are injected 15 and 30 min, respectively, prior to the formalin injection as positive controls. Then, 25 μL of a 5% formalin solution is injected into the plantar surface of the right hind paw of each mouse. Immediately after the formalin injection, the mice are placed individually in the beakers, and a mirror is placed under the beaker to allow clear observation of the paws of the animals. The time that the animals spent on biting/licking the injected paw is measured with a stopwatch every 5 min and considered as indication of nociception.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Pureza y Documentación
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Ficha de datos (281 KB)
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SDS (480 KB)
- English - EN (480 KB)
- Français - FR (480 KB)
- Deutsch - DE (480 KB)
- Norwegian - NO (480 KB)
- Español - ES (480 KB)
- Swedish - SV (480 KB)
- Italian - IT (480 KB)
- Korean - KR (480 KB)
- Portuguese - PT (480 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Xu Z, et al. Dehydrocorydaline inhibits breast cancer cells proliferation by inducing apoptosis in MCF-7 cells. Am J Chin Med. 2012;40(1):177-85. [Content Brief]
[2]. Yoo M, et al. Dehydrocorydaline promotes myogenic differentiation via p38 MAPK activation. Mol Med Rep. 2016 Oct;14(4):3029-36. [Content Brief]
[3]. Nonaka M, et al. Screening of a library of traditional Chinese medicines to identify anti-malarial compounds and extracts. Malar J. 2018 Jun 25;17(1):244. [Content Brief]
[4]. Yin ZY, et al. Antinociceptive effects of dehydrocorydaline in mouse models of inflammatory pain involve the opioid receptor and inflammatory cytokines. Sci Rep. 2016 Jun 7;6:27129 [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.4883 mL | 12.4415 mL | 24.8830 mL | 62.2076 mL |
| 5 mM | 0.4977 mL | 2.4883 mL | 4.9766 mL | 12.4415 mL | |
| 10 mM | 0.2488 mL | 1.2442 mL | 2.4883 mL | 6.2208 mL | |
| 15 mM | 0.1659 mL | 0.8294 mL | 1.6589 mL | 4.1472 mL | |
| 20 mM | 0.1244 mL | 0.6221 mL | 1.2442 mL | 3.1104 mL | |
| 25 mM | 0.0995 mL | 0.4977 mL | 0.9953 mL | 2.4883 mL | |
| 30 mM | 0.0829 mL | 0.4147 mL | 0.8294 mL | 2.0736 mL | |
| 40 mM | 0.0622 mL | 0.3110 mL | 0.6221 mL | 1.5552 mL | |
| 50 mM | 0.0498 mL | 0.2488 mL | 0.4977 mL | 1.2442 mL | |
| 60 mM | 0.0415 mL | 0.2074 mL | 0.4147 mL | 1.0368 mL |
Dehydrocorydaline chloride Related Classifications
HY-N0674A Related Classifications
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