1. Apoptosis
    Epigenetics
    Cell Cycle/DNA Damage
    MAPK/ERK Pathway
    Anti-infection
    Autophagy
  2. Bcl-2 Family
    Caspase
    PARP
    p38 MAPK
    Parasite
    Autophagy
  3. Dehydrocorydaline

Dehydrocorydaline (Synonyms: 13-Methylpalmatine)

Cat. No.: HY-N0674 Purity: 99.01%
Handling Instructions

Dehydrocorydaline (13-Methylpalmatine) is an alkaloid isolated from traditional Chinese herb Corydalis yanhusuo W.T. Wang. Dehydrocorydaline regulates protein expression of Bax, Bcl-2; activates caspase-7, caspase-8, and inactivates PARP. Dehydrocorydaline elevates p38 MAPK activation. Anti-inflammatory and anti-cancer activities.. Dehydrocorydaline shows strong anti-malarial effects (IC50 =38 nM), and low cytotoxicity (cell viability > 90%) using P. falciparum 3D7 strain.

For research use only. We do not sell to patients.

Dehydrocorydaline Chemical Structure

Dehydrocorydaline Chemical Structure

CAS No. : 30045-16-0

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 154 In-stock
Estimated Time of Arrival: December 31
5 mg USD 140 In-stock
Estimated Time of Arrival: December 31
10 mg USD 200 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 7 publication(s) in Google Scholar

Other Forms of Dehydrocorydaline:

Top Publications Citing Use of Products

    Dehydrocorydaline purchased from MCE. Usage Cited in: Biochem Biophys Res Commun. 2018 May 23;499(4):743-750.

    Astrocytes are cultured with p38 and JNK activator of DHC and ANS, respectively, at the indicated concentrations for 24 h. Then, all cells are harvested for western blot analysis of p-p38 and p-JNK. Astrocytes are pretreated with DHC (500 nM) or ANS (10 mM) for 24 h, followed by Fru (5 mM) for an additional 24 h.

    Dehydrocorydaline purchased from MCE. Usage Cited in: Biochem Biophys Res Commun. 2018 Sep 5;503(2):467-473.

    The increase of Bcl-2 and decrease of Bax, cleaved Caspase-3 and PARP induced by Ulk1- inhibition in LPS-exposed AST are abrogated by the Dehydrocorydaline chloride (DHC) or Anisomycin (ANS) pre-treatment
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    Description

    Dehydrocorydaline (13-Methylpalmatine) is an alkaloid isolated from traditional Chinese herb Corydalis yanhusuo W.T. Wang. Dehydrocorydaline regulates protein expression of Bax, Bcl-2; activates caspase-7, caspase-8, and inactivates PARP[1]. Dehydrocorydaline elevates p38 MAPK activation. Anti-inflammatory and anti-cancer activities.[2]. Dehydrocorydaline shows strong anti-malarial effects (IC50 =38 nM), and low cytotoxicity (cell viability > 90%) using P. falciparum 3D7 strain[3].

    IC50 & Target[1]

    Bcl-2

     

    Bax

     

    Caspase-7

     

    Caspase-8

     

    PARP

     

    In Vitro

    Dehydrocorydaline (0-200 μM) treatment significantly inhibits the growth of MCF-7 cells in a dose-dependent manner. The cell viability is decreased by approximate 40% after 24 h of 200 μM Dehydrocorydaline[1].
    Dehydrocorydaline (0-200 μM)dose-dependently increases Bax protein expression and decreases Bcl-2 protein expression[1].
    Dehydrocorydaline (0-200 μM)induces activation of caspase-7,-8 and the cleavage of PARP without affecting caspase-9[1].

    In Vivo

    Dehydrocorydaline manifests a low acute toxicity with an LD50 of about 277.5±19.0 mg/kg body weight in mice following oral administration and 21.1±1.4 mg/kg for intraperitoneal injection[4].

    Molecular Weight

    366.43

    Formula

    C₂₂H₂₄NO₄+

    CAS No.

    30045-16-0

    SMILES

    CC1=C(C=CC(OC)=C2OC)C2=C[N+]3=C1C4=CC(OC)=C(OC)C=C4CC3

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 100 mg/mL (272.90 mM; ultrasonic and warming and heat to 60°C)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.7290 mL 13.6452 mL 27.2903 mL
    5 mM 0.5458 mL 2.7290 mL 5.4581 mL
    10 mM 0.2729 mL 1.3645 mL 2.7290 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 6.25 mg/mL (17.06 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 6.25 mg/mL (17.06 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References

    Purity: 99.01%

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    Keywords:

    Dehydrocorydaline13-MethylpalmatineBcl-2 FamilyCaspasePARPp38 MAPKParasiteAutophagypoly ADP ribose polymeraseInhibitorinhibitorinhibit

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