1. Apoptosis
    Epigenetics
    Cell Cycle/DNA Damage
    MAPK/ERK Pathway
    Anti-infection
    Autophagy
  2. Bcl-2 Family
    Caspase
    PARP
    p38 MAPK
    Parasite
    Autophagy
  3. Dehydrocorydaline nitrate

Dehydrocorydaline nitrate (Synonyms: 13-Methylpalmatine nitrate)

Cat. No.: HY-N4238
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Dehydrocorydaline nitrate (13-Methylpalmatine nitrate) is an alkaloid isolated from traditional Chinese herb Corydalis yanhusuo W.T. Wang. Dehydrocorydaline regulates protein expression of Bax, Bcl-2; activates caspase-7, caspase-8, and inactivates PARP. Dehydrocorydaline nitrate elevates p38 MAPK activation. Anti-inflammatory and anti-cancer activities.. Dehydrocorydaline nitrate shows strong anti-malarial effects (IC50 =38 nM), and low cytotoxicity (cell viability > 90%) using P. falciparum 3D7 strain.

For research use only. We do not sell to patients.

Dehydrocorydaline nitrate Chemical Structure

Dehydrocorydaline nitrate Chemical Structure

CAS No. : 13005-09-9

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Top Publications Citing Use of Products

    Dehydrocorydaline nitrate purchased from MCE. Usage Cited in: Biochem Biophys Res Commun. 2018 May 23;499(4):743-750.

    Astrocytes are cultured with p38 and JNK activator of DHC and ANS, respectively, at the indicated concentrations for 24 h. Then, all cells are harvested for western blot analysis of p-p38 and p-JNK. Astrocytes are pretreated with DHC (500 nM) or ANS (10 mM) for 24 h, followed by Fru (5 mM) for an additional 24 h.

    Dehydrocorydaline nitrate purchased from MCE. Usage Cited in: Biochem Biophys Res Commun. 2018 Sep 5;503(2):467-473.

    The increase of Bcl-2 and decrease of Bax, cleaved Caspase-3 and PARP induced by Ulk1- inhibition in LPS-exposed AST are abrogated by the Dehydrocorydaline chloride (DHC) or Anisomycin (ANS) pre-treatment
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    Description

    Dehydrocorydaline nitrate (13-Methylpalmatine nitrate) is an alkaloid isolated from traditional Chinese herb Corydalis yanhusuo W.T. Wang. Dehydrocorydaline regulates protein expression of Bax, Bcl-2; activates caspase-7, caspase-8, and inactivates PARP[1]. Dehydrocorydaline nitrate elevates p38 MAPK activation. Anti-inflammatory and anti-cancer activities.[2]. Dehydrocorydaline nitrate shows strong anti-malarial effects (IC50 =38 nM), and low cytotoxicity (cell viability > 90%) using P. falciparum 3D7 strain[3].

    IC50 & Target

    IC50: 38 nM (P. falciparum 3D7 strain)[3]

    Molecular Weight

    428.44

    Formula

    C₂₂H₂₄N₂O₇

    CAS No.

    13005-09-9

    SMILES

    [O-][N+]([O-])=O.CC1=C(C=CC(OC)=C2OC)C2=C[N+]3=C1C4=CC(OC)=C(OC)C=C4CC3

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    Room temperature in continental US; may vary elsewhere.

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    Please store the product under the recommended conditions in the Certificate of Analysis.

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    Keywords:

    Dehydrocorydaline13-MethylpalmatineBcl-2 FamilyCaspasePARPp38 MAPKParasiteAutophagypoly ADP ribose polymeraseInhibitorinhibitorinhibit

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