TRAF3IP2 - TRAF3 interacting protein 2 Gene

Also Known as ACT1; CIKS; C6orf2; C6orf4; C6orf5; C6orf6; CANDF8; PSORS13

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10758

About TRAF3IP2

Cytogenetic location: 6q21 Genomic coordinates (GRCh38): 6:111,555,381-111,605,878 (from NCBI)

This gene has 21 transcripts (splice variants), 91 orthologues and is associated with 3 phenotypes. Ubiquitous expression in endometrium (RPKM 6.1), stomach (RPKM 4.8) and 25 other tissues.

Summary

This gene encodes a protein involved in regulating responses to cytokines by members of the Rel/NF-kappaB transcription factor family. These factors play a central role in innate immunity in response to pathogens, inflammatory signals and stress. This gene product interacts with TRAF proteins (tumor necrosis factor receptor-associated factors) and either I-kappaB kinase or MAP kinase to activate either NF-kappaB or Jun kinase. Several alternative transcripts encoding different isoforms have been identified. Another transcript, which does not encode a protein and is transcribed in the opposite orientation, has been identified. Overexpression of this transcript has been shown to reduce expression of at least one of the protein encoding transcripts, suggesting it has a regulatory role in the expression of this gene. [provided by RefSeq, Aug 2009]

TRAF3IP2 Products (4)

mRNA	Protein	Name
NM_001164281.3	NP_001157753.1	E3 ubiquitin ligase TRAF3IP2 isoform 3
NM_001164283.3	NP_001157755.1	E3 ubiquitin ligase TRAF3IP2 isoform 5
NM_147200.3	NP_671733.2	E3 ubiquitin ligase TRAF3IP2 isoform 1
NM_147686.4	NP_679211.2	E3 ubiquitin ligase TRAF3IP2 isoform 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12459498	GOA
enables ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	19825828	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in inflammatory response	IDA IDA: Inferred from direct assay	17277779	GOA
involved in interleukin-17-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	19825828	GOA
involved in interleukin-17A-mediated signaling pathway	IDA IDA: Inferred from direct assay	17277779	GOA
involved in positive regulation of canonical NF-kappaB signal transduction	IEP IEP: Inferred from expression pattern	12761501	GOA
involved in positive regulation of defense response to virus by host	IDA IDA: Inferred from direct assay	23066157	GOA
involved in protein K63-linked ubiquitination	IDA IDA: Inferred from direct assay	19825828	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRAF3IP2 Protein Structure

SEFIR

0
100
200
300
400
500
574 a.a.

Protein Preferred Names	Protein Names
E3 ubiquitin ligase TRAF3IP2	E3 ubiquitin-protein ligase CIKS

TRAF3IP2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TRAF3IP2	O43734	RIMBP3	Homo sapiens	Q9UFD9	Y2H Array	25416956
Intra	TRAF3IP2	O43734	FHL3	Homo sapiens	Q96C98	Y2H Prey Pooling	25416956
Intra	TRAF3IP2	O43734	TRAF6	Homo sapiens	Q9Y4K3	Validated Y2H	25416956
Intra	TRAF3IP2	O43734	MRPL28	Homo sapiens	Q13084	Validated Y2H	25416956
Intra	TRAF3IP2	O43734	MRPL28	Homo sapiens	Q13084	Y2H Prey Pooling	25416956
Intra	TRAF3IP2	O43734	MRPL28	Homo sapiens	Q13084	Y2H Array	25416956
Intra	TRAF3IP2	O43734	TRIP6	Homo sapiens	Q15654	Y2H Array	25416956
Intra	TRAF3IP2	O43734	STK16	Homo sapiens	O75716	Validated Y2H	25416956
Intra	TRAF3IP2	O43734	STK16	Homo sapiens	O75716	Y2H Array	25416956
Intra	TRAF3IP2	O43734	STK16	Homo sapiens	O75716	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Candidiasis, Familial, 8	CANDF8 Candidiasis, Familial Chronic Mucocutaneous, Autosomal Recessive Candidiasis Familial Chronic Mucocutaneous Autosomal Recessive Candidiasis, Familial, Type 8
Psoriasis 13	PSORS13 Psoriasis 13, Susceptibility To Psoriasis Psoriasis Vulgaris Psoriasis Susceptibility 13 Pv Psoriasis, Susceptibility To, Type 13
Discoid Lupus Erythematosus	Lupus Erythematosus Discoid Lupus Erythematosus, Discoid Cdle - [Chronic Discoid Lupus Erythematosus] Dle - [Discoid Lupus Erythematosus] Chronic Discoid Lupus Erythematosus Discoid Lupus Nos
Chronic Mucocutaneous Candidiasis	Candidiasis, Chronic Mucocutaneous Cmc Candidiasis Chronic Mucocutaneous
Candidiasis	Systemic Candidiasis Invasive Candidiasis Disseminated Candidiasis Systemic Candida Infections Candidiasis, Invasive
Folliculitis
Pericarditis
Immunodeficiency 29	Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Il12b Deficiency IMD29 Il12b Deficiency Immunodeficiency 29, Mycobacteriosis Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Interleukin 12b Deficiency Msmd Due To Complete Il12b Deficiency Msmd Due To Complete Interleukin 12b Deficiency Immunodeficiency, Type 29, Mycobacteriosis
Psoriasis
Psoriasis 10	PSORS10 Psoriasis Susceptibility 10 Psoriasis 10, Susceptibility To
Candidal Paronychia	Candidiasis Of Skin Candidiasis Of Skin And Nails Candidal Perionyxis
Psoriasis 7	PSORS7 Psoriasis 7, Susceptibility To Psoriasis Susceptibility 7 Psoriasis Psoriasis Vulgaris Pv
Nail Disease	Nail Diseases Abnormality Of The Nail Nail Anomaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14971	TRAF3IP2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22078	Traf3ip2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28597	Traf3ip2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	TRAF3IP2	VGNC	VGNC:36274
Mus musculus	TRAF3IP2	MGD	MGI:2143599
Macaca mulatta	TRAF3IP2	VGNC	VGNC:78921
Felis catus	TRAF3IP2	VGNC	VGNC:66498
Rattus norvegicus	TRAF3IP2	RGD	RGD:1593240
Canis familiaris	TRAF3IP2	VGNC	VGNC:47766