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MRPL28 - mitochondrial ribosomal protein L28 Gene

Also Known as p15; MAAT1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10573

About MRPL28

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:366,969-370,538 (from NCBI)

This gene has 10 transcripts (splice variants) and 202 orthologues. Ubiquitous expression in testis (RPKM 24.9), kidney (RPKM 19.3) and 25 other tissues.

Summary

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein, a part of which was originally isolated by its ability to recognize Tyrosinase in an HLA-A24-restricted fashion. [provided by RefSeq, Jul 2008]

MRPL28 Products (1)

mRNA	Protein	Name
NM_006428.5	NP_006419.2	39S ribosomal protein L28, mitochondrial

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	20601428	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of mitochondrial large ribosomal subunit	IDA IDA: Inferred from direct assay	25278503	GOA
located in mitochondrial ribosome	IDA IDA: Inferred from direct assay	20601428	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	28892042	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
39S ribosomal protein L28, mitochondrial	L28mt

MRPL28 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	MRPL28	Q13084	FAM9B	Homo sapiens	Q8IZU0	Y2H Prey Pooling	25416956
Intra	MRPL28	Q13084	NFKBID	Homo sapiens	Q8NI38	Y2H Array	32296183
Intra	MRPL28	Q13084	NFKBID	Homo sapiens	Q8NI38	Validated Y2H	32296183
Intra	MRPL28	Q13084	NFKBID	Homo sapiens	Q8NI38	Y2H Prey Pooling	32296183
Intra	MRPL28	Q13084	ABI2	Homo sapiens	Q9NYB9-2	Validated Y2H	32296183
Intra	MRPL28	Q13084	CDR2	Homo sapiens	Q01850	Y2H Array	25416956
Intra	MRPL28	Q13084	LARP1B	Homo sapiens	Q659C4-6	Validated Y2H	32296183
Intra	MRPL28	Q13084	HMBOX1	Homo sapiens	Q6NT76	Validated Y2H	25416956
Intra	MRPL28	Q13084	HMBOX1	Homo sapiens	Q6NT76	Y2H Array	25416956
Intra	MRPL28	Q13084	TEF	Homo sapiens	Q10587	Y2H Prey Pooling	25416956
Intra	MRPL28	Q13084	TEF	Homo sapiens	Q10587	Y2H Array	25416956
Intra	MRPL28	Q13084	TRAF4	Homo sapiens	Q9BUZ4	Y2H Array	25416956
Intra	MRPL28	Q13084	TRAF4	Homo sapiens	Q9BUZ4	Y2H Prey Pooling	25416956
Intra	MRPL28	Q13084	TSSK3	Homo sapiens	Q96PN8	Validated Y2H	32296183
Intra	MRPL28	Q13084	CDCA7L	Homo sapiens	Q96GN5	Validated Y2H	32296183
Intra	MRPL28	Q13084	ZNF655	Homo sapiens	Q8N720	Y2H Array	32296183
Intra	MRPL28	Q13084	ZNF655	Homo sapiens	Q8N720	Validated Y2H	32296183
Intra	MRPL28	Q13084	ZNF655	Homo sapiens	Q8N720	Y2H Prey Pooling	32296183
Intra	MRPL28	Q13084	LENG1	Homo sapiens	Q96BZ8	Validated Y2H	32296183
Intra	MRPL28	Q13084	ENKD1	Homo sapiens	Q9H0I2	Validated Y2H	32296183
Intra	MRPL28	Q13084	BANP	Homo sapiens	Q8N9N5	Validated Y2H	25416956
Intra	MRPL28	Q13084	BANP	Homo sapiens	Q8N9N5	Y2H Array	25416956
Intra	MRPL28	Q13084	IKZF3	Homo sapiens	Q9UKT9	Y2H Prey Pooling	25416956
Intra	MRPL28	Q13084	IKZF3	Homo sapiens	Q9UKT9	Validated Y2H	25416956
Intra	MRPL28	Q13084	IKZF3	Homo sapiens	Q9UKT9	Y2H Array	25416956
Intra	MRPL28	Q13084	SCNM1	Homo sapiens	Q9BWG6	Validated Y2H	32296183
Intra	MRPL28	Q13084	TSHZ3	Homo sapiens	Q63HK5	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Pancreatic Serous Cystadenoma
Megalencephalic Leukoencephalopathy With Subcortical Cysts 1	Van Der Knaap Disease Leukoencephalopathy With Swelling And Cysts MLC1 Vacuolating Megalencephalic Leukoencephalopathy With Subcortical Cysts Lvm Vl Leukoencephalopathy, Megalencephalic, With Subcortical Cysts, 1 Leukoencephalopathy, Megalencephalic, With Subcortical Cysts, Type 1 Megalencephalic Leukoencephalopathy With Subcortical Cysts
Melanoma	Malignant Melanoma Cutaneous Melanoma Naevocarcinoma Malignant Melanomas
Spastic Paraplegia 10, Autosomal Dominant	SPG10 Hereditary Spastic Paraplegia 10 Autosomal Dominant Spastic Paraplegia Type 10 Spastic Paraplegia 10 Spastic Paraplegia 10 With Or Without Peripheral Neuropathy Autosomal Dominant Spastic Paraplegia 10 Autosomal Dominant Spastic Paraplegia Spastic Paraplegia, Autosomal Dominant Paraplegia, Spastic, Autosomal Dominant, Type 10

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08668	MRPL28 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	MRPL28	RGD	RGD:1583741
Macaca mulatta	MRPL28	VGNC	VGNC:74758
Bos taurus	MRPL28	VGNC	VGNC:31629
Mus musculus	MRPL28	MGD	MGI:1915861
Canis familiaris	MRPL28	VGNC	VGNC:43389
Felis catus	MRPL28	VGNC	VGNC:107765
Others	MRPL28	NCBI