TSHZ3 - teashirt zinc finger homeobox 3 Gene

Also Known as TSH3; ZNF537

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 57616

About TSHZ3

Cytogenetic location: 19q12 Genomic coordinates (GRCh38): 19:31,149,876-31,350,877 (from NCBI)

This gene has 4 transcripts (splice variants), 206 orthologues and 2 paralogues. Broad expression in ovary (RPKM 16.6), endometrium (RPKM 15.6) and 19 other tissues.

Summary

This gene encodes a zinc-finger transcription factor that regulates smooth muscle cell differentiation in the developing urinary tract. Consistent with this role, mice in which this gene has been inactivated exhibit abnormal gene expression in urinary tract smooth muscle cell precursors and kidney defects including hydronephrosis. The encoded transcription factor comprises a gene silencing complex that inhibits Caspase expression. Reduced expression of this gene and consequent Caspase upregulation may be correlated with progression of Alzheimer's disease in human patients. [provided by RefSeq, Jul 2016]

TSHZ3 Products (1)

mRNA	Protein	Name
NM_020856.4	NP_065907.2	teashirt homolog 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables chromatin binding	IDA IDA: Inferred from direct assay	19343227	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19343227	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	19343227	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	19343227	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TSHZ3 Protein Structure

zf-C2H2_2

zf-C2H2_4

0
200
400
600
800
1000
1081 a.a.

Protein Preferred Names	Protein Names
teashirt homolog 3	teashirt family zinc finger 3

TSHZ3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TSHZ3	Q63HK5	KRT40	Homo sapiens	Q6A162	Y2H Array	25416956
Intra	TSHZ3	Q63HK5	KRT40	Homo sapiens	Q6A162	Y2H Prey Pooling	25416956
Intra	TSHZ3	Q63HK5	CTBP1	Homo sapiens	Q13363-2	Y2H Prey Pooling	25416956
Intra	TSHZ3	Q63HK5	CTBP2	Homo sapiens	P56545-3	Y2H Array	32296183
Intra	TSHZ3	Q63HK5	CTBP2	Homo sapiens	P56545-3	Y2H Prey Pooling	32296183
Intra	TSHZ3	Q63HK5	CCHCR1	Homo sapiens	Q8TD31-3	Y2H Prey Pooling	32296183
Intra	TSHZ3	Q63HK5	CCHCR1	Homo sapiens	Q8TD31-3	Y2H Array	32296183
Intra	TSHZ3	Q63HK5	CCHCR1	Homo sapiens	Q8TD31-3	Validated Y2H	32296183
Intra	TSHZ3	Q63HK5	ANKRA2	Homo sapiens	Q9H9E1	Y2H Prey Pooling	32296183
Intra	TSHZ3	Q63HK5	ANKRA2	Homo sapiens	Q9H9E1	Validated Y2H	32296183
Intra	TSHZ3	Q63HK5	ANKRA2	Homo sapiens	Q9H9E1	Y2H Array	32296183
Intra	TSHZ3	Q63HK5	TFIP11	Homo sapiens	Q9UBB9	Y2H Prey Pooling	32296183
Intra	TSHZ3	Q63HK5	TFIP11	Homo sapiens	Q9UBB9	Validated Y2H	32296183
Intra	TSHZ3	Q63HK5	TFIP11	Homo sapiens	Q9UBB9	Y2H Array	32296183
Intra	TSHZ3	Q63HK5	TFIP11	Homo sapiens	Q9UBB9	Y2H Array	31515488
Intra	TSHZ3	Q63HK5	TFIP11	Homo sapiens	Q9UBB9	Y2H Prey Pooling	25416956
Intra	TSHZ3	Q63HK5	TEPSIN	Homo sapiens	Q96N21	Validated Y2H	32296183
Intra	TSHZ3	Q63HK5	TEPSIN	Homo sapiens	Q96N21	Y2H Array	32296183
Intra	TSHZ3	Q63HK5	TEPSIN	Homo sapiens	Q96N21	Y2H Prey Pooling	32296183
Intra	TSHZ3	Q63HK5	MTUS2	Homo sapiens	Q5JR59-3	Y2H Prey Pooling	32296183
Intra	TSHZ3	Q63HK5	MTUS2	Homo sapiens	Q5JR59-3	Y2H Array	32296183
Intra	TSHZ3	Q63HK5	LRRC73	Homo sapiens	Q5JTD7	Y2H Prey Pooling	32296183
Intra	TSHZ3	Q63HK5	LRRC73	Homo sapiens	Q5JTD7	Y2H Array	32296183
Intra	TSHZ3	Q63HK5	TSC1	Homo sapiens	Q86WV8	Y2H Array	32296183
Intra	TSHZ3	Q63HK5	TSC1	Homo sapiens	Q86WV8	Y2H Prey Pooling	32296183
Intra	TSHZ3	Q63HK5	TSC1	Homo sapiens	Q86WV8	Validated Y2H	32296183
Intra	TSHZ3	Q63HK5	ROPN1	Homo sapiens	Q9HAT0	Validated Y2H	32296183
Intra	TSHZ3	Q63HK5	ROPN1	Homo sapiens	Q9HAT0	Y2H Array	32296183
Intra	TSHZ3	Q63HK5	ROPN1	Homo sapiens	Q9HAT0	Y2H Prey Pooling	32296183
Intra	TSHZ3	Q63HK5	PIBF1	Homo sapiens	Q4G0R1	Y2H Prey Pooling	32296183
Intra	TSHZ3	Q63HK5	PIBF1	Homo sapiens	Q4G0R1	Y2H Array	32296183
Intra	TSHZ3	Q63HK5	TRIM54	Homo sapiens	Q9BYV2	Y2H Prey Pooling	32296183
Intra	TSHZ3	Q63HK5	TRIM54	Homo sapiens	Q9BYV2	Validated Y2H	32296183
Intra	TSHZ3	Q63HK5	TRIM54	Homo sapiens	Q9BYV2	Y2H Array	32296183
Intra	TSHZ3	Q63HK5	TRAF2	Homo sapiens	Q12933	Y2H Prey Pooling	25416956
Intra	TSHZ3	Q63HK5	TRAF2	Homo sapiens	Q12933	Y2H Array	25416956
Intra	TSHZ3	Q63HK5	COG6	Homo sapiens	Q9Y2V7	Validated Y2H	32296183
Intra	TSHZ3	Q63HK5	COG6	Homo sapiens	Q9Y2V7	Y2H Array	32296183
Intra	TSHZ3	Q63HK5	COG6	Homo sapiens	Q9Y2V7	Y2H Prey Pooling	32296183
Intra	TSHZ3	Q63HK5	SPAG5	Homo sapiens	Q96R06	Validated Y2H	25416956
Intra	TSHZ3	Q63HK5	SPAG5	Homo sapiens	Q96R06	Y2H Array	25416956
Intra	TSHZ3	Q63HK5	TAX1BP1	Homo sapiens	Q86VP1	Y2H Prey Pooling	25416956
Intra	TSHZ3	Q63HK5	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	32296183
Intra	TSHZ3	Q63HK5	GOLGA2	Homo sapiens	Q08379	Y2H Array	32296183
Intra	TSHZ3	Q63HK5	HSF2BP	Homo sapiens	O75031	Y2H Prey Pooling	32296183
Intra	TSHZ3	Q63HK5	HSF2BP	Homo sapiens	O75031	Y2H Array	32296183
Intra	TSHZ3	Q63HK5	TRIM27	Homo sapiens	P14373	Validated Y2H	25416956
Intra	TSHZ3	Q63HK5	TRIM27	Homo sapiens	P14373	Y2H Prey Pooling	25416956
Intra	TSHZ3	Q63HK5	MRPL28	Homo sapiens	Q13084	Y2H Prey Pooling	32296183
Intra	TSHZ3	Q63HK5	MRPL28	Homo sapiens	Q13084	Y2H Array	32296183
Intra	TSHZ3	Q63HK5	RINT1	Homo sapiens	Q6NUQ1	Validated Y2H	32296183
Intra	TSHZ3	Q63HK5	RINT1	Homo sapiens	Q6NUQ1	Y2H Array	32296183
Intra	TSHZ3	Q63HK5	RINT1	Homo sapiens	Q6NUQ1	Y2H Prey Pooling	32296183
Intra	TSHZ3	Q63HK5	CEP70	Homo sapiens	Q8NHQ1	Y2H Array	25416956
Intra	TSHZ3	Q63HK5	CEP70	Homo sapiens	Q8NHQ1	Validated Y2H	25416956
Intra	TSHZ3	Q63HK5	TRIM23	Homo sapiens	P36406	Y2H Prey Pooling	25416956
Intra	TSHZ3	Q63HK5	TRIM23	Homo sapiens	P36406	Validated Y2H	25416956
Intra	TSHZ3	Q63HK5	CEP63	Homo sapiens	Q96MT8	Y2H Prey Pooling	25416956
Intra	TSHZ3	Q63HK5	CEP63	Homo sapiens	Q96MT8	Y2H Array	25416956
Intra	TSHZ3	Q63HK5	APEX2	Homo sapiens	Q9UBZ4	Y2H Prey Pooling	32296183
Intra	TSHZ3	Q63HK5	APEX2	Homo sapiens	Q9UBZ4	Validated Y2H	32296183
Intra	TSHZ3	Q63HK5	APEX2	Homo sapiens	Q9UBZ4	Y2H Array	32296183
Intra	TSHZ3	Q63HK5	MAD1L1	Homo sapiens	Q9Y6D9	Validated Y2H	25416956
Intra	TSHZ3	Q63HK5	MTUS2	Homo sapiens	Q5JR59	Validated Y2H	25416956
Intra	TSHZ3	Q63HK5	MTUS2	Homo sapiens	Q5JR59	Y2H Array	25416956
Intra	TSHZ3	Q63HK5	KRT31	Homo sapiens	Q15323	Y2H Array	32296183
Intra	TSHZ3	Q63HK5	KRT31	Homo sapiens	Q15323	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Hydronephrosis	Stricture Of Ureteropelvic Junction With Hydronephrosis Hydronephrosis With Ureteral Stricture, Not Elsewhere Classified
Prune Belly Syndrome	Eagle-Barrett Syndrome Abdominal Muscle Deficiency Syndrome PBS Abdominal Muscles, Absence Of, With Urinary Tract Abnormality And Cryptorchidism Egbrs Eagle-Barret Syndrome Urethral Obstruction Sequence Obrinsky Syndrome Triad Syndrome Obrisnksy Syndrome Euos Early Urethral Obstruction Sequence Renal Dysplasia Or Hydronephrosis, Oligohydramnios And Subsequent Lung Hypoplasia Due To Urethral Obstruction Absence Of Abdominal Muscles With Urinary Tract Abnormality And Cryptorchidism Abdomen Muscle Deficiency Syndrome Abdomen Muscular Deficiency Syndrome Abdominal Muscular Deficiency Syndrome Abdominal Muscle Aplasia Syndrome
Calvarial Doughnut Lesions With Bone Fragility	Calvarial Doughnut Lesions With Bone Fragility With Or Without Spondylometaphyseal Dysplasia Calvarial Doughnut Lesions-Bone Fragility Syndrome CDL Doughnut Lesions Of Skull, Familial Calvarial Doughnut Lesions With Bone Fragility And Spondylometaphyseal Dysplasia Familial Doughnut Lesions Of Skull CDLSMD
Urofacial Syndrome 1	Urofacial Syndrome Ochoa Syndrome Hydronephrosis With Peculiar Facial Expression Ufs Inverted Smile And Occult Neuropathic Bladder Partial Facial Palsy With Urinary Abnormalities UFS1 Urofacial Ochoa'S Syndrome Urofacial Syndrome Type 1 Facial Palsy, Partial, With Urinary Abnormalities Hydronephrosis-Inverted Smile Inverted Smile-Neurogenic Bladder Hydronephrosis-Inverted Smile Syndrome Inverted Smile-Neurogenic Bladder Syndrome Partial Facial Palsy Partial With Urinary Abnormalities Urologic Diseases
Lagophthalmos	Defective Lid Closure Poor Closure Eyelids
Autism Spectrum Disorder	Asd Autism Spectrum Disorders Autistic Continuum Pervasive Developmental Disorder Pervasive Development Disorder Autistic Behavior Autistic Disorder Autistic Autistic Disorder Of Childhood Onset Infantile Autism Childhood Autism Kanner Syndrome Pervasive Developmental Delay Nos Pervasive Developmental Disorder, Not Otherwise Specified
Autism	Autistic Disorder Autism Susceptibility 1 Childhood Autism Autistic Disorder Of Childhood Onset Infantile Autism Kanner'S Syndrome Autistic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15150	TSHZ3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	TSHZ3	VGNC	VGNC:47905
Mus musculus	TSHZ3	MGD	MGI:2442819
Felis catus	TSHZ3	VGNC	VGNC:66619
Rattus norvegicus	TSHZ3	RGD	RGD:1306322
Macaca mulatta	TSHZ3	VGNC	VGNC:79866
Bos taurus	TSHZ3	VGNC	VGNC:36420