1. Neuronal Signaling
  2. Amyloid-β
  3. Tabersonine hydrochloride

Tabersonine hydrochloride is an indole alkaloid mainly isolated from Catharanthus roseus. Tabersonine disrupts Aβ(1-42) aggregation and ameliorates Aβ aggregate-induced cytotoxicity. Tabersonine has anti-inflammatory activities and is a potential therapeutic candidate for the treatment of ALI/ARDS.

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Tabersonine hydrochloride Chemical Structure

Tabersonine hydrochloride Chemical Structure

CAS No. : 29479-00-3

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Top Publications Citing Use of Products

1 Publications Citing Use of MCE Tabersonine hydrochloride

IHC

    Tabersonine hydrochloride purchased from MedChemExpress. Usage Cited in: Phytother Res. 2023 Feb 8.  [Abstract]

    Tabersonine (Tab; 20 mg/kg; i.v; every 2 days for 12 weeks) significantly reduces the expression and transcription of these fibrotic related biomarkers (mRNA levels of Col1a1, Tgfb1, and Acta2, protein levels of COL-1 and TGF-β) in C57BL/6 mice.
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    Description

    Tabersonine hydrochloride is an indole alkaloid mainly isolated from Catharanthus roseus. Tabersonine disrupts Aβ(1-42) aggregation and ameliorates Aβ aggregate-induced cytotoxicity. Tabersonine has anti-inflammatory activities and is a potential therapeutic candidate for the treatment of ALI/ARDS[1].

    Molecular Weight

    372.89

    Formula

    C21H25ClN2O2

    CAS No.
    SMILES

    O=C(OC)C1=C2NC3=CC=CC=C3[C@@]24CCN5CC=C[C@@]([C@@]45[H])(CC)C1.Cl

    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.

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    Tabersonine hydrochloride Related Classifications

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      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    Product Name:
    Tabersonine hydrochloride
    Cat. No.:
    HY-N1431A
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