IRAK3 - interleukin 1 receptor associated kinase 3 Gene

Also Known as ASRT5; IRAKM

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 11213

About IRAK3

Cytogenetic location: 12q14.3 Genomic coordinates (GRCh38): 12:66,189,214-66,254,622 (from NCBI)

This gene has 3 transcripts (splice variants), 154 orthologues, 4 paralogues and is associated with 1 phenotype. Broad expression in bone marrow (RPKM 10.8), spleen (RPKM 8.1) and 21 other tissues.

Summary

This gene encodes a member of the interleukin-1 receptor-associated kinase protein family. Members of this family are essential components of the Toll/IL-R immune signal transduction pathways. This protein is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like Receptor signaling. Mutations in this gene are associated with a susceptibility to asthma. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

IRAK3 Products (2)

mRNA Protein Name
NM_001142523.2 NP_001135995.1 interleukin-1 receptor-associated kinase 3 isoform b
NM_007199.3 NP_009130.2 interleukin-1 receptor-associated kinase 3 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ATP binding IDA
IDA: Inferred from direct assay
10383454 GOA
enables magnesium ion binding IDA
IDA: Inferred from direct assay
10383454 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
29686383 GOA
enables protein heterodimerization activity IPI
IPI: Inferred from physical interaction
10383454 GOA
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
33238146 GOA
enables protein homodimerization activity IPI
IPI: Inferred from physical interaction
10383454 GOA
enables protein kinase binding IPI
IPI: Inferred from physical interaction
33238146 GOA
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
10383454 GOA
Biological Process GO Annotation Evidence References Source
involved in interleukin-1-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
10383454 GOA
involved in negative regulation of MAP kinase activity IMP
IMP: Inferred from mutant phenotype
17379480 GOA
involved in negative regulation of NF-kappaB transcription factor activity IMP
IMP: Inferred from mutant phenotype
10383454 GOA
involved in negative regulation of interleukin-12 production IMP
IMP: Inferred from mutant phenotype
18156187 GOA
involved in negative regulation of interleukin-6 production IMP
IMP: Inferred from mutant phenotype
18156187 GOA
involved in negative regulation of protein catabolic process IMP
IMP: Inferred from mutant phenotype
17379480 GOA
involved in negative regulation of protein-containing complex disassembly IMP
IMP: Inferred from mutant phenotype
12150927 GOA
involved in negative regulation of tumor necrosis factor production IMP
IMP: Inferred from mutant phenotype
15728517 GOA
involved in positive regulation of NF-kappaB transcription factor activity IMP
IMP: Inferred from mutant phenotype
10383454 GOA
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
10383454 GOA
involved in response to interleukin-1 IMP
IMP: Inferred from mutant phenotype
10383454 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
17379480 GOA
located in nucleus IDA
IDA: Inferred from direct assay
17379480 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IRAK3 Protein Structure

Death

Death: Death domain (27 - 105)

Pkinase

Pkinase: Protein kinase domain (170 - 442)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 596 a.a.
Protein Preferred Names Protein Names

interleukin-1 receptor-associated kinase 3

  • IL-1 receptor-associated kinase M

IRAK3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
IRAK3 Q9Y616 TRAF6 Homo sapiens Q9Y4K3
Anti Tag CoIP
10383454
Intra
IRAK3 Q9Y616 TRAF6 Homo sapiens Q9Y4K3
Y2H Prey Pooling
32296183
Intra
IRAK3 Q9Y616 TRAF6 Homo sapiens Q9Y4K3
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

IRAK3 Antibodies

Cat. No. Product Name Application Reactivity
HY-P83307 IRAKM Antibody (YA3052) WB, IP Human
HY-P84899 IRAKM Antibody (YA4596) IHC-P, ICC/IF, FC, ELISA Human
HY-P84899A IRAKM Antibody (YA4596)(PBS only) IHC-P, ICC/IF, FC, ELISA Human

Related Diseases

Diseases Alias
Asthma-Related Traits 5

  • Asthma-Related Traits, Susceptibility To, 5

  • ASRT5

  • Asthma Susceptibility 5

  • Asthma-Related Traits, Susceptibility To, Type 5
Multisystem Inflammatory Syndrome In Children

  • Mis-C

  • Multisystem Inflammatory Disorder In Children And Adolescents

  • Paediatric Inflammatory Multisystemic Syndrome

  • Mic
Asthma

  • Chronic Obstructive Asthma

  • Asthma, Diminished Response To Antileukotriene Treatment In

  • Bronchial Hyperreactivity

  • Asthma, Susceptibility To

  • Asthma, Bronchial

  • Asthma, Protection Against

  • Asthma, Nocturnal, Susceptibility To

  • Nocturnal Asthma

  • Asthma-Related Traits

  • Asthma-Related Traits, Susceptibility To

  • Asthma, Nocturnal

  • Chronic Obstructive Asthma With Acute Exacerbation

  • Chronic Obstructive Asthma With Status Asthmaticus

  • Exercise Induced Asthma

  • Exercise-Induced Asthma

  • Bronchial Asthma

  • Asthma, Exercise-Induced

  • Idiosyncratic Asthma

  • Unspecified Asthma With Acute Exacerbation

  • Asthma, Unspecified, With Stated Status Asthmaticus

  • Status Asthmaticus Nos

  • Acute Severe Asthma

  • Acute Severe Bronchial Asthma

  • Status Asthma

  • Status Post Asthmaticus
Dermatitis

  • Eczema

  • Skin Inflammation

  • Inflammatory Dermatosis
Melioidosis

  • Melioidosis, Susceptibility To

  • Acute And Fulminating Melioidosis

  • Nightcliff Gardener'S Disease

  • Pseudoglanders

  • Subacute And Chronic Melioidosis

  • Burkholderia Pseudomallei Infection

  • Whitmore Disease

  • Whitmore'S Disease

  • B Pseudomallei Infection

  • Epizootic Lymphangitis

  • Infection Due To Burkholderia Pseudomallei

  • Infection Due To Burkholderia Pseudomallei Nos

  • Infection Due To Malleomyces Pseudomallei

  • Infection Due To Pseudomonas Pseudomallei

  • Infection Due To Pseudomonas Pseudomallei Nos

  • Infection Due To Whitmore Bacillus

  • Stanton Disease
Middle East Respiratory Syndrome

  • Mers

  • Mers - [Middle East Respiratory Syndrome]
Lung Mucoepidermoid Carcinoma

  • Mucoepidermoid Carcinoma Of Lung
Deafness, Autosomal Recessive 74

  • DFNB74

  • Autosomal Recessive Nonsyndromic Deafness 74

  • Autosomal Recessive Deafness 74

  • Deafness, Autosomal Recessive, 74

  • Deafness, Autosomal Recessive, Type 74
Pleuropneumonia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-181899 IRAK3 ligand-3 Ligand / Unkown
HY-181898 PROTAC IRAK3 degrader-2 Degrader / Unkown
HY-142662 PROTAC IRAK3 degrader-1 Degrader / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus IRAK3 MGD MGI:1921164
Bos taurus IRAK3 VGNC VGNC:30267
Rattus norvegicus IRAK3 RGD RGD:1308846
Felis catus IRAK3 VGNC VGNC:62971
Macaca mulatta IRAK3 VGNC VGNC:81423
Canis familiaris IRAK3 VGNC VGNC:54151
Others IRAK3 NCBI