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Cat. No.: HY-181898

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PROTAC IRAK3 degrader-2

PROTAC IRAK3 degrader-2 (Compound 17) is a IRAK3 PROTAC degrader with a DC₅₀ ≤ 50 nM. It promotes ubiquitination and degradation of IRAK3, and is applicable to the research of immune diseases.
(Pink: IRAK3 ligand (HY-181899); Blue: Cereblon ligand (HY-W023573); Black: linker).

For research use only. We do not sell to patients.

CAS No.: 3072861-91-4
Formula: C₅₂H₆₉N₁₃O₈
Molecular Weight:1004.19

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

PROTAC IRAK3 degrader-2 Chemical Structure

CAS No.: 3072861-91-4

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

PROTAC IRAK3 degrader-2 (Compound 17) is a IRAK3 PROTAC degrader with a DC₅₀ ≤ 50 nM. It promotes ubiquitination and degradation of IRAK3, and is applicable to the research of immune diseases^[1]. (Pink: IRAK3 ligand (HY-181899); Blue: Cereblon ligand (HY-W023573); Black: linker).

IC₅₀ & Target^[1]

IRAK3

≤ 50 nM (DC₅₀)

Cereblon

All PROTACs Isoforms :

All IRAK Isoforms :

In Vitro

PROTAC IRAK3 degrader-2 (1 μM) potently degrades IRAK-M in U937 cells, inducing 99% degradation at 1 μM and exhibiting a DC₅₀ of ≤ 50 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3072861-91-4
Molecular Weight 1004.19
Formula C₅₂H₆₉N₁₃O₈
SMILES

CCOC(C1=C(N=C(N=C1)NC2=CN(N=C2)C)N[C@@H]3CC[C@@H](CC3)N4CCN(CC4)C([C@H]5CC[C@@H](CC5)C(N6CCC(CC6)CN7CCN(CC7)C8=CC9=C(C(N(C9=O)C%10CCC(NC%10=O)=O)=O)C=C8)=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Renner A, et al. Emerging Paradigms in Immune-Focused Drug Discovery. ACS Med Chem Lett. 2026 Feb 23;17(3):631-633. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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PROTAC IRAK3 degrader-2

All PROTACs Isoforms

All IRAK Isoforms