2. PROTAC Immunology/Inflammation
  3. PROTACs IRAK
  4. PROTAC IRAK3 degrader-2

PROTAC IRAK3 degrader-2 (Compound 17) is a IRAK3 PROTAC degrader with a DC50 ≤ 50 nM. It promotes ubiquitination and degradation of IRAK3, and is applicable to the research of immune diseases.
(Pink: IRAK3 ligand (HY-181899); Blue: Cereblon ligand (HY-W023573); Black: linker).

For research use only. We do not sell to patients.

PROTAC IRAK3 degrader-2

PROTAC IRAK3 degrader-2 Chemical Structure

CAS No. : 3072861-91-4

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PROTAC IRAK3 degrader-2 Related Antibodies

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Description

PROTAC IRAK3 degrader-2 (Compound 17) is a IRAK3 PROTAC degrader with a DC50 ≤ 50 nM. It promotes ubiquitination and degradation of IRAK3, and is applicable to the research of immune diseases[1]. (Pink: IRAK3 ligand (HY-181899); Blue: Cereblon ligand (HY-W023573); Black: linker).

IC50 & Target[1]

IRAK3

≤ 50 nM (DC50)

Cereblon

 

In Vitro

PROTAC IRAK3 degrader-2 (1 μM) potently degrades IRAK-M in U937 cells, inducing 99% degradation at 1 μM and exhibiting a DC50 of ≤ 50 nM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PROTAC IRAK3 degrader-2 Related Antibodies
Molecular Weight

1004.19

Formula

C52H69N13O8
CAS No.
SMILES

CCOC(C1=C(N=C(N=C1)NC2=CN(N=C2)C)N[C@@H]3CC[C@@H](CC3)N4CCN(CC4)C([C@H]5CC[C@@H](CC5)C(N6CCC(CC6)CN7CCN(CC7)C8=CC9=C(C(N(C9=O)C%10CCC(NC%10=O)=O)=O)C=C8)=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PROTAC IRAK3 degrader-2 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC IRAK3 degrader-23072861-91-4PROTACsIRAKInterleukin-1 receptor associated kinaseIL-1R associated kinasemonocytic cellsIRAK3IRAK-Minterleukin receptor-associated kinase MU937 cellsInhibitorinhibitorinhibit

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PROTAC IRAK3 degrader-2
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HY-181898
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