USP2 - ubiquitin specific peptidase 2 Gene

Also Known as USP9; UBP41

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9099

About USP2

Cytogenetic location: 11q23.3 Genomic coordinates (GRCh38): 11:119,355,215-119,381,690 (from NCBI)

This gene has 7 transcripts (splice variants), 178 orthologues and 71 paralogues. Biased expression in testis (RPKM 31.4), kidney (RPKM 15.4) and 10 other tissues.

Summary

This gene encodes a member of the family of de-ubiquitinating Enzymes, which belongs to the peptidase C19 superfamily. The encoded protein is a Ubiquitin-Specific Protease which is required for TNF-alpha (tumor necrosis factor alpha) -induced NF-kB (nuclear factor kB) signaling. This protein deubiquitinates polyubiquitinated target proteins such as fatty acid synthase, murine double minute 2 (MDM2), MDM4/MDMX and cyclin D1. MDM2 and MDM4 are negative regulators of the p53 tumor suppressor and cyclin D1 is required for cell cycle G1/S transition. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]

USP2 Products (3)

mRNA Protein Name
NM_001243759.2 NP_001230688.1 ubiquitin carboxyl-terminal hydrolase 2 isoform c
NM_004205.5 NP_004196.4 ubiquitin carboxyl-terminal hydrolase 2 isoform a
NM_171997.3 NP_741994.1 ubiquitin carboxyl-terminal hydrolase 2 isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables cyclin binding IPI
IPI: Inferred from physical interaction
19917254 GOA
enables cysteine-type deubiquitinase activity IDA
IDA: Inferred from direct assay
17290220 GOA
enables cysteine-type deubiquitinase activity IMP
IMP: Inferred from mutant phenotype
19917254 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
enables ubiquitin protein ligase binding IPI
IPI: Inferred from physical interaction
17290220 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
17290220 GOA
involved in positive regulation of mitotic cell cycle IMP
IMP: Inferred from mutant phenotype
17290220 GOA
involved in protein deubiquitination IDA
IDA: Inferred from direct assay
19838211 GOA
involved in protein stabilization IDA
IDA: Inferred from direct assay
17290220 GOA
involved in protein stabilization IMP
IMP: Inferred from mutant phenotype
19838211 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

USP2 Protein Structure

UCH

UCH: Ubiquitin carboxyl-terminal hydrolase (267 - 596)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 605 a.a.
Protein Preferred Names Protein Names

ubiquitin carboxyl-terminal hydrolase 2

  • 41 kDa ubiquitin-specific protease

USP2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
USP2 O75604 CCDC136 Homo sapiens Q96JN2-2
Y2H Prey Pooling
25416956
Intra
USP2 O75604 KRT40 Homo sapiens Q6A162
Validated Y2H
25416956
Intra
USP2 O75604 KRT40 Homo sapiens Q6A162
Validated Y2H
32296183
Intra
USP2 O75604 KRT40 Homo sapiens Q6A162
Y2H Array
25416956
Intra
USP2 O75604 KRT40 Homo sapiens Q6A162
Y2H Array
32296183
Intra
USP2 O75604 KRT40 Homo sapiens Q6A162
Y2H Prey Pooling
32296183
Intra
USP2 O75604 MID2 Homo sapiens Q9UJV3-2
Y2H Prey Pooling
32296183
Intra
USP2 O75604 MID2 Homo sapiens Q9UJV3-2
Validated Y2H
32296183
Intra
USP2 O75604 MID2 Homo sapiens Q9UJV3-2
Y2H Array
32296183
Intra
USP2 O75604 NEFL Homo sapiens I6L9F6
Y2H Array
25416956
Intra
USP2 O75604 CADPS Homo sapiens A2RRN7
Y2H Array
32296183
Intra
USP2 O75604 CADPS Homo sapiens A2RRN7
Y2H Prey Pooling
32296183
Intra
USP2 O75604 KRT34 Homo sapiens O76011
Validated Y2H
32296183
Intra
USP2 O75604 KRT34 Homo sapiens O76011
Y2H Prey Pooling
32296183
Intra
USP2 O75604 KRT34 Homo sapiens O76011
Y2H Array
32296183
Intra
USP2 O75604 KRT33B Homo sapiens Q14525
Y2H Prey Pooling
32296183
Intra
USP2 O75604 KRT33B Homo sapiens Q14525
Validated Y2H
32296183
Intra
USP2 O75604 KRT33B Homo sapiens Q14525
Y2H Array
32296183
Intra
USP2 O75604 KRT35 Homo sapiens Q92764
Y2H Array
32296183
Intra
USP2 O75604 KRT35 Homo sapiens Q92764
Validated Y2H
32296183
Intra
USP2 O75604 KRT35 Homo sapiens Q92764
Y2H Prey Pooling
32296183
Intra
USP2 O75604 HOOK2 Homo sapiens Q96ED9-2
Validated Y2H
32296183
Intra
USP2 O75604 HOOK2 Homo sapiens Q96ED9-2
Y2H Array
32296183
Intra
USP2 O75604 HOOK2 Homo sapiens Q96ED9-2
Y2H Prey Pooling
32296183
Intra
USP2 O75604 TFIP11 Homo sapiens Q9UBB9
Y2H Prey Pooling
32296183
Intra
USP2 O75604 TFIP11 Homo sapiens Q9UBB9
Y2H Array
32296183
Intra
USP2 O75604 TFIP11 Homo sapiens Q9UBB9
Validated Y2H
32296183
Intra
USP2 O75604 ABI2 Homo sapiens Q9NYB9-2
Validated Y2H
32296183
Intra
USP2 O75604 ABI2 Homo sapiens Q9NYB9-2
Y2H Array
32296183
Intra
USP2 O75604 ABI2 Homo sapiens Q9NYB9-2
Y2H Prey Pooling
32296183
Intra
USP2 O75604 GOLGA6A Homo sapiens Q9NYA3
Y2H Prey Pooling
32296183
Intra
USP2 O75604 GOLGA6A Homo sapiens Q9NYA3
Y2H Array
32296183
Intra
USP2 O75604 GOLGA6A Homo sapiens Q9NYA3
Validated Y2H
32296183
Intra
USP2 O75604 GPRASP3 Homo sapiens Q6PI77
Validated Y2H
32296183
Intra
USP2 O75604 GPRASP3 Homo sapiens Q6PI77
Y2H Prey Pooling
32296183
Intra
USP2 O75604 GPRASP3 Homo sapiens Q6PI77
Y2H Array
32296183
Intra
USP2 O75604 MTUS2 Homo sapiens Q5JR59-3
Validated Y2H
32296183
Intra
USP2 O75604 MTUS2 Homo sapiens Q5JR59-3
Y2H Prey Pooling
32296183
Intra
USP2 O75604 MTUS2 Homo sapiens Q5JR59-3
Y2H Array
32296183
Intra
USP2 O75604 CEP63 Homo sapiens Q96MT8-3
Validated Y2H
32296183
Intra
USP2 O75604 CEP63 Homo sapiens Q96MT8-3
Y2H Prey Pooling
32296183
Intra
USP2 O75604 CEP63 Homo sapiens Q96MT8-3
Y2H Array
32296183
Intra
USP2 O75604 CARD9 Homo sapiens Q9H257-2
Y2H Array
32296183
Intra
USP2 O75604 CARD9 Homo sapiens Q9H257-2
Y2H Prey Pooling
32296183
Intra
USP2 O75604 CARD9 Homo sapiens Q9H257-2
Validated Y2H
32296183
Intra
USP2 O75604 TLE5 Homo sapiens Q08117-2
Y2H Array
32296183
Intra
USP2 O75604 TLE5 Homo sapiens Q08117-2
Validated Y2H
32296183
Intra
USP2 O75604 TLE5 Homo sapiens Q08117-2
Y2H Prey Pooling
32296183
Intra
USP2 O75604 STAT5B Homo sapiens P51692
Y2H Array
32296183
Intra
USP2 O75604 STAT5B Homo sapiens P51692
Y2H Prey Pooling
32296183
Intra
USP2 O75604 STAT5B Homo sapiens P51692
Validated Y2H
32296183
Intra
USP2 O75604 ATN1 Homo sapiens Q86V38
Y2H Prey Pooling
32296183
Intra
USP2 O75604 ATN1 Homo sapiens Q86V38
Y2H Array
32296183
Intra
USP2 O75604 ATN1 Homo sapiens Q86V38
Validated Y2H
32296183
Intra
USP2 O75604 RUNDC3A Homo sapiens Q59EK9-3
Y2H Prey Pooling
32296183
Intra
USP2 O75604 RUNDC3A Homo sapiens Q59EK9-3
Validated Y2H
32296183
Intra
USP2 O75604 RUNDC3A Homo sapiens Q59EK9-3
Y2H Array
32296183
Intra
USP2 O75604 SPAG8 Homo sapiens Q99932-2
Y2H Prey Pooling
32296183
Intra
USP2 O75604 SPAG8 Homo sapiens Q99932-2
Validated Y2H
32296183
Intra
USP2 O75604 SPAG8 Homo sapiens Q99932-2
Y2H Array
32296183
Intra
USP2 O75604 ZIM2 Homo sapiens Q9NZV7
Validated Y2H
32296183
Intra
USP2 O75604 ZIM2 Homo sapiens Q9NZV7
Y2H Prey Pooling
32296183
Intra
USP2 O75604 ZIM2 Homo sapiens Q9NZV7
Y2H Array
32296183
Intra
USP2 O75604 BICD2 Homo sapiens Q8TD16-2
Validated Y2H
32296183
Intra
USP2 O75604 BICD2 Homo sapiens Q8TD16-2
Y2H Array
32296183
Intra
USP2 O75604 BICD2 Homo sapiens Q8TD16-2
Y2H Prey Pooling
32296183
Intra
USP2 O75604 USP54 Homo sapiens Q70EL1-9
Y2H Array
32296183
Intra
USP2 O75604 USP54 Homo sapiens Q70EL1-9
Y2H Prey Pooling
32296183
Intra
USP2 O75604 USP54 Homo sapiens Q70EL1-9
Validated Y2H
32296183
Intra
USP2 O75604 CRACR2B Homo sapiens Q8N4Y2-3
Y2H Prey Pooling
32296183
Intra
USP2 O75604 CRACR2B Homo sapiens Q8N4Y2-3
Validated Y2H
32296183
Intra
USP2 O75604 CRACR2B Homo sapiens Q8N4Y2-3
Y2H Array
32296183
Intra
USP2 O75604 DISC1 Homo sapiens Q9NRI5-2
Y2H Prey Pooling
32296183
Intra
USP2 O75604 DISC1 Homo sapiens Q9NRI5-2
Validated Y2H
32296183
Intra
USP2 O75604 DISC1 Homo sapiens Q9NRI5-2
Y2H Array
32296183
Intra
USP2 O75604 GRB7 Homo sapiens Q14451-3
Validated Y2H
32296183
Intra
USP2 O75604 GRB7 Homo sapiens Q14451-3
Y2H Prey Pooling
32296183
Intra
USP2 O75604 GRB7 Homo sapiens Q14451-3
Y2H Array
32296183
Intra
USP2 O75604 KAZN Homo sapiens Q674X7-2
Validated Y2H
32296183
Intra
USP2 O75604 KAZN Homo sapiens Q674X7-2
Y2H Array
32296183
Intra
USP2 O75604 KAZN Homo sapiens Q674X7-2
Y2H Prey Pooling
32296183
Intra
USP2 O75604 LHX3 Homo sapiens Q9UBR4-2
Y2H Array
32296183
Intra
USP2 O75604 LHX3 Homo sapiens Q9UBR4-2
Y2H Prey Pooling
32296183
Intra
USP2 O75604 LHX3 Homo sapiens Q9UBR4-2
Validated Y2H
32296183
Intra
USP2 O75604 SPDYE4 Homo sapiens A6NLX3
Y2H Array
32296183
Intra
USP2 O75604 SPDYE4 Homo sapiens A6NLX3
Y2H Prey Pooling
32296183
Intra
USP2 O75604 VPS28 Homo sapiens Q9UK41-2
Validated Y2H
32296183
Intra
USP2 O75604 VPS28 Homo sapiens Q9UK41-2
Y2H Array
32296183
Intra
USP2 O75604 VPS28 Homo sapiens Q9UK41-2
Y2H Prey Pooling
32296183
Intra
USP2 O75604 DEPDC5 Homo sapiens O75140-2
Y2H Prey Pooling
32296183
Intra
USP2 O75604 DEPDC5 Homo sapiens O75140-2
Y2H Array
32296183
Intra
USP2 O75604 MORN5 Homo sapiens Q5VZ52
Validated Y2H
32296183
Intra
USP2 O75604 MORN5 Homo sapiens Q5VZ52
Y2H Array
32296183
Intra
USP2 O75604 MORN5 Homo sapiens Q5VZ52
Y2H Prey Pooling
32296183
Intra
USP2 O75604 PIBF1 Homo sapiens Q4G0R1
Validated Y2H
32296183
Intra
USP2 O75604 PIBF1 Homo sapiens Q4G0R1
Y2H Array
32296183
Intra
USP2 O75604 PIBF1 Homo sapiens Q4G0R1
Y2H Prey Pooling
32296183
Intra
USP2 O75604 KIFC3 Homo sapiens Q9BVG8-5
Y2H Prey Pooling
32296183
Intra
USP2 O75604 KIFC3 Homo sapiens Q9BVG8-5
Validated Y2H
32296183
Intra
USP2 O75604 KIFC3 Homo sapiens Q9BVG8-5
Y2H Array
32296183
Intra
USP2 O75604 PRR5L Homo sapiens Q6MZQ0
Y2H Prey Pooling
32296183
Intra
USP2 O75604 PRR5L Homo sapiens Q6MZQ0
Validated Y2H
32296183
Intra
USP2 O75604 PRR5L Homo sapiens Q6MZQ0
Y2H Array
32296183
Intra
USP2 O75604 JRK Homo sapiens O75564-2
Y2H Prey Pooling
32296183
Intra
USP2 O75604 JRK Homo sapiens O75564-2
Y2H Array
32296183
Intra
USP2 O75604 ASPG Homo sapiens Q86U10
Y2H Prey Pooling
32296183
Intra
USP2 O75604 ASPG Homo sapiens Q86U10
Validated Y2H
32296183
Intra
USP2 O75604 ASPG Homo sapiens Q86U10
Y2H Array
32296183
Intra
USP2 O75604 SH2B2 Homo sapiens O14492-2
Y2H Prey Pooling
32296183
Intra
USP2 O75604 SH2B2 Homo sapiens O14492-2
Y2H Array
32296183
Intra
USP2 O75604 KIFC3 Homo sapiens Q9BVG8
Validated Y2H
25416956
Intra
USP2 O75604 KIFC3 Homo sapiens Q9BVG8
Y2H Prey Pooling
25416956
Intra
USP2 O75604 DTX3 Homo sapiens Q8N9I9
Y2H Array
32296183
Intra
USP2 O75604 DTX3 Homo sapiens Q8N9I9
Y2H Prey Pooling
32296183
Intra
USP2 O75604 DTX3 Homo sapiens Q8N9I9
Validated Y2H
32296183
Intra
USP2 O75604 EFHC2 Homo sapiens Q5JST6
Y2H Prey Pooling
32296183
Intra
USP2 O75604 EFHC2 Homo sapiens Q5JST6
Y2H Array
32296183
Intra
USP2 O75604 EFHC2 Homo sapiens Q5JST6
Validated Y2H
32296183
Intra
USP2 O75604 JAKMIP1 Homo sapiens Q96N16
Y2H Prey Pooling
32296183
Intra
USP2 O75604 JAKMIP1 Homo sapiens Q96N16
Validated Y2H
32296183
Intra
USP2 O75604 JAKMIP1 Homo sapiens Q96N16
Y2H Array
32296183
Intra
USP2 O75604 VPS52 Homo sapiens Q8N1B4
Y2H Prey Pooling
32296183
Intra
USP2 O75604 VPS52 Homo sapiens Q8N1B4
Validated Y2H
32296183
Intra
USP2 O75604 VPS52 Homo sapiens Q8N1B4
Y2H Array
25416956
Intra
USP2 O75604 VPS52 Homo sapiens Q8N1B4
Y2H Array
32296183
Intra
USP2 O75604 VPS52 Homo sapiens Q8N1B4
Validated Y2H
25416956
Intra
USP2 O75604 LMNB2 Homo sapiens Q03252
Y2H Array
32296183
Intra
USP2 O75604 LMNB2 Homo sapiens Q03252
Y2H Prey Pooling
32296183
Intra
USP2 O75604 LMNB2 Homo sapiens Q03252
Validated Y2H
32296183
Intra
USP2 O75604 LHX4 Homo sapiens Q969G2
Y2H Array
25416956
Intra
USP2 O75604 LHX4 Homo sapiens Q969G2
Y2H Array
31515488
Intra
USP2 O75604 ACTN3 Homo sapiens Q08043
Y2H Array
32296183
Intra
USP2 O75604 ACTN3 Homo sapiens Q08043
Y2H Prey Pooling
32296183
Intra
USP2 O75604 ACTN3 Homo sapiens Q08043
Validated Y2H
32296183
Intra
USP2 O75604 EIF4ENIF1 Homo sapiens Q9NRA8
Y2H Prey Pooling
32296183
Intra
USP2 O75604 EIF4ENIF1 Homo sapiens Q9NRA8
Validated Y2H
32296183
Intra
USP2 O75604 EIF4ENIF1 Homo sapiens Q9NRA8
Y2H Array
32296183
Intra
USP2 O75604 PNMA1 Homo sapiens Q8ND90
Y2H Prey Pooling
25416956
Intra
USP2 O75604 KRT27 Homo sapiens Q7Z3Y8
Validated Y2H
32296183
Intra
USP2 O75604 KRT27 Homo sapiens Q7Z3Y8
Y2H Array
32296183
Intra
USP2 O75604 KRT27 Homo sapiens Q7Z3Y8
Y2H Prey Pooling
32296183
Intra
USP2 O75604 CCDC88B Homo sapiens A6NC98
Y2H Array
32296183
Intra
USP2 O75604 CCDC88B Homo sapiens A6NC98
Y2H Prey Pooling
32296183
Intra
USP2 O75604 ACTN1 Homo sapiens P12814
Validated Y2H
32296183
Intra
USP2 O75604 ACTN1 Homo sapiens P12814
Y2H Prey Pooling
32296183
Intra
USP2 O75604 ACTN1 Homo sapiens P12814
Y2H Array
32296183
Intra
USP2 O75604 TRAF2 Homo sapiens Q12933
Y2H Array
32296183
Intra
USP2 O75604 TRAF2 Homo sapiens Q12933
Y2H Prey Pooling
25416956
Intra
USP2 O75604 TRAF2 Homo sapiens Q12933
Y2H Prey Pooling
32296183
Intra
USP2 O75604 TRAF2 Homo sapiens Q12933
Validated Y2H
32296183
Intra
USP2 O75604 TRAF2 Homo sapiens Q12933
Validated Y2H
25416956
Intra
USP2 O75604 GEMIN4 Homo sapiens P57678
Validated Y2H
32296183
Intra
USP2 O75604 GEMIN4 Homo sapiens P57678
Y2H Array
32296183
Intra
USP2 O75604 GEMIN4 Homo sapiens P57678
Y2H Prey Pooling
32296183
Intra
USP2 O75604 TRAF1 Homo sapiens Q13077
Y2H Array
32296183
Intra
USP2 O75604 TRAF1 Homo sapiens Q13077
Y2H Prey Pooling
32296183
Intra
USP2 O75604 TRAF1 Homo sapiens Q13077
Validated Y2H
32296183
Intra
USP2 O75604 TRAF6 Homo sapiens Q9Y4K3
Y2H Array
25416956
Intra
USP2 O75604 TRAF6 Homo sapiens Q9Y4K3
Y2H Prey Pooling
25416956
Intra
USP2 O75604 EXOSC8 Homo sapiens Q96B26
Y2H Array
32296183
Intra
USP2 O75604 EXOSC8 Homo sapiens Q96B26
Validated Y2H
32296183
Intra
USP2 O75604 EXOSC8 Homo sapiens Q96B26
Y2H Prey Pooling
32296183
Intra
USP2 O75604 MDM2 Homo sapiens Q00987
Pull Down
17290220
Intra
USP2 O75604 PRDM14 Homo sapiens Q9GZV8
Y2H Array
32296183
Intra
USP2 O75604 PRDM14 Homo sapiens Q9GZV8
Y2H Prey Pooling
32296183
Intra
USP2 O75604 PRDM14 Homo sapiens Q9GZV8
Validated Y2H
32296183
Intra
USP2 O75604 RABEP1 Homo sapiens Q15276
Y2H Prey Pooling
32296183
Intra
USP2 O75604 RABEP1 Homo sapiens Q15276
Validated Y2H
32296183
Intra
USP2 O75604 RABEP1 Homo sapiens Q15276
Y2H Array
32296183
Intra
USP2 O75604 NEFL Homo sapiens P07196
Y2H Prey Pooling
32296183
Intra
USP2 O75604 NEFL Homo sapiens P07196
Validated Y2H
32296183
Intra
USP2 O75604 NEFL Homo sapiens P07196
Y2H Array
32296183
Intra
USP2 O75604 BIRC7 Homo sapiens Q96CA5
Validated Y2H
32296183
Intra
USP2 O75604 BIRC7 Homo sapiens Q96CA5
Y2H Prey Pooling
32296183
Intra
USP2 O75604 BIRC7 Homo sapiens Q96CA5
Y2H Array
32296183
Intra
USP2 O75604 ZRANB1 Homo sapiens Q9UGI0
Y2H Prey Pooling
32296183
Intra
USP2 O75604 ZRANB1 Homo sapiens Q9UGI0
Validated Y2H
32296183
Intra
USP2 O75604 ZRANB1 Homo sapiens Q9UGI0
Y2H Array
32296183
Intra
USP2 O75604 TAX1BP1 Homo sapiens Q86VP1
Y2H Prey Pooling
32296183
Intra
USP2 O75604 TAX1BP1 Homo sapiens Q86VP1
Y2H Array
32296183
Intra
USP2 O75604 TAX1BP1 Homo sapiens Q86VP1
Validated Y2H
32296183
Intra
USP2 O75604 OIP5 Homo sapiens O43482
Y2H Prey Pooling
32296183
Intra
USP2 O75604 OIP5 Homo sapiens O43482
Y2H Array
32296183
Intra
USP2 O75604 GOLGA6L9 Homo sapiens A6NEM1
Y2H Array
32296183
Intra
USP2 O75604 GOLGA6L9 Homo sapiens A6NEM1
Y2H Prey Pooling
32296183
Intra
USP2 O75604 GOLGA2 Homo sapiens Q08379
Y2H Array
32296183
Intra
USP2 O75604 GOLGA2 Homo sapiens Q08379
Validated Y2H
25416956
Intra
USP2 O75604 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
32296183
Intra
USP2 O75604 GOLGA2 Homo sapiens Q08379
Validated Y2H
32296183
Intra
USP2 O75604 BCAR1 Homo sapiens P56945
Y2H Prey Pooling
32296183
Intra
USP2 O75604 BCAR1 Homo sapiens P56945
Validated Y2H
32296183
Intra
USP2 O75604 BCAR1 Homo sapiens P56945
Y2H Array
32296183
Intra
USP2 O75604 S100A10 Homo sapiens P60903
Validated Y2H
32296183
Intra
USP2 O75604 S100A10 Homo sapiens P60903
Y2H Array
32296183
Intra
USP2 O75604 S100A10 Homo sapiens P60903
Y2H Prey Pooling
32296183
Intra
USP2 O75604 GRIPAP1 Homo sapiens Q4V328
Y2H Prey Pooling
32296183
Intra
USP2 O75604 GRIPAP1 Homo sapiens Q4V328
Validated Y2H
32296183
Intra
USP2 O75604 GRIPAP1 Homo sapiens Q4V328
Y2H Array
32296183
Intra
USP2 O75604 TRIM27 Homo sapiens P14373
Y2H Prey Pooling
25416956
Intra
USP2 O75604 TRIM27 Homo sapiens P14373
Validated Y2H
25416956
Intra
USP2 O75604 TRIM27 Homo sapiens P14373
Y2H Prey Pooling
32296183
Intra
USP2 O75604 TRIM27 Homo sapiens P14373
Validated Y2H
32296183
Intra
USP2 O75604 TRIM27 Homo sapiens P14373
Y2H Array
25416956
Intra
USP2 O75604 TRIM27 Homo sapiens P14373
Y2H Array
32296183
Intra
USP2 O75604 MRPL28 Homo sapiens Q13084
Y2H Prey Pooling
32296183
Intra
USP2 O75604 MRPL28 Homo sapiens Q13084
Validated Y2H
32296183
Intra
USP2 O75604 MRPL28 Homo sapiens Q13084
Y2H Array
32296183
Intra
USP2 O75604 DUSP21 Homo sapiens Q9H596
Validated Y2H
32296183
Intra
USP2 O75604 DUSP21 Homo sapiens Q9H596
Y2H Array
32296183
Intra
USP2 O75604 DUSP21 Homo sapiens Q9H596
Y2H Prey Pooling
32296183
Intra
USP2 O75604 KRT15 Homo sapiens P19012
Y2H Array
25416956
Intra
USP2 O75604 KRT15 Homo sapiens P19012
Validated Y2H
25416956
Intra
USP2 O75604 KRT15 Homo sapiens P19012
Pull Down
16189514
Intra
USP2 O75604 CALCOCO2 Homo sapiens Q13137
Validated Y2H
32296183
Intra
USP2 O75604 CALCOCO2 Homo sapiens Q13137
Y2H Array
32296183
Intra
USP2 O75604 CALCOCO2 Homo sapiens Q13137
Y2H Prey Pooling
32296183
Intra
USP2 O75604 CEP70 Homo sapiens Q8NHQ1
Y2H Array
32296183
Intra
USP2 O75604 CEP70 Homo sapiens Q8NHQ1
Y2H Prey Pooling
32296183
Intra
USP2 O75604 CEP70 Homo sapiens Q8NHQ1
Validated Y2H
32296183
Intra
USP2 O75604 CRACR2A Homo sapiens Q9BSW2
Validated Y2H
32296183
Intra
USP2 O75604 CRACR2A Homo sapiens Q9BSW2
Y2H Array
32296183
Intra
USP2 O75604 CRACR2A Homo sapiens Q9BSW2
Y2H Prey Pooling
32296183
Intra
USP2 O75604 USHBP1 Homo sapiens Q8N6Y0
Y2H Array
32296183
Intra
USP2 O75604 USHBP1 Homo sapiens Q8N6Y0
Y2H Prey Pooling
32296183
Intra
USP2 O75604 USHBP1 Homo sapiens Q8N6Y0
Validated Y2H
32296183
Intra
USP2 O75604 ZBED1 Homo sapiens O96006
Y2H Prey Pooling
32296183
Intra
USP2 O75604 ZBED1 Homo sapiens O96006
Validated Y2H
32296183
Intra
USP2 O75604 ZBED1 Homo sapiens O96006
Y2H Array
32296183
Intra
USP2 O75604 TRIM23 Homo sapiens P36406
Validated Y2H
32296183
Intra
USP2 O75604 TRIM23 Homo sapiens P36406
Y2H Array
32296183
Intra
USP2 O75604 TRIM23 Homo sapiens P36406
Y2H Prey Pooling
32296183
Intra
USP2 O75604 DYDC1 Homo sapiens Q8WWB3
Y2H Prey Pooling
32296183
Intra
USP2 O75604 DYDC1 Homo sapiens Q8WWB3
Validated Y2H
32296183
Intra
USP2 O75604 DYDC1 Homo sapiens Q8WWB3
Y2H Array
32296183
Intra
USP2 O75604 LZTS2 Homo sapiens Q9BRK4
Validated Y2H
25416956
Intra
USP2 O75604 LZTS2 Homo sapiens Q9BRK4
Validated Y2H
32296183
Intra
USP2 O75604 LZTS2 Homo sapiens Q9BRK4
Y2H Array
25416956
Intra
USP2 O75604 LZTS2 Homo sapiens Q9BRK4
Y2H Array
32296183
Intra
USP2 O75604 LZTS2 Homo sapiens Q9BRK4
Y2H Prey Pooling
25416956
Intra
USP2 O75604 LZTS2 Homo sapiens Q9BRK4
Y2H Prey Pooling
32296183
Intra
USP2 O75604 SORBS3 Homo sapiens O60504
Y2H Prey Pooling
32296183
Intra
USP2 O75604 SORBS3 Homo sapiens O60504
Y2H Array
32296183
Intra
USP2 O75604 TRIP6 Homo sapiens Q15654
Validated Y2H
32296183
Intra
USP2 O75604 TRIP6 Homo sapiens Q15654
Y2H Prey Pooling
32296183
Intra
USP2 O75604 TRIP6 Homo sapiens Q15654
Y2H Array
32296183
Intra
USP2 O75604 MTUS2 Homo sapiens Q5JR59
Y2H Array
25416956
Intra
USP2 O75604 MTUS2 Homo sapiens Q5JR59
Y2H Prey Pooling
25416956
Intra
USP2 O75604 MTUS2 Homo sapiens Q5JR59
Validated Y2H
25416956
Intra
USP2 O75604 RFX6 Homo sapiens Q8HWS3
Validated Y2H
32296183
Intra
USP2 O75604 RFX6 Homo sapiens Q8HWS3
Y2H Array
32296183
Intra
USP2 O75604 RFX6 Homo sapiens Q8HWS3
Y2H Prey Pooling
32296183
Intra
USP2 O75604 HOOK1 Homo sapiens Q9UJC3
Validated Y2H
25416956
Intra
USP2 O75604 HOOK1 Homo sapiens Q9UJC3
Y2H Array
25416956
Intra
USP2 O75604 IKZF3 Homo sapiens Q9UKT9
Validated Y2H
32296183
Intra
USP2 O75604 IKZF3 Homo sapiens Q9UKT9
Y2H Array
32296183
Intra
USP2 O75604 IKZF3 Homo sapiens Q9UKT9
Y2H Prey Pooling
32296183
Intra
USP2 O75604 DDI1 Homo sapiens Q8WTU0
Validated Y2H
32296183
Intra
USP2 O75604 DDI1 Homo sapiens Q8WTU0
Y2H Prey Pooling
32296183
Intra
USP2 O75604 DDI1 Homo sapiens Q8WTU0
Y2H Array
32296183
Intra
USP2 O75604 INTS11 Homo sapiens Q5TA45
Y2H Array
32296183
Intra
USP2 O75604 INTS11 Homo sapiens Q5TA45
Y2H Prey Pooling
32296183
Intra
USP2 O75604 INTS11 Homo sapiens Q5TA45
Validated Y2H
32296183
Intra
USP2 O75604 HOMER3 Homo sapiens Q9NSC5
Validated Y2H
32296183
Intra
USP2 O75604 HOMER3 Homo sapiens Q9NSC5
Y2H Array
25416956
Intra
USP2 O75604 HOMER3 Homo sapiens Q9NSC5
Y2H Array
32296183
Intra
USP2 O75604 HOMER3 Homo sapiens Q9NSC5
Y2H Prey Pooling
25416956
Intra
USP2 O75604 HOMER3 Homo sapiens Q9NSC5
Validated Y2H
25416956
Intra
USP2 O75604 HOMER3 Homo sapiens Q9NSC5
Y2H Prey Pooling
32296183
Intra
USP2 O75604 OPTN Homo sapiens Q96CV9
Validated Y2H
32296183
Intra
USP2 O75604 OPTN Homo sapiens Q96CV9
Y2H Prey Pooling
32296183
Intra
USP2 O75604 OPTN Homo sapiens Q96CV9
Y2H Array
32296183
Intra
USP2 O75604 TEKT4 Homo sapiens Q8WW24
Validated Y2H
32296183
Intra
USP2 O75604 TEKT4 Homo sapiens Q8WW24
Y2H Prey Pooling
32296183
Intra
USP2 O75604 TEKT4 Homo sapiens Q8WW24
Y2H Array
32296183
Intra
USP2 O75604 ACTN2 Homo sapiens P35609
Validated Y2H
32296183
Intra
USP2 O75604 ACTN2 Homo sapiens P35609
Y2H Array
32296183
Intra
USP2 O75604 ACTN2 Homo sapiens P35609
Y2H Prey Pooling
32296183
Intra
USP2 O75604 PICK1 Homo sapiens Q9NRD5
Y2H Array
32296183
Intra
USP2 O75604 PICK1 Homo sapiens Q9NRD5
Y2H Prey Pooling
32296183
Intra
USP2 O75604 PICK1 Homo sapiens Q9NRD5
Validated Y2H
32296183
Intra
USP2 O75604 TNFAIP2 Homo sapiens Q03169
Y2H Prey Pooling
32296183
Intra
USP2 O75604 TNFAIP2 Homo sapiens Q03169
Validated Y2H
32296183
Intra
USP2 O75604 TNFAIP2 Homo sapiens Q03169
Y2H Array
32296183
Intra
USP2 O75604 IHO1 Homo sapiens Q8IYA8
Validated Y2H
25416956
Intra
USP2 O75604 IHO1 Homo sapiens Q8IYA8
Y2H Prey Pooling
25416956
Intra
USP2 O75604 NAB2 Homo sapiens Q15742
Y2H Prey Pooling
32296183
Intra
USP2 O75604 NAB2 Homo sapiens Q15742
Y2H Array
32296183
Intra
USP2 O75604 NAB2 Homo sapiens Q15742
Validated Y2H
32296183
Intra
USP2 O75604 NDEL1 Homo sapiens Q9GZM8
Y2H Prey Pooling
32296183
Intra
USP2 O75604 NDEL1 Homo sapiens Q9GZM8
Validated Y2H
25416956
Intra
USP2 O75604 NDEL1 Homo sapiens Q9GZM8
Validated Y2H
32296183
Intra
USP2 O75604 NDEL1 Homo sapiens Q9GZM8
Y2H Array
32296183
Intra
USP2 O75604 NDEL1 Homo sapiens Q9GZM8
Y2H Prey Pooling
25416956
Intra
USP2 O75604 POU2AF1 Homo sapiens Q16633
Y2H Prey Pooling
32296183
Intra
USP2 O75604 POU2AF1 Homo sapiens Q16633
Validated Y2H
32296183
Intra
USP2 O75604 POU2AF1 Homo sapiens Q16633
Y2H Array
32296183
Intra
USP2 O75604 KRT31 Homo sapiens Q15323
Y2H Prey Pooling
32296183
Intra
USP2 O75604 KRT31 Homo sapiens Q15323
Validated Y2H
32296183
Intra
USP2 O75604 KRT31 Homo sapiens Q15323
Y2H Array
32296183
Intra
USP2 O75604 PLEKHG4 Homo sapiens Q58EX7
Y2H Array
32296183
Intra
USP2 O75604 PLEKHG4 Homo sapiens Q58EX7
Y2H Prey Pooling
32296183
Intra
USP2 O75604 PLEKHG4 Homo sapiens Q58EX7
Validated Y2H
32296183
Intra
USP2 O75604 EXOC5 Homo sapiens O00471
Y2H Prey Pooling
32296183
Intra
USP2 O75604 EXOC5 Homo sapiens O00471
Y2H Array
32296183
Intra
USP2 O75604 TRIM50 Homo sapiens Q86XT4
Y2H Prey Pooling
32296183
Intra
USP2 O75604 TRIM50 Homo sapiens Q86XT4
Validated Y2H
32296183
Intra
USP2 O75604 TRIM50 Homo sapiens Q86XT4
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant USP2 Proteins

Cat. No. Product Name Accession Purity
HY-P79457 USP2 Catalytic Domain Protein, Human (His) O75604-1 (N259-M605) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Machado-Joseph Disease

  • SCA3

  • MJD

  • Spinocerebellar Ataxia 3

  • Azorean Disease

  • Spinocerebellar Ataxia Type 3

  • Spinocerebellar Atrophy

  • Azorean Neurologic Disease

  • Spinopontine Atrophy

  • Nigrospinodentatal Degeneration

  • Spinocerebellar Atrophy Iii

  • Spinocerebellar Atrophy Type 3

  • Azorean Ataxia

  • Azorean Disease Of The Nervous System

  • Machado Disease

  • Nigro-Spino-Dentatal Degeneration With Nuclear Ophthalmoplegia

  • Disease, Machado-Joseph

  • Ataxia, Spinocerebellar
Fasciitis
Liddle Syndrome 1

  • Liddle Syndrome

  • Pseudoaldosteronism

  • Liddle'S Syndrome

  • LIDLS1

  • Lidls

  • Pseudohyperaldosteronism

  • Pseudoprimary Hyperaldosteronism

  • Pseudohyperaldosteronism Type 1

  • Liddles Syndrome
Spermatogenic Failure

  • Azoospermia

  • Spgf

  • Spermatogenic Failure, Susceptibility To

  • Absent Sperm

  • Aspermatogenesis

  • Infertility Due To Azoospermia

  • Hypospermatogenesis

  • Azoospermatism
Autosomal Dominant Cerebellar Ataxia

  • Spinocerebellar Ataxia

  • Adca

  • Pierre Marie Cerebellar Ataxia

  • Ataxia, Spinocerebellar

  • Sca

  • Autosomal Dominant Spinocerebellar Ataxia

  • Spinocerebellar Ataxias
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-162312 LLK203 Inhibitor 98.58% Unkown
HY-RS15530 USP2 Human Pre-designed siRNA Set A Inhibitor / Unkown
HY-179630 MS102 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus USP2 RGD RGD:621073
Macaca mulatta USP2 VGNC VGNC:101425
Felis catus USP2 VGNC VGNC:81096
Mus musculus USP2 MGD MGI:1858178
Bos taurus USP2 VGNC VGNC:54894
Others USP2 NCBI