USP2 - ubiquitin specific peptidase 2 Gene

Homo sapiens

Also known as USP9; UBP41

Gene ID: 9099 | Gene type: protein coding

About USP2

Cytogenetic location: 11q23.3 Genomic coordinates (GRCh38): 11:119,355,215-119,381,690 (from NCBI)

This gene has 7 transcripts (splice variants), 178 orthologues and 71 paralogues. Biased expression in testis (RPKM 31.4), kidney (RPKM 15.4) and 10 other tissues.

Summary

This gene encodes a member of the family of de-ubiquitinating enzymes, which belongs to the peptidase C19 superfamily. The encoded protein is a Ubiquitin-Specific Protease which is required for TNF-alpha (tumor necrosis factor alpha) -induced NF-kB (nuclear factor kB) signaling. This protein deubiquitinates polyubiquitinated target proteins such as fatty acid synthase, murine double minute 2 (MDM2), MDM4/MDMX and cyclin D1. MDM2 and MDM4 are negative regulators of the p53 tumor suppressor and cyclin D1 is required for cell cycle G1/S transition. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]

USP2 Products(3)

mRNA	Protein	Name
NM_001243759.2	NP_001230688.1	ubiquitin carboxyl-terminal hydrolase 2 isoform c
NM_004205.5	NP_004196.4	ubiquitin carboxyl-terminal hydrolase 2 isoform a
NM_171997.3	NP_741994.1	ubiquitin carboxyl-terminal hydrolase 2 isoform b

USP2 Protein Structure

UCH

0
100
200
300
400
500
605 a.a.

Protein Preferred Names

Protein Names

ubiquitin carboxyl-terminal hydrolase 2

41 kDa ubiquitin-specific protease

Recombinant USP2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P79457	USP2 Catalytic Domain Protein, Human (His)	O75604 (N259-M605)	≥95%

Related Diseases

Diseases

Alias

Machado-Joseph Disease

SCA3	MJD
Spinocerebellar Ataxia 3	Azorean Disease
Spinocerebellar Ataxia Type 3	Spinocerebellar Atrophy
Azorean Neurologic Disease	Spinopontine Atrophy
Nigrospinodentatal Degeneration	Spinocerebellar Atrophy Iii
Spinocerebellar Atrophy Type 3	Azorean Ataxia
Azorean Disease Of The Nervous System	Machado Disease
Nigro-Spino-Dentatal Degeneration With Nuclear Ophthalmoplegia	Disease, Machado-Joseph
Ataxia, Spinocerebellar

Fasciitis

Liddle Syndrome 1

Liddle Syndrome	Pseudoaldosteronism
Liddle'S Syndrome	LIDLS1
Lidls	Pseudohyperaldosteronism
Pseudoprimary Hyperaldosteronism	Pseudohyperaldosteronism Type 1
Liddles Syndrome

Spermatogenic Failure

Azoospermia	Spgf
Spermatogenic Failure, Susceptibility To	Absent Sperm
Aspermatogenesis	Infertility Due To Azoospermia
Hypospermatogenesis	Azoospermatism

Autosomal Dominant Cerebellar Ataxia

Spinocerebellar Ataxia	Adca
Pierre Marie Cerebellar Ataxia	Ataxia, Spinocerebellar
Sca	Autosomal Dominant Spinocerebellar Ataxia
Spinocerebellar Ataxias

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-162312	LLK203	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	USP2	RGD	RGD:621073
Macaca mulatta	USP2	VGNC	VGNC:101425
Felis catus	USP2	VGNC	VGNC:81096
Mus musculus	USP2	MGD	MGI:1858178
Bos taurus	USP2	VGNC	VGNC:54894
Others	USP2	NCBI