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HOOK1 - hook microtubule tethering protein 1 Gene

Also Known as HK1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 51361

About HOOK1

Cytogenetic location: 1p32.1 Genomic coordinates (GRCh38): 1:59,814,949-59,876,322 (from NCBI)

This gene has 10 transcripts (splice variants), 205 orthologues and 5 paralogues. Broad expression in testis (RPKM 15.7), colon (RPKM 10.0) and 21 other tissues.

Summary

This gene encodes a member of the hook family of coiled-coil proteins, which bind to microtubules and organelles through their N- and C-terminal domains, respectively. The encoded protein localizes to discrete punctuate subcellular structures, and interacts with several members of the Rab GTPase family involved in endocytosis. It is thought to link endocytic membrane trafficking to the microtubule Cytoskeleton. Several alternatively spliced transcript variants have been identified, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]

HOOK1 Products (1)

mRNA	Protein	Name
NM_015888.6	NP_056972.1	protein Hook homolog 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	18799622	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15471887	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	32073997	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in early endosome to late endosome transport	IMP IMP: Inferred from mutant phenotype	18799622	GOA
involved in endosome organization	IMP IMP: Inferred from mutant phenotype	18799622	GOA
involved in endosome to lysosome transport	IMP IMP: Inferred from mutant phenotype	18799622	GOA
involved in lysosome organization	IMP IMP: Inferred from mutant phenotype	18799622	GOA
involved in protein localization to perinuclear region of cytoplasm	IMP IMP: Inferred from mutant phenotype	32073997	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of FHF complex	IDA IDA: Inferred from direct assay	18799622	GOA
part of HOPS complex	IDA IDA: Inferred from direct assay	18799622	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	15471887	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HOOK1 Protein Structure

HOOK

0
200
400
600
728 a.a.

Protein Preferred Names	Protein Names
protein Hook homolog 1	h-hook1

HOOK1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	HOOK1	Q9UJC3	TFIP11	Homo sapiens	Q9UBB9	Y2H Array	31515488
Intra	HOOK1	Q9UJC3	TFIP11	Homo sapiens	Q9UBB9	Y2H Prey Pooling	32296183
Intra	HOOK1	Q9UJC3	TFIP11	Homo sapiens	Q9UBB9	Y2H Array	25416956
Intra	HOOK1	Q9UJC3	TFIP11	Homo sapiens	Q9UBB9	Y2H Array	32296183
Intra	HOOK1	Q9UJC3	TFIP11	Homo sapiens	Q9UBB9	Validated Y2H	25416956
Intra	HOOK1	Q9UJC3	ZNF80	Homo sapiens	P51504	Y2H Prey Pooling	32296183
Intra	HOOK1	Q9UJC3	ZNF80	Homo sapiens	P51504	Y2H Array	32296183
Intra	HOOK1	Q9UJC3	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	HOOK1	Q9UJC3	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	HOOK1	Q9UJC3	HOOK3	Homo sapiens	Q86VS8	Y2H	32073997
Intra	HOOK1	Q9UJC3	CDK4	Homo sapiens	P11802	Y2H Prey Pooling	32296183
Intra	HOOK1	Q9UJC3	CDK4	Homo sapiens	P11802	Y2H Array	31515488
Intra	HOOK1	Q9UJC3	CDK4	Homo sapiens	P11802	Validated Y2H	25416956
Intra	HOOK1	Q9UJC3	CDK4	Homo sapiens	P11802	Y2H Array	32296183
Intra	HOOK1	Q9UJC3	TBC1D7	Homo sapiens	Q9P0N9	Y2H Array	31515488
Intra	HOOK1	Q9UJC3	TBC1D7	Homo sapiens	Q9P0N9	Validated Y2H	25416956
Intra	HOOK1	Q9UJC3	TBC1D7	Homo sapiens	Q9P0N9	Y2H Array	25416956
Intra	HOOK1	Q9UJC3	NCOR1	Homo sapiens	O75376	Validated Y2H	32814053
Intra	HOOK1	Q9UJC3	NCOR1	Homo sapiens	O75376	Y2H Array	32814053
Intra	HOOK1	Q9UJC3	NCOR1	Homo sapiens	O75376	Y2H Pooling	32814053
Intra	HOOK1	Q9UJC3	PIAS2	Homo sapiens	O75928-2	Y2H Prey Pooling	32296183
Intra	HOOK1	Q9UJC3	PIAS2	Homo sapiens	O75928-2	Y2H Array	32296183
Intra	HOOK1	Q9UJC3	CDC5L	Homo sapiens	Q99459	Y2H	17043677
Intra	HOOK1	Q9UJC3	ZNF785	Homo sapiens	A8K8V0	Y2H Prey Pooling	25416956
Intra	HOOK1	Q9UJC3	ZNF785	Homo sapiens	A8K8V0	Validated Y2H	25416956
Intra	HOOK1	Q9UJC3	ZNF785	Homo sapiens	A8K8V0	Y2H Array	25416956
Intra	HOOK1	Q9UJC3	ANKRD23	Homo sapiens	Q86SG2	Y2H Array	32296183
Intra	HOOK1	Q9UJC3	ANKRD23	Homo sapiens	Q86SG2	Y2H Prey Pooling	32296183
Intra	HOOK1	Q9UJC3	ZNF655	Homo sapiens	Q8N720	Y2H Prey Pooling	32296183
Intra	HOOK1	Q9UJC3	ZNF655	Homo sapiens	Q8N720	Y2H Array	32296183
Intra	HOOK1	Q9UJC3	SYCE1	Homo sapiens	Q8N0S2	Validated Y2H	25416956
Intra	HOOK1	Q9UJC3	AKTIP	Homo sapiens	Q9H8T0	Y2H Array	25416956
Intra	HOOK1	Q9UJC3	AKTIP	Homo sapiens	Q9H8T0	Y2H	32073997
Intra	HOOK1	Q9UJC3	LMO2	Homo sapiens	P25791	Y2H Array	25416956
Intra	HOOK1	Q9UJC3	USP2	Homo sapiens	O75604	Y2H Prey Pooling	25416956
Intra	HOOK1	Q9UJC3	BSG	Homo sapiens	P35613	Anti Bait CoIP	29423001
Intra	HOOK1	Q9UJC3	BSG	Homo sapiens	P35613	Confocal	29423001

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Spermatogenic Failure 16	SPGF16 Acephalic Spermatozoa Syndrome Spermatozoa, Acephalic
Male Infertility Due To Acephalic Spermatozoa	Acephalic Spermatozoa Syndrome
Metanephric Adenoma
Renal Adenoma	Renal Cell Adenoma
Cranioectodermal Dysplasia 1	Sensenbrenner Syndrome CED1 Levin Syndrome I Cranio-Ectodermal Dysplasia Dysplasia, Cranioectodermal, Type 1 Cranioectodermal Dysplasia
Ceroid Lipofuscinosis, Neuronal, 3	Batten Disease Juvenile Neuronal Ceroid Lipofuscinosis Neuronal Ceroid Lipofuscinosis 3 CLN3 Jncl Spielmeyer-Vogt Disease Vogt-Spielmeyer Disease Spielmeyer-Sjogren Disease Cln3 Disease Neuronal Ceroid Lipofuscinosis, Juvenile Cln3 Disease, Juvenile Spielmeyer Sjogren Disease Vogt Spielmeyer Disease Batten-Mayou Disease Batten-Spielmeyer-Vogt Disease Cln3-Related Neuronal Ceroid-Lipofuscinosis Juvenile Batten Disease Juvenile Cerebroretinal Degeneration Classic Juvenile Ncl Classic Juvenile Neuronal Ceroid Lipofuscinosis Juvenile Ncl Lipofuscinosis, Ceroid, Neuronal, Type 3
Neuronal Ceroid Lipofuscinosis	Hereditary Ceroid Lipofuscinosis Batten Disease Ncl Neuronal Ceroid-Lipofuscinoses Lipofuscinosis, Ceroid, Neuronal Juvenile Neuronal Ceroid Lipofuscinosis Cerebromacular Dystrophy Cerebromacular Degeneration Ceroid-Lipofuscinosis Ncl - [Neuronal Ceroid Lipofuscinosis] Amaurotic Familial Idiocy Amaurotic Idiocy Amaurotic Idiot Neuronal Lipofuscinosis Pigmentary Retinal Lipoid Neuronal Heredodegeneration
Spermatogenic Failure	Azoospermia Spgf Spermatogenic Failure, Susceptibility To Absent Sperm Aspermatogenesis Infertility Due To Azoospermia Hypospermatogenesis Azoospermatism

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N4307	Laetanine	Inhibitor	/	Unkown
HY-168619	DNA crosslinker 6	Inhibitor	/	Unkown
HY-N17911	Plicatol D		/	Unkown
HY-RS06287	HOOK1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	HOOK1	MGD	MGI:1925213
Rattus norvegicus	HOOK1	RGD	RGD:1309987
Canis familiaris	HOOK1	VGNC	VGNC:41740
Macaca mulatta	HOOK1	VGNC	VGNC:73424
Bos taurus	HOOK1	VGNC	VGNC:29905
Felis catus	HOOK1	VGNC	VGNC:62832
Others	HOOK1	NCBI