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製品番号: HY-168619

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DNA crosslinker 6

DNA crosslinker 6 (compound 1) is an anti-kinetoplastid compound. DNA crosslinker 6 has a strong ability to bind AT-DNA and can inhibit the binding of AT-hook 1 to DNA (IC₅₀=0.03 µM). In addition, DNA crosslinker 6 also has antiprotozoal activity, with an EC₅₀ value of 0.83 µM for the inhibition of T. brucei.

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 272791-87-4
分子式: C₁₉H₂₁N₇O
分子量:363.42

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

DNA crosslinker 6 構造式

CAS 番号: 272791-87-4

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Parasite アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
HEK-293T	CC₅₀	>200 μM Compound: 1	Cytotoxicity against HEK293T cells after 30 hrs by Alamar Blue assay Cytotoxicity against HEK293T cells after 30 hrs by Alamar Blue assay	[PMID: 26231081]
L929	CC₅₀	>200 μM Compound: 1a	Cytotoxicity against mouse L929 cells incubated for 72 hrs by fluorescence based microplate reader analysis Cytotoxicity against mouse L929 cells incubated for 72 hrs by fluorescence based microplate reader analysis	[PMID: 37729094]

化学情報

CAS 番号 272791-87-4
分子量 363.42
分子式 C₁₉H₂₁N₇O
SMILES

O=C(NC1=CC=C(NC2=NCCN2)C=C1)C3=CC=C(NC4=NCCN4)C=C3
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

プロトコル

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (265 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Nué-Martinez J J, et al. Crystal structure of the HMGA AT-hook 1 domain bound to the minor groove of AT-rich DNA and inhibition by antikinetoplastid drugs[J]. Scientific Reports, 2024, 14(1): 26173. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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