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Cat. No.: HY-168619

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DNA crosslinker 6

DNA crosslinker 6 (compound 1) is an anti-kinetoplastid compound. DNA crosslinker 6 has a strong ability to bind AT-DNA and can inhibit the binding of AT-hook 1 to DNA (IC₅₀=0.03 µM). In addition, DNA crosslinker 6 also has antiprotozoal activity, with an EC₅₀ value of 0.83 µM for the inhibition of T. brucei.

For research use only. We do not sell to patients.

CAS No.: 272791-87-4
Formula: C₁₉H₂₁N₇O
Molecular Weight:363.42

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

DNA crosslinker 6 Chemical Structure

CAS No.: 272791-87-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

All Parasite Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HEK-293T	CC₅₀	>200 μM Compound: 1	Cytotoxicity against HEK293T cells after 30 hrs by Alamar Blue assay Cytotoxicity against HEK293T cells after 30 hrs by Alamar Blue assay	[PMID: 26231081]
L929	CC₅₀	>200 μM Compound: 1a	Cytotoxicity against mouse L929 cells incubated for 72 hrs by fluorescence based microplate reader analysis Cytotoxicity against mouse L929 cells incubated for 72 hrs by fluorescence based microplate reader analysis	[PMID: 37729094]

Chemical Information

CAS No. 272791-87-4
Molecular Weight 363.42
Formula C₁₉H₂₁N₇O
SMILES

O=C(NC1=CC=C(NC2=NCCN2)C=C1)C3=CC=C(NC4=NCCN4)C=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Nué-Martinez J J, et al. Crystal structure of the HMGA AT-hook 1 domain bound to the minor groove of AT-rich DNA and inhibition by antikinetoplastid drugs[J]. Scientific Reports, 2024, 14(1): 26173. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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