DNA crosslinker 6
DNA crosslinker 6 (compound 1) is an anti-kinetoplastid compound. DNA crosslinker 6 has a strong ability to bind AT-DNA and can inhibit the binding of AT-hook 1 to DNA (IC50=0.03 µM). In addition, DNA crosslinker 6 also has antiprotozoal activity, with an EC50 value of 0.83 µM for the inhibition of T. brucei.
For research use only. We do not sell to patients.
- CAS No.: 272791-87-4
- Formula: C19H21N7O
- Molecular Weight:363.42
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
All Parasite Isoforms
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK-293T | CC50 |
>200 μM
Compound: 1
|
Cytotoxicity against HEK293T cells after 30 hrs by Alamar Blue assay
Cytotoxicity against HEK293T cells after 30 hrs by Alamar Blue assay
|
[PMID: 26231081] |
| L929 | CC50 |
>200 μM
Compound: 1a
|
Cytotoxicity against mouse L929 cells incubated for 72 hrs by fluorescence based microplate reader analysis
Cytotoxicity against mouse L929 cells incubated for 72 hrs by fluorescence based microplate reader analysis
|
[PMID: 37729094] |
Chemical Information
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CAS No. 272791-87-4
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Molecular Weight 363.42
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Formula C19H21N7O
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SMILES
O=C(NC1=CC=C(NC2=NCCN2)C=C1)C3=CC=C(NC4=NCCN4)C=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)