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Cat. No.: HY-168619

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DNA crosslinker 6

DNA crosslinker 6 (compound 1) is an anti-kinetoplastid compound. DNA crosslinker 6 has a strong ability to bind AT-DNA and can inhibit the binding of AT-hook 1 to DNA (IC₅₀=0.03 µM). In addition, DNA crosslinker 6 also has antiprotozoal activity, with an EC₅₀ value of 0.83 µM for the inhibition of T. brucei.

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CAS No.: 272791-87-4
화학식: C₁₉H₂₁N₇O
분자량:363.42

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

DNA crosslinker 6 Chemical Structure

CAS No.: 272791-87-4

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All Parasite Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HEK-293T	CC₅₀	>200 μM Compound: 1	Cytotoxicity against HEK293T cells after 30 hrs by Alamar Blue assay Cytotoxicity against HEK293T cells after 30 hrs by Alamar Blue assay	[PMID: 26231081]
L929	CC₅₀	>200 μM Compound: 1a	Cytotoxicity against mouse L929 cells incubated for 72 hrs by fluorescence based microplate reader analysis Cytotoxicity against mouse L929 cells incubated for 72 hrs by fluorescence based microplate reader analysis	[PMID: 37729094]

Chemical Information

CAS No. 272791-87-4
분자량 363.42
화학식 C₁₉H₂₁N₇O
SMILES

O=C(NC1=CC=C(NC2=NCCN2)C=C1)C3=CC=C(NC4=NCCN4)C=C3
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Nué-Martinez J J, et al. Crystal structure of the HMGA AT-hook 1 domain bound to the minor groove of AT-rich DNA and inhibition by antikinetoplastid drugs[J]. Scientific Reports, 2024, 14(1): 26173. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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