272791-87-4
272791-87-4
Chemical Structure
DNA crosslinker 6
- CAS No.: 272791-87-4
- Formula:C19H21N7O
- Molecular Weight:363.42
SMILES: O=C(NC1=CC=C(NC2=NCCN2)C=C1)C3=CC=C(NC4=NCCN4)C=C3
Biological Activity: DNA crosslinker 6 (compound 1) is an anti-kinetoplastid compound. DNA crosslinker 6 has a strong ability to bind AT-DNA and can inhibit the binding of AT-hook 1 to DNA (IC50=0.03 µM). In addition, DNA crosslinker 6 also has antiprotozoal activity, with an EC50 value of 0.83 µM for the inhibition of T. brucei[1].
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DNA crosslinker 6 | DNA crosslinker 6 (compound 1) is an anti-kinetoplastid compound. DNA crosslinker 6 has a strong ability to bind AT-DNA and can inhibit the binding of AT-hook 1 to DNA (IC50=0.03 µM). In addition, DNA crosslinker 6 also has antiprotozoal activity, with an EC50 value of 0.83 µM for the inhibition of T. brucei. | |||||||||||||||||||||
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