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HOOK3 - hook microtubule tethering protein 3 Gene

Also Known as HK3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 84376

About HOOK3

Cytogenetic location: 8p11.21 Genomic coordinates (GRCh38): 8:42,896,978-43,030,535 (from NCBI)

This gene has 6 transcripts (splice variants), 217 orthologues, 5 paralogues and is associated with 77 phenotypes. Ubiquitous expression in thyroid (RPKM 6.6), fat (RPKM 4.5) and 25 other tissues.

Summary

Hook proteins are cytosolic coiled-coil proteins that contain conserved N-terminal domains, which attach to microtubules, and more divergent C-terminal domains, which mediate binding to organelles. The Drosophila Hook protein is a component of the endocytic compartment.[supplied by OMIM, Apr 2004]

HOOK3 Products (1)

mRNA	Protein	Name
NM_032410.4	NP_115786.1	protein Hook homolog 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables dynactin binding	IDA IDA: Inferred from direct assay	27482052	GOA
enables dynein intermediate chain binding	IDA IDA: Inferred from direct assay	27482052	GOA
enables dynein light chain binding	IPI IPI: Inferred from physical interaction	27482052	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	18799622	GOA
enables microtubule binding	IDA IDA: Inferred from direct assay	11238449	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17237231	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in Golgi localization	IMP IMP: Inferred from mutant phenotype	11238449	GOA
involved in cytoplasmic microtubule organization	IMP IMP: Inferred from mutant phenotype	11238449	GOA
involved in early endosome to late endosome transport	IMP IMP: Inferred from mutant phenotype	18799622	GOA
involved in endosome organization	IMP IMP: Inferred from mutant phenotype	18799622	GOA
involved in endosome to lysosome transport	IMP IMP: Inferred from mutant phenotype	18799622	GOA
involved in lysosome organization	IMP IMP: Inferred from mutant phenotype	18799622	GOA
involved in protein localization to perinuclear region of cytoplasm	IMP IMP: Inferred from mutant phenotype	32073997	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of FHF complex	IDA IDA: Inferred from direct assay	18799622	GOA
part of HOPS complex	IDA IDA: Inferred from direct assay	18799622	GOA
located in cis-Golgi network	IDA IDA: Inferred from direct assay	11238449	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HOOK3 Protein Structure

HOOK

0
200
400
600
718 a.a.

Protein Preferred Names	Protein Names
protein Hook homolog 3	h-hook3

HOOK3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	HOOK3	Q86VS8	PNMA5	Homo sapiens	Q96PV4	Validated Y2H	32296183
Intra	HOOK3	Q86VS8	PNMA5	Homo sapiens	Q96PV4	Y2H Array	32296183
Intra	HOOK3	Q86VS8	PNMA5	Homo sapiens	Q96PV4	Y2H Prey Pooling	32296183
Intra	HOOK3	Q86VS8	CTIF	Homo sapiens	O43310-2	Y2H Prey Pooling	32296183
Intra	HOOK3	Q86VS8	CTIF	Homo sapiens	O43310-2	Y2H Array	32296183
Intra	HOOK3	Q86VS8	KRT13	Homo sapiens	P13646	Y2H Prey Pooling	32296183
Intra	HOOK3	Q86VS8	KRT13	Homo sapiens	P13646	Y2H Array	32296183
Intra	HOOK3	Q86VS8	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	HOOK3	Q86VS8	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	HOOK3	Q86VS8	MSR1	Homo sapiens	P21757	Pull Down	17237231
Intra	HOOK3	Q86VS8	MSR1	Homo sapiens	P21757	Anti Tag CoIP	17237231
Intra	HOOK3	Q86VS8	KRT27	Homo sapiens	Q7Z3Y8	Y2H Array	32296183
Intra	HOOK3	Q86VS8	KRT27	Homo sapiens	Q7Z3Y8	Y2H Prey Pooling	32296183
Intra	HOOK3	Q86VS8	AKTIP	Homo sapiens	Q9H8T0	Y2H	32073997
Intra	HOOK3	Q86VS8	HOOK1	Homo sapiens	Q9UJC3	Y2H	32073997
Intra	HOOK3	Q86VS8	HOOK1	Homo sapiens	Q9UJC3	Anti Tag CoIP	33961781
Intra	HOOK3	Q86VS8	HOOK1	Homo sapiens	Q9UJC3	Y2H Prey Pooling	32296183
Intra	HOOK3	Q86VS8	HOOK1	Homo sapiens	Q9UJC3	Anti Tag CoIP	28514442
Intra	HOOK3	Q86VS8	HOOK1	Homo sapiens	Q9UJC3	Validated Y2H	32296183
Intra	HOOK3	Q86VS8	HOOK1	Homo sapiens	Q9UJC3	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Small Intestine Neuroendocrine Neoplasm	Small Intestine Neuroendocrine Tumor Neuroendocrine Tumor Of The Small Intestine Net Of The Small Intestine Neuroendocrine Neoplasm Of The Small Intestine Neuroendocrine Tumor Of Small Bowel Small Intestinal Neuroendocrine Neoplasm
Dystonia 6, Torsion	DYT6 Torsion Dystonia 6 Dystonia 6 Idiopathic Torsion Dystonia Of Mixed Type Primary Dystonia, Dyt6 Type Torsion Dystonia, Adult-Onset, Mixed Type Dyt-Thap1 Adolescent-Onset Dystonia Of Mixed Type Torsion Dystonia Adult Onset Mixed Type Dyt6 Dystonia Thap1 Dystonia Generalized Cervical And Upper-Limb-Onset Dystonia Adult-Onset Torsion Dystonia Mixed Type Autosomal Dominant Torsion Dystonia 6 Dystonia-6 Torsion Dystonia Type 6 Dystonia, Type 6, Torsion
Hermansky-Pudlak Syndrome 9	HPS9 Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Delta Storage Pool Disease Hermansky-Pudlak Syndrome, Type 9 Platelet Storage Pool Deficiency Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Cells
Small Intestine Benign Neoplasm	Neoplasm Of Small Intestine Small Intestinal Neoplasm Neoplasm Of The Small Intestine Small Bowel Cancer Small Intestine Cancer Malignant Neoplasm Of Small Intestine, Unspecified Malignant Tumour Of Small Bowel Malignant Tumour Of Small Intestine Primary Malignant Neoplasm Of Meckel Diverticulum
Spinal Muscular Atrophy With Lower Extremity Predominant	Spinal Muscular Atrophy With Lower Extremity Predominance Autosomal Dominant Childhood-Onset Proximal Spinal Muscular Atrophy With Contractures Kugelberg-Welander Syndrome, Autosomal Dominant Lower Extremity-Predominant Autosomal Dominant Proximal Spinal Muscular Atrophy With Contractures Sma-Led Spinal Muscular Atrophy, Childhood, Proximal, Autosomal Dominant Spinal Muscular Atrophy, Juvenile, Proximal, Autosomal Dominant Spinal Muscular Atrophy, Lower Extremity, Autosomal Dominant Spinal Muscular Atrophy, Lower Extremity, Dominant

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06289	HOOK3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	HOOK3	MGD	MGI:2443554
Rattus norvegicus	HOOK3	RGD	RGD:1560960
Macaca mulatta	HOOK3	VGNC	VGNC:73433
Bos taurus	HOOK3	VGNC	VGNC:50090
Canis familiaris	HOOK3	VGNC	VGNC:41742
Felis catus	HOOK3	VGNC	VGNC:62834
Others	HOOK3	NCBI