KRT13 - keratin 13 Gene

Also Known as K13; CK13; WSN2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3860

About KRT13

Cytogenetic location: 17q21.2 Genomic coordinates (GRCh38): 17:41,500,981-41,505,612 (from NCBI)

This gene has 9 transcripts (splice variants), 30 orthologues, 68 paralogues and is associated with 3 phenotypes. Restricted expression toward esophagus (RPKM 15373.8).

Summary

The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. This type I cytokeratin is paired with keratin 4 and expressed in the suprabasal layers of non-cornified stratified epithelia. Mutations in this gene and keratin 4 have been associated with the autosomal dominant disorder White Sponge Nevus. The type I cytokeratins are clustered in a region of chromosome 17q21.2. Alternative splicing of this gene results in multiple transcript variants; however, not all variants have been described. [provided by RefSeq, Jul 2008]

KRT13 Products (2)

mRNA	Protein	Name
NM_002274.4	NP_002265.3	keratin, type I cytoskeletal 13 isoform b
NM_153490.3	NP_705694.3	keratin, type I cytoskeletal 13 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25910212	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cytoskeleton organization	IDA IDA: Inferred from direct assay	21371075	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in extracellular exosome	IDA IDA: Inferred from direct assay	21557262	GOA
located in intermediate filament cytoskeleton	IDA IDA: Inferred from direct assay	21371075	GOA
located in keratin filament	IDA IDA: Inferred from direct assay	9714826	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KRT13 Protein Structure

Filament

0
100
200
300
400
458 a.a.

Protein Preferred Names	Protein Names
keratin, type I cytoskeletal 13	CK-13

KRT13 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	KRT13	P13646	DES	Homo sapiens	P17661	Validated Y2H	32296183
Intra	KRT13	P13646	KRT72	Homo sapiens	Q14CN4	Validated Y2H	32296183
Intra	KRT13	P13646	KRT2	Homo sapiens	P35908	Y2H Array	31515488
Intra	KRT13	P13646	HOOK3	Homo sapiens	Q86VS8	Validated Y2H	32296183
Intra	KRT13	P13646	KRT4	Homo sapiens	P19013	Y2H Prey Pooling	32296183
Intra	KRT13	P13646	KRT4	Homo sapiens	P19013	Validated Y2H	32296183
Intra	KRT13	P13646	PSMA1	Homo sapiens	P25786	Validated Y2H	32296183
Intra	KRT13	P13646	TXLNB	Homo sapiens	Q8N3L3	Validated Y2H	32296183
Intra	KRT13	P13646	KRT6A	Homo sapiens	P02538	MAPPIT	32296183
Intra	KRT13	P13646	SPG21	Homo sapiens	Q9NZD8	Validated Y2H	32296183
Intra	KRT13	P13646	GFAP	Homo sapiens	P14136	Validated Y2H	32296183
Intra	KRT13	P13646	GLYCTK	Homo sapiens	Q8IVS8	Validated Y2H	32296183
Intra	KRT13	P13646	KRT74	Homo sapiens	Q7RTS7	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

KRT13 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81164	Pan Cytokeratin Antibody	WB, IHC-P, IHC-F, ICC/IF, FC	Human, Mouse, Rat, Cow
HY-P82950	Cytokeratin 13 Antibody (YA2695)	WB, IHC-P, ICC/IF	Human
HY-P84088	Cytokeratin 13 Antibody (YA3785)	WB, IHC-P, FC, ELISA	Human
HY-P84088A	Cytokeratin 13 Antibody (YA3785)(PBS only)	WB, IHC-P, FC, ELISA	Human
HY-P85900	Cytokeratin 13 Antibody (YA5592)	IHC-P, WB, ICC/IF, ELISA	Human
HY-P85938	Cytokeratin Antibody (YA5630)	IHC-P, WB, ICC/IF, ELISA	Human, Mouse, Rat
HY-P86026	Cytokeratin Antibody (YA5718)	IHC-P, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
White Sponge Nevus 2	WSN2
White Sponge Nevus 1	White Sponge Nevus Of Cannon Leukokeratosis, Hereditary Mucosal Hereditary Mucosal Leukokeratosis White Sponge Nevus WSN1 Wsn Cannon'S Disease Familial White Folded Mucosal Dysplasia Hereditary Leukokeratosis Hereditary Oral Keratosis Leukokeratosis Of Oral Mucosa Nevus Of Cannon White Folded Gingivostomatosis White Gingivostomatitis White Sponge Naevus White Sponge Nevus Of Mucosa
Inverted Papilloma	Inverted Papilloma, Squamous Cell Papilloma Inverted Papilloma, Inverted Inverted Squamous Cell Papilloma
Cholesteatoma Of Middle Ear	Cholesteatoma Epidermosis Of Ear Epidermosis Of Middle Ear Middle Ear Cholesteatoma Cholesteatoma Of Middle Ear And Mastoid Cholesteatoma Of Middle Ear And/Or Mastoid Cholesteatoma Of The Middle Ear Congenital Cholesteatoma Primary Acquired Cholesteatoma Secondary Acquired Cholesteatoma Cholesteatoma Middle Ear Cholesteatoma, Middle Ear Cholesterolosis Of Middle Ear Cholesterosis Of Ear Cholesterosis Of Middle Ear Cholesteatoma Nos Epidermoid Cholesteatoma Middle Ear Granuloma
Frontal Sinus Inverted Papilloma	Inverted Papilloma Of The Frontal Sinus
Papilloma	Papillomatosis
Leukoplakia	Leukoplakia Of Gingiva Leukoplakia Of Oral Epithelium Leucoplakia Of Oral Mucosa Leukokeratosis Of Oral Mucosa
Frontal Sinus Benign Neoplasm	Neoplasm Of Frontal Sinus Tumor Of The Frontal Sinus
Lichen Planus	Lichen Ruber Planus Lichen, Ruber Planus Ruber Planus Lp - [Lichen Planus] Lichen Planus Of Wilson Wilson Lichen Ruber
Human Papillomavirus Infectious Disease	Hpv Papillomavirus Infections Human Papilloma Virus Infection
Thymic Carcinoma	Malignant Thymoma Thymoma, Malignant
Transitional Papilloma	Transitional Cell Papilloma Transitional Cell Papilloma, Benign
Ovarian Brenner Tumor	Benign Ovarian Brenner Tumor Brenner Tumor Benign Ovarian Brenner Tumour Ovarian Brenner Tumour Brenner Tumor Of Ovary Benign Brenner Tumor
Mucoepidermoid Carcinoma	Mec Salivary Gland Mucoepidermoid Carcinoma C3772 Carcinoma Mucoepidermoid Carcinoma, Mucoepidermoid
Vulva Cancer	Vulvar Carcinoma Malignant Neoplasm Of Vulva Vulva Carcinoma Carcinoma Of Vulva Vulvar Cancer Vulval Cancer Vulvar Neoplasms Ca Vulva Malignant Tumor Of Vulva Malignant Vulvar Tumor Neoplasm Of Vulva Vulval Neoplasm Vulvar Neoplasm Vulvar Tumor Cancer Of Vulva Malignant Tumour Of Vulva
Keratitis, Hereditary	Keratitis Autosomal Dominant Keratitis Hereditary Keratitis Dominantly Inherited Keratitis Keratitis Hereditary KERH
Squamous Cell Carcinoma	Epidermoid Carcinoma Squamous Cell Cancer Carcinoma, Squamous Cell Squamous Cell Skin Cancer Malignant Squamous Cell Tumor Squamous Carcinoma Squamous Cell Epithelioma Carcinoma Squamous Cell Neoplasms, Squamous Cell Squamous Cell Carcinoma - Category Malignant Squamous Cell Neoplasm Squamous Cell Carcinoma Of Skin
Pigmented Basal Cell Carcinoma	Skin Pigmented Basal Cell Carcinoma
Skin Benign Neoplasm	Neoplasm Of Skin By Site Tumor Of The Skin Skin Tumor Benign Neoplasm Of Skin Skin Neoplasms
Lip And Oral Cavity Cancer	Oral Cancer Lip And Oral Cavity Carcinoma Malignant Neoplasm Of Mouth
Cicatricial Pemphigoid	Mucous Membrane Pemphigoid Ocular Pemphigoid Benign Mucous Membrane Pemphigoid Benign Mucous Membrane Pemphigoid With Ocular Involvement Benign Mucosal Pemphigoid Pemphigoid, Benign Mucous Membrane Cicatricial Pemphigoid With Ocular Involvement Ocular Pemphigus Cicatricial Pemphigoid Disease Mucosal Pemphigoid Mucosynechial Pemphigoid Pemphigoid Cicatricial Cicatricial Pemphigoid Involving The Eye Ocular Cicatricial Pemphigoid
Cortical Thymoma	Polygonal Cell Thymoma Thymoma, Cortical Thymoma, Type B2
Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip/Palate Syndrome 1	Eec Syndrome Rudiger Syndrome 1 Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip-Palate Syndrome 1 EEC1 Eec Syndrome 1 Eec Syndrome-1 Walker-Clodius Syndrome Ectrodactyly-Ectodermal Dysplasia-Cleft Lip/Palate Syndrome Eec Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip-Palate Syndrome Ectrodactyly-Ectodermal Dysplasia-Clefting Syndrome Ectrodactyly-Cleft Lip/Palate Syndrome Ectrodactyly-Ectodermal Dysplasia-Cleft Lip/Cleft Palate Ectrodactyly-Ectodermal Dysplasia-Clefting Syndrome Ectrodactyly, Ectodermal Dysplasia, Clefting Syndrome Ectrodactyly-Cleft Lip-Palate Syndrome Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip/Palate Syndrome
Bladder Exstrophy-Epispadias-Cloacal Exstrophy Complex	Exstrophy-Epispadias Complex Bladder Exstrophy-Epispadias-Cloacal Extrophy Complex Beec Eec Exstrophy Of The Bladder Bladder Exstrophy Bladder Exstrophy And Epispadias Complex
Cystic Fibrosis	Mucoviscidosis CF Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis Cystic Fibrosis Lung Disease, Modifier Of Cystic Fibrosis Of Pancreas Fibrocystic Disease Of Pancreas Cf - [Cystic Fibrosis] Cystic Fibrosis Nos Fibrocystic Disease Fibrocystic Disease Of The Pancreas Mucoviscidosis Of Pancreas Nonproliferative Fibrocystic Disease Pancreatic Cystic Fibrosis
Sarcoma, Synovial	Synovial Sarcoma Synovialosarcoma Synovial Cell Sarcoma Sarcoma Synovial
Bladder Exstrophy	Exstrophy Of The Bladder Classic Exstrophy Of The Bladder
Severe Cutaneous Adverse Reaction	Stevens-Johnson Syndrome Toxic Epidermal Necrolysis Drug-Induced Stevens Johnson Syndrome Stevens-Johnson Syndrome Toxic Epidermal Necrolysis Spectrum Susceptibility To Severe Cutaneous Adverse Reaction Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis Lyell'S Syndrome Lyell Syndrome Severe Cutaneous Adverse Reaction, Susceptibility To Hypersensitivity Syndrome, Carbamazepine-Induced, Susceptibility To Hypersensitivity Syndrome, Carbamazepine-Induced Stevens-Johnson Syndrome, Susceptibility To Toxic Epidermal Necrolysis, Susceptibility To Sjs/Ten Susceptibility To Severe Cutaneous Adverse Reaction Ity To Mycoplasma-Induced Stevens Johnson Syndrome Dermatostomatitis, Stevens Johnson Type Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis Spectrum Sjs-Ten Toxic Epidermolysis SJS Dermatostomatitis Stevens Johnson Type Ten Sjs/Ten - [Stevens-Johnson Syndrome And Toxic Epidermal Necrolysis] Ten - [Toxic Epidermal Necrolysis]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07436	KRT13 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	KRT13	MGD	MGI:101925
Canis familiaris	KRT13	VGNC	VGNC:55619
Rattus norvegicus	KRT13	RGD	RGD:1302937
Others	KRT13	NCBI