KRT74 - keratin 74 Gene

Also Known as ADWH; ECTD7; HTSS2; HYPT3; KRT5C; K6IRS4; KRT6IRS4

Species: Homo sapiens (human)

Gene Type: protein coding
Gene ID: 121391

Summary

Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. This protein belongs to a family of keratins that are specifically expressed in the inner root sheath of hair follicles.[provided by RefSeq, Jun 2009]

KRT74 Products (1)

mRNA Protein Name
NM_175053.4 NP_778223.2 keratin, type II cytoskeletal 74

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables keratin filament binding IPI
IPI: Inferred from physical interaction
20346438 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence References Source
involved in intermediate filament cytoskeleton organization IDA
IDA: Inferred from direct assay
20346438 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
20346438 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

keratin, type II cytoskeletal 74

  • CK-74

  • K5C

  • K74

  • cytokeratin-74

  • keratin 5c

  • keratin 6 irs4

  • keratin 74, type II

  • type II inner root sheath-specific keratin-K6irs4

  • type-II keratin Kb37

KRT74 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
KRT74 Q7RTS7 KRT37 Homo sapiens O76014
Y2H Prey Pooling
32296183
Intra
KRT74 Q7RTS7 KRT37 Homo sapiens O76014
MAPPIT
32296183
Intra
KRT74 Q7RTS7 KRT37 Homo sapiens O76014
Y2H Array
32296183
Intra
KRT74 Q7RTS7 KRT34 Homo sapiens O76011
Y2H Array
32296183
Intra
KRT74 Q7RTS7 KRT34 Homo sapiens O76011
Y2H Prey Pooling
32296183
Intra
KRT74 Q7RTS7 KRT38 Homo sapiens O76015
Y2H Prey Pooling
32296183
Intra
KRT74 Q7RTS7 KRT38 Homo sapiens O76015
Y2H Array
32296183
Intra
KRT74 Q7RTS7 KRT35 Homo sapiens Q92764
Validated Y2H
32296183
Intra
KRT74 Q7RTS7 KRT35 Homo sapiens Q92764
Y2H Prey Pooling
32296183
Intra
KRT74 Q7RTS7 KRT35 Homo sapiens Q92764
Y2H Array
32296183
Intra
KRT74 Q7RTS7 KRT39 Homo sapiens Q6A163
Y2H Prey Pooling
32296183
Intra
KRT74 Q7RTS7 KRT39 Homo sapiens Q6A163
Y2H Array
32296183
Intra
KRT74 Q7RTS7 KRT25 Homo sapiens Q7Z3Z0
Y2H Array
32296183
Intra
KRT74 Q7RTS7 KRT25 Homo sapiens Q7Z3Z0
Y2H Prey Pooling
32296183
Intra
KRT74 Q7RTS7 KRT25 Homo sapiens Q7Z3Z0
Validated Y2H
32296183
Intra
KRT74 Q7RTS7 KRT26 Homo sapiens Q7Z3Y9
Y2H Prey Pooling
32296183
Intra
KRT74 Q7RTS7 KRT26 Homo sapiens Q7Z3Y9
Validated Y2H
32296183
Intra
KRT74 Q7RTS7 KRT26 Homo sapiens Q7Z3Y9
Y2H Array
32296183
Intra
KRT74 Q7RTS7 KRT13 Homo sapiens P13646
Y2H Array
32296183
Intra
KRT74 Q7RTS7 KRT13 Homo sapiens P13646
Y2H Prey Pooling
32296183
Intra
KRT74 Q7RTS7 KRT27 Homo sapiens Q7Z3Y8
Y2H Array
32296183
Intra
KRT74 Q7RTS7 KRT27 Homo sapiens Q7Z3Y8
Y2H Prey Pooling
32296183
Intra
KRT74 Q7RTS7 KRT27 Homo sapiens Q7Z3Y8
Validated Y2H
32296183
Intra
KRT74 Q7RTS7 KRT16 Homo sapiens P08779
Y2H Prey Pooling
32296183
Intra
KRT74 Q7RTS7 KRT16 Homo sapiens P08779
Y2H Array
32296183
Intra
KRT74 Q7RTS7 KRT15 Homo sapiens P19012
Y2H Prey Pooling
32296183
Intra
KRT74 Q7RTS7 KRT15 Homo sapiens P19012
Y2H Array
32296183
Intra
KRT74 Q7RTS7 KRT19 Homo sapiens P08727
Y2H Prey Pooling
32296183
Intra
KRT74 Q7RTS7 KRT19 Homo sapiens P08727
Y2H Array
32296183
Intra
KRT74 Q7RTS7 KRT31 Homo sapiens Q15323
Y2H Prey Pooling
32296183
Intra
KRT74 Q7RTS7 KRT31 Homo sapiens Q15323
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction