KRT16 - keratin 16 Gene

Also Known as K16; PC1; CK16; K1CP; NEPPK; FNEPPK; KRT16A

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3868

About KRT16

Cytogenetic location: 17q21.2 Genomic coordinates (GRCh38): 17:41,609,778-41,612,767 (from NCBI)

This gene has 4 transcripts (splice variants), 85 orthologues, 68 paralogues and is associated with 7 phenotypes. Biased expression in skin (RPKM 209.9) and esophagus (RPKM 198.8).

Summary

The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains and are clustered in a region of chromosome 17q12-q21. This keratin has been coexpressed with keratin 14 in a number of epithelial tissues, including esophagus, tongue, and hair follicles. Mutations in this gene are associated with type 1 pachyonychia congenita, non-epidermolytic palmoplantar keratoderma and unilateral palmoplantar verrucous nevus. [provided by RefSeq, Jul 2008]

KRT16 Products (1)

mRNA	Protein	Name
NM_005557.4	NP_005548.2	keratin, type I cytoskeletal 16

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15731013	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in hair cycle	IDA IDA: Inferred from direct assay	21916889	GOA
involved in negative regulation of cell migration	IDA IDA: Inferred from direct assay	20403371	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoskeleton	IDA IDA: Inferred from direct assay	20403371	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KRT16 Protein Structure

Filament

0
100
200
300
400
473 a.a.

Protein Preferred Names	Protein Names
keratin, type I cytoskeletal 16	cytokeratin 16

KRT16 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	KRT16	P08779	CCHCR1	Homo sapiens	Q8TD31-3	Validated Y2H	32296183
Intra	KRT16	P08779	GNG10	Homo sapiens	P50151	Validated Y2H	32296183
Intra	KRT16	P08779	KRT83	Homo sapiens	P78385	Validated Y2H	32296183
Intra	KRT16	P08779	SEMA4C	Homo sapiens	Q9C0C4	Validated Y2H	32296183
Intra	KRT16	P08779	POLL	Homo sapiens	Q9UGP5-2	Validated Y2H	32296183
Intra	KRT16	P08779	KRT85	Homo sapiens	P78386	Validated Y2H	32296183
Intra	KRT16	P08779	KRT78	Homo sapiens	Q8N1N4	Validated Y2H	32296183
Intra	KRT16	P08779	CCDC146	Homo sapiens	Q8IYE0	Validated Y2H	32296183
Intra	KRT16	P08779	CYTH4	Homo sapiens	Q9UIA0	Validated Y2H	32296183
Intra	KRT16	P08779	CARD9	Homo sapiens	Q9H257-2	Validated Y2H	32296183
Intra	KRT16	P08779	PUS10	Homo sapiens	Q3MIT2	Validated Y2H	32296183
Intra	KRT16	P08779	KRT80	Homo sapiens	Q6KB66-2	Validated Y2H	32296183
Intra	KRT16	P08779	KRT73	Homo sapiens	Q86Y46-2	Validated Y2H	32296183
Intra	KRT16	P08779	CCDC17	Homo sapiens	Q96LX7-5	Validated Y2H	32296183
Intra	KRT16	P08779	KRT72	Homo sapiens	Q14CN4	Validated Y2H	32296183
Intra	KRT16	P08779	KRT2	Homo sapiens	P35908	Validated Y2H	32296183
Intra	KRT16	P08779	PRKAA2	Homo sapiens	P54646	Validated Y2H	32296183
Intra	KRT16	P08779	KIFC3	Homo sapiens	Q9BVG8-5	Validated Y2H	32296183
Intra	KRT16	P08779	KRT4	Homo sapiens	P19013	Validated Y2H	32296183
Intra	KRT16	P08779	KRT3	Homo sapiens	P12035	Validated Y2H	32296183
Intra	KRT16	P08779	KRT79	Homo sapiens	Q5XKE5	Validated Y2H	32296183
Intra	KRT16	P08779	PPP1R18	Homo sapiens	Q6NYC8	Validated Y2H	32296183
Intra	KRT16	P08779	KRT6C	Homo sapiens	P48668	Validated Y2H	32296183
Intra	KRT16	P08779	KRT71	Homo sapiens	Q3SY84	Validated Y2H	32296183
Intra	KRT16	P08779	KRT76	Homo sapiens	Q01546	Validated Y2H	32296183
Intra	KRT16	P08779	TSG101	Homo sapiens	Q99816	Validated Y2H	32296183
Intra	KRT16	P08779	SMARCD1	Homo sapiens	Q96GM5	Y2H Prey Pooling	32296183
Intra	KRT16	P08779	SMARCD1	Homo sapiens	Q96GM5	Validated Y2H	32296183
Intra	KRT16	P08779	CCNC	Homo sapiens	P24863	Validated Y2H	32296183
Intra	KRT16	P08779	SMARCE1	Homo sapiens	Q969G3	Validated Y2H	32296183
Intra	KRT16	P08779	PKN1	Homo sapiens	Q16512	Validated Y2H	32296183
Intra	KRT16	P08779	TXLNB	Homo sapiens	Q8N3L3	Validated Y2H	32296183
Intra	KRT16	P08779	EPM2AIP1	Homo sapiens	Q7L775	Validated Y2H	32296183
Intra	KRT16	P08779	ARFIP2	Homo sapiens	P53365	Validated Y2H	32296183
Intra	KRT16	P08779	KRT5	Homo sapiens	P13647	Validated Y2H	32296183
Intra	KRT16	P08779	KRT81	Homo sapiens	Q14533	Validated Y2H	32296183
Intra	KRT16	P08779	LNX1	Homo sapiens	Q8TBB1	Validated Y2H	32296183
Intra	KRT16	P08779	USHBP1	Homo sapiens	Q8N6Y0	Validated Y2H	32296183
Intra	KRT16	P08779	TCHP	Homo sapiens	Q9BT92	Validated Y2H	32296183
Intra	KRT16	P08779	SGF29	Homo sapiens	Q96ES7	Validated Y2H	32296183
Intra	KRT16	P08779	SGF29	Homo sapiens	Q96ES7	Anti Tag CoIP	33961781
Intra	KRT16	P08779	CDK18	Homo sapiens	Q07002	Validated Y2H	32296183
Intra	KRT16	P08779	C1orf216	Homo sapiens	Q8TAB5	Validated Y2H	32296183
Intra	KRT16	P08779	PRPH	Homo sapiens	P41219	Validated Y2H	32296183
Intra	KRT16	P08779	LMO1	Homo sapiens	P25800	Validated Y2H	32296183
Intra	KRT16	P08779	AIRIM	Homo sapiens	Q9NX04	Validated Y2H	32296183
Intra	KRT16	P08779	TTC23	Homo sapiens	Q5W5X9-3	Validated Y2H	32296183
Intra	KRT16	P08779	KLC4	Homo sapiens	Q9NSK0	Validated Y2H	32296183
Intra	KRT16	P08779	KRT74	Homo sapiens	Q7RTS7	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

KRT16 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81266	Cytokeratin 16 Antibody (YA948)	WB, IHC-P	Human, Mouse, Rat
HY-P81266A	Cytokeratin 16 Antibody (YA949)	WB, IHC-P	Human
HY-P81266AA	Cytokeratin 16 Antibody (YA949)(PBS only)	WB, IHC-P	Human
HY-P85902	Cytokeratin 16 Antibody (YA5594)	IHC-P, WB, ICC/IF, ELISA	Human
HY-P85938	Cytokeratin Antibody (YA5630)	IHC-P, WB, ICC/IF, ELISA	Human, Mouse, Rat
HY-P86026	Cytokeratin Antibody (YA5718)	IHC-P, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Pachyonychia Congenita 1	Pachyonychia Congenita Jadassohn-Lewandowsky Syndrome Pachyonychia Congenita Syndrome PC1 Pachyonychia Congenita, Jadassohn-Lewandowsky Type Congenital Pachyonychia Pachyonychia Congenita, Type 1 Pachyonychia Congenita, Jadassohn-Lewandowsky Type, Formerly Jadassohn-Lewandowsky Syndrome, Formerly Jackson-Lawler Type Pachyonychia Congenita Pachyonychia Congenita Type 1 Jackson-Lawler Syndrome Jadassohn-Lewandowski Syndrome Pc Pachyonychia Congenita Jackson-Lawler Type Pachyonychia Congenita Jadassohn-Lewandowsky Type Pachyonychia Congenita Jackson Lawler Type Pc-1 Pachyonychia Congenita, Jadassohn Lewandowsky Type Pachyonychia Congenita, Type 2
Palmoplantar Keratoderma, Nonepidermolytic, Focal 1	Focal Nonepidermolytic Palmoplantar Keratoderma Isolated Focal Non-Epidermolytic Palmoplantar Keratoderma FNEPPK1 Ppkfne Keratoderma, Focal Nonepidermolytic Palmoplantar Palmoplantar Keratoderma, Nonepidermolytic, Focal Hyperkeratosis Of The Palms And Soles And Esophageal Papillomas Fneppk Focal Nonepidermolytic Palmoplantar Keratoderma 1 Keratoderma, Palmoplantar, Non-Epidermolytic, Focal 1 Keratoderma, Palmoplantar, Nonepidermolytic, Focal, Type 1
Palmoplantar Keratoderma, Epidermolytic	Epidermolytic Palmoplantar Keratoderma EPPK Keratosis Palmaris Et Plantaris Familiaris Tylosis Keratosis Of Greither Diffuse Nonepidermolytic Palmoplantar Keratoderma Keratoderma, Palmoplantar, Epidermolytic Unna-Thost Palmoplantar Keratoderma Epidermolytic Palmoplantar Keratoderma Of Voerner Ppke Keratoderma, Epidermolytic Palmoplantar Palmoplantar Keratoderma, Vorner Type Hyperkeratosis, Localized Epidermolytic Diffuse Erythrodermic Palmoplantar Keratoderma, Vörner Type Epidermolytic Palmoplantar Keratoderma Of Vörner Hyperkeratosis Palmoplantar Localized Epidermolytic Diffuse Neppk Ppk Diffusa Circumscripta Thost-Unna Disease Thost-Unna Palmoplantar Keratoderma Diffuse Erythrodermic Palmoplantar Keratoderma, Voerner Type Diffuse Erythrodermic Palmoplantar Keratoderma, Vorner Type Epidermolytic Palmoplantar Keratoderma Of Vorner Ehppk Epidermolytic Unna-Thost Disease Localized Epidermolytic Hyperkeratosis Palmoplantar Keratoderma Vorner Type Unilateral Palmoplantar Verrucous Nevus UPVN Keratoderma, Palmoplantar, Diffuse Hyperkeratosis Palmoplantar Keratoderma, Nonepidermolytic Epidermolytic Palmoplantar Keratoderma Vorner Type Type B Tylosis Hyperkeratosis Of The Palms And Soles And Esophageal Papillomas Type A Tylosis
Contact Dermatitis	Contact Dermatitis/Eczema Contact Eczema Dermatitis Venenata Dermatitis, Venenata Dermatitis Contact Dermatitis, Contact
Bowen'S Disease	Bowens Disease
Palmoplantar Keratoderma, Nonepidermolytic	Nonepidermolytic Palmoplantar Keratoderma NEPPK Tylosis Unna-Thost Syndrome Keratoderma, Palmoplantar, Diffuse Ppkne Keratoderma, Nonepidermolytic Palmoplantar Diffuse Nonepidermolytic Palmomplantar Keratoderma Thost-Unna Syndrome Non-Epidermolytic Palmoplantar Keratoderma Autosomal Dominant Diffuse Palmoplantar Keratoderma, Norrbotten Type Diffuse Palmoplantar Keratoderma, Bothnian Type Krt1-Related Diffuse Nonepidermolytic Keratoderma Krt1-Related Diffuse Neppk Keratoderma, Palmoplantar, Non-Epidermolytic Nonepidermolytic Unna-Thost Disease Non-Epidermolytic Unna-Thost Disease Keratoderma, Palmoplantar, Nonepidermolytic Hyperkeratosis
Steatocystoma Multiplex	Sebocystomatosis Multiple Sebaceous Cysts Multiplex Steatocystoma Sebaceous Cysts, Multiple SM
Epidermolytic Hyperkeratosis	Bullous Congenital Ichthyosiform Erythroderma Bullous Ichthyosiform Erythroderma EHK Bullous Erythroderma Ichthyosiformis Congenita Of Brocq Bcie Bie Epidermolytic Ichthyosis Ichthyosis Bullosa Of Siemens Superficial Epidermolytic Ichthyosis Hyperkeratosis, Epidermolytic Congenital Bullous Ichthyosiform Erythroderma Bullous Type Ichthyosis Epidermolytic Palmoplantar Hyperkeratosis Bullous Ichthyosiform Erythroderma Congenita Bullous Erythroderma Ichthyosiforme Sei Epidermolytic Hyperkeratosis Late-Onset Epidermolytic Hyperkeratosis, Late-Onset
Pachyonychia Congenita 2	Pachyonychia Congenita, Type 2 PC2 Pachyonychia Congenita, Jackson-Lawler Type, Formerly Pachyonychia Congenita Jackson-Lawler Type
Palmoplantar Keratosis	Palmoplantar Keratoderma Keratosis Palmaris Et Plantaris Palmo-Plantar Keratodermas Keratoderma, Palmoplantar Keratoderma Palmoplantar Keratoderma, Palmoplantar, Diffuse Hyperkeratosis Of Palms And Soles Palmoplantar Hyperkeratosis
Hypertrophic Scars	Scars Hypertrophic Hypertrophic Scarring
Psoriasis
Monilethrix	Beaded Hair MNLIX Nodose Hair Moniliform Hair Syndrome
Cholesteatoma Of Middle Ear	Cholesteatoma Epidermosis Of Ear Epidermosis Of Middle Ear Middle Ear Cholesteatoma Cholesteatoma Of Middle Ear And Mastoid Cholesteatoma Of Middle Ear And/Or Mastoid Cholesteatoma Of The Middle Ear Congenital Cholesteatoma Primary Acquired Cholesteatoma Secondary Acquired Cholesteatoma Cholesteatoma Middle Ear Cholesteatoma, Middle Ear Cholesterolosis Of Middle Ear Cholesterosis Of Ear Cholesterosis Of Middle Ear Cholesteatoma Nos Epidermoid Cholesteatoma Middle Ear Granuloma
Focal Palmoplantar Keratoderma	Focal Ppk Focal Keratosis Palmoplantaris Focal Palmoplantar Hyperkeratosis
Keratosis	Actinic Keratosis Hyperkeratosis
Epidermolysis Bullosa Simplex	Ebs Epidermolysis Bullosa Intraepidermic Epidermolytic Epidermolysis Bullosa
Lichen Planus	Lichen Ruber Planus Lichen, Ruber Planus Ruber Planus Lp - [Lichen Planus] Lichen Planus Of Wilson Wilson Lichen Ruber
Ichthyosis	Ichthyoses Non-Syndromic Ichthyosis Congenital Ichthyosis
Epidermolysis Bullosa	Acantholysis Bullosa Eb
Basal Cell Carcinoma	Basal Cell Cancer Basal Cell Neoplasm Basal Cell Carcinoma Of Skin Malignant Basal Cell Tumor Basal Cell Tumor Epithelioma Basal Cell Malignant Basal Cell Neoplasm Rodent Ulcer Carcinoma Basal Cell Neoplasms, Basal Cell Basal Cell Carcinomas Experimental Organism Basal Cell Carcinoma Nodulo-Ulcerative Basal Cell Carcinoma Basalioma Basal Cell Epithelioma Of Skin Bcc - [Basal Cell Carcinoma] Of Skin Rodent Ulcer Of Skin Rodent Ulcer Of Unspecified Site Basal Cell Epithelioma Of Unspecified Site
Palmoplantar Keratoderma, Nonepidermolytic, Focal Or Diffuse	PPKNEFD Focal Or Diffuse Nonepidermolytic Palmoplantar Keratoderma Autosomal Dominant Focal Non-Epidermolytic Palmoplantar Keratoderma With Plantar Blistering Palmoplantar Keratoderma, Non-Epidermolytic, Focal Or Diffuse Nonepidermolytic Focal Or Diffuse Palmoplantar Keratoderma Keratoderma, Palmoplantar, Nonepidermolytic, Focal Or Diffuse
Keratoacanthoma	Ka - [Keratoacanthoma] Well-Differentiated Squamous Cell Carcinoma
Glossitis	Inflammation Of Tongue Tongue Inflammation Glazed Tongue
Dermatitis	Eczema Skin Inflammation Inflammatory Dermatosis
Skin Disease	Skin Diseases Genodermatosis Abnormality Of The Skin Skin Diseases, Genetic Skin And Subcutaneous Tissue Disease Dermatologic Disorders
Ectodermal Dysplasia	Congenital Ectodermal Defect Congenital Ectodermal Dysplasia Ectodermal Dysplasia Syndrome Dysplasia, Ectodermal
Alopecia Areata	Aa Alopecia Celsi Alopecia Circumscripta Cazenave'S Vitiligo Celsus' Vitiligo Diffuse Alopecia Jonston'S Alopecia Marginal Alopecia Pseudopelade Circumscribed Alopecia Alopecia Cicatrisata Patchy Alopecia Alopecia Aa - [Alopecia Areata] Pelade
Corneal Dystrophy
Irritant Dermatitis	Irritant Contact Dermatitis Primary Irritant Dermatitis Dermatitis, Irritant Contact Dermatitis, Irritant Irritant Contact Eczema Icd - [Irritant Contact Dermatitis] Irritant Contact Dermatitis, Unspecified Cause Non-Allergic Contact Dermatitis Irritant Contact Eczema Due To Wet Work Irritant Contact Dermatitis Due To Detergents Irritant Contact Eczema Due To Solvents Irritant Contact Eczema Due To Exposure To Acids, Alkalis Or Other Chemical Irritants Irritant Contact Eczema Due To Cosmetics Or Emollients Irritant Contact Eczema Due To Topical Medicaments Or Antimicrobials Irritant Contact Eczema Due To Plants Or Other Vegetable Matter Irritant Contact Eczema Due To Foods Irritant Contact Eczema Due To Friction, Sweating Or Contact With Body Fluids Irritant Contact Eczema Due To Saliva Irritant Contact Eczema Due To Incontinence Incontinence-Associated Dermatitis
Epidermolysis Bullosa Simplex Localized Type	Epidermolysis Bullosa Simplex, Weber-Cockayne Type Weber-Cockayne Syndrome Ebs-Loc Epidermolysis Bullosa Simplex Of Palms And Soles Epidermolysis Bullosa Simplex Weber-Cockayne Type Epidermolysis Bullosa Simplex, Localized Epidermolysis Bullosa Of Hands And Feet Weber-Cockayne Type Epidermolysis Bullosa Simplex Localized Epidermolysis Bullosa Simplex Localized Ebs
Autoimmune Disease Of Skin And Connective Tissue
Porokeratosis	Disseminated Superficial Actinic Porokeratosis Dsap Porokeratosis Of Mibelli Porokeratosis, Disseminated Superficial Actinic Porokeratosis, Disseminated Superficial Actinic, 1
Autosomal Recessive Congenital Ichthyosis	Lamellar Ichthyosis Congenital Ichthyosiform Erythroderma Li Congenital Nonbullous Ichthyosiform Erythroderma Arci Congenital Lamellar Ichthyosis Nonbullous Congenital Ichthyosiform Erythroderma Cie Congenital Non-Bullous Ichthyosiform Erythroderma Erythrodermic Ichthyosis Nbcie Ncie Non-Bullous Congenital Ichthyosiform Erythroderma Collodion Baby Ichthyosis, Lamellar Non Bullous Congenital Ichthyosiform Erythroderma Ichthyosiform Erythroderma, Brocq Congenital, Nonbullous Form Ichthyosiform Erythroderma, Congenital, Nonbullous, 1 Collodion Baby Syndrome Ichthyoses, Lamellar Nbie Nonbullous Ichthyosiform Erythroderma Classic Lamellar Ichthyosis Ichthyosiform Erythroderma Nonbullous Congenital Ichthyosiform Erythroderma Congenital Ichthyosis, Congenital, Autosomal Recessive Ichthyosiform Erythroderma, Congenital Collodion Fetus Non-Bullous Ichthyosiform Erythroderma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07439	KRT16 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	KRT16	MGD	MGI:96690
Rattus norvegicus	KRT16	RGD	RGD:1590901
Macaca mulatta	KRT16	VGNC	VGNC:74210
Others	KRT16	NCBI