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KLC4 - kinesin light chain 4 Gene

Also Known as KNSL8; bA387M24.3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 89953

About KLC4

This gene has 19 transcripts (splice variants), 381 orthologues and 5 paralogues. Ubiquitous expression in duodenum (RPKM 24.3), small intestine (RPKM 22.1) and 25 other tissues.

Summary

Predicted to be located in cytoplasm and microtubule. Predicted to be part of Kinesin complex. [provided by Alliance of Genome Resources, Apr 2022]

KLC4 Products (6)

mRNA	Protein	Name
NM_001289034.2	NP_001275963.1	kinesin light chain 4 isoform a
NM_001289035.2	NP_001275964.1	kinesin light chain 4 isoform d
NM_138343.4	NP_612352.1	kinesin light chain 4 isoform c
NM_201521.3	NP_958929.1	kinesin light chain 4 isoform a
NM_201522.3	NP_958930.1	kinesin light chain 4 isoform a
NM_201523.3	NP_958931.1	kinesin light chain 4 isoform b

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KLC4 Protein Structure

Rab5-bind

TPR_2

TPR_12

TPR_10

0
100
200
300
400
500
619 a.a.

Protein Preferred Names	Protein Names
kinesin light chain 4	kinesin-like protein 8

KLC4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	KLC4	Q9NSK0	NECAB2	Homo sapiens	Q7Z6G3-2	Y2H Prey Pooling	25416956
Intra	KLC4	Q9NSK0	NECAB2	Homo sapiens	Q7Z6G3-2	Y2H Prey Pooling	32296183
Intra	KLC4	Q9NSK0	NECAB2	Homo sapiens	Q7Z6G3-2	Y2H Array	32296183
Intra	KLC4	Q9NSK0	CEP57L1	Homo sapiens	Q8IYX8-2	Y2H Prey Pooling	25416956
Intra	KLC4	Q9NSK0	SLC16A9	Homo sapiens	Q7RTY1	Y2H Prey Pooling	25416956
Intra	KLC4	Q9NSK0	ZNF343	Homo sapiens	Q6P1L6	Y2H Prey Pooling	32296183
Intra	KLC4	Q9NSK0	ZNF343	Homo sapiens	Q6P1L6	Y2H Array	32296183
Intra	KLC4	Q9NSK0	KRT34	Homo sapiens	O76011	Y2H Prey Pooling	32296183
Intra	KLC4	Q9NSK0	KRT34	Homo sapiens	O76011	Y2H Array	32296183
Intra	KLC4	Q9NSK0	KRT33B	Homo sapiens	Q14525	Y2H Array	32296183
Intra	KLC4	Q9NSK0	KRT33B	Homo sapiens	Q14525	Y2H Prey Pooling	32296183
Intra	KLC4	Q9NSK0	CEP57	Homo sapiens	Q86XR8-3	Y2H Prey Pooling	32296183
Intra	KLC4	Q9NSK0	CEP57	Homo sapiens	Q86XR8-3	Y2H Array	32296183
Intra	KLC4	Q9NSK0	KRT16	Homo sapiens	P08779	Y2H Prey Pooling	32296183
Intra	KLC4	Q9NSK0	KRT16	Homo sapiens	P08779	Y2H Array	32296183
Intra	KLC4	Q9NSK0	YWHAE	Homo sapiens	P62258	Crosslink	36931259
Intra	KLC4	Q9NSK0	SYNE4	Homo sapiens	Q8N205	Y2H Array	25416956
Intra	KLC4	Q9NSK0	SYNE4	Homo sapiens	Q8N205	Y2H Prey Pooling	25416956
Intra	KLC4	Q9NSK0	SYNE4	Homo sapiens	Q8N205	Validated Y2H	25416956
Intra	KLC4	Q9NSK0	KRT15	Homo sapiens	P19012	Validated Y2H	25416956
Intra	KLC4	Q9NSK0	KRT15	Homo sapiens	P19012	Y2H Prey Pooling	25416956
Intra	KLC4	Q9NSK0	USHBP1	Homo sapiens	Q8N6Y0	Y2H Array	25416956
Intra	KLC4	Q9NSK0	TADA2A	Homo sapiens	O75478	Validated Y2H	25416956
Intra	KLC4	Q9NSK0	TADA2A	Homo sapiens	O75478	Y2H Prey Pooling	25416956
Intra	KLC4	Q9NSK0	KATNAL1	Homo sapiens	Q9BW62	Y2H Prey Pooling	25416956
Intra	KLC4	Q9NSK0	KATNAL1	Homo sapiens	Q9BW62	Validated Y2H	25416956
Intra	KLC4	Q9NSK0	KATNAL1	Homo sapiens	Q9BW62	Y2H Prey Pooling	32296183
Intra	KLC4	Q9NSK0	KATNAL1	Homo sapiens	Q9BW62	Y2H Array	32296183
Intra	KLC4	Q9NSK0	MEOX2	Homo sapiens	P50222	Y2H Array	25416956
Intra	KLC4	Q9NSK0	MEOX2	Homo sapiens	P50222	Y2H Prey Pooling	25416956
Intra	KLC4	Q9NSK0	SERTAD1	Homo sapiens	Q9UHV2	Validated Y2H	32296183
Intra	KLC4	Q9NSK0	SERTAD1	Homo sapiens	Q9UHV2	Y2H Prey Pooling	32296183
Intra	KLC4	Q9NSK0	SERTAD1	Homo sapiens	Q9UHV2	Y2H Array	32296183
Intra	KLC4	Q9NSK0	KRT31	Homo sapiens	Q15323	Y2H Prey Pooling	32296183
Intra	KLC4	Q9NSK0	KRT31	Homo sapiens	Q15323	Y2H Array	25416956
Intra	KLC4	Q9NSK0	KRT31	Homo sapiens	Q15323	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Hereditary Spastic Paraplegia	Familial Spastic Paraplegia Hereditary Spastic Paraparesis Strumpell-Lorrain Disease Familial Spastic Paraparesis Hsp Spg Strümpell-Lorrain Disease Spastic Paraplegia, Hereditary French Settlement Disease Strumpell-Lorrain Syndrome Fsp Spastic Paraplegia, Familial Spastic Paraplegia Hereditary Spastic Paraplegia 3, Autosomal Dominant Spastic Paraparesis Hereditary Spastic Paralysis Familial Spastic Paralysis Hereditary Spastic Ataxia
Spastic Paraplegia, Optic Atrophy, And Neuropathy	Spoan Syndrome SPOAN Spastic Paraplegia, Optic Atropy, And Neuropathy Spastic Paraplegia, Optic Atropy, And Neuropathy Syndrome Spastic Paraplegia-Optic Atrophy-Neuropathy Syndrome
Ehlers-Danlos Syndrome, Vascular Type	Eds Iv Eds4 Vascular Ehlers-Danlos Syndrome Veds Sack-Barabas Syndrome EDSVASC Ehlers-Danlos Syndrome, Type Iv, Autosomal Dominant Vascular Type Ehlers-Danlos Syndrome Arterial-Ecchymotic Eds Ehlers-Danlos Syndrome Type 4 Vascular Eds Ehlers-Danlos Syndrome, Type 4 Ehlers-Danlos Syndrome, Type Iv Ehlers-Danlos Syndrome, Arterial Type Ehlers-Danlos Syndrome, Ecchymotic Type Ehlers-Danlos Syndrome, Sack-Barabas Type Autosomal Dominant Type Iv Ehlers-Danlos Syndrome Eds Type Iv Eds Type 4 Ehlers Danlos Syndrome, Sack-Barabas Type Ehlers Danlos Syndrome, Arterial Type Ehlers Danlos Syndrome, Ecchymotic Type Ehlers-Danlos Syndrome Type Iv Ehlers-Danlos Syndrome 4 Ehlers-Danlos Syndrome Arterial Type Ehlers-Danlos Syndrome Ecchymotic Type Ehlers-Danlos Syndrome, Type 4 Variant Ehlers-Danlos, Vascular Type Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07329	KLC4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	KLC4	VGNC	VGNC:73880
Felis catus	KLC4	VGNC	VGNC:63129
Canis familiaris	KLC4	VGNC	VGNC:42429
Rattus norvegicus	KLC4	RGD	RGD:1306555
Mus musculus	KLC4	MGD	MGI:1922014
Bos taurus	KLC4	VGNC	VGNC:30625
Others	KLC4	NCBI