KATNAL1 - katanin catalytic subunit A1 like 1 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 84056

About KATNAL1

Cytogenetic location: 13q12.3 Genomic coordinates (GRCh38): 13:30,202,630-30,307,551 (from NCBI)

This gene has 5 transcripts (splice variants), 208 orthologues and 9 paralogues. Broad expression in testis (RPKM 4.9), brain (RPKM 4.4) and 24 other tissues.

Summary

Enables identical protein binding activity and microtubule-severing ATPase activity. Involved in microtubule severing. Located in cytoplasm; microtubule; and spindle pole. [provided by Alliance of Genome Resources, Apr 2022]

KATNAL1 Products (2)

mRNA Protein Name
NM_001014380.3 NP_001014402.1 katanin p60 ATPase-containing subunit A-like 1
NM_032116.5 NP_115492.1 katanin p60 ATPase-containing subunit A-like 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
enables microtubule severing ATPase activity IDA
IDA: Inferred from direct assay
26929214 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
Biological Process GO Annotation Evidence References Source
involved in microtubule severing IDA
IDA: Inferred from direct assay
26929214 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
26929214 GOA
part of katanin complex IPI
IPI: Inferred from physical interaction
26929214 GOA
located in microtubule IDA
IDA: Inferred from direct assay
26929214 GOA
located in spindle IDA
IDA: Inferred from direct assay
26929214 GOA
located in spindle pole IDA
IDA: Inferred from direct assay
26929214 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KATNAL1 Protein Structure

AAA

AAA: ATPase family associated with various cellular activities (AAA) (244 - 380)

Vps4_C

Vps4_C: Vps4 C terminal oligomerisation domain (446 - 488)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 490 a.a.
Protein Preferred Names Protein Names

katanin p60 ATPase-containing subunit A-like 1

  • katanin catalytic subunit A like 1

KATNAL1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
KATNAL1 Q9BW62 CEP57L1 Homo sapiens Q8IYX8-2
Validated Y2H
25416956
Intra
KATNAL1 Q9BW62 CEP57L1 Homo sapiens Q8IYX8-2
Y2H Prey Pooling
25416956
Intra
KATNAL1 Q9BW62 CEP57L1 Homo sapiens Q8IYX8
Y2H Array
32296183
Intra
KATNAL1 Q9BW62 CEP57L1 Homo sapiens Q8IYX8
Y2H Prey Pooling
25416956
Intra
KATNAL1 Q9BW62 CEP57L1 Homo sapiens Q8IYX8
Y2H Prey Pooling
32296183
Intra
KATNAL1 Q9BW62 KATNB1 Homo sapiens Q9BVA0
TAP
26929214
Intra
KATNAL1 Q9BW62 KATNB1 Homo sapiens Q9BVA0
Anti Tag CoIP
26929214
Intra
KATNAL1 Q9BW62 CTNNA3 Homo sapiens Q9UI47-2
Validated Y2H
32296183
Intra
KATNAL1 Q9BW62 ZNF69 Homo sapiens Q9UC07-2
Y2H Prey Pooling
32296183
Intra
KATNAL1 Q9BW62 ZNF69 Homo sapiens Q9UC07-2
Validated Y2H
32296183
Intra
KATNAL1 Q9BW62 ZNF69 Homo sapiens Q9UC07-2
Y2H Array
32296183
Intra
KATNAL1 Q9BW62 PITPNC1 Homo sapiens Q9UKF7-2
Validated Y2H
32296183
Intra
KATNAL1 Q9BW62 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra
KATNAL1 Q9BW62 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra
KATNAL1 Q9BW62 PGAM2 Homo sapiens P15259
Y2H Array
32296183
Intra
KATNAL1 Q9BW62 PGAM2 Homo sapiens P15259
Y2H Prey Pooling
32296183
Intra
KATNAL1 Q9BW62 ASCC2 Homo sapiens Q9H1I8
Y2H Array
32296183
Intra
KATNAL1 Q9BW62 ASCC2 Homo sapiens Q9H1I8
Y2H Prey Pooling
32296183
Intra
KATNAL1 Q9BW62 ASCC2 Homo sapiens Q9H1I8
Validated Y2H
32296183
Intra
KATNAL1 Q9BW62 COX17 Homo sapiens Q14061
Validated Y2H
25416956
Intra
KATNAL1 Q9BW62 COX17 Homo sapiens Q14061
Y2H Array
25416956
Intra
KATNAL1 Q9BW62 COX17 Homo sapiens Q14061
Y2H Prey Pooling
25416956
Intra
KATNAL1 Q9BW62 KATNBL1 Homo sapiens Q9H079
Validated Y2H
32296183
Intra
KATNAL1 Q9BW62 KATNBL1 Homo sapiens Q9H079
TAP
26929214
Intra
KATNAL1 Q9BW62 KATNBL1 Homo sapiens Q9H079
Anti Tag CoIP
26929214
Intra
KATNAL1 Q9BW62 KATNBL1 Homo sapiens Q9H079
Y2H Prey Pooling
32296183
Intra
KATNAL1 Q9BW62 KATNBL1 Homo sapiens Q9H079
Y2H Array
32296183
Intra
KATNAL1 Q9BW62 KATNBL1 Homo sapiens Q9H079
Y2H Prey Pooling
25416956
Intra
KATNAL1 Q9BW62 SIAH1 Homo sapiens Q8IUQ4
Y2H Array
25416956
Intra
KATNAL1 Q9BW62 SIAH1 Homo sapiens Q8IUQ4
Y2H Prey Pooling
25416956
Intra
KATNAL1 Q9BW62 AIRIM Homo sapiens Q9NX04
Y2H Prey Pooling
25416956
Intra
KATNAL1 Q9BW62 AIRIM Homo sapiens Q9NX04
Validated Y2H
25416956
Intra
KATNAL1 Q9BW62 AIRIM Homo sapiens Q9NX04
Validated Y2H
32296183
Intra
KATNAL1 Q9BW62 KLC4 Homo sapiens Q9NSK0
Validated Y2H
32296183
Intra
KATNAL1 Q9BW62 KLC4 Homo sapiens Q9NSK0
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Joubert Syndrome 26

  • JBTS26
Gluten Allergy

  • Allergy To Gluten

  • Gluten Allergic Reaction
Microcephaly

  • Microencephaly

  • Microcephalus

  • Microcephalic

  • Nanocephaly

  • Congenital Microcephaly

  • Brain Hypoplasia

  • Brain Nondevelopment

  • Cephalic Hypoplasia

  • Undeveloped Cerebrum

  • Undeveloped Brain

  • Micrencephalon

  • Micrencephaly
Congenital Nervous System Abnormality

  • Congenital Neurologic Anomaly

  • Congenital Nervous System Disorder
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07085 KATNAL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris KATNAL1 VGNC VGNC:42217
Macaca mulatta KATNAL1 VGNC VGNC:73917
Rattus norvegicus KATNAL1 RGD RGD:1359252
Bos taurus KATNAL1 VGNC VGNC:30406
Mus musculus KATNAL1 MGD MGI:2387638
Felis catus KATNAL1 VGNC VGNC:63028
Others KATNAL1 NCBI