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KATNB1 - katanin regulatory subunit B1 Gene

Also Known as KAT; LIS6

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10300

About KATNB1

Cytogenetic location: 16q21 Genomic coordinates (GRCh38): 16:57,735,770-57,757,244 (from NCBI)

This gene has 10 transcripts (splice variants), 209 orthologues and is associated with 3 phenotypes. Broad expression in testis (RPKM 14.6), brain (RPKM 7.5) and 24 other tissues.

Summary

Microtubules, Polymers of alpha and beta tubulin subunits, form the mitotic spindle of a dividing cell and help to organize membranous organelles during interphase. Katanin is a heterodimer that consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDa accessory protein (p80 subunit B 1). The p60 subunit acts to sever and disassemble microtubules, while the p80 subunit targets the enzyme to the centrosome. Katanin is a member of the AAA family of ATPases. [provided by RefSeq, Jul 2008]

KATNB1 Products (1)

mRNA	Protein	Name
NM_005886.3	NP_005877.2	katanin p80 WD40 repeat-containing subunit B1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ATPase regulator activity	IDA IDA: Inferred from direct assay	10751153	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	24486153	GOA
enables protein heterodimerization activity	IPI IPI: Inferred from physical interaction	10751153	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of microtubule depolymerization	IMP IMP: Inferred from mutant phenotype	10751153	GOA
involved in positive regulation of microtubule depolymerization	IMP IMP: Inferred from mutant phenotype	10751153	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	10751153	GOA
part of katanin complex	IDA IDA: Inferred from direct assay	9568719	GOA
part of katanin complex	IPI IPI: Inferred from physical interaction	26929214	GOA
located in microtubule	IDA IDA: Inferred from direct assay	26929214	GOA
located in spindle	IDA IDA: Inferred from direct assay	26929214	GOA
located in spindle pole	IDA IDA: Inferred from direct assay	10751153	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KATNB1 Protein Structure

WD40

Katanin_con80

0
200
400
600
655 a.a.

Protein Preferred Names	Protein Names
katanin p80 WD40 repeat-containing subunit B1	katanin (80 kDa)

KATNB1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	KATNB1	Q9BVA0	KATNA1	Homo sapiens	O75449	Anti Tag CoIP	26929214
Intra	KATNB1	Q9BVA0	KATNA1	Homo sapiens	O75449	TAP	26929214
Intra	KATNB1	Q9BVA0	BTK	Homo sapiens	Q06187	Anti Tag CoIP	33961781
Intra	KATNB1	Q9BVA0	BTK	Homo sapiens	Q06187	Anti Tag CoIP	28514442
Intra	KATNB1	Q9BVA0	KATNAL1	Homo sapiens	Q9BW62	Anti Tag CoIP	26929214
Intra	KATNB1	Q9BVA0	KATNAL1	Homo sapiens	Q9BW62	TAP	26929214

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Lissencephaly 6 With Microcephaly	Lissencephaly 6, With Microcephaly LIS6 Lissencephaly, Type 6, With Microcephaly
Lissencephaly 2	Norman-Roberts Syndrome Lissencephaly Syndrome, Norman-Roberts Type LIS2 Lissencephaly With Cerebellar Hypoplasia Lch Lissencephaly Syndrome Norman-Roberts Type Norman Roberts Lissencephaly Syndrome Lissencephaly 3 Lis3 Microlissencephaly Type A Norman-Roberts Lissencephaly Syndrome Lissencephaly, Type 2 Cobblestone Lissencephaly
Lissencephaly 6	Lis6
Hereditary Spastic Paraplegia	Familial Spastic Paraplegia Hereditary Spastic Paraparesis Strumpell-Lorrain Disease Familial Spastic Paraparesis Hsp Spg Strümpell-Lorrain Disease Spastic Paraplegia, Hereditary French Settlement Disease Strumpell-Lorrain Syndrome Fsp Spastic Paraplegia, Familial Spastic Paraplegia Hereditary Spastic Paraplegia 3, Autosomal Dominant Spastic Paraparesis Hereditary Spastic Paralysis Familial Spastic Paralysis Hereditary Spastic Ataxia
Microlissencephaly
Acromelic Frontonasal Dysostosis	AFND Acromelic Frontonasal Dysplasia Frontonasal Dysplasia Acromelic Toriello Syndrome Dysostosis, Acromelic Frontonasal Sweet Syndrome
Lissencephaly	Pachygyria Broad Gyri Of Cerebrum Large Gyri Of Cerebrum Macrogyria
Joubert Syndrome 26	JBTS26
Polymicrogyria, Bilateral Temporooccipital	Bilateral Parasagittal Parieto-Occipital Polymicrogyria BTOP Bilateral Temporooccipital Polymicrogyria Polymicrogyria
Oligoasthenoteratozoospermia	Oat Oligoasthenoteratospermia
Microcephaly 5, Primary, Autosomal Recessive	MCPH5 Primary Autosomal Recessive Microcephaly 5 Microcephaly Primary Autosomal Recessive 5 With Simplified Gyral Pattern Microcephaly, Primary Autosomal Recessive, 5
Mannosidosis, Beta A, Lysosomal	Beta-Mannosidosis Lysosomal Beta-Mannosidase Deficiency Beta-Mannosidase Deficiency Beta-D-Mannosidosis Mannosidosis, Beta MANSB Lysosomal Beta A Mannosidosis
Band Heterotopia	Subcortical Band Heterotopia Double Cortex Syndrome Subcortical Laminar Heterotopia Double Cortex Band Heterotopia Of Brain BH Heco Heterotopic Cortex Familial Band Heterotopia Dc Dc Syndrome Heterotopia, Subcortical Band Sbh Sclh Bhy
Primary Autosomal Recessive Microcephaly	Autosomal Recessive Primary Microcephaly Mcph True Microcephaly Microcephalia Vera Microcephaly Vera Microcephaly Primary Hereditary Microcephaly, Primary, Autosomal Recessive Primary Microcephaly
Primary Microcephaly	True Microcephaly Microcephaly, Primary
Microcephaly	Microencephaly Microcephalus Microcephalic Nanocephaly Congenital Microcephaly Brain Hypoplasia Brain Nondevelopment Cephalic Hypoplasia Undeveloped Cerebrum Undeveloped Brain Micrencephalon Micrencephaly
Periventricular Nodular Heterotopia	Periventricular Heterotopia Pvnh Familial Nodular Heterotopia Heterotopia, Periventricular Periventricular Heterotopia, X-Linked
Congenital Nervous System Abnormality	Congenital Neurologic Anomaly Congenital Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07087	KATNB1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	KATNB1	RGD	RGD:1311256
Felis catus	KATNB1	VGNC	VGNC:67888
Mus musculus	KATNB1	MGD	MGI:1921437
Macaca mulatta	KATNB1	VGNC	VGNC:73962
Bos taurus	KATNB1	VGNC	VGNC:30408
Canis familiaris	KATNB1	VGNC	VGNC:54758
Others	KATNB1	NCBI