KATNA1 - katanin catalytic subunit A1 Gene
Species: Homo sapiens
Gene Type: protein coding
Gene ID: 11104
Summary
Microtubules, Polymers of Alpha and beta tubulin subunits, form the mitotic spindle of a dividing cell and help to organize membranous organelles during interphase. Katanin is a heterodimer that consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDa accessory protein (p80 subunit B 1). The p60 subunit acts to sever and disassemble microtubules, while the p80 subunit targets the enzyme to the centrosome. This gene encodes the p80 subunit. This protein is a member of the AAA family of ATPases. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Feb 2011]
Broad expression in testis (RPKM 18.8), ovary (RPKM 7.2) and 24 other tissues.
KATNA1 Products (2)
| mRNA | Protein | Name |
|---|---|---|
| NM_001204076.2 | NP_001191005.1 | katanin p60 ATPase-containing subunit A1 isoform 2 |
| NM_007044.4 | NP_008975.1 | katanin p60 ATPase-containing subunit A1 isoform 1 |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables microtubule binding |
IDA
IDA: Inferred from direct assay
|
10751153 | GOA |
| enables microtubule severing ATPase activity |
IDA
IDA: Inferred from direct assay
|
10751153 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
19261606 | GOA |
| enables protein heterodimerization activity |
IPI
IPI: Inferred from physical interaction
|
10751153 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in cytoplasmic microtubule organization |
IDA
IDA: Inferred from direct assay
|
26929214 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in cytoplasm |
IDA
IDA: Inferred from direct assay
|
19261606 | GOA |
| part of katanin complex |
IPI
IPI: Inferred from physical interaction
|
26929214 | GOA |
| located in midbody |
IDA
IDA: Inferred from direct assay
|
19261606 | GOA |
| located in mitotic spindle pole |
IDA
IDA: Inferred from direct assay
|
26929214 | GOA |
| located in spindle |
IDA
IDA: Inferred from direct assay
|
19261606 | GOA |
| located in spindle pole |
IDA
IDA: Inferred from direct assay
|
10751153 | GOA |
EXP: Inferred from Experiment
IDA: Inferred from direct assay
IPI: Inferred from physical interaction
IMP: Inferred from mutant phenotype
IGI: Inferred from genetic interaction
IEP: Inferred from expression pattern
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KATNA1 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
KATNA1 | O75449 | KATNB1 | Homo sapiens | Q9BVA0 | 28514442 | |
|
Intra
|
KATNA1 | O75449 | KATNB1 | Homo sapiens | Q9BVA0 | 26496610 | |
|
Intra
|
KATNA1 | O75449 | KATNB1 | Homo sapiens | Q9BVA0 | 26929214 | |
|
Intra
|
KATNA1 | O75449 | KATNB1 | Homo sapiens | Q9BVA0 | 26929214 | |
|
Intra
|
KATNA1 | O75449 | KATNB1 | Homo sapiens | Q9BVA0 | 33961781 | |
|
Intra
|
KATNA1 | O75449 | KATNBL1 | Homo sapiens | Q9H079 | 26929214 | |
|
Intra
|
KATNA1 | O75449 | KATNBL1 | Homo sapiens | Q9H079 | 26929214 | |
|
Intra
|
KATNA1 | O75449 | KATNBL1 | Homo sapiens | Q9H079 | 26496610 | |
|
Intra
|
KATNA1 | O75449 | KATNBL1 | Homo sapiens | Q9H079 | 33961781 |
Cross: Cross-species interaction
Intra: Intraspecies interaction
KATNA1 Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P81766 | p60 Katanin Antibody (YA1511) | WB | Human |
| HY-P81766A | p60 Katanin Antibody (YA1511)(PBS only) | WB | Human |