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TADA2A - transcriptional adaptor 2A Gene

Also Known as ADA2; ADA2A; KL04P; hADA2; TADA2L

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6871

About TADA2A

Cytogenetic location: 17q12 Genomic coordinates (GRCh38): 17:37,406,886-37,479,725 (from NCBI)

This gene has 16 transcripts (splice variants), 1 gene allele, 218 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 5.3), brain (RPKM 4.5) and 25 other tissues.

Summary

Many DNA-binding transcriptional activator proteins enhance the initiation rate of RNA polymerase II-mediated gene transcription by interacting functionally with the general transcription machinery bound at the basal promoter. Adaptor proteins are usually required for this activation, possibly to acetylate and destabilize nucleosomes, thereby relieving chromatin constraints at the promoter. The protein encoded by this gene is a transcriptional activator adaptor and has been found to be part of the PCAF histone acetylase complex. Several alternatively spliced transcript variants encoding different isoforms of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Oct 2009]

TADA2A Products (4)

mRNA	Protein	Name
NM_001166105.3	NP_001159577.2	transcriptional adapter 2-alpha isoform a
NM_001291918.2	NP_001278847.1	transcriptional adapter 2-alpha isoform b
NM_001488.5	NP_001479.4	transcriptional adapter 2-alpha isoform a
NM_133439.4	NP_597683.3	transcriptional adapter 2-alpha isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
contributes to histone acetyltransferase activity	IDA IDA: Inferred from direct assay	9674425	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	19936620	GOA
involved in regulation of cell cycle	IMP IMP: Inferred from mutant phenotype	19103755	GOA
involved in regulation of cell division	IDA IDA: Inferred from direct assay	20562830	GOA
involved in regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	22055187	GOA
involved in regulation of tubulin deacetylation	IMP IMP: Inferred from mutant phenotype	20562830	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of ATAC complex	IDA IDA: Inferred from direct assay	19936620	GOA
part of SAGA complex	IDA IDA: Inferred from direct assay	9674425	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TADA2A Protein Structure

Myb_DNA-binding

SWIRM

0
100
200
300
400
443 a.a.

Protein Preferred Names	Protein Names
transcriptional adapter 2-alpha	ADA2-like protein

TADA2A Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TADA2A	O75478	CCHCR1	Homo sapiens	Q8TD31-3	Validated Y2H	25416956
Intra	TADA2A	O75478	RTL8B	Homo sapiens	Q17RB0	Y2H Array	25416956
Intra	TADA2A	O75478	FBF1	Homo sapiens	Q8TES7-6	Validated Y2H	25416956
Intra	TADA2A	O75478	FBF1	Homo sapiens	Q8TES7-6	Y2H Array	25416956
Intra	TADA2A	O75478	ZNF564	Homo sapiens	Q8TBZ8	Y2H Prey Pooling	25416956
Intra	TADA2A	O75478	ZNF564	Homo sapiens	Q8TBZ8	Y2H Array	25416956
Intra	TADA2A	O75478	PPP1R16B	Homo sapiens	Q96T49	Validated Y2H	25416956
Intra	TADA2A	O75478	PPP1R16B	Homo sapiens	Q96T49	Y2H Prey Pooling	25416956
Intra	TADA2A	O75478	PPP1R16B	Homo sapiens	Q96T49	Y2H Array	25416956
Intra	TADA2A	O75478	MFAP1	Homo sapiens	P55081	Validated Y2H	25416956
Intra	TADA2A	O75478	MFAP1	Homo sapiens	P55081	Y2H Array	25416956
Intra	TADA2A	O75478	MFAP1	Homo sapiens	P55081	Y2H Prey Pooling	25416956
Intra	TADA2A	O75478	SF3A3	Homo sapiens	Q12874	Validated Y2H	25416956
Intra	TADA2A	O75478	PRPF31	Homo sapiens	Q8WWY3	Y2H Array	25416956
Intra	TADA2A	O75478	PRPF31	Homo sapiens	Q8WWY3	Validated Y2H	25416956
Intra	TADA2A	O75478	THOC1	Homo sapiens	Q96FV9	Validated Y2H	32296183
Intra	TADA2A	O75478	MKRN3	Homo sapiens	Q13064	Validated Y2H	32296183
Intra	TADA2A	O75478	TTC9C	Homo sapiens	Q8N5M4	Y2H Prey Pooling	25416956
Intra	TADA2A	O75478	MAGOH	Homo sapiens	P61326	Y2H Prey Pooling	25416956
Intra	TADA2A	O75478	MAGOH	Homo sapiens	P61326	Y2H Array	25416956
Intra	TADA2A	O75478	QARS1	Homo sapiens	P47897	Validated Y2H	32296183
Intra	TADA2A	O75478	GPSM3	Homo sapiens	Q9Y4H4	Y2H Prey Pooling	25416956
Intra	TADA2A	O75478	GPSM3	Homo sapiens	Q9Y4H4	Validated Y2H	25416956
Intra	TADA2A	O75478	KPNA2	Homo sapiens	P52292	Y2H Prey Pooling	25416956
Intra	TADA2A	O75478	AATF	Homo sapiens	Q9NY61	Y2H	29232376
Intra	TADA2A	O75478	EIF4E2	Homo sapiens	O60573	Validated Y2H	25416956
Intra	TADA2A	O75478	EIF4E2	Homo sapiens	O60573	Y2H Array	25416956
Intra	TADA2A	O75478	TADA3	Homo sapiens	O75528	Y2H Pooling	16189514
Intra	TADA2A	O75478	KAT2A	Homo sapiens	Q92830	Anti Bait CoIP	20562830
Intra	TADA2A	O75478	KAT2A	Homo sapiens	Q92830	Anti Tag CoIP	33961781
Intra	TADA2A	O75478	KAT2A	Homo sapiens	Q92830	Anti Bait CoIP	20508642
Intra	TADA2A	O75478	CDCA7L	Homo sapiens	Q96GN5	Y2H Array	25416956
Intra	TADA2A	O75478	CDCA7L	Homo sapiens	Q96GN5	Validated Y2H	25416956
Intra	TADA2A	O75478	KLHL38	Homo sapiens	Q2WGJ6	Y2H Prey Pooling	25416956
Intra	TADA2A	O75478	TTC23	Homo sapiens	Q5W5X9	Validated Y2H	25416956
Intra	TADA2A	O75478	HGS	Homo sapiens	O14964	Y2H Pooling	16189514
Intra	TADA2A	O75478	ZNF417	Homo sapiens	Q8TAU3	Validated Y2H	32296183
Intra	TADA2A	O75478	MTX2	Homo sapiens	O75431	Validated Y2H	25416956
Intra	TADA2A	O75478	VPS25	Homo sapiens	Q9BRG1	Validated Y2H	32296183
Intra	TADA2A	O75478	CCDC116	Homo sapiens	Q8IYX3	Validated Y2H	32296183
Intra	TADA2A	O75478	MAGOHB	Homo sapiens	Q96A72	Validated Y2H	32296183
Intra	TADA2A	O75478	ZCCHC12	Homo sapiens	Q6PEW1	Validated Y2H	32296183
Intra	TADA2A	O75478	TEKT4	Homo sapiens	Q8WW24	Y2H Array	25416956
Intra	TADA2A	O75478	LMO1	Homo sapiens	P25800	Validated Y2H	32296183
Intra	TADA2A	O75478	AIRIM	Homo sapiens	Q9NX04	Validated Y2H	32296183
Intra	TADA2A	O75478	AIRIM	Homo sapiens	Q9NX04	Validated Y2H	25416956
Intra	TADA2A	O75478	AIRIM	Homo sapiens	Q9NX04	Y2H Prey Pooling	32296183
Intra	TADA2A	O75478	ZFYVE26	Homo sapiens	Q68DK2-5	Validated Y2H	25416956
Intra	TADA2A	O75478	ZFYVE26	Homo sapiens	Q68DK2-5	Y2H Prey Pooling	25416956
Intra	TADA2A	O75478	KLC4	Homo sapiens	Q9NSK0	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Chromosome 17q12 Deletion Syndrome	17q12 Microdeletion Syndrome Del(17)(Q12) Monosomy 17q12

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14154	TADA2A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	TADA2A	VGNC	VGNC:78086
Canis familiaris	TADA2A	VGNC	VGNC:47070
Rattus norvegicus	TADA2A	RGD	RGD:1309959
Mus musculus	TADA2A	MGD	MGI:2144471
Bos taurus	TADA2A	VGNC	VGNC:35565
Felis catus	TADA2A	VGNC	VGNC:99555
Others	TADA2A	NCBI