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  3. TADA2A - transcriptional adaptor 2A Gene

TADA2A - transcriptional adaptor 2A Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as ADA2; ADA2A; KL04P; hADA2; TADA2L

Gene ID: 6871 | Gene type: protein coding

About TADA2A

Cytogenetic location: 17q12 Genomic coordinates (GRCh38): 17:37,406,886-37,479,725 (from NCBI)

This gene has 16 transcripts (splice variants), 1 gene allele, 218 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 5.3), brain (RPKM 4.5) and 25 other tissues.

Summary

Many DNA-binding transcriptional activator proteins enhance the initiation rate of RNA polymerase II-mediated gene transcription by interacting functionally with the general transcription machinery bound at the basal promoter. Adaptor proteins are usually required for this activation, possibly to acetylate and destabilize nucleosomes, thereby relieving chromatin constraints at the promoter. The protein encoded by this gene is a transcriptional activator adaptor and has been found to be part of the PCAF histone acetylase complex. Several alternatively spliced transcript variants encoding different isoforms of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Oct 2009]

TADA2A Products(4)

mRNA Protein Name
NM_001166105.3 NP_001159577.2 transcriptional adapter 2-alpha isoform a
NM_001291918.2 NP_001278847.1 transcriptional adapter 2-alpha isoform b
NM_001488.5 NP_001479.4 transcriptional adapter 2-alpha isoform a
NM_133439.4 NP_597683.3 transcriptional adapter 2-alpha isoform b

TADA2A Protein Structure

Myb_DNA-binding

Myb_DNA-binding: Myb-like DNA-binding domain (74 - 117)

SWIRM

SWIRM: SWIRM domain (365 - 441)

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  • 400
  • 443 a.a.
Protein Preferred Names Protein Names

transcriptional adapter 2-alpha

ADA2-like protein

Related Diseases

Diseases Alias
Chromosome 17q12 Deletion Syndrome

17q12 Microdeletion Syndrome

Del(17)(Q12)

Monosomy 17q12
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS14154 TADA2A Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta TADA2A VGNC VGNC:78086
Canis familiaris TADA2A VGNC VGNC:47070
Rattus norvegicus TADA2A RGD RGD:1309959
Mus musculus TADA2A MGD MGI:2144471
Bos taurus TADA2A VGNC VGNC:35565
Felis catus TADA2A VGNC VGNC:99555