THOC1 - THO complex subunit 1 Gene

Also Known as P84; HPR1; P84N5

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9984

About THOC1

Cytogenetic location: 18p11.32 Genomic coordinates (GRCh38): 18:214,520-268,047 (from NCBI)

This gene has 19 transcripts (splice variants) and 221 orthologues. Ubiquitous expression in testis (RPKM 6.7), bone marrow (RPKM 6.1) and 25 other tissues.

Summary

HPR1 is part of the TREX (transcription/export) complex, which includes TEX1 (MIM 606929), THO2 (MIM 300395), ALY (MIM 604171), and UAP56 (MIM 142560).[supplied by OMIM, Nov 2010]

THOC1 Products (1)

mRNA Protein Name
NM_005131.3 NP_005122.2 THO complex subunit 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15870275 GOA
Biological Process GO Annotation Evidence References Source
involved in mRNA export from nucleus IMP
IMP: Inferred from mutant phenotype
22144908 GOA
Cellular Component GO Annotation Evidence References Source
part of THO complex IDA
IDA: Inferred from direct assay
15998806 GOA
part of THO complex part of transcription export complex IDA
IDA: Inferred from direct assay
15998806 GOA
colocalizes with chromosome, telomeric region IDA
IDA: Inferred from direct assay
24270157 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
15358532 GOA
located in nucleus IDA
IDA: Inferred from direct assay
15358532 GOA
part of transcription export complex IDA
IDA: Inferred from direct assay
15833825 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

THOC1 Protein Structure

efThoc1

efThoc1: THO complex subunit 1 transcription elongation factor (71 - 552)

Death

Death: Death domain (573 - 651)

  • 0
  • 200
  • 400
  • 600
  • 657 a.a.
Protein Preferred Names Protein Names

THO complex subunit 1

  • THO complex 1

THOC1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
THOC1 Q96FV9 REL Homo sapiens Q04864-2
Y2H Array
32296183
Intra
THOC1 Q96FV9 REL Homo sapiens Q04864-2
Y2H Prey Pooling
32296183
Intra
THOC1 Q96FV9 GPRASP3 Homo sapiens Q6PI77
Y2H Array
32296183
Intra
THOC1 Q96FV9 GPRASP3 Homo sapiens Q6PI77
Y2H Prey Pooling
32296183
Intra
THOC1 Q96FV9 AKAP9 Homo sapiens Q6PJH3
Y2H Array
32296183
Intra
THOC1 Q96FV9 CTAG1A Homo sapiens P78358
Y2H Prey Pooling
32296183
Intra
THOC1 Q96FV9 CTAG1A Homo sapiens P78358
Y2H Array
32296183
Intra
THOC1 Q96FV9 ZMYND12 Homo sapiens Q9H0C1
Y2H Array
32296183
Intra
THOC1 Q96FV9 ZMYND12 Homo sapiens Q9H0C1
Validated Y2H
32296183
Intra
THOC1 Q96FV9 THOC5 Homo sapiens Q13769
Anti Bait CoIP
23299939
Intra
THOC1 Q96FV9 THOC5 Homo sapiens Q13769
Anti Tag CoIP
26496610
Intra
THOC1 Q96FV9 THOC5 Homo sapiens Q13769
Y2H
22365833
Intra
THOC1 Q96FV9 THOC5 Homo sapiens Q13769
Anti Tag CoIP
28514442
Intra
THOC1 Q96FV9 THOC5 Homo sapiens Q13769
Anti Tag CoIP
33961781
Intra
THOC1 Q96FV9 THOC5 Homo sapiens Q13769
IF
19165146
Intra
THOC1 Q96FV9 THOC5 Homo sapiens Q13769
Anti Bait CoIP
19165146
Intra
THOC1 Q96FV9 AGR2 Homo sapiens O95994
Y2H Prey Pooling
32296183
Intra
THOC1 Q96FV9 AGR2 Homo sapiens O95994
Y2H Array
32296183
Intra
THOC1 Q96FV9 TRIM27 Homo sapiens P14373
Y2H Prey Pooling
32296183
Intra
THOC1 Q96FV9 TRIM27 Homo sapiens P14373
Y2H Array
32296183
Intra
THOC1 Q96FV9 PPP1R12C Homo sapiens Q9BZL4
Y2H Array
32296183
Intra
THOC1 Q96FV9 PPP1R12C Homo sapiens Q9BZL4
Y2H Prey Pooling
32296183
Intra
THOC1 Q96FV9 PPP1R12C Homo sapiens Q9BZL4
Validated Y2H
32296183
Intra
THOC1 Q96FV9 MOAP1 Homo sapiens Q96BY2
Y2H Array
25416956
Intra
THOC1 Q96FV9 MOAP1 Homo sapiens Q96BY2
Validated Y2H
25416956
Intra
THOC1 Q96FV9 MOAP1 Homo sapiens Q96BY2
Y2H Array
31515488
Intra
THOC1 Q96FV9 MOAP1 Homo sapiens Q96BY2
Y2H Prey Pooling
25416956
Intra
THOC1 Q96FV9 USHBP1 Homo sapiens Q8N6Y0
Y2H Prey Pooling
25416956
Intra
THOC1 Q96FV9 TADA2A Homo sapiens O75478
Y2H Prey Pooling
32296183
Intra
THOC1 Q96FV9 TADA2A Homo sapiens O75478
Y2H Array
32296183
Intra
THOC1 Q96FV9 PAX6 Homo sapiens P26367
Y2H Array
32296183
Intra
THOC1 Q96FV9 PAX6 Homo sapiens P26367
Y2H Prey Pooling
32296183
Intra
THOC1 Q96FV9 MAGEB4 Homo sapiens O15481
Y2H Array
32296183
Intra
THOC1 Q96FV9 MAGEB4 Homo sapiens O15481
Y2H Prey Pooling
32296183
Intra
THOC1 Q96FV9 RABGEF1 Homo sapiens Q9UJ41
Y2H Prey Pooling
25416956
Intra
THOC1 Q96FV9 EXOC5 Homo sapiens O00471
Y2H Prey Pooling
32296183
Intra
THOC1 Q96FV9 EXOC5 Homo sapiens O00471
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

THOC1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P81479 Nuclear Matrix Protein p84 Antibody (YA1224) IHC-P Human
HY-P81479A Nuclear Matrix Protein p84 Antibody (YA1224)(PBS only) IHC-P Human
HY-P81692 Nuclear Matrix Protein p84 Antibody (YA1437) WB, ICC/IF Human
HY-P81692A Nuclear Matrix Protein p84 Antibody (YA1437)(PBS only) WB, ICC/IF Human

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14491 THOC1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta THOC1 VGNC VGNC:79175
Canis familiaris THOC1 VGNC VGNC:47348
Bos taurus THOC1 VGNC VGNC:35840
Mus musculus THOC1 MGD MGI:1919668
Felis catus THOC1 VGNC VGNC:66166
Rattus norvegicus THOC1 RGD RGD:1308657
Others THOC1 NCBI