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VPS25 - vacuolar protein sorting 25 homolog Gene

Also Known as DERP9; EAP20; FAP20

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 84313

About VPS25

Cytogenetic location: 17q21.2 Genomic coordinates (GRCh38): 17:42,773,449-42,779,599 (from NCBI)

This gene has 6 transcripts (splice variants) and 186 orthologues. Ubiquitous expression in esophagus (RPKM 14.2), colon (RPKM 12.6) and 25 other tissues.

Summary

This gene encodes a protein that is a subunit of the endosomal sorting complex required for transport II (ESCRT-II). This protein complex functions in sorting of ubiquitinated membrane proteins during endocytosis. A pseudogene of this gene is present on chromosome 1. [provided by RefSeq, Jul 2013]

VPS25 Products (1)

mRNA	Protein	Name
NM_032353.4	NP_115729.1	vacuolar protein-sorting-associated protein 25

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	14505570	GOA
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	14519844	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of epidermal growth factor-activated receptor activity	IMP IMP: Inferred from mutant phenotype	16973552	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of ESCRT II complex	IDA IDA: Inferred from direct assay	16973552	GOA
part of ESCRT II complex	IPI IPI: Inferred from physical interaction	18539118	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	16973552	GOA
located in cytosol	IDA IDA: Inferred from direct assay	17010938	GOA
located in endosome membrane	IDA IDA: Inferred from direct assay	16371348	GOA
located in nucleus	IDA IDA: Inferred from direct assay	16371348	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

VPS25 Protein Structure

ESCRT-II

0
100
176 a.a.

Protein Preferred Names	Protein Names
vacuolar protein-sorting-associated protein 25	ELL-associated protein of 20 kDa

VPS25 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	VPS25	Q9BRG1	CHMP6	Homo sapiens	Q96FZ7	Y2H Prey Pooling	32296183
Intra	VPS25	Q9BRG1	CHMP6	Homo sapiens	Q96FZ7	Y2H	16730941
Intra	VPS25	Q9BRG1	CHMP6	Homo sapiens	Q96FZ7	Y2H Array	32296183
Intra	VPS25	Q9BRG1	ASPG	Homo sapiens	Q86U10	Y2H Prey Pooling	32296183
Intra	VPS25	Q9BRG1	ASPG	Homo sapiens	Q86U10	Y2H Array	32296183
Intra	VPS25	Q9BRG1	SEPTIN14	Homo sapiens	Q6ZU15	Y2H Prey Pooling	32296183
Intra	VPS25	Q9BRG1	SEPTIN14	Homo sapiens	Q6ZU15	Y2H Array	32296183
Intra	VPS25	Q9BRG1	CRLF3	Homo sapiens	Q8IUI8	Y2H Prey Pooling	25416956
Intra	VPS25	Q9BRG1	CRLF3	Homo sapiens	Q8IUI8	Validated Y2H	25416956
Intra	VPS25	Q9BRG1	CRLF3	Homo sapiens	Q8IUI8	Y2H Prey Pooling	32296183
Intra	VPS25	Q9BRG1	CRLF3	Homo sapiens	Q8IUI8	Y2H Array	32296183
Intra	VPS25	Q9BRG1	REL	Homo sapiens	Q04864	Validated Y2H	25416956
Intra	VPS25	Q9BRG1	VPS36	Homo sapiens	Q86VN1	Anti Tag CoIP	33961781
Intra	VPS25	Q9BRG1	VPS36	Homo sapiens	Q86VN1	Y2H Prey Pooling	32296183
Intra	VPS25	Q9BRG1	VPS36	Homo sapiens	Q86VN1	Y2H Array	32296183
Intra	VPS25	Q9BRG1	VPS36	Homo sapiens	Q86VN1	Anti Tag CoIP	35271311
Intra	VPS25	Q9BRG1	SYCE1	Homo sapiens	Q8N0S2	Y2H Prey Pooling	32296183
Intra	VPS25	Q9BRG1	SYCE1	Homo sapiens	Q8N0S2	Y2H Array	32296183
Intra	VPS25	Q9BRG1	B9D2	Homo sapiens	Q9BPU9	Y2H Prey Pooling	32296183
Intra	VPS25	Q9BRG1	B9D2	Homo sapiens	Q9BPU9	Y2H Array	32296183
Intra	VPS25	Q9BRG1	TRIM27	Homo sapiens	P14373	Y2H Array	32296183
Intra	VPS25	Q9BRG1	TRIM27	Homo sapiens	P14373	Validated Y2H	25416956
Intra	VPS25	Q9BRG1	TRIM27	Homo sapiens	P14373	Y2H Prey Pooling	25416956
Intra	VPS25	Q9BRG1	TRIM27	Homo sapiens	P14373	Y2H Prey Pooling	32296183
Intra	VPS25	Q9BRG1	BEND5	Homo sapiens	Q7L4P6	Validated Y2H	25416956
Intra	VPS25	Q9BRG1	TADA2A	Homo sapiens	O75478	Y2H Array	32296183
Intra	VPS25	Q9BRG1	TADA2A	Homo sapiens	O75478	Y2H Prey Pooling	32296183
Intra	VPS25	Q9BRG1	SDCBP2	Homo sapiens	Q9H190	Validated Y2H	32296183
Intra	VPS25	Q9BRG1	SDCBP2	Homo sapiens	Q9H190	Y2H Array	32296183
Intra	VPS25	Q9BRG1	SDCBP2	Homo sapiens	Q9H190	Y2H Prey Pooling	32296183
Intra	VPS25	Q9BRG1	SPG21	Homo sapiens	Q9NZD8	Validated Y2H	32296183
Intra	VPS25	Q9BRG1	SPG21	Homo sapiens	Q9NZD8	Y2H Prey Pooling	32296183
Intra	VPS25	Q9BRG1	SPG21	Homo sapiens	Q9NZD8	Y2H Array	32296183
Intra	VPS25	Q9BRG1	SNF8	Homo sapiens	Q96H20	Anti Tag CoIP	35271311
Intra	VPS25	Q9BRG1	SNF8	Homo sapiens	Q96H20	Y2H	21516116
Intra	VPS25	Q9BRG1	SNF8	Homo sapiens	Q96H20	Y2H Array	31515488
Intra	VPS25	Q9BRG1	SNF8	Homo sapiens	Q96H20	Y2H Prey Pooling	25416956
Intra	VPS25	Q9BRG1	SNF8	Homo sapiens	Q96H20	Validated Y2H	25416956
Intra	VPS25	Q9BRG1	SNF8	Homo sapiens	Q96H20	Y2H Prey Pooling	32296183
Intra	VPS25	Q9BRG1	SNF8	Homo sapiens	Q96H20	Y2H Array	32296183
Intra	VPS25	Q9BRG1	SNF8	Homo sapiens	Q96H20	Y2H Array	25416956
Intra	VPS25	Q9BRG1	SNF8	Homo sapiens	Q96H20	Anti Tag CoIP	33961781
Intra	VPS25	Q9BRG1	PICK1	Homo sapiens	Q9NRD5	Y2H Array	32296183
Intra	VPS25	Q9BRG1	PICK1	Homo sapiens	Q9NRD5	Validated Y2H	32296183
Intra	VPS25	Q9BRG1	PICK1	Homo sapiens	Q9NRD5	Y2H Prey Pooling	32296183
Intra	VPS25	Q9BRG1	BPIFA1	Homo sapiens	Q9NP55	Validated Y2H	32296183
Intra	VPS25	Q9BRG1	BPIFA1	Homo sapiens	Q9NP55	Y2H Array	32296183
Intra	VPS25	Q9BRG1	BPIFA1	Homo sapiens	Q9NP55	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 7	Ftd3 Frontotemporal Dementia, Chromosome 3-Linked Amyotrophic Lateral Sclerosis, Chmp2b-Related Chromosome 3-Linked Frontotemporal Dementia FTDALS7 Chmp2b-Related Frontotemporal Dementia Amyotrophic Lateral Sclerosis 17, Formerly Als17, Formerly Amyotrophic Lateral Sclerosis Type 17 Dtm1 Ftd-3 Ftd-Chmp2b Als17 Amyotrophic Lateral Sclerosis 17 Sclerosis, Lateral, Amyotrophic, Type 17 Dementia, Frontotemporal, Chromosome 3-Linked

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15678	VPS25 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	VPS25	MGD	MGI:106354
Felis catus	VPS25	VGNC	VGNC:99572
Bos taurus	VPS25	VGNC	VGNC:36813
Macaca mulatta	VPS25	VGNC	VGNC:79685
Rattus norvegicus	VPS25	RGD	RGD:1584685
Others	VPS25	NCBI