CRLF3 - cytokine receptor like factor 3 Gene

Also Known as FRWS; CRLM9; p48.2; CREME9; CYTOR4; CREME-9

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 51379

About CRLF3

Cytogenetic location: 17q11.2 Genomic coordinates (GRCh38): 17:30,782,684-30,824,692 (from NCBI)

This gene has 6 transcripts (splice variants), 203 orthologues and 1 paralogue. Broad expression in lymph node (RPKM 15.5), appendix (RPKM 12.1) and 24 other tissues.

Summary

This gene encodes a cytokine receptor-like factor that may negatively regulate cell cycle progression at the G0/G1 phase. Studies of the related rat protein suggest that it may regulate neuronal morphology and synaptic vesicle biogenesis. This gene is one of several genes located in the neurofibromatosis type I tumor suppressor region on the q arm of chromosome 17, a region that is subject to microdeletions, duplications, chromosomal breaks and rearrangements. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 2 and 5. [provided by RefSeq, Aug 2012]

CRLF3 Products (1)

mRNA	Protein	Name
NM_015986.4	NP_057070.3	cytokine receptor-like factor 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of G1/S transition of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	19427400	GOA
involved in negative regulation of cell growth	IDA IDA: Inferred from direct assay	19427400	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	19427400	GOA
involved in positive regulation of receptor signaling pathway via JAK-STAT	IDA IDA: Inferred from direct assay	19427400	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	19427400	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	19427400	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
cytokine receptor-like factor 3	cytokine receptor-like molecule 9

CRLF3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CRLF3	Q8IUI8	LGALS14	Homo sapiens	Q8TCE9	Validated Y2H	25416956
Intra	CRLF3	Q8IUI8	LGALS14	Homo sapiens	Q8TCE9	Validated Y2H	32296183
Intra	CRLF3	Q8IUI8	LGALS14	Homo sapiens	Q8TCE9	Y2H Array	25416956
Intra	CRLF3	Q8IUI8	MAT2A	Homo sapiens	P31153	Validated Y2H	32814053
Intra	CRLF3	Q8IUI8	MAT2A	Homo sapiens	P31153	Y2H Array	32814053
Intra	CRLF3	Q8IUI8	MAT2A	Homo sapiens	P31153	Y2H Pooling	32814053
Intra	CRLF3	Q8IUI8	JPH3	Homo sapiens	Q8WXH2	Validated Y2H	32814053
Intra	CRLF3	Q8IUI8	JPH3	Homo sapiens	Q8WXH2	Y2H Array	32814053
Intra	CRLF3	Q8IUI8	JPH3	Homo sapiens	Q8WXH2	Y2H Pooling	32814053
Intra	CRLF3	Q8IUI8	KIF1B	Homo sapiens	O60333-2	Validated Y2H	32814053
Intra	CRLF3	Q8IUI8	KIF1B	Homo sapiens	O60333-2	Y2H Pooling	32814053
Intra	CRLF3	Q8IUI8	KIF1B	Homo sapiens	O60333-2	Y2H Array	32814053
Intra	CRLF3	Q8IUI8	DMWD	Homo sapiens	G5E9A7	Y2H Pooling	32814053
Intra	CRLF3	Q8IUI8	DMWD	Homo sapiens	G5E9A7	Validated Y2H	32814053
Intra	CRLF3	Q8IUI8	DMWD	Homo sapiens	G5E9A7	Y2H Array	32814053
Intra	CRLF3	Q8IUI8	BAG6	Homo sapiens	P46379-2	Y2H Pooling	32814053
Intra	CRLF3	Q8IUI8	BAG6	Homo sapiens	P46379-2	Validated Y2H	32814053
Intra	CRLF3	Q8IUI8	BAG6	Homo sapiens	P46379-2	Y2H Array	32814053
Intra	CRLF3	Q8IUI8	KCTD21	Homo sapiens	Q4G0X4	Y2H Array	32296183
Intra	CRLF3	Q8IUI8	KCTD21	Homo sapiens	Q4G0X4	Y2H Prey Pooling	32296183
Intra	CRLF3	Q8IUI8	L3MBTL3	Homo sapiens	Q96JM7-2	Validated Y2H	32296183
Intra	CRLF3	Q8IUI8	L3MBTL3	Homo sapiens	Q96JM7-2	Y2H Array	32296183
Intra	CRLF3	Q8IUI8	L3MBTL3	Homo sapiens	Q96JM7-2	Y2H Prey Pooling	32296183
Intra	CRLF3	Q8IUI8	TSC1	Homo sapiens	Q86WV8	Validated Y2H	32814053
Intra	CRLF3	Q8IUI8	TSC1	Homo sapiens	Q86WV8	Y2H Array	32814053
Intra	CRLF3	Q8IUI8	TSC1	Homo sapiens	Q86WV8	Y2H Pooling	32814053
Intra	CRLF3	Q8IUI8	NOS3	Homo sapiens	P29474	Validated Y2H	32814053
Intra	CRLF3	Q8IUI8	NOS3	Homo sapiens	P29474	Y2H Array	32814053
Intra	CRLF3	Q8IUI8	NOS3	Homo sapiens	P29474	Y2H Pooling	32814053
Intra	CRLF3	Q8IUI8	VPS25	Homo sapiens	Q9BRG1	Y2H Prey Pooling	32296183
Intra	CRLF3	Q8IUI8	VPS25	Homo sapiens	Q9BRG1	Y2H Array	25416956
Intra	CRLF3	Q8IUI8	CRLF3	Homo sapiens	Q8IUI8	Y2H Prey Pooling	32296183
Intra	CRLF3	Q8IUI8	VPS25	Homo sapiens	Q9BRG1	Y2H Array	32296183
Intra	CRLF3	Q8IUI8	CRLF3	Homo sapiens	Q8IUI8	Validated Y2H	32296183
Intra	CRLF3	Q8IUI8	VPS25	Homo sapiens	Q9BRG1	Y2H Array	29892012
Intra	CRLF3	Q8IUI8	CRLF3	Homo sapiens	Q8IUI8	Y2H Array	25416956
Intra	CRLF3	Q8IUI8	VPS25	Homo sapiens	Q9BRG1	Validated Y2H	32296183
Intra	CRLF3	Q8IUI8	CRLF3	Homo sapiens	Q8IUI8	Y2H Array	32296183
Intra	CRLF3	Q8IUI8	HSPB1	Homo sapiens	P04792	Y2H Pooling	32814053
Intra	CRLF3	Q8IUI8	HSPB1	Homo sapiens	P04792	Validated Y2H	32814053
Intra	CRLF3	Q8IUI8	HSPB1	Homo sapiens	P04792	Y2H Array	32814053
Intra	CRLF3	Q8IUI8	SNRPB	Homo sapiens	P14678-2	Validated Y2H	32814053
Intra	CRLF3	Q8IUI8	SNRPB	Homo sapiens	P14678-2	Y2H Array	32814053
Intra	CRLF3	Q8IUI8	SNRPB	Homo sapiens	P14678-2	Y2H Pooling	32814053
Intra	CRLF3	Q8IUI8	NEFL	Homo sapiens	P07196	Validated Y2H	32814053
Intra	CRLF3	Q8IUI8	NEFL	Homo sapiens	P07196	Y2H Pooling	32814053
Intra	CRLF3	Q8IUI8	NEFL	Homo sapiens	P07196	Y2H Array	32814053
Intra	CRLF3	Q8IUI8	PMP22	Homo sapiens	A0A6Q8PF08	Validated Y2H	32814053
Intra	CRLF3	Q8IUI8	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Array	32814053
Intra	CRLF3	Q8IUI8	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Pooling	32814053
Intra	CRLF3	Q8IUI8	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	CRLF3	Q8IUI8	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	CRLF3	Q8IUI8	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	CRLF3	Q8IUI8	MYOZ3	Homo sapiens	Q8TDC0	Y2H Prey Pooling	32296183
Intra	CRLF3	Q8IUI8	MYOZ3	Homo sapiens	Q8TDC0	Validated Y2H	32296183
Intra	CRLF3	Q8IUI8	MYOZ3	Homo sapiens	Q8TDC0	Y2H Array	32296183
Intra	CRLF3	Q8IUI8	ICAM5	Homo sapiens	Q9UMF0	Validated Y2H	32814053
Intra	CRLF3	Q8IUI8	ICAM5	Homo sapiens	Q9UMF0	Y2H Array	32814053
Intra	CRLF3	Q8IUI8	ICAM5	Homo sapiens	Q9UMF0	Y2H Pooling	32814053
Intra	CRLF3	Q8IUI8	NDUFV2	Homo sapiens	P19404	Y2H Array	32814053
Intra	CRLF3	Q8IUI8	NDUFV2	Homo sapiens	P19404	Validated Y2H	32814053
Intra	CRLF3	Q8IUI8	NDUFV2	Homo sapiens	P19404	Y2H Pooling	32814053
Intra	CRLF3	Q8IUI8	PHYH	Homo sapiens	O14832	Validated Y2H	32814053
Intra	CRLF3	Q8IUI8	PHYH	Homo sapiens	O14832	Y2H Array	32814053
Intra	CRLF3	Q8IUI8	PHYH	Homo sapiens	O14832	Y2H Pooling	32814053
Intra	CRLF3	Q8IUI8	DDIT4L	Homo sapiens	Q96D03	Y2H Prey Pooling	32296183
Intra	CRLF3	Q8IUI8	DDIT4L	Homo sapiens	Q96D03	Validated Y2H	32296183
Intra	CRLF3	Q8IUI8	DDIT4L	Homo sapiens	Q96D03	Y2H Array	32296183
Intra	CRLF3	Q8IUI8	GFAP	Homo sapiens	P14136	Y2H Pooling	32814053
Intra	CRLF3	Q8IUI8	GFAP	Homo sapiens	P14136	Validated Y2H	32814053
Intra	CRLF3	Q8IUI8	GFAP	Homo sapiens	P14136	Y2H Array	32814053
Intra	CRLF3	Q8IUI8	PRPS1	Homo sapiens	P60891	Y2H Pooling	32814053
Intra	CRLF3	Q8IUI8	PRPS1	Homo sapiens	P60891	Validated Y2H	32814053
Intra	CRLF3	Q8IUI8	PRPS1	Homo sapiens	P60891	Y2H Array	32814053
Intra	CRLF3	Q8IUI8	RBM14	Homo sapiens	Q96PK6	Validated Y2H	26871637
Intra	CRLF3	Q8IUI8	FLNA	Homo sapiens	P21333-2	Y2H Array	32814053
Intra	CRLF3	Q8IUI8	FLNA	Homo sapiens	P21333-2	Validated Y2H	32814053
Intra	CRLF3	Q8IUI8	FLNA	Homo sapiens	P21333-2	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

CRLF3 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P86824	CRLF3 Antibody (YA6517)	WB, ICC/IF	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Neurofibromatosis	Neurofibromatoses Acoustic Neurofibromatosis Central Neurofibromatosis Peripheral Neurofibromatosis Recklinghausen'S Neurofibromatosis Von Reklinghausen Disease Neurofibromatosis Type 1
Actinic Keratosis	Solar Keratosis Actinic Keratosis Senile Hyperkeratosis Sk - Solar Keratosis Keratosis, Actinic Seborrheic Keratosis Ak - [Actinic Keratosis] Sk - [Solar Keratosis]
Neurofibromatosis, Type I	Von Recklinghausen Disease Neurofibromatosis 1 Neurofibromatosis, Type 1 NF1 Neurofibromatosis, Peripheral Type Neurofibromatosis Type I Neurofibromatosis Type 1 Due To Nf1 Mutation Or Intragenic Deletion Familial Spinal Neurofibromatosis Fsnf Peripheral Neurofibromatosis Von Recklinghausen'S Neurofibromatosis Von Recklinghausen Disease Due To Nf1 Mutation Or Intragenic Deletion Neurofibromatosis Peripheral Type Von Recklinghausen Syndrome Neurofibromatosis Type 1 Von Recklinghausen Neuropathy Nf1 - [Neurofibromatosis Type 1] Recklinghausen Disease
Chromosome 17q11.2 Deletion Syndrome	Nf1 Microdeletion Syndrome 17q11 Microdeletion Syndrome Neurofibromatosis Type 1 Microdeletion Syndrome Van Asperen Syndrome Del(17)(Q11) Monosomy 17q11 Chromosome 17q11.2 Deletion Syndrome, 1.4mb
Chromosome 15q26-Qter Deletion Syndrome	Drayer Syndrome 15q26 Deletion Syndrome Distal 15q Deletion Syndrome Distal Monosomy 15q Telomeric 15q Deletion Syndrome Monosomy 15q26
Epiphyseal Dysplasia, Multiple, 5	EDM5 Multiple Epiphyseal Dysplasia 5 Bhmed Multiple Epiphyseal Dysplasia Type 5 Multiple Epiphyseal Dysplasia, Matn3-Related Microepiphyseal Dysplasia, Bilateral Hereditary Bilateral Hereditary Microepiphyseal Dysplasia Multiple Epiphyseal Dysplasia Matn3-Related Epiphyseal Dysplasia Multiple 5 Multiple Epiphyseal Dysplasia, Matn3 Related Bilateral Hereditary Micro-Epiphyseal Dysplasia Med5 Polyepiphyseal Dysplasia Type 5 Dysplasia, Epiphyseal, Multiple, Type 5
Dysgraphia	Agraphia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03188	CRLF3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26177	Ggps1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	CRLF3	VGNC	VGNC:39622
Felis catus	CRLF3	VGNC	VGNC:61184
Macaca mulatta	CRLF3	VGNC	VGNC:71428
Rattus norvegicus	CRLF3	RGD	RGD:621517
Mus musculus	CRLF3	MGD	MGI:1860086
Bos taurus	CRLF3	VGNC	VGNC:27718
Others	CRLF3	NCBI