KCTD21 - potassium channel tetramerization domain containing 21 Gene
Also Known as KCASH2
Species: Homo sapiens
Gene Type: protein coding
Gene ID: 283219
Summary
Enables cullin family protein binding activity; histone deacetylase binding activity; and identical protein binding activity. Involved in negative regulation of smoothened signaling pathway and ubiquitin-dependent protein catabolic process. [provided by Alliance of Genome Resources, Jul 2025]
Ubiquitous expression in thyroid (RPKM 3.5), brain (RPKM 3.4) and 25 other tissues.
KCTD21 Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_001029859.3 | NP_001025030.1 | BTB/POZ domain-containing protein KCTD21 |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables cullin family protein binding |
IDA
IDA: Inferred from direct assay
|
21472142 | GOA |
| enables histone deacetylase binding |
IDA
IDA: Inferred from direct assay
|
21472142 | GOA |
| enables identical protein binding |
IPI
IPI: Inferred from physical interaction
|
21472142 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
32296183 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in negative regulation of smoothened signaling pathway |
IDA
IDA: Inferred from direct assay
|
21472142 | GOA |
| involved in ubiquitin-dependent protein catabolic process |
IDA
IDA: Inferred from direct assay
|
21472142 | GOA |
EXP: Inferred from Experiment
IDA: Inferred from direct assay
IPI: Inferred from physical interaction
IMP: Inferred from mutant phenotype
IGI: Inferred from genetic interaction
IEP: Inferred from expression pattern
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KCTD21 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
KCTD21 | Q4G0X4 | NMRK1 | Homo sapiens | Q9NWW6 | 32296183 | |
|
Intra
|
KCTD21 | Q4G0X4 | KCTD21 | Homo sapiens | Q4G0X4 | 32296183 | |
|
Intra
|
KCTD21 | Q4G0X4 | RNF25 | Homo sapiens | Q96BH1 | 32296183 | |
|
Intra
|
KCTD21 | Q4G0X4 | NTAQ1 | Homo sapiens | Q96HA8 | 32296183 | |
|
Intra
|
KCTD21 | Q4G0X4 | KCTD21 | Homo sapiens | Q4G0X4 | 32296183 | |
|
Intra
|
KCTD21 | Q4G0X4 | CRLF3 | Homo sapiens | Q8IUI8 | 32296183 | |
|
Intra
|
KCTD21 | Q4G0X4 | KCTD21 | Homo sapiens | Q4G0X4 | 32296183 | |
|
Intra
|
KCTD21 | Q4G0X4 | C22orf15 | Homo sapiens | Q8WYQ4-2 | 32296183 | |
|
Intra
|
KCTD21 | Q4G0X4 | ZMYND19 | Homo sapiens | Q96E35 | 32296183 | |
|
Intra
|
KCTD21 | Q4G0X4 | KCTD21 | Homo sapiens | Q4G0X4 | 21472142 |
Cross: Cross-species interaction
Intra: Intraspecies interaction
KCTD21 Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P83389 | KCTD21 Antibody (YA3134) | WB | Human, Mouse, Rat |
| HY-P83389A | KCTD21 Antibody (YA3134)(PBS only) | WB | Human, Mouse, Rat |