NMRK1 - nicotinamide riboside kinase 1 Gene

Also Known as NRK1; C9orf95; bA235O14.2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 54981

About NMRK1

Cytogenetic location: 9q21.13 Genomic coordinates (GRCh38): 9:75,060,577-75,088,155 (from NCBI)

This gene has 7 transcripts (splice variants), 184 orthologues and 3 paralogues. Ubiquitous expression in thyroid (RPKM 7.5), skin (RPKM 6.5) and 25 other tissues.

Summary

Nicotinamide adenine dinucleotide (NAD+) is essential for life in all organisms, both as a coenzyme for oxidoreductases and as a source of ADP-ribosyl groups used in various reactions. Nicotinic acid and nicotinamide, collectively known as niacin, are the vitamin precursors of NAD+. Nicotinamide riboside kinases, such as NRK1, function to synthesize NAD+ through nicotinamide mononucleotide using nicotinamide riboside as the precursor (Bieganowski and Brenner, 2004 [PubMed 15137942]).[supplied by OMIM, Mar 2008]

NMRK1 Products (4)

mRNA Protein Name
NM_001127603.2 NP_001121075.1 nicotinamide riboside kinase 1 isoform 2
NM_001330678.2 NP_001317607.1 nicotinamide riboside kinase 1 isoform 3
NM_001330679.2 NP_001317608.1 nicotinamide riboside kinase 1 isoform 3
NM_017881.3 NP_060351.1 nicotinamide riboside kinase 1 isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
enables ribosylnicotinamide kinase activity EXP
EXP: Inferred from Experiment
15137942 GOA
enables ribosylnicotinate kinase activity EXP
EXP: Inferred from Experiment
15137942 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NMRK1 Protein Structure

AAA_18

AAA_18: AAA domain (6 - 140)

  • 0
  • 100
  • 199 a.a.
Protein Preferred Names Protein Names

nicotinamide riboside kinase 1

  • NRK 1

NMRK1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
NMRK1 Q9NWW6 REL Homo sapiens Q04864-2
Y2H Prey Pooling
32296183
Intra
NMRK1 Q9NWW6 REL Homo sapiens Q04864-2
Y2H Array
32296183
Intra
NMRK1 Q9NWW6 KCTD21 Homo sapiens Q4G0X4
Y2H Array
32296183
Intra
NMRK1 Q9NWW6 KCTD21 Homo sapiens Q4G0X4
Y2H Prey Pooling
32296183
Intra
NMRK1 Q9NWW6 TAX1BP1 Homo sapiens Q86VP1
Y2H Array
32296183
Intra
NMRK1 Q9NWW6 TAX1BP1 Homo sapiens Q86VP1
Y2H Prey Pooling
32296183
Intra
NMRK1 Q9NWW6 TAX1BP1 Homo sapiens Q86VP1
Validated Y2H
25416956
Intra
NMRK1 Q9NWW6 INCA1 Homo sapiens Q0VD86
Y2H Array
32296183
Intra
NMRK1 Q9NWW6 INCA1 Homo sapiens Q0VD86
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09386 NMRK1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22680 Nmrk1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29194 Nmrk1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus NMRK1 RGD RGD:1564687
Bos taurus NMRK1 VGNC VGNC:32135
Canis familiaris NMRK1 VGNC VGNC:43865
Mus musculus NMRK1 MGD MGI:2147434
Macaca mulatta NMRK1 VGNC VGNC:75262
Felis catus NMRK1 VGNC VGNC:102955