MAT2A - methionine adenosyltransferase 2A Gene

Also Known as MATA2; MATII; SAMS2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4144

About MAT2A

Cytogenetic location: 2p11.2 Genomic coordinates (GRCh38): 2:85,539,168-85,545,281 (from NCBI)

This gene has 6 transcripts (splice variants), 292 orthologues, 1 paralogue and is associated with 1 phenotype. Ubiquitous expression in thyroid (RPKM 234.0), adrenal (RPKM 141.3) and 25 other tissues.

Summary

The protein encoded by this gene catalyzes the production of S-adenosylmethionine (AdoMet) from methionine and ATP. AdoMet is the key methyl donor in cellular processes. [provided by RefSeq, Jun 2011]

MAT2A Products (1)

mRNA	Protein	Name
NM_005911.6	NP_005902.1	S-adenosylmethionine synthase isoform type-2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables methionine adenosyltransferase activity	IDA IDA: Inferred from direct assay	7665609	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10644686	GOA
enables small molecule binding	EXP EXP: Inferred from Experiment	26858410	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in S-adenosylmethionine biosynthetic process	IDA IDA: Inferred from direct assay	10644686	GOA
involved in cellular response to methionine	IDA IDA: Inferred from direct assay	38006878	GOA
involved in positive regulation of TORC1 signaling	IDA IDA: Inferred from direct assay	38006878	GOA
involved in protein heterooligomerization	IDA IDA: Inferred from direct assay	25075345	GOA
involved in protein hexamerization	IDA IDA: Inferred from direct assay	25075345	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of methionine adenosyltransferase complex	IDA IDA: Inferred from direct assay	10644686	GOA
part of methionine adenosyltransferase complex	IPI IPI: Inferred from physical interaction	25075345	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAT2A Protein Structure

S-AdoMet_synt_N

S-AdoMet_synt_M

S-AdoMet_synt_C

0
100
200
300
395 a.a.

Protein Preferred Names	Protein Names
S-adenosylmethionine synthase isoform type-2	MAT 2

MAT2A Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	MAT2A	P31153	MAT2B	Homo sapiens	Q9NZL9	Validated Y2H	25416956
Intra	MAT2A	P31153	MAT2B	Homo sapiens	Q9NZL9	Y2H Array	25416956
Intra	MAT2A	P31153	MAT2B	Homo sapiens	Q9NZL9	Anti Tag CoIP	33961781
Intra	MAT2A	P31153	MAT2B	Homo sapiens	Q9NZL9	Y2H Prey Pooling	25416956
Intra	MAT2A	P31153	MAT1A	Homo sapiens	Q00266	Y2H Array	32296183
Intra	MAT2A	P31153	MAT2A	Homo sapiens	P31153	Y2H Array	32296183
Intra	MAT2A	P31153	MAT2A	Homo sapiens	P31153	Y2H Prey Pooling	32296183
Intra	MAT2A	P31153	MAT1A	Homo sapiens	Q00266	Y2H Prey Pooling	32296183
Intra	MAT2A	P31153	MAT1A	Homo sapiens	Q00266	Validated Y2H	32296183
Intra	MAT2A	P31153	MAT2A	Homo sapiens	P31153	Validated Y2H	32296183
Intra	MAT2A	P31153	MAT2A	Homo sapiens	P31153	Y2H Array	25416956
Intra	MAT2A	P31153	IFI35	Homo sapiens	P80217-2	Y2H Array	32814053
Intra	MAT2A	P31153	IFI35	Homo sapiens	P80217-2	Y2H Pooling	32814053
Intra	MAT2A	P31153	IFI35	Homo sapiens	P80217-2	Validated Y2H	32814053
Intra	MAT2A	P31153	ZMYM6	Homo sapiens	O95789-4	Y2H Array	32814053
Intra	MAT2A	P31153	ZMYM6	Homo sapiens	O95789-4	Validated Y2H	32814053
Intra	MAT2A	P31153	ZMYM6	Homo sapiens	O95789-4	Y2H Pooling	32814053
Intra	MAT2A	P31153	KLF15	Homo sapiens	Q9UIH9	Validated Y2H	32814053
Intra	MAT2A	P31153	KLF15	Homo sapiens	Q9UIH9	Y2H Array	32814053
Intra	MAT2A	P31153	KLF15	Homo sapiens	Q9UIH9	Y2H Pooling	32814053
Intra	MAT2A	P31153	FAM117B	Homo sapiens	Q6P1L5	Y2H Array	32814053
Intra	MAT2A	P31153	FAM117B	Homo sapiens	Q6P1L5	Y2H Pooling	32814053
Intra	MAT2A	P31153	FAM117B	Homo sapiens	Q6P1L5	Validated Y2H	32814053
Intra	MAT2A	P31153	CAMK1G	Homo sapiens	Q96NX5	Y2H Pooling	32814053
Intra	MAT2A	P31153	CAMK1G	Homo sapiens	Q96NX5	Validated Y2H	32814053
Intra	MAT2A	P31153	CAMK1G	Homo sapiens	Q96NX5	Y2H Array	32814053
Intra	MAT2A	P31153	CCDC141	Homo sapiens	Q6ZP82-1	Validated Y2H	32814053
Intra	MAT2A	P31153	CCDC141	Homo sapiens	Q6ZP82-1	Y2H Pooling	32814053
Intra	MAT2A	P31153	CCDC141	Homo sapiens	Q6ZP82-1	Y2H Array	32814053
Intra	MAT2A	P31153	SNW1	Homo sapiens	Q13573	Validated Y2H	32814053
Intra	MAT2A	P31153	SNW1	Homo sapiens	Q13573	Y2H Array	32814053
Intra	MAT2A	P31153	SNW1	Homo sapiens	Q13573	Y2H Pooling	32814053
Intra	MAT2A	P31153	PRC1	Homo sapiens	O43663	Y2H Array	32296183
Intra	MAT2A	P31153	PRC1	Homo sapiens	O43663	Y2H Prey Pooling	32296183
Intra	MAT2A	P31153	RBM11	Homo sapiens	P57052	Validated Y2H	32814053
Intra	MAT2A	P31153	RBM11	Homo sapiens	P57052	Y2H Array	32814053
Intra	MAT2A	P31153	RBM11	Homo sapiens	P57052	Y2H Pooling	32814053
Intra	MAT2A	P31153	GATA1	Homo sapiens	P15976-2	Validated Y2H	32814053
Intra	MAT2A	P31153	GATA1	Homo sapiens	P15976-2	Y2H Array	32814053
Intra	MAT2A	P31153	GATA1	Homo sapiens	P15976-2	Y2H Pooling	32814053
Intra	MAT2A	P31153	MT2A	Homo sapiens	P02795	Validated Y2H	32814053
Intra	MAT2A	P31153	MT2A	Homo sapiens	P02795	Y2H Array	32814053
Intra	MAT2A	P31153	MT2A	Homo sapiens	P02795	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

MAT2A Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83181	MAT2A Antibody (YA2926)	WB, ICC/IF	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Glycine N-Methyltransferase Deficiency	GNMT DEFICIENCY Hypermethioninemia Due To Glycine N-Methyltransferase Deficiency Hypermethioninemia Due To Gnmt Deficiency Hypermethioninemia Hepatic Methionine Adenosyltransferase Deficiency
Aortic Aneurysm, Familial Thoracic 1	Thoracic Aortic Aneurysm Annuloaortic Ectasia Familial Thoracic Aortic Aneurysm And Aortic Dissection Familial Aortic Dissection Familial Taad Familial Thoracic Aortic Aneurysm Congenital Aneurysm Of Ascending Aorta Familial Aortic Aneurysm Familial Thoracic Aortic Aneurysm And Dissection Aortic Aneurysm, Thoracic AAT1 Faa1 Aortic Dissection, Familial Aortic Aneurysm, Familial Thoracic Aneurysm, Thoracic Aortic Faa Ftaad Taa Taad Cystic Medial Necrosis Of Aorta Familial Non-Syndromic Thoracic Aortic Aneurysm And Aortic Dissection Aortic Aneurysm Thoracic Familial Aortic Aneurysms Aneurysm, Aortic, Thoracic, Familial, Type 1 Aneurysm Of Thoracic Aorta Intrathoracic Aneurysm Thoracic Aorta Aneurysm Thoracic Aortic Aneurysm Without Rupture Thoracic Aneurysm Thorax Arterial Aneurysm Thoracic Artery Aneurysm Thoracic Arterial Aneurysm Thorax Aneurysm Thorax Aortic Aneurysm Dissection Of Thoracic Aorta
Hypermethioninemia	Hepatic Methionine Adenosyltransferase Deficiency Deficiency Of Methionine Adenosyltransferase Glycine N-Methyltransferase Deficiency Met S-Adenosylhomocysteine Hydrolase Deficiency Gnmt Deficiency Mat Deficiency Methionine Adenosyltransferase Deficiency Methioninemia Deficiency Of Acetyl-Coa Acetyltransferase
Aortic Valve Disease 1	Aortic Valve Disease Bicuspid Aortic Valve Aortic Valve Disorder AOVD1 Bav Bicuspid Aortic Valve Disease Familial Bicuspid Aortic Valve Aortic Valve Calcification Aovd Aortic Valve, Bicuspid Aortic Valve, Calcification Of Aortic Stenosis, Calcific Familial Bav Calcific Aortic Stenosis Calcification Of Aortic Valve Abnormality Of The Aortic Valve Aortic Valve Disease, Type 1 Aortic Valve Disease 2 Bicommissural Aortic Valve
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Carcinoma, Hepatocellular Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Loeys-Dietz Syndrome	Loeys-Dietz Aortic Aneurysm Syndrome Lds Aortic Aneurysm Syndrome Due To Tgf-Beta Receptors Anomalies Furlong Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-138630	AG-270		99.97%	Phase 1
HY-112569	MAT2A inhibitor 2	Inhibitor	99.10%	Phase 1

Pre-clinical Phase

Bioactive Molecules (43)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-107778	PF-9366		99.94%	Unkown
HY-136144	FIDAS-5		98.46%	Unkown
HY-112130	AGI-24512	Inhibitor	99.46%	Unkown
HY-145778	AGI-41998	Inhibitor	98.72%	Unkown
HY-169257	SCR-7952	Inhibitor	99.77%	Unkown
HY-162353	AZ'9567		99.19%	Unkown
HY-145777	AGI-43192	Inhibitor	99.47%	Unkown
HY-112131	MAT2A inhibitor 1		99.57%	Unkown
HY-139139	MAT2A inhibitor 3		99.27%	Unkown
HY-136145	FIDAS-3	Inhibitor	99.40%	Unkown
HY-139536	MAT2A inhibitor 4		99.60%	Unkown
HY-RS16583	Mat2a Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS08167	MAT2A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23017	Mat2a Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-142928	MAT2A-IN-1	Inhibitor	/	Unkown
HY-142929	MAT2A-IN-2	Inhibitor	/	Unkown
HY-142930	MAT2A-IN-3	Inhibitor	/	Unkown
HY-144179	MAT2A-IN-4	Inhibitor	/	Unkown
HY-144181	MAT2A-IN-5	Inhibitor	/	Unkown
HY-144184	MAT2A-IN-6	Inhibitor	/	Unkown
HY-144185	MAT2A-IN-7	Inhibitor	/	Unkown
HY-149915	MAT2A-IN-10	Inhibitor	/	Unkown
HY-155148	MAT2A-IN-11	Inhibitor	/	Unkown
HY-155149	MAT2A-IN-12	Inhibitor	/	Unkown
HY-159156	MAT2A inhibitor 6		/	Unkown
HY-161298	MAT2A-IN-15	Inhibitor	/	Unkown
HY-162010	MAT2A-IN-13	Inhibitor	/	Unkown
HY-162135	MAT2A-IN-14		/	Unkown
HY-163656	MAT2A inhibitor 5	Inhibitor	98.80%	Unkown
HY-168445	MAT2A-IN-21	Inhibitor	/	Unkown
HY-170421	MAT2A-IN-16	Inhibitor	/	Unkown
HY-170500	MAT2A-IN-17	Inhibitor	/	Unkown
HY-170501	MAT2A-IN-18	Inhibitor	/	Unkown
HY-170502	MAT2A-IN-19	Inhibitor	/	Unkown
HY-170503	MAT2A-IN-20	Inhibitor	/	Unkown
HY-170905S	MAT2A-IN-22	Inhibitor	/	Unkown
HY-170906S	MAT2A-IN-23	Inhibitor	/	Unkown
HY-173281	MAT2A-IN-24	Inhibitor	/	Unkown
HY-179622	ZS34		/	Unkown
HY-181772	MCULE-3064932370	Inhibitor	/	Unkown
HY-182400	AGI-25696	Inhibitor	/	Unkown
HY-183568	MAT2A-IN-26	Inhibitor	/	Unkown
HY-181285	MAT2A ligand 1	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	MAT2A	VGNC	VGNC:50214
Canis familiaris	MAT2A	VGNC	VGNC:49922
Felis catus	MAT2A	VGNC	VGNC:68193
Rattus norvegicus	MAT2A	RGD	RGD:619985
Mus musculus	MAT2A	MGD	MGI:2443731
Macaca mulatta	MAT2A	VGNC	VGNC:74664
Others	MAT2A	NCBI